Chance in the House of Fate
Award-winning science writer Jennifer Ackerman investigates the endless mysteries of genetics, offering an elegant natural history of humanity as seen through the lens of our genes and cells. Combining the gifts of vision and language with in-depth knowledge, Ackerman explores the ways in which, at the most fundamental level, humans are genetically linked to every part of the natural world. CHANCE IN THE HOUSE OF FATE is a rich and often personal tour through the surprising turns of heredity, informed by the ways genetic inheritance has affected Ackerman's own life. From a younger sister's profound retardation and her mother's illness to the births of her own healthy daughters, Ackerman reveals her own experiences as telling touchpoints, ultimately illuminating the the hidden biological connections among all forms of life.
The Beauty of the Beastly
Natalie Angier knows all that scientists know - and sometimes more - about the power of symmetry in sexual relations, about the brutal courting habits of dolphins, about the grand deceit of orchids, about the impact of female and male preferences on evolution. She knows how scientists go about their work, and she describes their ways, their visions, and their arguments. Perhaps most poignantly, she understands the complexities and the sad necessity of death. "The beauty of the natural world lies in the details, and most of those details are not the stuff of calendar art," she points out. Few writers have ever covered so many facets of biology so evocatively in one book. The Beauty of the Beastly tells us how the genius of the biological universe resides in its details and proves why, according to Timothy Ferris, author of the acclaimed Coming of Age in the Milky Way, Angier is "one of the strongest and wittiest science writers in the world today."
Shrinking the Cat
In this timely and controversial work, Sue Hubbell contends that the concept of genetic engineering is anything but new, for humans have been tinkering with genetics for centuries. Focusing on four specific examples -- corn, silkworms, domestic cats, and apples -- she traces the histories of species that have been fundamentally altered over the centuries by the whims and needs of people.
Redesigning Humans
A groundbreaking work, Redesigning Humans tackles the controversial subject of engineering the human germline -- the process of permanently altering the genetic code of an individual so that the changes are passed on to the offspring. Gregory Stock, an expert on the implications of recent advances in reproductive biology, has glimpsed the inevitable future of biomedical engineering. Within decades, Stock asserts, technological advances will bring meaningful changes to our offspring; this scientific revolution promises to fundamentally alter the human species. With recent findings presented in a new afterword, Stock's provocative assessment cuts through the debate to envision an age of radical biotechnological advancement and unprecedented human choice.
The Monkey in the Mirror
Nothing fascinates us more than explorations of human origins, and nobody tells the story better than Ian Tattersall. What makes us so different? How did we get this way? How do we know? And what exactly are we? These questions are what make human evolution a subject of general fascination. Ian Tattersall, one of those rare scientists who is also a graceful writer, addresses them in this delightful book. Writing in an informal essay style, Tattersall leads the reader around the world and into the far reaches of the past, showing what the science of human evolution is up against-from the sparsity of evidence to the pressures of religious fundamentalism. Looking with dispassion and humor at our origins, Tattersall offers a wholly new definition of what it is to be human. Delightful stories, scientific wisdom, fresh insight-the perfect science book.
Genetic Determinants of Human Longevity
In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, although a plethora of variants were indicated to be associated with human longevity, only very few were successfully replicated in different populations, probably because of population specificity, missing heritability as well as a complex interaction among genetic factors with lifestyle and cultural factors, which modulate the individual chance of living longer. Thus, many challenges remain to be addressed in the search for the genetic components of human longevity. This Special Issue is aimed to unify the progress in the analysis of the genetic determinants of human longevity, to take stock of the situation and point to future directions of the field. We invite submissions for reviews, research articles, short-communications dealing with genetic association studies in human longevity, including all types of genetic variation, as well as the characterization of longevity-related genes.
The Origin and Early Evolution of Life
Studying the origin of life is one of man's greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems.
A Pocket History of Human Evolution
Prehistory has never been more exciting: New discoveries are overturning long-held theories left and right. Stone tools in Australia date back 65,000 years--a time when, we once thought, the first Sapiens had barely left Africa. DNA sequencing has unearthed a new hominid group--the Denisovans--and confirmed that crossbreeding with them (and Neanderthals) made Homo sapiens who we are today.A Pocket History of Human Evolution brings us up-to-date on the exploits of all our ancient relatives. Paleoanthropologist Silvana Condemi and science journalist Fran癟ois Savatier consider what accelerated our evolution: Was it tools, our "large" brains, language, empathy, or something else entirely? And why are we the sole survivors among many early bipedal humans? Their conclusions reveal the various ways ancient humans live on today--from gossip as modern "grooming" to our gendered division of labor--and what the future might hold for our strange and unique species.
