Advances in Cancer Therapy from Research to Clinical Practice
Cancer remains one of the most challenging diseases from an epidemiologic, clinical and therapeutic perspective. The rhythm of changes in various aspects of oncological diseases, the molecular characterization of new subtypes of classical primary-type tumors, new pathways in carcinogenesis and new classes of therapeutical agents make it very difficult to follow all relevant findings in this research field. Most significantly, what remains are each of our personal clinical observations and experiences. We all know the level of trust required in these matters, but we remain doctors who treat real-life patients, not those selected for clinical trials.This Special Issue of Medicina was proposed in order to facilitate the presentation of the research or institutional experience of colleagues who are involved in treating cancer patients or are in the fundamental research field. Their clinical experience and research represent a very precious tool for each and every one of us.
Vascular Inflammation
"Vascular Inflammation: From Target Molecules to Therapeutic Approaches" aims to highlight the latest advances in vascular inflammation research. This Special Issue brought together experts to explore new target molecules, biomarkers, and innovative therapeutic strategies.Key Topics: Pathophysiology of Vascular Inflammation: the impact of COVID-19; Emerging Biomarkers and Target Molecules: exploring microRNA, PCSK9, and APE1/Ref-1; Understanding Vasculitis: the study of coronary vasculitis, lupus vasculitis, and Kawasaki disease; Learning about cutting-edge strategies: the study of targeted drug delivery.Our Special Issue comprises a collection of nine review articles and five research papers, uncovering novel biomarkers and therapeutic target proteins.
Digital Innovations in Agriculture
The world population is increasing significantly, and is expected to reach almost 10 billion in the year 2050. At the same time, observed climate change is accelerating and strongly affecting agricultural production. These aspects, as well as the latest socioeconomic limitations caused by the COVID-19 pandemic, bring new challenges to modern agriculture and the need to have high production efficiency combined with a high quality of obtained products in accordance with the principles of sustainable production. This applies to both crop and livestock production, as well as the other domains related to food production.To meet these challenges, advanced digital innovation techniques are more and more frequently being used, including those based on machine learning, artificial neural networks, the Internet of things (IoT), and big data. They are widely applied in solving various optimization tasks in the agri-food production processes in the context of the increasing use of precision and digital farming technologies on the path from Agriculture 3.0 to 5.0.The publications in this Special Issue include original research, research concepts, communications, and reviews related to digital innovation in the agri-food sector.
Digital Innovations in Agriculture
The world population is increasing significantly, and is expected to reach almost 10 billion in the year 2050. At the same time, observed climate change is accelerating and strongly affecting agricultural production. These aspects, as well as the latest socioeconomic limitations caused by the COVID-19 pandemic, bring new challenges to modern agriculture and the need to have high production efficiency combined with a high quality of obtained products in accordance with the principles of sustainable production. This applies to both crop and livestock production, as well as the other domains related to food production.To meet these challenges, advanced digital innovation techniques are more and more frequently being used, including those based on machine learning, artificial neural networks, the Internet of things (IoT), and big data. They are widely applied in solving various optimization tasks in the agri-food production processes in the context of the increasing use of precision and digital farming technologies on the path from Agriculture 3.0 to 5.0.The publications in this Special Issue include original research, research concepts, communications, and reviews related to digital innovation in the agri-food sector.
Macromolecular Protein Complexes IV
This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, the result of an impressive integration of structural data from X-ray crystallography and cryo-electron microscopy. The functional aspects of protein-protein interactions are also given a high priority.
Quantum Dots for Plant Systems
Quantum dots (QDs) are important in the research and industrial fields due to their diverse properties and technological importance. Recently, QDs have been found to be suitable for biological, biomedical, agricultural, and food science applications. Many research articles, review papers, and internet sources have published on the use of QDs to improve plant growth and yield, but a comprehensive overview in book form has not been available to date. This book provides detailed information on synthesis, functionalization, and the use of various types of quantum dots for plant systems. It also addresses the current state of knowledge on sensing mechanisms of QD-based biosensors used for microorganisms, including bacteria, fungi, and plant virus detection. This book also offers in-depth knowledge related to QDs used for plant growth, nutrients, and plant protection from micro-organisms. This volume is beneficial as one comprehensive resource for students, researchers, scientists, technicians, academicians, and industrialists.
