Advances in Structure, Function and Molecular Targeting of DNA Topoisomerases
This Special Issue, titled "Advances in Structure, Function and Molecular Targeting of DNA Topoisomerases", includes reports on new findings and topics of current interest in the topoisomerase field. Topics include structural, biochemical, and pharmacological studies and reviews for both eukaryotic and prokaryotic topoisomerases.
Biological Control of the Plant Pathogens
One of the greatest challenges facing agricultural scientists is developing efficient technologies for sustainable and eco-friendly management of crop losses caused by plant pathogens. The effectiveness of microbial biocontrol agents (BCAs) in ensuring food security has garnered global attention, both for halting pre-harvest crop losses and for enhancing crop yields. Harnessing the potential of BCAs could not only aid in the transition to sustainable agriculture, but it would ultimately benefit farmers by reducing the crop loss burden. Considering the recent developments in this area, this volume offers novel insights into the management strategies for major soilborne plant pathogens. Additionally, it explores the biocontrol potential of novel volatile compounds, defense inducers, and genetically engineered strains of BCAs.
Quantitative detection of equine babesiosis by molecular techniques
Equine babesiosis is one of the main parasitic diseases of horses and causes great damage to animal health, so detecting it as soon as possible makes treatment more successful. The aim of this book was to apply the real-time PCR technique (Q-PCR) to quantify equine Babesiosis using primers specific to the Babesia equi haemoparasite. The method used was the extraction of blood DNA from horses followed by amplification with specific primers for Babesia equi parasites. Two types of test were carried out: nested-PCR and Q-PCR to identify and quantify the parasite. Seven horses of the breed were analysed, three of which showed high levels of the parasite, although they had no clinical symptoms of the disease at the time of collection, but fell ill months later. This study opens up the prospect of using the Q-PCR technique to diagnose this equine pathology.
Lectures on Evolution
"Lectures on Evolution" is a collection of insightful discourses brought through the renowned nineteenth-century biologist and educator, Thomas Henry Huxley. These lectures provide a comprehensive review of Huxley's views on the concept of evolution, which changed into a groundbreaking and controversial idea on the time. In these lectures, Huxley explores the foundational ideas put forth by means of Charles Darwin in his concept of natural selection. Huxley was a staunch propose for Darwin's principle, and his lectures played a pivotal role in popularizing and protecting the idea of evolution by using herbal selection. He eloquently affords the evidence helping the idea, drawing from the fields of comparative anatomy, paleontology, and embryology to demonstrate the interconnectedness of all lifestyles forms. Huxley's "Lectures on Evolution" additionally addresses the religious and philosophical implications of the concept, in particular its capability conflicts with traditional spiritual beliefs. Huxley argues for the compatibility of technological know-how and faith, putting forward that evolution want now not undermine one's non-secular convictions. These lectures show off Huxley's eloquence as a speaker and his capability to speak complex scientific thoughts to a wide target market. They continue to be a big contribution to the expertise of evolution and its effect on both technological know-how and society.
Contributions to the Theory of Natural Selection A Series of Essays
Alfred Russel Wallace's key work "Contributions to the Theory of Natural Selection" is a foundational work. Wallace, a prominent naturalist and Charles Darwin's colleague, made vital contributions to the development of natural selection theory, and this collection of writings is a testimony to his trailblazing views. Wallace provides his views into the mechanisms of evolution and natural selection in a series of articles and papers in the book. He explores several elements of evolutionary biology in these essays, such as the concept of adaptive coloration in animals, species distribution, and the function of sexual selection in evolution. The notion of "Wallace's Line," which delineates the boundary between distinct zoogeographical zones in Southeast Asia, is one of Wallace's most important achievements. This concept has aided our knowledge of how species are dispersed over the world. Wallace's work also includes his opinions on human evolution and the probable impact of natural selection on human mental and moral qualities. In this sense, his theories provoked significant discussions and controversies within the scientific world. "Contributions to the Theory of Natural Selection" showcases Alfred Russel Wallace's extraordinary intelligence as well as his pivotal role in developing the discipline of evolutionary biology.
Evolution, Old & New
"Evolution, Old & New" is a notable work by Samuel Butler. This book makes an important addition to the debates over Charles Darwin's theory of evolution and its implications for understanding the origins and development of life. Samuel Butler was Charles Darwin's contemporary, and in "Evolution, Old & New," he offers a sophisticated critique of Darwin's beliefs. Butler acknowledges Darwin's idea while also providing his own thoughts on evolution. One of Butler's main points is that evolution is not simply based on natural selection and survival of the fittest, as Darwin proposed. Instead, he proposes that acquired qualities, or the inheritance of acquired traits, may play a larger role in evolution than previously imagined. Butler's work digs into philosophical and ethical issues concerning the consequences of evolution. He examines the link between science and religion, as well as the influence of evolutionary theory on traditional beliefs. "Evolution, Old & New" is distinguished by thought-provoking and frequently contentious ideas. Butler's willingness to challenge dominant scientific and philosophical assumptions of the period fueled vigorous debates in evolutionary biology and the broader intellectual discourse of the late nineteenth century.