Molecular Mechanism of Alzheimer’s Disease
Alzheimer's disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer's disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.
Nine Pints
An eye-opening exploration of blood, the life giving substance with the power of taboo, the value of diamonds and the promise of breakthrough science. Blood carries life, yet the sight of it makes people faint. It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don't even know their own blood type. And for all its ubiquitousness, the few tablespoons of blood discharged by 800 million women are still regarded as taboo: menstruation is perhaps the single most demonized biological event. Rose George, author of The Big Necessity, is renowned for her intrepid work on topics that are invisible but vitally important. In Nine Pints, she takes us from ancient practices of bloodletting to the breakthrough of the "liquid biopsy," which promises to diagnose cancer and other diseases with a simple blood test. She introduces Janet Vaughan, who set up the world's first system of mass blood donation during the Blitz, and Arunachalam Muruganantham, known as "Menstrual Man" for his work on sanitary pads for developing countries. She probes the lucrative business of plasma transfusions, in which the US is known as the "OPEC of plasma." And she looks to the future, as researchers seek to bring synthetic blood to a hospital near you. Spanning science and politics, stories and global epidemics, Nine Pints reveals our life's blood in an entirely new light. Nine Pints was named one of Bill Gates' recommended summer reading titles for 2019.
The Body
AN INSTANT NEW YORK TIMES BESTSELLER - A BEST BOOK OF THE YEAR BY THE WASHINGTON POST - LONGLISTED FOR THE PEN E.O. WILSON LITERARY SCIENCE WRITING AWARD"Glorious. . .You will marvel at the brilliance and vast weirdness of your design." --The Washington Post Bill Bryson, bestselling author of A Short History of Nearly Everything, takes us on a head-to-toe tour of the marvel that is the human body. As addictive as it is comprehensive, this is Bryson at his very best, a must-read owner's manual for everybody. Bill Bryson once again proves himself to be an incomparable companion as he guides us through the human body--how it functions, its remarkable ability to heal itself, and (unfortunately) the ways it can fail. Full of extraordinary facts (your body made a million red blood cells since you started reading this) and irresistible Bryson-esque anecdotes, The Body will lead you to a deeper understanding of the miracle that is life in general and you in particular. As Bill Bryson writes, "We pass our existence within this wobble of flesh and yet take it almost entirely for granted." The Body will cure that indifference with generous doses of wondrous, compulsively readable facts and information.
Stem Cell and Biologic Scaffold Engineering
Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of "artificial" tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.
Ultrasound B-Mode Imaging
Ultrasound medical imaging stands out among the other diagnostic imaging modalities for its patient-friendliness, high temporal resolution, low cost, and absence of ionizing radiation. On the other hand, it may still suffer from limited detail level, low signal-to-noise ratio, and narrow field-of-view. In the last decade, new beamforming and image reconstruction techniques have emerged which aim at improving resolution, contrast, and clutter suppression, especially in difficult-to-image patients. Nevertheless, achieving a higher image quality is of the utmost importance in diagnostic ultrasound medical imaging, and further developments are still indispensable. From this point of view, a crucial role can be played by novel beamforming techniques as well as by non-conventional image formation techniques (e.g., advanced transmission strategies, and compounding, coded, and harmonic imaging). This Special Issue includes novel contributions on both ultrasound beamforming and image formation techniques, particularly addressed at improving B-mode image quality and related diagnostic content. This indeed represents a hot topic in the ultrasound imaging community, and further active research in this field is expected, where many challenges still persist.
The Making of You
A quirky and inspired guide to your very own origin story. This enlightening and irresistible book for adults explains how you were made--not with the standard euphemisms told to us as children, but with vivid, exacting prose that unveils all the complex processes we never knew produced human life. With a brilliant talent for thoughtful, charming science writing, Katharina Vestre takes us from cell to human and shares surprising facts along the way--such as that sperm have a sense of smell and that hiccups were likely inherited from our ancient, underwater ancestors. She also shows why gender is more complicated than we think and reveals the questions scientists still ponder about how we came to be. A miniature drama of cosmic significance, this is the incredible story of you.