Animal Genetics Erosion, Endangerment, Extinctions and Conservation Strategies
Seminar paper from the year 2023 in the subject Biology - Genetics / Gene Technology, grade: 3.95, Haramaya University (CAES), course: Animal and Range Scineces, language: English, abstract: There is an urgent need to document the diversity of our livestock genetic resources and to design strategies for their sustainable conservation and the main objective of this review is to exploring. The world watch list for domestic animal diversity documents more than 6 300 breeds and 7616 breeds of livestock belonging to 30 domesticated species. These breeds were developed following domestication and natural and human selection over the past 12 000 years. The current number of breeds is likely an underestimation since a large proportion of indigenous livestock populations of the developing world, where most animal genetic resources are found today; have yet to be described at phenotypic and genetic levels. The predominant species include cattle, sheep, goats, pigs, chickens, horses and buffalo. Several other domesticated animals like camels, donkeys, elephants, reindeer and rabbits are also valuable to different regions of the world. Cattle, sheep, chickens, are predominantly found all over the world, while goats and pigs are less uniformly distributed. Livestock populations have evolved a unique adaptation to their agricultural production system and agro ecological environments. Their genetic diversity has provided the material for the very successful breeding improvement programmes of the developed world in the 19th and 20th century. This represents a unique resource to respond to the present and future needs of livestock production, both in developed and developing countries. Recognizes The well importance of animal production for food security and rural livelihoods and particularly AnGR supply over 30% of total human requirements for food and agriculture and contribute to the livelihood of 70% of the world's rural poor. However, the purposes of raising livestock go bey
What a Mushroom Lives for
How the prized matsutake mushroom is remaking human communities in China-and providing new ways to understand human and more-than-human worlds What a Mushroom Lives For pushes today's mushroom renaissance in compelling new directions. For centuries, Western science has promoted a human- and animal-centric framework of what counts as action, agency, movement, and behavior. But, as Michael Hathaway shows, the world-making capacities of mushrooms radically challenge this orthodoxy by revealing the lively dynamism of all forms of life. The book tells the fascinating story of one particularly prized species, the matsutake, and the astonishing ways it is silently yet powerfully shaping worlds, from the Tibetan plateau to the mushrooms' final destination in Japan. Many Tibetan and Yi people have dedicated their lives to picking and selling this mushroom-a delicacy that drives a multibillion-dollar global trade network and that still grows only in the wild, despite scientists' intensive efforts to cultivate it in urban labs. But this is far from a simple story of humans exploiting a passive, edible commodity. Rather, the book reveals the complex, symbiotic ways that mushrooms, plants, humans, and other animals interact. It explores how the world looks to the mushrooms, as well as to the people who have grown rich harvesting them. A surprise-filled journey into science and human culture, this exciting and provocative book shows how fungi shape our planet and our lives in strange, diverse, and often unimaginable ways.
Biodiversity
Species are not functionally independent. From a long-term perspective, only ecosystem with a fully integrated nutrient cycle is alive. The lack of trophic autonomy should be considered one of the key factors that ensure and maintain biodiversity. The variability of abiotic conditions, both in space and in time, also creates a huge diversity of niches and subniches for genotypes and species. In addition, life maintains its essential variables (biomass and productivity) as stable as possible due to the diversity of structures (genes, macromolecules, metabolic pathways, genotypes, species, etc.): the structures that reach optima are multiplied and thus activated, while the functioning of those which lost their optima is suppressed. The facts and concepts presented in this monograph thus support the conclusions that (a) genotype and species diversity is supported by trophic specialisation (b) biodiversity helps to stabilise the functions (essential variables) ofindividuals, populations, and ecological communities (c) in evolution, the emergence of biodiversity is determined by heritable variation and the advantage of specialised (more effective) structures over non-specialised ones (d) biodiversity is characterised by its ability to increase itself and to organise itself into relatively consistent structures, which we call production pyramids and nutrient cycles. This book therefore provides an answer to the question "why the diversity of life is of such and such a nature".
Archaea
This volume provides an overview of well-established methods optimized for diverse archaeal model organisms and is a source of protocols facilitating access to the molecular and cellular biology characterization of these fascinating organisms. Chapters are divided into five parts detailing available genetic tools, molecular and cellular biology methods, strategies to study the ecophysiology of archaea, and classroom protocol. Each main thematic part is also introduced by future-oriented and authoritative primers. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Archaea: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.
Lung Ultrasound
Since the time I met Dr. Soldati, we have never stopped investigating LUS (lung ultrasound) vertical artifacts and the latter have slowly revealed their physical nature. Acoustic traps exist in pathological conditions that trap part of the energy of US pulses and gradually return it over time. Ultrasound scanners interpret what comes next as echoes of more distant structures, and this simple fact explains the nature of vertical signs: they are the visible representation of acoustic energy emitted from isolated, non-aerated spaces located beneath the pleura. In short, a vertical sign is a bit like the signature of an acoustic trap that generates it, similar to footprints left by animals in the woods-we just have to learn to recognize these signs. When we began our collaboration, lung ultrasound was a tool with limited application by pulmonary physicians. Today, the application of LUS is widespread, and medical and nonmedical doctors are collaborating to provide scientific answers to many questions that still arise when observing the aforementioned phenomenon. We must never get tired of reiterating the importance of collaboration between medical and nonmedical doctors in the development of new diagnostic devices.