Cisgenic Crops: Safety, Legal and Social Issues
This book is the first comprehensive compilation of existing knowledge on the impact of cisgenic crops on biodiversity, environment, and ecosystem. Strategies to create and access cisgenic crops, potential risks assessment, and legal implications across the globe (European Union, North and South Americas, Africa, and Asia) are enumerated. Ethics, economics, safety, social concerns, and consumer acceptance of cisgenic foods are deliberated. Policy paradigm and ways to overcome GM regulations through cisgenic crops are highlighted. The book has 12 chapters authored by internationally leading experts on the subject. This book will be useful especially for the policy makers and GMO regulators, while the students, teachers, and researchers from across the globe will be equally benefited.
Heavy Metals in Mushrooms
Numerous scientific research projects are concerned with improving and protecting the environment. The first steps towards solving the problem of environmental pollution include researching and monitoring the presence and concentration of pollutants, especially heavy metals. It is known from previous studies that fungi bioaccumulate high concentrations of heavy metals, the concentration of which depends, to a greater or lesser extent, on factors such as the species, sampling area, and anatomical parts of the fungus, but also the substrate on which they grow. As the concentration of heavy metals in fungi increases, the importance of fungi as bioindicators of environmental pollution also increases. However, extremely high concentrations of toxic heavy metals in fungi can have negative effects on human health. Constantly monitoring and controlling the levels of metals and metalloids in the human diet is necessary, both in foods of plant and animal origin and in food supplements, or in this case edible mushrooms, whose availability on the market and general popularity are constantly increasing. Therefore, this reprint provides good insights into the development of science and technology in relation to heavy metal concentrations in mushrooms.
Chemical Bond and Intermolecular Interactions
This reprint focuses on the geometrical and spectroscopic features as well as potential applications of halogen, chalcogen, pnictogen, tetrel, and triel bonds in chemical reactions, crystal engineering, molecular recognition, and biological systems. We particularly aim to present studies concerning the bonds formed between some novel important electron donors and acceptors, similarities and differences between these bonds, structures of the complexes composed of these bonds in solution and gas phases, spectroscopic methods for measuring these bonds in solution and gas phases, and applications of these bonds in chemical reactions, crystal engineering, molecular recognition, and biological systems.
ME/CFS - the Severely and Very Severely Affected
Manuscripts in this monograph are sorted into five categories: 1. Case Reports: a description of living as a bedridden patient; structured interviews with severely affected ME/CFS patients; how past events contribute to severe ME/CFS; a comparison of moderately ill, severely ill, and very severely ill; case reports of ME/CFS in children. 2. A healthcare provider's view of managing ME/CFS patients. 3. Characterization of the Severely and Very Severely Affected: (1) the most troubling symptoms; (2) disease severity diminishes capacity for exercise, (3) operationalized definitions of the severely ill and very severely ill; (4) the usefulness of a modified Korean Chalder Fatigue Scale Questionnaire; (5) cardiac dimensions and function in patients; (6) an easier tilt test; and (7) review of sleep studies. 4. Progress in Diagnosis and Treatment: (1) objective measures for grading ME/CFS; (2) a sitting tilt test for orthostatic intolerance; (3) the benefits of IVIgG; (4) risks and protective factors in suicidality; (5) malnutrition and overcoming it; (7) partnerships between patients, caregivers, and providers, and the use of technology; (8) a holistic model of care, "Compassion in Practice; and (9) the effects of suffering, utilizing a four-phase model. 5. Impact of the Disease: (1) a historical perspective; (2) the impact of ME/CFS on psychosocial dynamics; (3) the educational needs of school-aged; and (4) the economic impact of ME/CFS
The Principles Of Breeding
"The Principles of Breeding" by using S.L. Goodale is a seminal work that marries the geographical regions of technological know-how and literature, presenting readers a unique and insightful exploration of the problematic world of breeding practices. This e book stands as a testomony to Goodale's understanding and his capacity to talk complex thoughts in a compelling and accessible way. Goodale's paintings is a complete guide to the ideas and techniques of breeding, masking a extensive variety of topics from animal husbandry to agricultural cultivation. Through meticulous studies and a clean, engaging writing style, he demystifies the intricacies of breeding, making it available to each experts and the overall reader. What sets "The Principles of Breeding" apart is its seamless integration of scientific information with fascinating storytelling. Goodale's narrative skillfully weaves historical examples and case studies into the textual content, permitting readers to no longer most effective grasp the technical elements of breeding but additionally appreciate its ancient and societal importance. The book is a testomony to Goodale's ardour for the concern rely and his willpower to fostering a deeper know-how of the technology and artwork of breeding. "The Principles of Breeding" continues to be a valuable resource for students, fans, and everyone intrigued via the captivating world of genetic inheritance and cultivation practices, firmly organising S.L. Goodale as a reputable authority within the subject.