Sex Hormone Receptor Signals in Human Malignancies
Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors. Meanwhile, emerging evidence has indicated that sex hormone receptor signals are involved in the outgrowth of some malignancies, such as prostate and breast carcinomas, as well as others that have not traditionally been considered as endocrine-related neoplasms. This Special Issue "Sex Hormone Receptor Signals in Human Malignancies" covers various aspects of the potential role of sex hormone receptors and related signals in prostate cancer, breast cancer, and other neoplastic conditions by depicting promising findings derived from in vitro and in vivo experiments as well as the analyses of surgical specimens. The current observations described may thus provide a unique insight into novel or known functions of sex hormone receptors and related molecules.]
Recent Progress in Solid Dispersion Technology
Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
Biotechnological Applications of Phage and Phage-Derived Proteins
Phages have shown a high biotechnological potential with numerous applications. The advent of high-resolution microscopy techniques aligned with omic and molecular tools have revealed innovative phage features and enabled new processes that can be further exploited for biotechnological applications in a wide variety of fields. The high-quality original articles and reviews presented in this Special Issue demonstrate the incredible potential of phages and their derived proteins in a wide range of biotechnological applications for human benefit. Considering the emergence of amazing new available bioengineering tools and the high abundance of phages and the multitude of phage proteins yet to be discovered and studied, we believe that the upcoming years will present us with many more fascinating and new previously unimagined phage-based biotechnological applications.
Dynamical Models of Biology and Medicine
Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine
Mitochondrial Dysfunction in Aging and Diseases of Aging
This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
Venom and Toxin as Targeted Therapy
Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.
Brewing and Craft Beer
Beer is a beverage with more than 8000 years of history, and the process of brewing has not changed much over the centuries. However, important technical advances have allowed us to produce beer in a more sophisticated and efficient way. The proliferation of specialty hop varieties has been behind the popularity of craft beers seen in the past few years around the world. Craft brewers interpret historic beer with unique styles. Craft beers are undergoing an unprecedented period of growth, and more than 150 beer styles are currently recognized.
Synthetic Biology: A Very Short Introduction (Very Short Introductions)
Synthetic biology is one of the 21st century's fastest growing fields of research, as important for technology as for basic science. Building on traditional genetic engineering, which was restricted to changing one or two genes, synthetic biology uses multi-gene modules and pathways to make very significant changes to what cells can do. Synthetic biologists aim to have an impact in fields as diverse as drug manufacture, biofuel production, tackling pollution, and medical diagnostics. Further ahead, synthetic biology may even make possible the long-standing goal of creating new life from non-living starting materials. This Very Short Introduction provides a concise explanation of what synthetic biology is, and how it is beginning to affect many fields of technology. Jamie Davies also discusses the considerable controversies surrounding synthetic biology, from questions over the assumption that engineering concepts can be applied to living systems easily, to scepticism over the claims for commercial promise, fears that the dangers of engineering life are worse than its benefits, and concerns over whether humans should be designing living systems at all. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Focus On Middle School Biology Teacher’s Manual, 3rd Edition
The Focus On Middle School Biology Teacher's Manual, 3rd Edition accompanies the Focus On Middle School Biology Student Textbook and Laboratory Notebook, 3rd Edition. This Teacher's Manual includes guides and instructions for the hands-on experiments in the Laboratory Notebook, objectives for each experiment, suggested questions to guide open inquiry, and complete materials lists for the experiments.The Focus On Middle School Biology Teacher's Manual, 3rd Edition contains 12 black and white chapters. 92 pages. Grades 5-8.
Why We Believe
A wide-ranging argument by a renowned anthropologist that the capacity to believe is what makes us human Why are so many humans religious? Why do we daydream, imagine, and hope? Philosophers, theologians, social scientists, and historians have offered explanations for centuries, but their accounts often ignore or even avoid human evolution. Evolutionary scientists answer with proposals for why ritual, religion, and faith make sense as adaptations to past challenges or as by-products of our hyper-complex cognitive capacities. But what if the focus on religion is too narrow? Renowned anthropologist Agust穩n Fuentes argues that the capacity to be religious is actually a small part of a larger and deeper human capacity to believe. Why believe in religion, economies, love? A fascinating intervention into some of the most common misconceptions about human nature, this book employs evolutionary, neurobiological, and anthropological evidence to argue that belief--the ability to commit passionately and wholeheartedly to an idea--is central to the human way of being in the world.