The Impact of LED (Light-Emitting Diode) Spectra on Plant Growth and Quality
We are delighted to announce the release of a highly anticipated Special Issue of our esteemed journal, which focuses on exploring the profound impact of LED (Light-Emitting Diode) spectra on the growth and quality of plants. This collection of pioneering research articles presents an in-depth examination of the interactions between LED light and plant physiology, shedding light on the future of sustainable agriculture and horticulture.Within this Special Issue, leading experts and scientists from around the globe delve into the intricate relationship between LED spectra and various aspects of plant development. By meticulously investigating the effects of different wavelengths, intensities, and combinations of LED light on diverse plant species, this compilation promises to revolutionize our understanding of photosynthetic processes and optimize cultivation practices.The articles presented in this Special Issue encompass a wide range of disciplines, including plant physiology, biochemistry, genetics, and biotechnology. They provide captivating insights into the ways in which LED spectra influence plant growth, biomass accumulation, photosynthesis, morphogenesis, flowering, fruiting, secondary metabolite production, and overall crop quality.
Principles of Computational Modelling in Neuroscience
Taking a step-by-step approach to modelling neurons and neural circuitry, this textbook teaches students how to use computational techniques to understand the nervous system at all levels, using case studies throughout to illustrate fundamental principles. Starting with a simple model of a neuron, the authors gradually introduce neuronal morphology, synapses, ion channels and intracellular signalling. This fully updated new edition contains additional examples and case studies on specific modelling techniques, suggestions on different ways to use this book, and new chapters covering plasticity, modelling extracellular influences on brain circuits, modelling experimental measurement processes, and choosing appropriate model structures and their parameters. The online resources offer exercises and simulation code that recreate many of the book's figures, allowing students to practice as they learn. Requiring an elementary background in neuroscience and high-school mathematics, this is an ideal resource for a course on computational neuroscience.
Genome-Scale Algorithm Design
Presenting the fundamental algorithms and data structures that power bioinformatics workflows, this book covers a range of topics from the foundations of sequence analysis (alignments and hidden Markov models) to classical index structures (k-mer indexes, suffix arrays, and suffix trees), Burrows-Wheeler indexes, graph algorithms, network flows, and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualizations, and exercises, providing graduate students, researchers, and practitioners with a powerful algorithmic toolkit for the applications of high-throughput sequencing. An accompanying website (www.genome-scale.info) offers supporting teaching material. The second edition strengthens the toolkit by covering minimizers and other advanced data structures and their use in emerging pangenomics approaches.
Breathless
National Book Award finalist Breathless tells the story of the worldwide scientific race to decipher the coronavirus SARS-CoV-2, trace its source, and make possible the vaccines to fight the Covid-19 pandemic--a "luminous, passionate account of the defining crisis of our time" (The New York Times). Breathless is a "gripping" (The Atlantic) but "clear-eyed analysis" (Time) of SARs-CoV-2 and its fierce journey through the human population, as seen by the scientists who study its origin, its ever-changing nature, and its capacity to kill us. David Quammen expertly shows how strange new viruses emerge from animals into humans as we disrupt wild ecosystems and how those viruses adapt to their human hosts, sometimes causing global catastrophe. He explains why this coronavirus will probably be a "forever virus," destined to circulate among humans and bedevil us endlessly, in one variant form or another. As scientists labor to catch it, comprehend it, and control it, with their high-tech tools and methods, the virus finds ways of escape. Based on interviews with nearly one hundred scientists, including leading virologists in China and around the world, Quammen explains that: -Infectious disease experts saw this pandemic coming -Some scientists, for more than two decades, warned that "the next big one" would be caused by a changeable new virus--very possibly a coronavirus--but such warnings were ignored for political or economic reasons -The precise origins of this virus may not be known for years, but some clues are compelling, and some suppositions can be dismissed -And much more Written by "one of our finest explainers of the natural world for decades" (Chicago Tribune), This "compelling and terrifying" (The New York Times) account is an unparalleled look inside the frantic international race to understand and control SARS-CoV-2--and what it might mean for the next potential global health crisis.