Implementing the 3Rs in Laboratory Animal Research
This reprint focuses on the latest advances in the field of the 3Rs, as applied to laboratory animals. The continuous progress in the application of the 3Rs will allow for us to achieve a more humane and equally competitive science, improving animal welfare.
Equine Respiratory Medicine and Cardiology
Recent years have seen growing interest in equine lung and heart health, and advances in technology and a focus on equine welfare have driven this research. This Special Issue explores novel diagnostic and therapeutic approaches, including imaging techniques and lung function testing, immunological features, and immunomodulatory treatments for equine asthma and common racehorse respiratory issues. Moreover, it reports on novel echocardiography data of donkeys. This collection offers valuable insights into equine cardio-respiratory medicine.
New Insights into Novel Catalysts for Treatment of Pollutants in Wastewater
This compilation of scientific work delves into innovative wastewater treatment technologies, focusing primarily on the development and optimization of novel catalysts for the effective removal of pollutants. Covering a range of catalysts, including precious metals and nanomaterials, the research offers new insights into cost-effective and efficient pollutant removal methods. Aimed at environmental scientists, engineers, and policymakers, this publication represents a significant contribution from top researchers in the field. It serves as a key resource for those looking to understand and apply the latest advancements in wastewater treatment.
Soilless Culture
Soilless Culture Systems (SCSs) have expanded globally into protected and open-field horticulture. However, it is crucial to ensure the sustainability of this system in order to address resource challenges, minimize environmental impacts and establish a resilient and efficient agricultural system in the face of global challenges. This Special Issue reprint emphasizes the significance of transitioning to sustainable horticultural practices, outlines the challenges encountered, and presents various strategies to reduce or eliminate the utilization of peat in growing media. Additionally, it introduces cascade systems strategies that include recycling nutrient solutions, minimizing pesticide emissions, and integrating eco-friendly practices. Utilizing microorganisms has been identified as a potential strategy to augment the resilience of plants against the onslaught of pests and diseases. This approach is expected to reduce the utilization of chemicals for the same purpose considerably. This Special Issue reprint significantly contributes to advancing sustainable SCSs and growing media, providing diverse strategies and insights in order to propel its progress as a viable form of sustainable agriculture. It comprises 11 original contributions and an editorial written by 45 authors from 10 different countries. These numbers differ slightly from what was reported in the Editorial, as the Editorial was written before the last article was published.
Medicinal Plants
Medicinal Plants: Microbial Interactions, Molecular Techniques, and Therapeutic Trends is a comprehensive exploration of the fascinating world of medicinal plants, their therapeutic advancements, and the application of molecular techniques to unlock their full potential. This book is structured into three illuminating sections, each shedding light on different facets of this rapidly developing field. Section 1: Exploring Plant-Microbe InteractionsCovers the relationship between microbes and plants, the historical context and the pivotal role of microbes in shaping the future of medicinal plants. Discover the diverse array of bacteria associated with these plants and grasp their significance in enhancing the medicinal value of plants. Section 2: Harnessing Molecular Techniques Covers cutting-edge molecular techniques such as genome editing and modern breeding methods to optimize the genetic traits of medicinal plants. By understanding these techniques, readers will learn how to enhance plant growth, yield and quality. Section 3: Nanotechnology for Therapeutic Enhancement Covers nanotechnology and its transformative impact on medicinal plants. The section highlights emerging nano-engineering technology that can revolutionize the therapeutic properties of these plants. Medicinal Plants: Microbial Interactions, Molecular Techniques, and Therapeutic Trends is a book for Interdisciplinary readers: students, scientists, academics, and industry professionals alike. Whether you're a student, scientist, academic, or industry professional, this book is your gateway to the evolving world of plant-based medicine.
Novel Approaches for Targeting Metalloproteinases
This Special Issue is a collection of eleven articles (five reviews and six studies) that describe a wide range of approaches to modulating metalloproteinase activity in disease. The techniques described are in vitro, in vivo, and ex vivo.
Agricultural Water Conservation
Drought and climate change have decreased water availability for agriculture in arid and semiarid regions, and therefore efficiency enhancements in irrigation water management aimed at conserving water are key to adjust to limits in water supply, as well as improve the profitability and sustainability of agricultural production. Agricultural water management tools and practices that reduce water uses with acceptable impacts on crop production are viable strategies required to cope with diminished water supplies and generate new sources of irrigation water. This Special Issue focuses on "Agricultural Water Conservation: Tools, Strategies, and Practices", which aims to bring together a collection of recent cutting-edge research and advancements in applied agricultural water conservation. It provides a broad overview focusing on irrigation decision support systems, drought management plans, deficit irrigation strategies, soil mulching, surface and subsurface drip irrigation, conservation tillage, and optimal water and fertilizer management practices.
