The Covid-19 Pandemic
The COVID-19 Pandemic: A Global High-Tech Challenge at the Interface of Science, Politics, and Illusions discusses COVID-19 as the first pandemic in the Internet era and our current reality of continuous reports, news, and updates. Since its beginning, we were daily bombarded with news of what was happening around the world. There was no global political leadership. The United States was politically partially paralyzed. Russia and China hoped to gain diplomatic profile worldwide, but their vaccines are of limited efficacy, and trust in their clinical data is rightly low. The European Union did not order enough vaccines in time, but sued a large manufacturer for delivery delays. Now it is setting up yet another bureaucratic institution. At least the pharmaceutical or life science industry paved the way out, but is not enthusiastically praised for it. It would be too easy and superficial to blame mistakes of governments and leaders on stupidity. Idiocy exists, but we have to go deeper to understand how illusions and blind spots in today's common perception and science, inertia, arrogance, conflicts of interest, competition of individuals, and states and institutions for public recognition have contributed to a multitude of flawed assessments and direct mistakes. Healthcare professionals and anyone interested in an in-depth understanding of humankind's response to the COVID-19 challenge will not get around the key conclusions of this book.
Cambridge Lower Secondary Complete Biology Student Book 2nd Edition Set
What Is Regeneration?
Two historians and philosophers of science offer an essential primer on the meaning and limits of regeneration. In punishment for his stealing fire, the Greek gods chained Prometheus to a rock, where every day an eagle plucked out his liver, and every night the liver regenerated. While Prometheus may be a figure of myth, scholars today ask whether ancient Greeks knew that the human liver does, in fact, have a special capacity to regenerate. Some organs and tissues can regenerate, while others cannot, and some organisms can regenerate more fully and more easily than others. Cut an earthworm in half, and two wiggly worms may confront you. Cut off the head of a hydra, and it may grow a new head. Cut off a human arm, and the human will be missing an arm. Why the differences? What are the limits of regeneration, and how, when, and why does it occur? In this book, historians and philosophers of science Jane Maienschein and Kate MacCord explore biological regeneration, delving into a topic of increasing interest in light of regenerative medicine, new tools in developmental and neurobiology, and the urgent need to understand and repair damage to ecosystems brought on by climate change. Looking across scales, from germ, nerve, and stem cells to individual organisms and complex systems, this short and accessible introduction poses a range of deep and provocative questions: What conditions allow some damaged microbiomes to regenerate where others do not? Why are forests following a fire said to regenerate sometimes but not always? And in the face of climate change in the era called the Anthropocene, can the planet regenerate to become healthy again, or will the global ecosystem collapse?
A Dictionary for Invertebrate Zoology
With over 19,000 entries, this reference work fulfills the need for an academic work that combines the concise presentation of a dictionary, with an etymology for each term, and includes the general terms one would meet while studying invertebrate zoology. Invertebrate zoology is not studied in isolation, therefore the more common terms from the fields of Anatomy, Animal Behavior, Ecology, Embryology, Endocrinology, Evolution, Genetics, Physiology, Taxonomy and Zoogeography, as well as many terms covering sizes, shapes, colors, forms and textures have been included. There is a comprehensive taxonomic coverage of every invertebrate phylum and many families and species that are of particular interest. Appendix 1 provides a brief, alphabetical, descriptive summary of the 37 invertebrate phyla, including the higher level taxonomy down to the level of family in most cases. Appendix 2 defines Biogeographical and Zoogeographical Regions. Appendix 3 is an Outline of Geological Time and provides information about the principle Eons, Eras, Periods, and Epochs, plus other geological time periods. Appendix 4 lists commonly encountered color terms. Appendix 5 is a brief bibliography. Additionally there is a brief introduction to scientific Latin and Greek. This dictionary is a standard reference and will be invaluable to anyone with an interest in Invertebrate Zoology.