Experiments in Bacterial Genetics
Bacteria are powerful systems for genetic research. They are fast growing and easy to propagate and maintain, and many tools have been developed for their genomic analyses and genetic manipulation. The study of bacteria and their viruses allowed deciphering the genetic code and has shaped our understanding of fundamental biological processes such as DNA replication, transcription, and translation. This manual provides a collection of experimental procedures for genetic research in bacteria. It describes basic methods for the isolation and propagation of bacteria and phages, purification of genomic DNA and plasmids, and introduction of DNA into bacteria. Diverse strategies for generating and confirming mutations and for creating gene deletions and gene fusions are described, using allelic exchange, random transposition, recombineering, and CRISPR-Cas technologies. Protocols for bacterial genome sequencing and resequencing, as well as for high-throughput mutant screening via transposon sequencing, are provided. Although specific bacterial species such as Escherichia coli, Salmonella enterica, Vibrio cholerae, and Staphylococcus aureus are used for some of the protocols, the methodologies herein described can readily be adapted for use with other bacteria. This manual thus represents a valuable resource for those seeking to perform genetic experiments in bacteria.
Botulinum Toxins
Animal and clinical studies have extensively reported the therapeutic efficacy of botulinum neurotoxins in many diseases characterized by excessive muscle contractions. The therapeutic effects of botulinum neurotoxins originate from their elective action as inhibitors of cholinergic transmission, this fact has given extraordinary support to the clinical use of botulinum neurotoxins in pathologies such as dystonia, torticollis, blepharospasm, and many others originating from hypercholinergic dysfunctions. Today, the list of human pathologies in which treatment with botulinum neurotoxins produces favorable results is constantly growing. This reprint presents a collection of research into new therapeutic applications of botulinum neurotoxins. Review and research articles discussing animal models, clinical studies, case reports, and off-label indications are presented. The goal of this reprint is to provide an updated framework regarding the development of new applications of botulinum neurotoxins to enable their future clinical use.
Oxidative Stress in Human Toxicology
The role of oxidative stress and antioxidants in the field of human toxicology is increasingly gaining attention. Intracellular levels of reactive oxygen species (ROS) can impact differentiating cells, e.g., normal stem and precancerous cells, and elevated ROS levels can also cause damage to biomolecules. Both foreign (xenobiotics, e.g., natural antioxidants and toxicants such as quinones) and endogenous substances and metals (e.g., iron) affect ROS levels and play roles in disease development. "Oxidative Stress in Human Toxicology" consists of twelve papers (nine original articles and three reviews) written by an international board of authors where exposure to xenobiotics is a common denominator. The reprint covers recent developments in the field of oxidative stress related to human toxicology with suggestions of novel mechanisms of action and hypotheses based on findings in clinical (human), in vivo (animal), in vitro (cell culture), and in chemico studies.
Antimicrobial and Anti-infective Activity of Natural Products
This reprint, organized with the recent publications of the Special Issue Antimicrobial and Anti-infective Activity of Natural Products in the journal Antibiotics, is a collection of the recent advances in the discovery of new antimicrobial compounds from natural products, mechanisms of action of pure compounds, in silico evidence of antimicrobial activity, synergistic associations with antibiotics, compounds with antiviral activity or capable of neutralizing bacterial resistance to antibiotics, as well as in vivo studies to demonstrate the effectiveness of compounds.
Marine Ecosystem Dynamics Models
This book presents the fundamental theories, methodologies and case studies of marine ecosystem modeling with a special focus on marine ecological dynamics that could provide scientists and researchers with a stabile and reliabile technical framework to study marine life and their developments.This book also clarifies the research objective and model classification methods of marine ecosystem dynamics research and analyzes the key marine ecological processes that affect modeling. The technical framework for improving the performance of modeling is also proposed, and the latest progress in research, as well as existing difficulties and challenges in end-to-end dynamics models are reviewed and analyzed. A dimensionality reduction theorem is established and derived for analyzing the stability of the solutions of a class of self-conserving marine ecosystem dynamic models. Also included in this work are several new types of marine ecosystem dynamics models constructed by modern computing methods -- including artificial neural networks, cellular automata, and statistical dynamics -- and case studies.This book is a suitable reference for professional and technical personnel, managers and graduate students specializing in the evolution mechanism, simulation, predication and regulation of marine ecosystems.
Kinesis
Our universe is characterized by constant motion. From electrons to galaxies, all things are on the move. This resonates within the human condition; we are born to move. From the earliest hunters, sailors, and horse-riders to the modern world of trains, bicycles, and cars, movement is everywhere in human life. Our history as nomads compares starkly to our increasingly sedentary life today. This fundamental disruption of the human as a moving being led to the invention of the wheel, new religious cultures, and even the rational mind. This book considers the full depth of the link between humanity and motion, examining how it manifests in us and how we embody it. Broad and multidisciplinary, it blends history, geography, psychology, philosophy, architecture, anthropology, and spirituality.