Wine Aromas
Wine has a complex matrix with many volatile compounds present, which evolves over time. These volatile compounds are important to wine quality as they contribute to the aroma and varietal characteristics of wine. Recent development in the analysis of volatile compounds in wine has greatly improved our understanding of the complexity of wine aroma. Analytical methods used for wine aroma fingerprinting have shown potential in determining the origin and quality of wine. Thus, research on volatile compounds responsible for wine aroma and their correlation with wine provenance and wine quality have increasingly attracted great interest from researchers and winegrowers. This Special Issue presents the latest research regarding wine aroma compounds, including, but not limited to, the topics on the characterization of aroma compounds in grapes and wine, factors influencing the production of aroma compounds in wine during fermentation and maturation, and analytical methods for wine aroma analysis.
Oral Cancer
Oral cancer is a commonly occurring head and neck cancer, with 90% of cases diagnosed as oral squamous cell carcinoma (OSCC). Histologically, OSCC is derived from a multistep mechanism known as oral carcinogenesis, which progresses from normal epithelium to hyperplasia, followed by dysplasia and carcinoma in situ, and precedes the development of invasive squamous cell carcinoma. This multistep mechanism is characterized by mutations related to copy number alteration and epigenetic modifications. Precision medicine based on genomic profiling is also becoming more prevalent. It relies on the genetic information of individual patients or specific cancer cells and how their genes interact with each other and the environment. This method can potentially provide more effective treatment strategies as approaches can be customized for the specific genetic profiles of patients. Completing the TCGA HNSCC database has led to the development of new therapeutic approaches and targeted therapies. Lately, immune checkpoint inhibitors have been recognized as one of the standards of care in HNSCC. However, although treating invasive SCC is crucial, implementing prevention strategies to preclude malignant transformation has been useful in clinical management. Topics of interest for this Special Issue include, but are not limited to: Precision medicine, i.e., targeted therapies that inhibit oral carcinogenesis and tumorigenesis mechanisms; Combination of novel therapeutic approaches with standard-of-care regimens in OSCC; Biomarkers, i.e., predictive and prognostic markers for therapeutic approaches.
Physiology and Pathophysiology of Iron Metabolism
This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health. The present reprint gives an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body. For the readership, this relevant information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism.
Soilless Culture, Growing Media and Horticultural Plants
This reprint showcases a collection of a Special Issue entitled "Soilless Culture, Growing Media and Horticultural Plants". Within its pages, readers will find an assortment of 22 original papers accompanied by 1 review paper and 1 editorial. Representing a collaborative effort involving by 84 authors from 15 different countries, this Special Issue explores cutting-edge advancements in soilless culture, investigating the interaction between soilless and environmental factors while also exploring their consequential impacts on plant growth and physiology. Additionally, these studies meticulously scrutinize the accumulation of secondary metabolites. The compositions of nutrient solutions and the physical attributes of substrates and mixtures are illuminated through rigorous analyses. Furthermore, a spotlight is placed on the dynamic interactions between microorganisms and plant-growing media. In the near future, climate change and environmental and ecological issues will steer the trajectory of soilless culture systems and the choice of growing media constituents.
Angelfish Research
"Angelfish Research: Translating Findings for Human Health" is a pioneering exploration into the world of scientific inquiry, where the delicate and vibrant angelfish serves as a key protagonist in unraveling secrets that may have profound implications for human well-being. This illuminating journey delves into the research endeavors focused on these aquatic angels and the potential crossover of their findings into the realm of human health.Within the pages of this interdisciplinary narrative, readers embark on a quest through laboratories and marine environments, witnessing scientists meticulously studying angelfish behavior, genetics, and physiological responses. The metaphorical angelfish becomes a symbol of biological inquiry, offering insights into the intricacies of life processes that may hold valuable lessons for improving human health.The book goes beyond the traditional boundaries of marine biology, weaving together the threads of research findings and their potential applications in medicine. From understanding the angelfish's immune system to deciphering genetic clues, each chapter unfolds as a bridge between the aquatic and human domains, where scientific discoveries in one realm inform and inspire progress in the other.This narrative doesn't merely showcase the fascinating aspects of angelfish research but emphasizes the translational journey, exploring how insights gained from these studies can be harnessed to address human health challenges. It highlights the interconnectedness of scientific disciplines and the potential for groundbreaking discoveries when lessons from the natural world are applied to medical research."Angelfish Research" is a testament to the collaborative spirit of scientific exploration, where marine biology converges with medical science to create a narrative that resonates with both researchers and the general audience. Whether you're a scientist at the forefront of research or an intrigued reader, this book offers a compelling perspective on the symbiotic relationship between the aquatic realm and advancements in human health.