Towards Mechanism-based Treatments for Fragile X Syndrome
It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the expansion mutation and the resulting gene silencing still remain elusive. Our understanding of the pathways impacted by the loss of FMRP function has grown tremendously, and has opened new avenues for targeted treatments for FXS. However, the failure of recent clinical trials that were based on successful preclinical studies using the Fmr1 knockout mouse model has forced the scientific community to revisit clinical trial design and identify objective outcome measures. There has also been a renewed interest in restoring FMR1 gene expression as a possible treatment approach for FXS. This special issue of Brain Sciences highlights the progress that has been made towards understanding the disease mechanisms and how this has informed the development of treatment strategies that are being explored for FXS.
Human Cloning and Human Dignity
Few avenues of scientific inquiry raise more thorny ethical questions than the cloning of human beings, a radical way to control our DNA. In August 2001, in conjunction with his decision to permit limited federal funding for stem-cell research, President George W. Bush created the President's Council on Bioethics to address the ethical ramifications of biomedical innovation. Over the past year the Council, whose members comprise an all-star team of leading scientists, doctors, ethicists, lawyers, humanists, and theologians, has discussed and debated the pros and cons of cloning, whether to produce children or to aid in scientific research. This book is its insightful and thought-provoking report. The questions the Council members confronted do not have easy answers, and they did not seek to hide their differences behind an artificial consensus. Rather, the Council decided to allow each side to make its own best case, so that the American people can think about and debate these questions, which go to the heart of what it means to be a human being. Just as the dawn of the atomic age created ethical dilemmas for the United States, cloning presents us with similar quandaries that we are sure to wrestle with for decades to come.
Cancer Metabolomics 2018
The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
The Problem of Increasing Human Energy
2019 Reprint of 1900 Edition First Published in The Century Illustrated Monthly Magazine, Volume LX, June, 1900. Full facsimile of the original edition, not reproduced with Optical Recognition software. In this short essay Tesla speculates on the nature of man and energy. "Though we may never be able to comprehend human life, we know certainly that it is a movement, of whatever nature it be. The existence of movement unavoidably implies a body which is being moved and a force which is moving it. Hence, wherever there is life, there is a mass moved by a force. All mass possesses inertia, all force tends to persist. Owing to this universal property and condition, a body, be it at rest or in motion, tends to remain in the same state, and a force, manifesting itself anywhere and through whatever cause, produces an equivalent opposing force, and as an absolute necessity of this it follows that every movement in nature must be rhythmical." Illustrations include burning the nitrogen of the atmosphere, a diagram of the three ways of increasing human energy, the first practical Telautomaton, an experiment to illustrate the supplying of electrical energy through a single wire without return, the experiment to illustrate the transmission of electrical energy through the earth without wire, a photographic view of the coils responding to electrical oscillations, a view of the essential parts of the electrical oscillator used in the experiment, an experiment to illustrate an inductive effect of an electrical oscillator of great power, the experiment to illustrate the capacity of the oscillator for producing electrical explosions, an experiment to illustrate the capacity of the oscillator for creating a great electrical movement, a photographic view of an experiment to illustrate the effect of an electrical oscillator delivering energy at a rate of seventy-five thousand horse-power, and small diagrams of wireless telegraphy mechanically illustrated, and obtaining energy from the ambient medium.