Father Time
A sweeping account of male nurturing, explaining how and why men are biologically transformed when they care for babies It has long seemed self-evident that women care for babies and men do other things. Hasn't it always been so? When evolutionary science came along, it rubber-stamped this venerable division of labor: mammalian males evolved to compete for status and mates, while females were purpose-built to gestate, suckle, and otherwise nurture the victors' offspring. But come the twenty-first century, increasing numbers of men are tending babies, sometimes right from birth. How can this be happening? Puzzled and dazzled by the tender expertise of new fathers around the world--several in her own family--celebrated evolutionary anthropologist and primatologist Sarah Blaffer Hrdy set out to trace the deep history of male nurturing and explain a surprising departure from everything she had assumed to be "normal." In Father Time, Hrdy draws on a wealth of research to argue that this ongoing transformation in men is not only cultural, but profoundly biological. Men in prolonged intimate contact with babies exhibit responses nearly identical to those in the bodies and brains of mothers. They develop caring potential few realized men possessed. In her quest to explain how men came to nurture babies, Hrdy travels back through millions of years of human, primate, and mammalian evolution, then back further still to the earliest vertebrates--all while taking into account recent economic and social trends and technological innovations and incorporating new findings from neuroscience, genetics, endocrinology, and more. The result is a masterful synthesis of evolutionary and historical perspectives that expands our understanding of what it means to be a man--and what the implications might be for society and our species.
Medical Product Regulatory Affairs
Durch die Behandlung einer Vielzahl unterschiedlicher Produkttypen und der wichtigsten globalen M瓣rkte ist dieses Lehrwerk genau richtig f羹r Kurse rund um Zulassungsfragen medizinischer Ger瓣te. Eignet sich auch hervorragend als Einf羹hrung in das Thema.
Chemical Substitutes from Agricultural and Industrial By-Products
Chemical Substitutes from Agricultural and Industrial By-Products A comprehensive resource presenting different manufacturing bioprocesses of chemical substitutes, from agricultural and industrial by-products to value-added biorefinery products Chemical Substitutes from Agricultural and Industrial By-Products: Bioconversion, Bioprocessing, and Biorefining discusses the biorefinery of chemical substitutes from agricultural and industrial by-products, covering the consolidated bioconversion, bioprocessing, and downstream process of the significant chemical substitutes produced. In each chapter, the individual aspects of bioconversion, bioprocessing, and downstream process of chemical substitutes produced from selected agricultural and industrial by-products to selected chemical substitutes are discussed. The text includes helpful case studies of specific processes to aid in reader comprehension. Edited by four highly qualified academics, Chemical Substitutes from Agricultural and Industrial By-Products: Bioconversion, Bioprocessing, and Biorefining includes information on: Common substitutes for chemicals obtained from biomass of agricultural wastes and industrial by-products, including antioxidants, oleoresin, nanocarbon materials, enzymes, essential oils, bio-bleaching agents, and biosugars Alternative substitutes, including biofertilizers, cocoa butter substitutes, bio-succinic acids, furfural derivatives, levulinic acids, and cellulases Economic calculations, such as cost analysis, of different bioprocesses to analyze their feasibility in business and general industry Environmental impact analysis of chemical substitutes from agricultural and industrial by-products for a sustainable agriculture system Enabling readers to create a change in the perception of the waste agricultural biomass from waste to resource, Chemical Substitutes from Agricultural and Industrial By-Products: Bioconversion, Bioprocessing, and Biorefining is an essential resource for biotechnologists, chemists in industry, natural products chemists, process engineers, chemical engineers, and environmental chemists.
Sensors and Robotics for Digital Agriculture
This reprint provides insight into the recent advances in systems and processes in the field of sensors and robotics and their applicability in agricultural environments within the concept of digitizing agriculture with the aim of maximizing the efficiency and sustainability of crop and livestock production. Special focus is given to the areas of artificial intelligence and machine learning for the development of applications and tools to support farmers and farm managers in making timely and informed decisions for both crop and livestock management. Unmanned aerial and ground systems are gaining popularity. In this reprint, emphasis is given to the application of autonomous systems and robotics in agriculture for the automated performance of different tasks such as field scouting, soil sampling and analysis, and crop harvesting, among others. The interaction between machines and humans in agricultural environments is also discussed.