From Cells to Scalpels
16-year-old Yasmine Ben Salmi invites readers on a captivating journey into the realm where science, compassion, and resilience converge. From ancient healers to modern pioneers, the book explores the lifelong fascination with the art and science of healing.In this compelling narrative, Yasmine Ben Salmi unveils the intricate mysteries of the human body, emphasizing the profound responsibility of healing. The path to becoming a doctor is depicted as a winding road with challenges that serve as opportunities for growth and resilience.The book celebrates extraordinary and ordinary moments in medicine-the remarkable cases and the subtle gestures of compassion. Through the author's lens, readers witness the highs and lows, trials and triumphs, and the immeasurable impact of a commitment to the noble pursuit of healing. "Welcome to the World of Medicine" is a testament to the rewards found in making a difference, earning patients' trust, and contributing to the ever-evolving tapestry of medical knowledge.
Forest Management and Biodiversity Conservation
In the current context of global change and global interconnectedness, our role in connecting the dots and finding solutions to current and future problems is very important. When talking specifically about the management of forests, we can see its continuous evolution and, more importantly, its adaptation to contemporary challenges. As is well known, forest ecosystems play an essential role in our economy, human wellbeing and global wellbeing. More specifically, one of the main challenges in forest management is represented by the sustainability of resources and need to conserve biological diversity. The best way is to think globally, to find patterns that repeat themselves and to investigate solutions that can help us to prepare a better future. In this regard, we think that it is essential to review papers that present interesting findings that could guide us. The first step was to select 18 articles from a wide range of countries located on three continents, including Brazil, Bulgaria, Ecuador, Germany, Malaysia, Peru, Poland, Romania, Slovakia, and Slovenia. Our main goal was to analyse the regionally specific aspects, as well as general aspects that can be applied worldwide. Using this approach, we narrowed our research to eight sub-domains: natural and human disturbances, genetics, site conditions, tropical forest, peri-urban forest, forest soils, forest reserves, and mountain ecosystems. These articles tackle themes such as peri-urban forests and their impact on urban agglomerations, ecoturism, cultural heritages and practices from local communities, human interventions and best practices.
Agriculture 4.0 - The Future of Farming Technology
The agricultural sector is undergoing a profound transformation derived from the introduction of new technologies and tools from industry 4.0, giving rise to what has been called Agriculture 4.0. This Reprint contains a selection of some interesting recent advances in this field, including new techniques for remote crop sensing and agricultural machinery, the development of novel vision and deep learning algorithms, advances in aquaculture technologies, and a review on the state of the art in Horticulture 4.0.
The End Of Thought
The End Of ThoughtThe theory of evolution has time as its underlying principle such that without enormous amounts of time evolution is an untenable idea. In the pages of this book the historical setting of where the theory of evolution originated will be investigated resulting in the discovery that scientific merit had little to do with its acceptance. Following that a serious study will show that in reality there never was all that much time. Attention will then be turned to an analysis of who or what has maintained such an iron grip on people's thinking to the point where evolution has become a doctrine of modern materialism. Such a belief, from which none may deviate, leads to a paralysis of the mind and The End Of Thought.
Cave Communities
From a biological perspective, the subterranean realm is one of the less studied, but at the same time, one of the most promising, theatres for new findings and research. Compared to those on the surface, the ecological conditions occurring in subterranean habitats are relatively simple, and this may be an optimal scenario for understanding the mechanisms allowing the colonization, adaptation, and evolution of species, as well as their interactions within local communities. Diversity in subterranean habitats is often overlooked, and few studies embrace whole communities or try to assess functional relationships between species.This Special Issue reprint comprises papers covering a wide range of aspects related to the distribution, composition, and roles of subterranean communities occurring in different typologies of subterranean habitats.
Nanometre-Scale Biosensors for Applications in Medicine/Environment/Food/Biomedical Research
This reprint serves as an introduction to the groundbreaking research work that explores the remarkable advancements in biosensor technology and its profound impact on the fields of biomedicine and environmental research. It aims to elucidate the subject's scope, provide future research directions, and highlight potential applications. This reprint is dedicated to the scientific community, researchers, and professionals seeking to expand their knowledge of biosensing. We express our gratitude to all those who have supported and contributed to this scientific endeavor.
Innovation in Chemical Plant Design
Innovation in chemical plant design is driving improvements in efficiency, safety, and environmental sustainability. This progress is influenced by factors such as safety standards, environmental regulations, market dynamics, and technological advancements. Innovations encompass process intensification, modular design, automation, data analytics, and sustainability solutions, addressing modern challenges. These innovations have diverse applications, spanning drug delivery systems, textile technologies, spray drying, extraction, and active packaging. Notably, supercritical fluid-assisted production of liposomes in pharmaceuticals promises improved therapeutic outcomes through meticulous optimization and sustainability. The textile industry sees advancements in natural dyeing and antibacterial properties, while spray-drying and extraction processes enhance product development and sustainability. Integration of remote sensing and microelectronics aids land surface temperature understanding for applications like agriculture and climate change studies. Convolutional Neural Networks benefit material science, facilitating material identification for energy storage and lubrication applications. Techno-economics for gas-to-liquid processes in natural gas are vital for energy and environmental sustainability. The industry's ongoing evolution prioritizes safety, sustainability, and efficiency, relying on innovative approaches and technologies to create safer, more sustainable, and economically viable chemical processes with reduced environmental impact, contributing to a prosperous and sustainable future.