DNA Replication Stress
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging.As Guest Editor for this IJMS
Extinction: A Very Short Introduction
Most people are familiar with the dodo and the dinosaur, but extinction has occurred throughout the history of life, with the result that nearly all the species that have ever existed are now extinct. Today, species are disappearing at an ever increasing rate, whilst past losses have occurred during several great crises. Issues such as habitat destruction, conservation, climate change, and, during major crises, volacanism and meteorite impact, can all contribute towards the demise of a group. In this Very Short Introduction, Paul B. Wignall looks at the causes and nature of extinctions, past and present, and the factors that can make a species vulnerable. Summarising what we know about all of the major and minor exctinction events, he examines some of the greatest debates in modern science, such as the relative role of climate and humans in the death of the Pleistocene megafauna, including mammoths and giant ground sloths, and the roles that global warming, ocean acidification, and deforestation are playing in present-day extinctions ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Human Evolution
This Very Short Introduction traces the history of paleoanthropology from its beginnings in the eighteenth century to the latest fossil finds. Although concentrating on the fossil evidence for human evolution, it also covers the latest genetic evidence about regional variations in the modern human genome that relate to our evolutionary history. Bernard Wood draws on over thirty years of experience to provide an insider's view of the field and some of the personalities in it, and demonstrates that our understanding of human evolution is critically dependent on advances in related sciences such as paleoclimatology, geochronology, systematics, genetics, and developmental biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Hurdles for Phage Therapy (PT) to Become a Reality
Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage-bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.
Staphylococcus aureus Toxins
Staphylococcus aureus is a common inhabitant of the human body with which we co-exist. However, this species can also cause disease in humans when an appropriate opportunity arises, such as a cut or some other breakdown in our body's defenses. S. aureus is able to initiate infections due, in part, to the diverse group of toxins that they secrete. The exotoxins produced by S. aureus can cause direct damage, thwart our own body's defenses, or trigger massive amounts of cytokines that lead to indirect damage within the human body. In this book are 12 research articles that deal with different aspects of staphylococcal exotoxins. Some of the work gives an overview about how the toxins contribute to the disease process. Other articles discuss different aspects of several exotoxins, and two articles are centered on countermeasures against S. aureus infections. Overall, this book will give the reader a good overview of how staphylococcal exotoxins contribute to initiating and sustaining infections in humans.
Molecular Advances in Wheat and Barley
Allohexaploid bread wheat and diploid barley are two of the most cultivated crops in the world. This book reports novel research and reviews concerning the use of modern technologies to understand the molecular bases for wheat and barley improvement. The contributions published in this book illustrate research advances in wheat and barley knowledge using modern molecular techniques. These molecular approaches cover genomic, transcriptomic, proteomic, and phenomic levels, together with new tools for gene identification and the development of novel molecular markers. Overall, the contributions for this book lead to a further understanding of regulatory systems in order to improve wheat and barley performance.
Aging and Age-Related Disorders
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson's, Alzheimer's, and Huntington's diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Human and Animal Sensitivity
veterinary student; animal ethics; pain perception; animal; animal welfare; Animal welfare; husbandry practices; lambs; pain; sheep farmers; perception; agreement; aggression; animal welfare; desensitization; perception; pigs; animal welfare; young adult; animal attitudes; children; farm animals; animal welfare; education; technology; animal welfare; Asia; knowledge; slaughter; transport; training; animal welfare; benefit; profit; human health; Asia; livestock; farmer perception; citizen perception; qualitative research; free elicitation narrative interviews; animal welfare; consumer; willingness to pay; pig; castration; immunocastration; information; survey; human-animal relationship; fear; laying hen; stockpeople attitudes; stockperson behaviour; egg farm; albumen corticosterone; welfare; animal welfare; stakeholder perception; text mining; horse; donkey; goat; sheep; turkey; farm animal welfare (FAW); willingness to pay; food safety concerns; ethical concerns; perceived consumer effectiveness; broiler; dairy buffalo; human-animal relationship; animal behavior; test-retest reliability; avoidance distance; milk production; animal welfare; animal welfare; stunning; religious slaughter; veterinary students; Halal meat; racehorse welfare; staff shortages; horse-human relationship; standards of care; employee relations; consumer demand; economics; farm animal welfare; producer perspective
The Doctrine of Natural Selection
This early work by Alfred Russel Wallace was originally published in 1873 and we are now republishing it with a brand new introductory biography. 'The Doctrine of Natural Selection' is a short article on Wallace's most lasting contribution to evolutionary theory. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Mr. Wallace on the Phenomena of Variation and Geographical Distribution as Illustrated by the Malayan Papilionid疆