Obesity Epidemic and the Environment
Obesity Epidemic and the Environment: Latin America and the Caribbean Region provides a broad analysis of the macroeconomic impact of the obesity epidemic on environmental degradation in the LAC region. Case studies combine theory and practice to achieve critical conclusions (and subsequent policy implications), providing useful tools for those working on actual health, energy and environmental challenges. Written for researchers, policymakers, international organizations and practitioners in various fields, especially those in public health, health economics, energy and environmental economics and social sciences, this book thoroughly highlights the obesity epidemic in this region. In the LAC region, obesity has become a public health issue. The increase of this problem is related to the economic gains obtained from the process of liberalization and privatization, the increase of foreign investment, and infrastructure investments.
Ultrasound Guided Musculoskeletal Procedures in Sports Medicine
Ultrasound Guided Musculoskeletal Procedures in Sports Medicine: A Practical Atlas provides the support practitioners need based on practical, first-hand experience of a Sports and Exercise Medicine Physician who trained in musculoskeletal sonography. Over the years, and with much practice, the lessons learned and techniques developed are summarized with relevant pictures that guide those undertaking the procedure. As musculoskeletal ultrasound forms an important tool for physicians working in this field of medicine, this book helps physicians provide increasing expectation for patients who want a safe, guided procedure when clinically warranted. While an understanding of ultrasound imaging is essential prior to ultrasound guided procedures, there are few practical guides that provide practicing clinicians with a quick reference when faced with a procedure. This book fills that void.
Human-Wildlife Conflict Management
The latest edition of this classic guide details how to understand and resolve a broad array of human-wildlife conflicts.This new edition of Human-Wildlife Conflict Management updates our understanding of the human dimensions, as well as biological and ecological concepts, underlying human-wildlife conflicts. While it provides wildlife professionals and students with the knowledge and adaptive management strategies to resolve such conflicts, it uniquely explores negative interactions with a wide range of wildlife taxa beyond those typically covered in traditional wildlife damage management, including invasive plants, invertebrates, and fish.Designed to help students and natural resource practitioners gain a deeper understanding of how to successfully avoid and resolve conflict between humans and wildlife, it is informed by author Russell F. Reidinger's decades of teaching students and professionals how to anticipate and manage human-wildlife conflicts, as well as his experience leading a national research program devoted to this work.The book covers important human-wildlife topics such as: - individual-, population-, and ecosystem-level effects- survey techniques- management methods- human dimensions- economic issues- legal and political aspects- damage management strategiesFeaturing explanations of important terminology and pertinent biological and ecological concepts, Reidinger also shares the latest research, provides a plethora of real-world examples, and includes suggestions for additional resources.
Computational Approaches
This book is a collection of original research articles in the field of computer-aided drug design. It reports the use of current and validated computational approaches applied to drug discovery as well as the development of new computational tools to identify new and more potent drugs.
Kinetoplastid Phylogenomics and Evolution
This Special Issue, Kinetoplastid Phylogenomics and Evolution, unites a series of research and review papers related to kinetoplastid parasites. The diverse topics represented in this collection display a variety of scientific questions and methodological approaches currently used to study these fascinating organisms.
Sexual Endocrinology of Non-mammalian Vertebrates
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface.We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Tuco-Tucos
Preface.- The history of Ctenomys in the fossil record: a young radiation of an ancient family.- A short overview of the systematics of Ctenomys: species limits and phylogenetic relationships.- Speciation in the genus Ctenomys: an attempt to find models.- Geographical and macroecological patterns of tuco-tucos.- Phylogeography and landscape genetics in the subterranean rodents of the genus Ctenomys.- Skull shape and size diversification in the Genus Ctenomys (Rodentia: Ctenomyidae).- Biomechanics and strategies of digging.- Adaptive pelage coloration in Ctenomys.- Environmental and ecological features of the genus Ctenomys.- The diet of ctenomyids.- Ecological physiology and behavior in the genus Ctenomys.- Effects of environmental pollution on the conservation of Ctenomys.- Index.