Recent Developments in Food Gels
This Reprint provides the most relevant and state-of-the-art research in the field, including the use of novel gelation agents, the characterization of the structure and rheological properties of food gels, and the application of food gels in novel food products.
Nutrition and Specific Diseases by Women during the Life Course
The prevalence rates of risk factors for premature mortality and early non-communicable diseases are growing due to the increasing prevalence of poor nutrition habits, increasing levels of stress, and sedentary lifestyles. The life course epidemiology offers an integrative approach which guides research on health, human development, and ageing. The translation of this life course approach to women's health is indispensable. It comprises the investigation of risk factors across the life that influence the timing of menarche, fertility, pregnancy outcomes, gynaecological disorders, and age at menopause. It also recognises the important influence of reproductive health on later non-communicable disease risks. The continuity of reproductive health and the relationship between different biomarkers and risk factors are taken into account in this integrative approach. Within women's life courses, lifestyle plays an essential role, ranging from young age to pregnancy, menopause, and healthy aging. The underlying mechanisms and the effect sizes between nutrition and many diseases are only partly known due to the often multifactorial disease processes. The link between lifestyle and the growing rates of different diseases (e.g., cervical, ovarian carcinoma, breast cancer, cardiovascular diseases, or diabetes mellitus) needs to be investigated further. New scientific approaches are being used to try to relate individual biomarkers to dietary patterns and changes in the microbiome in order to make risk potentials visible earlier. The collection of scientific contributions on nutrition and women's health is presented here.
Wild Plant Species as Potential Horticultural Crops
There are about 30,000 plant species that are considered edible, but at present, very few of them are crops grown or cultivated on a commercially significant scale. On the other hand, there are several plants or their parts (leaves, shoots, fruits, seeds, hypogeal organs, and flowers) that are collected in the wild and consumed as raw or cooked food. Ethnobotany may offer a source of inspiration for agriculture, as wild edible species have the potential to lead food systems to be healthier, more sustainable, and resilient to climate change. Good tolerance to several abiotic and biotic stresses, as well as high nutritional value and excellent nutraceutical properties, are common traits of wild plants, making them promising candidates as new crops. Novel approaches for the outdoor/indoor cultivation of wild or underutilized species are needed to provide new opportunities for growers to produce new food categories, which would be particularly appealing to modern consumers. Cultivating wild species is also a way to preserve ethnobotanical heritage and promote genetic diversity. Furthermore, the cultivation of food plants normally gathered in the wild could reduce the health-related risks associated with pollution and biological contamination.
Improving Fertilizer Use Efficiency
The term fertilizer use efficiency (FUE) is not new. However, in recent years, improving the FUE has become particularly significant. This is due to growing demographic pressure, limited natural resources, climate change, and challenges related to environmental protection. This Special Issue of Plants contains papers that describe the current status of the knowledge and outlook of FUE improvement. The two review articles included provide an opportunity to become acquainted with the factors influencing FUE and contemporary trends in the development of fertilization strategies and technologies aimed at maximizing the value of this indicator. Of note, the concept of effective fertilization is presented and defined as the soil fertility clock (SFC). The 19 original articles included in this reprint present the results of research on the following: optimal N dose determination, balanced N fertilization, nitrogen use efficiency (NUE), foliar fertilization, improving the effectiveness of phosphorus use, and the possibility of improving FUE through the application of innovative fertilizers. Thanks to all the articles, this Special Issue enriches our knowledge in terms of the assessment methods of FUE in plant production. Moreover, it indicates new possibilities, perspectives, and directions for the development of scientific research within this field in the coming future.
Food Safety and Toxicology
Safety assurance of consumer goods has become a global challenge. The presence of natural and synthetic contaminants in food compromises food safety and poses a risk to public health. This book discusses biological and chemical food contaminants, predictive and detection methods of food toxicants, survival mechanism of food pathogens, legislation on microbial contaminants to prevent public health risks and strategies to mitigate contamination.
In Search of Human Evolution
Why would a researcher be willing to subject themselves to scorching heat, frigid conditions, or swarms of Anopheles mosquitoes? For author Michael H. Crawford, the answer is clear. Field research in anthropological genetics helps us answer several basic, universal questions. Who are we? Where did we come from? How did we get here? In Search of Human Evolution synthesizes more than 50 years of Crawford's research on the effects of migration on the evolution of human populations relocated to a series of unique environments. It documents the history of the field of anthropological genetics from its inception in 1973, through the information/computer revolution of the 1980s to the development of molecular characterization of human populations and the sequencing of the human genome. Crawford focuses on various facets of human evolution and migration in eight distinctive regions of the world, including sub-Arctic islands, tropical islands and coastal regions in the northern Caribbean, high valleys and arid regions in Mexico, the Artic taiga, and the plains of the Midwestern United States. Throughout the book, Crawford provides an overview of the importance of conducting fieldwork and the ethics of field research. He examines why individuals and communities participate in such research, and what the future of field research is in these times of epidemics and political instability.