Aquatic Organisms Research with DNA Barcodes
This issue focuses on DNA barcoding of aquatic life from temperate regions to the tropics. It includes studies discovering an unknown diversity, describing new species with integrative taxonomy, and studies on phylogenies.It also contains applications to species of interest for fisheries, aquaculture, bioindicators, invasive exotics, and new insights for controlling the latter. It comprises proposals for new-generation sequencing and automation methods of DNA barcoding for biomonitoring and conservation, and has some implications for fisheries derived from these methods' use. Other promising applications include identifying all life stages, from larvae to adults, from fish to invertebrates such as the chironomids, and applying the baselines created in the analyses of gut contents for some predators.Finally, a global review of the advances of studies on DNA barcoding of aquatic organisms is included, highlighting the need to promote and continue the efforts of these studies.
Integrative Bioinformatics for Biomedical Big Data
The volume and complexity of biological and biomedical research continues to grow exponentially with cutting-edge technologies such as high-throughput sequencing. Unfortunately, bioinformatics analysis is often considered only after data have been generated, which significantly limits the ability to make sense of complex big data. This unique book introduces the idea of No-Boundary Thinking (NBT) in biological and biomedical research, which aims to access, integrate, and synthesize data, information, and knowledge from bioinformatics to define important problems and articulate impactful research questions. This interdisciplinary volume brings together a team of bioinformatics specialists who draw on their own experiences with NBT to illustrate the importance of collaborative science. It will help stimulate discussion and application of NBT, and will appeal to all biomedical researchers looking to maximize their use of bioinformatics for making scientific discoveries.
Dolphin Communication and Cognition
Experts survey the latest research on dolphin communication and cognition, offering a comprehensive reference to findings in the laboratory and from the field. Dolphin researchers have collected an impressive amount of data over the last twenty years, thanks to advances in technology for monitoring, recording, and analyzing dolphin behavior as well as increasing interest in exploring and modeling dolphins' cognitive capacities. This volume offers a comprehensive reference to the latest research on dolphin communication and cognition, reporting on findings from both the laboratory and the field. The contributors review a wide range of topics, including vocalization, abstract reasoning abilities, imitation and learning, social cognition, echolocation, and ethical issues in working with cetaceans. The book begins by examining the dolphin brain and its evolution, the anatomy of its unique sound production and reception systems, and its sensory abilities. It next treats communication, reviewing the complexity of dolphins' vocalization, and then describes research on cognition, from both experimental and developmental perspectives. Finally, the book considers the future of dolphin research, including a series of provocative questions that remain unanswered, posed by the volume's expert contributors. Contributors Mats Amundin, Whitlow Au, Ted W. Cranford, Nicola Erdsack, John Ford, Wolf Hanke, Louis M. Herman, Denise L. Herzing, Christine M. Johnson, Petr Krysl, Stan Kuczaj, Marc Lammers, Lori Marino, Paul Nachtigall, Julie Oswald, Adam A. Pack, Heidi Pearson, Sam Ridgway, Jeanette Thomas, Randall Wells, Thomas I. White, Hal Whitehead, Kelley Winship, Bernd W羹rsig
Evolutionary Quantitative Genetics
Evolutionary quantitative genetics (EQG) provides a formal theoretical foundation for quantitatively linking natural selection and genetic variation to the rate and expanse of adaptive evolution. It has become the dominant conceptual framework for interpreting the evolution of quantitative traits in terms of elementary forces (mutation, inheritance, selection, and drift). Despite this success, the relevance of EQG to many biological scenarios remains relatively unappreciated, with numerous fields yet to fully embrace its approach. Part of the reason for this lag is that conceptual advances in EQG have not yet been fully synthesized and made accessible to a wider academic audience. A comprehensive, accessible overview is therefore now timely, and Evolutionary Quantitative Genetics provides this much-needed synthesis. The central argument of the book is that an adaptive landscape concept can be used to understand both evolutionary process within lineages and the pattern of adaptive radiations. In particular, it provides a convincing argument that models with a moving adaptive peak carry us further than any other conceptual approach yet devised. Although additive theory holds center stage, the book mentions and references departures from additivity including non-Gaussian distributions of allelic effects, dominance, epistasis, maternal effects and phenotypic plasticity. This accessible, advanced textbook is aimed principally at students (from senior undergraduate to postgraduate) as well as practising scientists in the fields of evolutionary biology, ecology, physiology, functional morphology, developmental biology, comparative biology, paleontology, and beyond who are interested in how adaptive radiations are produced by evolutionary and ecological processes.