The Amazing Biological Revolution and The Amazing New Health Care
Development Strategies and Biodiversity
Part 1 - Evolutionary meaning of development: how and why early life experience generates diversity(1) Trans-generational inheritance of early life effects and evolution (Ethienne Danchin, University of Toulouse, France)(2) Adaptive meaning of early life experience in species that go through metamorphosis (Yui Suzuki, Duke University, USA; Takashi Koyama, Univ. of Copenhagen, Denmark)(3) Cross-talk between early life and population frequency-based mechanisms in driving the evolutionary success of personalities (Heiko Rodel, Paris-Sud University, France; Claudio Carere, Univ. La Tuscia, Italy)Part 2 - Endogenous mechanisms underlying the interactions between the individual and the early-life environment(4) Developmental stress and the resistant phenotype: the good and the bad of it (Valeria Marasco, Univ. of Veterinary Medicine Vienna, Austria; Karen Spencer, Univ. of St. Andrews, UK; Susanne Huber, University of Vienna, Austria)(5) Early immunological development and sensitivity to parasites and infectious diseases in later life (Gabriele Sorci, Univ. of Bourgogne, France)(6) Early life nutrition and the programming of the phenotype (Katherine Buchanan, Deakin Univ., Australia)Part 3 - Anthropocene opens new horizons to reveal the evolutionary meaning of early life(7) Adaptive and maladaptive consequences of developing in changing environments (Robby Stoks, Univ. of Leuven, Belgium)(8) How developmental strategies shape success of invasive species (Daniele Canestrelli, Univ. La Tuscia, Italy)(9) Consequences of pre- and post-natal exposure to pollution: from the individual to the population (Prof Caroline Isakssoon, Lund University, Sweden and Dr. Frederic Angelier, CNRS, France)
Operational Research Tools for Solving Sustainable Engineering Problems
The need for operational research (OR) tools and techniques is manifested in its ability to balance conflicting objectives (goals or interests) where there are many alternative courses of action available to the decision-maker when resources, time, and funds are limited. Therefore, beyond the domain of theoretical knowledge and model-building activities, OR has all of the pervasive applications in decision making regarding problems in sustainable engineering, sustainable society, and business. OR tools and techniques find applications in all aspects of sustainability operations, such as sustainable supply chain planning, sustainable distribution, sustainable traffic flow optimization, industrial waste reduction, energy conservation, sustainable city planning, etc. Over the years, the applications of OR have been extended to solving the problems of communication of information and socio-economic fields. In this context, the academic community needs to take the lead in the design, development, and demonstration of sustainable operational research models, endowed and supported by organizations.
New Approaches in Social, Environmental Management and Policy to Address SDGs
The book comprises a selection of papers addressing some of the most relevant challenges and opportunities for addressing SDGs from many different perspectives. Papers in this collection cover the most recent lines and approaches of research in addressing SDGs and are all novel propositions that deepen the analysis of environmental, social and governance strategies in the adaptation of the society to meet the 17 SDGs.
An Introduction to Modern Genetics
First published in 1939 (second impression in 1950), this book provides an account of the changes in, and main principles of, genetics at that time. These are illustrated by references to the most authoritative and then recent investigations. Special attention is paid to the way in which genetics overlaps with other fields of inquiry, since it is often in these border-line subjects that the most important advances are to be expected. The book is particularly arranged to suit the convenience of students whose previous knowledge of genetics is small, and contains annotated bibliographies of suggestions for further reading.
How Animals Develop
First published in 1935 (this edition in 1946), this short account of the science of embryology was the first book in English to provide a simple outline of the whole of this important subject. The study of development is perhaps the best method of approach to the most fundamental of all biological problems, the problem of how all the diverse activities are integrated so as to make up a complete individual organism. This volume is simply written in order to enable the general reader to understand the revolutionary advances made in the subject at that time.
Molecular Mechanisms of Leaf Morphogenesis
Leaf morphology is obviously determined in a plant. By contrast, its morphology is often changeable when the plant copes with various environmental changes. To update our understanding of the regulatory mechanisms of leaf morphogenesis with robustness and flexibility, this book provides a series of academic papers that cover molecular mechanism of leaf morphogenesis and offers readers' opportunities to find beautiful mechanisms that plants develop.