Vegetable and Fruit Production
To ensure global food and nutrition security, there is a need for a sustainable year-round supply of nutritious food systems such as fruits and vegetables. Over the years, there has been a surge in fruit and vegetable consumption due to their composition of health-promoting biomarkers such as vitamins, minerals, fiber, and bioactive polyphenols. However, producing fruits and vegetables with the valuable contents of these health-promoting biomarkers is dependent on various factors, such as growing degree days, genetic pool, and management practices. Thereby, the goal of this Special Issue (Fruits and Vegetables Production) of the MDPI journal Plants was to provide up-to-date knowledge on traditional and emerging novel technologies applicable in sustainable production of high-value fruits and vegetables at various stages of their field and greenhouse production chains. In summary, this reprint is produced from the Special Issue that reported 12 peer-reviewed manuscripts, with foci on: (1) crop response to different elicitors and (2) green non-destructive technologies for efficient profiling of biomarkers, quality parameters, and cultivar evaluation. Thus, this reprint bridges the gaps among stakeholders (i.e., researchers, policymakers, and industry) for efficient production of consumer-centric crops with high productivity, appreciable nutritional value, and post-harvest resilience.
Plant-Derived Natural Products and Their Biomedical Properties
This Special Issue addresses recent advances in the research of plant-derived natural products, their mechanisms of action and how they can influence health and disease. Plant-derived natural products have been well known since antiquity due to their beneficial effects on human health, and since then, they have attracted the interest of the scientific community, leading to the identification, isolation and quantification of their compounds and research on their biomedical properties. They have been found to be rich in phytochemicals, such as terpenes and phenolic compounds, with proven antioxidant, anti-inflammatory, antimicrobial, antitumor and prebiotic properties, and therefore, they have been suggested as potential candidates for the therapeutic management of several chronic diseases. Some of them include inflammatory bowel disease, diabetes, non-alcoholic fatty liver disease, arthritis and cancer, in which inflammation, oxidative stress and dysbiosis mechanisms are implicated. Furthermore, given the increased economic burden, the side effects and the low compliance rates of patients who receive standard medical treatments, plant-derived natural products could possibly serve as adjunct therapeutic agents for chronic diseases.
Biological Applications of Nanoparticles
This textbook for graduate and postgraduate students provides comprehensive applications of nanoparticles in medicine, agriculture, and environmental sciences. The initial chapter covers basic topics related to types, synthesis, structure, and properties of various nanoparticles. It further discusses the wide range of applications of nanoparticles in medicine, agriculture, and the environment. The book presents nano-electronic biosensors that are used to diagnose and monitor the progression of human diseases. It summarizes the opportunities and challenges of nanotechnology in the agriculture and food sector highlighting the scientific, technical, regulatory, safety, and societal impacts. Additionally, it illustrates the applications of nanotechnology in the field of aquaculture medicine, bioinformatics and food technology. The textbook examines the development and administration of nano-medicines, their applications, advantages, and limitations for the treatmentand prophylaxis of a broad range of diseases. Lastly, the textbook explores the recent advances in the field of nanobusiness and nanotechnology issues in intellectual property management( IPR).
New Techniques in Marine Aquaculture
This reprint delves into the latest advancements in aquaculture techniques emerging from China. It provides a comprehensive update on the research and technological developments in various aspects of aquaculture, including biotechnology, ecotechnology, feeding technology, and environmental technology. The reprint covers a wide range of topics, such as the use of biotechnology to identify and characterize genes that enhance resistance to bacterial infection and environmental stress. It also explores feeding technology that improves immunity and stress resistance in aquatic organisms. Additionally, the reprint discusses the detection of the impact of thermal stress on marine fish immunity, the manipulation of light color to enhance algal growth, and the utilization of integrated multi-trophic systems to boost production. With a focus on marine fish, shrimp, sea cucumbers, sea urchins, and algae, this reprint showcases groundbreaking research that paves the way for future advancements in aquaculture. These innovative technologies are expected to have far-reaching implications for other species in the field of aquaculture.
Soil Carbon and Microbial Processes in Agriculture Ecosystem
As the global population and demand for food steadily increase, the maintenance and enhancement of soil productivity to ensure food security is becoming an important issue at the global level as global warming continues to progress. Soil carbon acts as a global carbon sink, playing a crucial role in soil fertility maintenance. Soil carbon is a complex product resulting from various microbial processes; it is a fragile entity, vulnerable to inappropriate human activity and global climate change. Soil microbes that utilize carbon efficiently may help to reduce carbon losses and increase carbon storage.This Special Issue highlights the current understanding of the dynamics of soil carbon and the microbial processes in agricultural ecosystems from the molecular level to the regional and global scales. The topics of interest in this Special Issue include carbon dynamics in plant-soil systems, the carbon balance, approaches to managing soil carbon maintenance and carbon sequestration, and related microbial processes in agricultural ecosystems.