Agrobiodiversity
Experts discuss the challenges faced in agrobiodiversity and conservation, integrating disciplines that range from plant and biological sciences to economics and political science. Wide-ranging environmental phenomena--including climate change, extreme weather events, and soil and water availability--combine with such socioeconomic factors as food policies, dietary preferences, and market forces to affect agriculture and food production systems on local, national, and global scales. The increasing simplification of food systems, the continuing decline of plant species, and the ongoing spread of pests and disease threaten biodiversity in agriculture as well as the sustainability of food resources. Complicating the situation further, the multiple systems involved--cultural, economic, environmental, institutional, and technological--are driven by human decision making, which is inevitably informed by diverse knowledge systems. The interactions and linkages that emerge necessitate an integrated assessment if we are to make progress toward sustainable agriculture and food systems. This volume in the Str羹ngmann Forum Reports series offers insights into the challenges faced in agrobiodiversity and sustainability and proposes an integrative framework to guide future research, scholarship, policy, and practice. The contributors offer perspectives from a range of disciplines, including plant and biological sciences, food systems and nutrition, ecology, economics, plant and animal breeding, anthropology, political science, geography, law, and sociology. Topics covered include evolutionary ecology, food and human health, the governance of agrobiodiversity, and the interactions between agrobiodiversity and climate and demographic change.
How We Age
How recent breakthroughs in longevity research offer clues about human aging All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging. Understanding the fundamental biological rules that govern aging in model systems provides clues about how we might slow human aging, which could lead in turn to new therapeutics and treatments for age-related disease. Among other vivid examples, Murphy describes research that shows how changing a single gene in the nematode worm C. elegans doubles its lifespan, extending not only the end of life but also the youthful, healthy part of life. Drawing on work in her own lab as well as other recent research, Murphy chronicles the history and current state of the field, explaining longevity's links to reproduction and mating, sensory and cognitive function, inheritances from our ancestors, and the gut microbiome. Written with clarity and wit, How We Age provides a guide to the science: what we know about aging, how we know what we know, and what we can do with this new knowledge.
PRAXIS 5236 Biology
The PRAXIS 5236 Biology book comprises more than 400 real PRAXIS 5236 Biology exam practice questions. It formulates fresh PRAXIS 5236 Biology exam questions that precisely match the content of the actual exam. The book covers all the exam-related topics with its extensive question bank. It also provides detailed rationales for each PRAXIS 5236 Biology question, delivering comprehensive content knowledge for the PRAXIS 5236 Biology exam.
TX PACT 738 Life Science
The TX PACT 738 Life Science book includes over 400 authentic TX PACT 738 Life Science exam practice questions. It generates new TX PACT 738 Life Science exam questions, perfectly aligned with the actual exam content. Covering all the topics found on the exam, the TX PACT 738 Life Science book boasts a vast question pool. Each TX PACT 738 Life Science question in the book features a detailed rationale, offering comprehensive content knowledge for the TX PACT 738 Life Science exam.
AEPA Biology
The AEPA Biology book offers more than 400 genuine AEPA Biology exam practice questions. It introduces fresh AEPA Biology exam questions, perfectly matching the exam's content. With its extensive question bank, the AEPA Biology book encompasses all exam-related topics. Each AEPA Biology question includes a comprehensive explanation, enhancing your content knowledge for the AEPA Biology exam.
MTEL 66 Biology
The MTEL 66 Biology book boasts an impressive collection of over 400 genuine MTEL 66 Biology exam practice questions. It goes the extra mile by crafting brand-new MTEL 66 Biology exam questions meticulously tailored to mirror the exact content encountered in the official exam. This comprehensive resource leaves no stone unturned, encompassing all the content topics that candidates will face on the exam. Furthermore, each MTEL 66 Biology question within the book is accompanied by an in-depth rationale. These rationales serve as invaluable learning tools, offering a thorough and insightful breakdown of the question's content. This added layer of detail ensures that individuals preparing for the MTEL 66 Biology exam gain a profound understanding of the subject matter, ultimately enhancing their chances of success.
Dna-Encoded Chemical Libraries
This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries: Methods and Protocols is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.
MTLE Life Science
The MTLE Life Science book offers more than 400 genuine MTLE Life Science exam practice questions. It introduces fresh MTLE Life Science exam questions, perfectly matching the exam's content. With its extensive question bank, the MTLE Life Science book encompasses all exam-related topics. Each MTLE Life Science question includes a comprehensive explanation, enhancing your content knowledge for the MTLE Life Science exam.
GACE Biology
The GACE Biology book includes over 400 authentic GACE Biology exam practice questions. It generates new GACE Biology exam questions, perfectly aligned with the actual exam content. Covering all the topics found on the exam, the GACE Biology book boasts a vast question pool. Each GACE Biology question in the book features a detailed rationale, offering comprehensive content knowledge for the GACE Biology exam.