This early work by Alfred Russel Wallace was originally published in 1864 and we are now republishing it with a brand new introductory biography. 'Mr. Wallace on the Phenomena of Variation and Geographical Distribution as Illustrated by the Malayan Papilionid疆' is an article detailing Wallace's observations of a particular genus of butterfly he studied whilst travelling in Asia. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
On the Tendency of Varieties to Depart Indefinitely From the Original Type
This early work by Alfred Russel Wallace was originally published in 1858 and we are now republishing it with a brand new introductory biography. 'On the Tendency of Varieties to Depart Indefinitely From the Original Type' is a short article on variation and evolutionary theory. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
On the Law Which Has Regulated the Introduction of New Species
This early work by Alfred Russel Wallace was originally published in 1855 and we are now republishing it with a brand new introductory biography. 'On the Law Which Has Regulated the Introduction of New Species' is an article that details Wallace's ideas on the natural arrangement of species and their successive creation. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Human Selection
This early work by Alfred Russel Wallace was originally published in 1890 and we are now republishing it with a brand new introductory biography. 'Human Selection' is an essay on the future of human evolution in relation to Darwin's suggestion that natural selection was having a reduced or non-existent effect on modern humanity. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Difficulties of Development as Applied to Man
This early work by Alfred Russel Wallace was originally published in 1876 and we are now republishing it with a brand new introductory biography. 'Difficulties of Development as Applied to Man' is an article on evolutionary theory in regard to the origins of the human race. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Evolution and Character
This early work by Alfred Russel Wallace was originally published in 1908 and we are now republishing it with a brand new introductory biography. 'Evolution and Character' is an essay on explaining the key concepts and historical state of evolutionary theory. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Are Individually Acquired Characters Inherited?
This early work by Alfred Russel Wallace was originally published in 1893 and we are now republishing it with a brand new introductory biography. 'Are Individually Acquired Characters Inherited?' is an essay that discusses the important question of whether traits acquired during an organism's life are passed on to the next generation. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Mimicry, and Other Protective Resemblances Among Animals
This early work by Alfred Russel Wallace was originally published in 1867 and we are now republishing it with a brand new introductory biography. 'Mimicry, and Other Protective Resemblances Among Animals' outlines the many uses of mimicry employed by creatures such as insects, lizards, and birds. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
The Origin of Human Races and the Antiquity of Man Deduced From the Theory of Natural Selection
This early work by Alfred Russel Wallace was originally published in 1864 and we are now republishing it with a brand new introductory biography. 'The Origin of Human Races and the Antiquity of Man Deduced From the Theory of "Natural Selection"' is an essay on the development of humans and the evolutionary evidence for natural selection. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Darwinism Applied to Man
This early work by Alfred Russel Wallace was originally published in 1889 and we are now republishing it with a brand new introductory biography. 'Darwinism Applied to Man' contains an account of of the general identity of human and animal structure, diseases common to man and other animals, summary of the animal characteristics of man, and other aspects of evolutionary theory. Alfred Russel Wallace was born on 8th January 1823 in the village of Llanbadoc, in Monmouthshire, Wales. Wallace was inspired by the travelling naturalists of the day and decided to begin his exploration career collecting specimens in the Amazon rainforest. He explored the Rio Negra for four years, making notes on the peoples and languages he encountered as well as the geography, flora, and fauna. While travelling, Wallace refined his thoughts about evolution and in 1858 he outlined his theory of natural selection in an article he sent to Charles Darwin. Wallace made a huge contribution to the natural sciences and he will continue to be remembered as one of the key figures in the development of evolutionary theory.
Strong Drink and Tobacco Smoke - The Structure, Growth, and Uses of Malt, Hops, Yeast, and Tobacco
This vintage book contains a detailed treatise on the structure, growth, and uses of malt, hops, yeast, and tobacco. A fascinating and in-depth investigation into the scientific properties of tobacco and brewing ingredients, "Strong Drink and Tobacco Smoke" is highly recommended for those with an interest in the history and development of these industries, and is not to be missed by the discerning collector of related literature. Contents include: "Introductory", "Materials", "How Barley Grows", "Structure of Barley and Some Other Seeds", "Hops and Yeast", "Malt, Beer, Spirit", and "Tobacco and Some Other Leaves". Many vintage books such as this are increasingly scarce and expensive. It is with this in mind that we are republishing this volume now in an affordable, modern edition complete with a specially commissioned new introduction on beer brewing.