3D Analysis of Human Movement, Sport, and Health Promotion
The 3D analysis of human movement aims to objectively and quantitatively assess motor functions and alterations. It is a valuable method for sport scientists, coaches, and clinicians to evaluate sport performance, common movements, and alterations. The feasibility of 3D analysis is increasing because it can be adopted both in a laboratory setting or directly in the field, in static or dynamic conditions, and for physiological or pathological movements. This evaluation technique can be adopted for many people, including children, adolescents, adults, and older people, whether they are sedentary or athletes and whether they are healthy or motor-impaired people.
Molecular Toxicology and Cancer Prevention
Molecular toxicology is a field that investigates the interactions between chemical or biological molecules and organisms at the molecular level. In this Special Issue, we focus on the toxic effects and mechanisms of action of chemical and biological molecules, will be of great interest of readers in molecular toxicology and applied pharmacology.
Clinical Pharmacology and Pharmacy of Antimicrobial Agents
In this Special Issue, our aim was to collect studies on clinical pharmacology and pharmacy of antimicrobial agents from both human and veterinary medicine as the complex problem of AMR requires actions taken within the One Health approach that involve both fields. Studies covered here are about new or optimized usage of already authorized antimicrobials, as well as discoveries about new agents, new combinations of drugs, and drug repositioning. Pharmacodynamic, pharmacokinetic, and toxicological aspects of individual and combinational drug use are areas covered in this Special Issue.
Advances in Legumes for Human Nutrition
We are very excited to introduce this Special Issue of Nutrients, "Advances in Legumes for Human Nutrition". Recently, legumes have contributed to a sustainable and increased food supply for the rapidly growing global population due to climate change. Legume seeds that are intact or milled into flour offer a complex array of macro- and micronutrients and phytochemicals for human nutrition. Additionally, they can be fractionated into their component proteins, starches, lipids and dietary fibre as health- and techno-functional food ingredients. These ingredients are in great demand by the food industry, for example, in the manufacture of vegetarian and vegan dairy products and meat analogues with good nutritional profiles. However, the issues, such as micronutrient availability, antinutrients and allergenicity, still require solutions for the maximum uptake of legumes by humans. We invited manuscripts that address any aspect of this broad topic, including the impact of innovative food technologies on the nutritional value of legumes and those focusing on nutritional properties of seeds from underutilised members of the Fabaceae (Leguminosae) family.
The Evolution of Biological Information
Why information is the unifying principle that allows us to understand the evolution of complexity in nature More than 150 years after Darwin's revolutionary On the Origin of Species, we are still attempting to understand and explain the amazing complexity of life. Although we now know how evolution proceeds to build complexity from simple ingredients, quantifying this complexity is still a difficult undertaking. In this book, Christoph Adami offers a new perspective on Darwinian evolution by viewing it through the lens of information theory. This novel theoretical stance sheds light on such matters as how viruses evolve drug resistance, how cells evolve to communicate, and how intelligence evolves. By this account, information emerges as the central unifying principle behind all of biology, allowing us to think about the origin of life--on Earth and elsewhere--in a systematic manner. Adami, a leader in the field of computational biology, first provides an accessible introduction to the information theory of biomolecules and then shows how to apply these tools to measure information stored in genetic sequences and proteins. After outlining the experimental evidence of the evolution of information in both bacteria and digital organisms, he describes the evolution of robustness in viruses; the cooperation among cells, animals, and people; and the evolution of brains and intelligence. Building on extensive prior work in bacterial and digital evolution, Adami establishes that (expanding on Dobzhansky's famous remark) nothing in biology makes sense except in the light of information. Understanding that information is the foundation of all life, he argues, allows us to see beyond the particulars of our way of life to glimpse what life might be like in other worlds.
Dynein
This volume provides a collection of protocols from leading researchers in the dynein field. The enclosed chapters guide readers through a broad range of powerful techniques that can be used to understand the complexities of dynein activity and regulation. These include how to perform live-cell microscopy on various fungi and metazoan cells, how to purify, assemble, and measure the force generation and motility characteristics of various dynein assemblies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Dynein: Methods and Protocols is a valuable resource for both novice and expert scientists in this developing field.
Retinitis Pigmentosa
This volume details the history of Retinitis Pigmentosa and current treatment options. Chapters guide readers through CRISPR, gene therapy, stem cell therapy, next-generation sequencing methods, gene editing, and translational applications of other therapies to the treatment of Retinitis Pigmentosa. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Retinitis Pigmentosa aims to be a useful practical guide to researches to help further their study in this field.