Exploring Genome's Junkyard
Exploring Genome's Junkyard: In the Labyrinth of Evolution narrates the progress of biological evolution, beginning with the conceptual introspection of gene and continuing with the contemporary understanding of the structural and function aspects of the human genome. Recent advances in human genome research have led scientists to the term "biological dark matter," which refers to genetic material whose functionalities are not yet properly understood. Such "dark matter" has been recognized as non-coding, or "junk DNA," and non-coding RNA, which was thought to be devoid of protein encrypting potential but contained 98-99% of the human genome. The mysteries of missing genes from its "Dark DNA" region are a hotbed of recurrent mutations. Hence, the presence of "missing genes" in evolutionary sibling species has indicated that the "missing genes" are not really missing but rather hidden in the mutational hotbeds of "Dark DNA" where they have steered the continuation of life's evolutionary journey.
European Hair, Eye, and Skin Color
Europeans, especially those from northern and eastern Europe, are unique in having diverse hair and eye colors and a skin almost as pale as an albino's. Those colors are not only brighter than the original black and brown but also "purer"-they lie within thin slices of the visible spectrum. Overall, that color scheme is more developed in women, who naturally have a higher incidence of red hair, blonde hair, and green eyes. They also have fairer skin. The distinguishing features of Europeans began as female features.A visual transformation occurred among ancestral humans on the open plains of Europe, and it began among their women. It also occurred over a short span of time-less than ten thousand years. Why? How? That is the puzzle this book will address.
Oligonucleotide, Therapy, and Applications
Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice. In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs.
Natural Products and Derivatives in Human Disorders
With this Special Issue, we have aimed to collect, publish and disseminate some of the most significant and recent contributions using both natural compounds present in living organisms and some of their chemical derivatives aimed at reducing the risk of developing inflammatory and oxidative diseases such as cancer, metabolic syndrome and other human disorders related to the bone, vascular and ocular systems. The publication of articles on the anticancer and antioxidant activity of natural compounds and their derivatives is particularly encouraged. Natural products, many of them phytochemicals, are bioactive compounds. They have traditionally been used by different cultures for the prevention and treatment of various human diseases. Subsequently, their chemical derivatives are being used to enhance their bioactivities. antiproliferative, antitumour, growth stimulating, as well as cardio- and neuroprotective activities, with particular attention being paid to the study of their antitumour capacity, through potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis and metastatic dissemination. Furthermore, a considerable number of studies have shown that the relationship of the anticancer effect to its anti-inflammatory and antioxidant activities are directly proportional. In addition to these capabilities, the use of natural compounds and their derivatives represents one of the most promising strategies for treating other metabolic disorders such as oxidative stress, diabetes, obesity, metabolic syndrome, etc.
Micro/Nanofluidic Devices for Single Cell Analysis, Volume II
This Special Issue book entitled "Micro/nanofluidic devices for Single Cell Analysis, Volume II" covers different aspects of single-cell analysis. This book emphasizes in detail single-cell separation, manipulation, and analysis and diagnosis. It also covers single-nucleus electrical characterization, hydrodynamic stretching, microsieve filtration for genetic, phenotypic analysis which links to cellular deformability and the clinical application of an integrated microfluidic device for the isolation of circulating tumor cells and analysis. Moreover, this book describes single-cell mechanophenotyping to evaluate the behavior of U87 Glioma cells, with the heterogeneity being quantified according to the deformation of the U937 monocytes and U937-differentiated macrophages. Finally, this book also demonstrated the real-time monitoring and detection of single-cell level cytokine secretion using LSPR technology.
Impact of Pre-Mortem Factors on Meat Quality
Meat quality is associated with the chemical composition and metabolic state of skeletal muscle. This Special Issue aims to compile the recent literature with a focus on meat quality and pre-mortem factors that affect muscle metabolism. It includes nine research articles about various types of meat, as well as one review article about beef quality.
Advanced Research on Glucosinolates in Food Products
Glucosinolate-containing foods, such as vegetables from the plant order Brassicales and its derivative products, are valued for their health-beneficial properties. The latter are linked to glucosinolate hydrolysis products, such as isothiocyanates. The book "Advanced Research on Glucosinolates in Food Products" collects the latest research on the impact of the whole food supply chain, including production, as well as domestic food preparation, on glucosinolates and the formation and chemistry of their breakdown products in vegetables and further foods. In this context, the consequences for human health are important, too. The book contains articles that cover research on the effect of pre-harvest factors on glucosinolates, their hydrolyzing enzymes, and the formation of volatile hydrolysis products. Further topics include the linkage between glucosinolates and sensory aspects, and the effects of food preparation and follow-up reactivity. Finally, research on the bioavailability and functional effects of isothiocyanates for human health is included.