MEGA 075 Biology
The MEGA 075 Biology book boasts an impressive collection of over 400 genuine MEGA 075 Biology exam practice questions. It goes the extra mile by crafting brand-new MEGA 075 Biology exam questions meticulously tailored to mirror the exact content encountered in the official exam. This comprehensive resource leaves no stone unturned, encompassing all the content topics that candidates will face on the exam. Furthermore, each MEGA 075 Biology question within the book is accompanied by an in-depth rationale. These rationales serve as invaluable learning tools, offering a thorough and insightful breakdown of the question's content. This added layer of detail ensures that individuals preparing for the MEGA 075 Biology exam gain a profound understanding of the subject matter, ultimately enhancing their chances of success.
OAE 007 Biology
The OAE 007 Biology book contains an extensive compilation of more than 400 authentic OAE 007 Biology exam practice questions. It takes a proactive approach by crafting fresh OAE 007 Biology exam questions that precisely align with the exam's content. This comprehensive resource leaves no content topic unaddressed, covering all areas examined. Furthermore, the book accompanies each OAE 007 Biology question with a detailed rationale. These explanations offer a deep dive into the question's content, providing a comprehensive understanding of the subject matter. This additional level of detail empowers individuals preparing for the OAE 007 Biology exam with the knowledge needed for success.
MTTC 017 Biology
The MTTC 017 Biology book comprises more than 400 real MTTC 017 Biology exam practice questions. It formulates fresh MTTC 017 Biology exam questions that precisely match the content of the actual exam. The book covers all the exam-related topics with its extensive question bank. It also provides detailed rationales for each MTTC 017 Biology question, delivering comprehensive content knowledge for the MTTC 017 Biology exam.
CSET 217 Life Sciences
The CSET 217 Life Sciences book contains an extensive compilation of more than 400 authentic CSET 217 Life Sciences exam practice questions. It takes a proactive approach by crafting fresh CSET 217 Life Sciences exam questions that precisely align with the exam's content. This comprehensive resource leaves no content topic unaddressed, covering all areas examined. Furthermore, the book accompanies each CSET 217 Life Sciences question with a detailed rationale. These explanations offer a deep dive into the question's content, providing a comprehensive understanding of the subject matter. This additional level of detail empowers individuals preparing for the CSET 217 Life Sciences exam with the knowledge needed for success.
CEOE 110 Biological Sciences
The CEOE 110 Biological Sciences book includes over 400 authentic CEOE 110 Biological Sciences exam practice questions. It generates new CEOE 110 Biological Sciences exam questions, perfectly aligned with the actual exam content. Covering all the topics found on the exam, the CEOE 110 Biological Sciences book boasts a vast question pool. Each CEOE 110 Biological Sciences question in the book features a detailed rationale, offering comprehensive content knowledge for the CEOE 110 Biological Sciences exam.
ILTS 239 Biology
The ILTS 239 Biology book comprises more than 400 real ILTS 239 Biology exam practice questions. It formulates fresh ILTS 239 Biology exam questions that precisely match the content of the actual exam. The book covers all the exam-related topics with its extensive question bank. It also provides detailed rationales for each ILTS 239 Biology question, delivering comprehensive content knowledge for the ILTS 239 Biology exam.
NES 305 Biology
The NES 305 Biology book comprises more than 400 real NES 305 Biology exam practice questions. It formulates fresh NES 305 Biology exam questions that precisely match the content of the actual exam. The book covers all the exam-related topics with its extensive question bank. It also provides detailed rationales for each NES 305 Biology question, delivering comprehensive content knowledge for the NES 305 Biology exam.
FTCE Biology 6-12
The FTCE Biology 6-12 book contains an extensive compilation of more than 400 authentic FTCE Biology 6-12 exam practice questions. It takes a proactive approach by crafting fresh FTCE Biology 6-12 exam questions that precisely align with the exam's content. This comprehensive resource leaves no content topic unaddressed, covering all areas examined. Furthermore, the book accompanies each FTCE Biology 6-12 question with a detailed rationale. These explanations offer a deep dive into the question's content, providing a comprehensive understanding of the subject matter. This additional level of detail empowers individuals preparing for the FTCE Biology 6-12 exam with the knowledge needed for success.
ORELA Biology
The ORELA Biology book offers more than 400 genuine ORELA Biology exam practice questions. It introduces fresh ORELA Biology exam questions, perfectly matching the exam's content. With its extensive question bank, the ORELA Biology book encompasses all exam-related topics. Each ORELA Biology question includes a comprehensive explanation, enhancing your content knowledge for the ORELA Biology exam.