Hemorheology and Metabolism
This e-book version of the Special Issue "Hemorheology and Metabolites" has been dedicated to the novel findings and recent advances in hemorheology, presenting clinical or clinically oriented experimental research and review articles in the context of metabolites, metabolic alterations and blood macro- and micro-rheology.
An Introduction to Making Graphs and Maps for Biologists using R
This workbook introduces biologists to the key practical skills they need to create high quality graphs and maps in R. It is aimed both at students who are taking their first courses on data processing, analysis and visualisation and at biologists who wish to teach themselves how to use R. As well as providing a quick-start guide to using R itself, this workbook provides a series of practical exercises based on easy-to-follow flow diagrams that show biologists exactly how to do a variety of key tasks in it. These include: 1. Creating your first graphs in R using the GGPlot package, including making basic graphs, such as frequency distribution histograms, creating high quality graphs suitable for inclusion in presentations and publications, creating different types of graphs from the same data set, and making graphs that display data from more than data series.2. Creating graphs to display groups of data using GGPlot, including bar graphs of count data, graphs of summary statistics for one variable with error bars, point graphs of summary statistics for two variables with vertical and horizontal error bars, and box plots. 3. Creating graphs of individual data points, including scatter plots, line graphs of time series data, and matrices of pair plots.4. Creating other types of graphs from biological data including pie charts, bubble graphs, mixed type graphs, and X-Y graphs of tracking data.5. Creating maps from biological data in R using the GGPlot package.Together, these represent the key tasks that biologists need to be able to create high quality and informative graphs and maps using R.This is the second book in the Practical Statistics for Biologists Workbooks series. This series aims to fill the gap between learning about statistical theory and learning how to actually use statistics in a practical and biological meaningful way. The focus of this series is, therefore, on the development of practical skills, based on learning appropriate workflows, rather than teaching statistical theory.The PSLS series of books uses Task-Oriented Learning (TOL) to teach the practical application of research skills to the life sciences. This involves demonstrating how skills can be used in the specific circumstances in which they are likely to be required rather than concentrating on teaching theoretical frameworks or on teaching skills in a generic or abstract manner. By seeing how similar processes are used to achieve a variety of different goals within a specific field, it becomes easier for the reader to understand the general rules behind the practical application of these processes and, therefore, to transfer them to novel situations they may encounter in their own work.
Novel Techniques to Measure the Sensory, Emotional, and Physiological (Biometric) Responses of Consumers toward Foods and Packaging
This book reprinted from articles published in the Special Issue "Novel Techniques to Measure the Sensory, Emotional, and Physiological (Biometric) Responses of Consumers toward Foods and Packaging" of the journal Foods aims to provide a deeper understanding of novel techniques to measure the different sensory, emotional, and physiological responses toward foods. The editor hopes that the findings from this Special Issue can help the broader scientific community to understand the use of novel sensory science techniques that can be used in the evaluation of products.
Meaning of Life, Human Nature, and Delusions
Integrating information from diverse scientific fields, this book argues against the widely accepted idea that wonder in the purpose of life constitutes one of the noblest human qualities. As such, its arguments are intended for biologists, historians and philosophers of science alike. Students, teachers, and researchers of any scientific field, as well as all those who are fascinated by questions about their daily inner-lives and their "cosmic purpose" will be intrigued by unique discussions into themes like racism, colonialism, and eugenics.
Translational Research for Zoonotic Parasites
In this book is reported novel information on diagnosis, treatment, and control of parasites that are naturally transmitted from animal reservoirs to humans. Subjects: Public Health and Healthcare: Prevention; Medicine and Pharmacology: Therapy.
O-GlcNAcylation and Cancer
This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.
Monoclonal Antibody-Directed Therapy
The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.
Animal Nutrition and Welfare in Sustainable Production Systems
Today, food animal production systems demand high energy, land, chemicals, and water-all of which are increasingly becoming scarce. Thus, change and innovation are required in many animal production systems to meet the present and future demands for animal products sustainably. Over the last four decades, inexpensive grain, energy, and protein have enabled the economic development of intensive meat, eggs, and milk production systems based on feeding grains and other ingredients sourced from far-off places. The poultry and pig intensive production systems have become highly capital intensive, and they have resulted in many environmental challenges.Food animal feed, nutrition, and welfare are the foundation of successful animal systems. They directly or indirectly affect the entire animal production sector, associated services, public goods, and services, including animal productivity, health and welfare, product quality and safety, land use and land-use change, and greenhouse gas emissions. The sustainability of food animal nutrition and welfare is crucial in developing animal production across production systems. The sustainable increase in animal productivity, which is key to meeting the large current and future demands for animal origin products, cannot be achieved without sustainable animal nutrition and welfare.
Genetics of Alzheimer’s Disease
This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
How Genome Editing is Revolutionizing Medicine
Bachelor Thesis from the year 2020 in the subject Biology - Genetics / Gene Technology, grade: 1,1, Management Center Innsbruck, course: Biotechnology, language: English, abstract: CRISPR continues to drive the world of gene editing. About seven years ago, scientists reported that CRISPR technology can enable precise and efficient genome editing in living eukaryotic cells. Since then, interest in the method has spread extensively across the globe. Not long after its sudden headstart in 2013, already thousands of laboratories started taking up the technique and investors began funding startups to harness its potential. This ultimately resulted in major improvements being made in incredibly short periods of time. Simultaneously, this also initiated and continues to drive an increasing gap between new innovative applications in the field of gene editing and the overall awareness of the general public. Ethical concerns have remained a steady companion of this rise. With myriads of research papers about CRISPR related topics being published every year, trying to stay on top of developments can be a cumbersome task. The goal of this paper is to summarize current practice and research areas that are part of modern gene editing. Following a brief summary of CRISPR basics, used endonucleases and techniques, its impact on the treatment of hereditary diseases, viral infections and cancer is illustrated based on recent examples. Effects of gene editing on cell line engineering efforts are described using studies focusing on glycosylation, impurities, cultivation and production efficiency issues of CHO cell lines. Besides discussing CRISPR applications for rapid SARS-CoV-2 diagnosis, current challenges for clinical use including off-targets, immune responses and lacking drug delivery efficiencies as well as promising developments are being reviewed. This paper is supposed to support quick elucidation of future potential of the rapidly evolving world of CRISPR Cas genome editin
In Memory of Stefan Kunz
This issue of Viruses is a living memorial dedicated to Professor Stefan Kunz, who passed away too early in life, at 54. During his scientific career, Stefan made major contributions to the field of virology. He made seminal contributions to our understanding of how mammarenaviruses gain access to and are trafficked within their target cells. This issue of Viruses contains a collection of articles by leading researchers in different areas of virus-host cell interactions and who crossed pathways with Stefan. The topics covered in the issue include novel insights on mammeranavirus cell entry, host innate and adaptive immune responses to infection, recent developments on therapeutics against human pathogenic arenaviruses, as well as mammarenavirus ecology and molecular pathogenesis. The collection of articles is also a reflection of Stefan's enthusiasm for exploring new ideas and his very collegial attitude reflected by his many collaborations, including the colleagues who have contributed sections to this memorial issue.
Reviews of Environmental Contamination and Toxicology Volume 253
Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.
Acidophiles
Acidophiles are an important category of microorganisms defined by their ability to withstand and even grow in acidic environments. They are present in terrestrial and marine environments as well as the human body. The diversity, adaptation, and functions of these microorganisms can contribute to the development and application of new biotechnologies for resolving problems of resource exploitation, pollution, and human disease. This book presents breakthroughs and insights into the research on acidophiles. Chapters cover such topics as the two-component system (TCS) in the regulation of the sulfur metabolic process, adaptation mechanisms of acidophiles to low pH, regulation mechanisms and application strategy of quorum sensing in bioleaching bacteria, and Lactobacillus acidophilus and its potential role as a therapeutic for human bone disorders.
About Life
This book uses modern biological knowledge to tackle the question of what distinguishes living organisms from the non-living world. The authors first draw on recent advances in cell and molecular biology to develop an account of the living state that applies to all organisms (and only to organisms). This account is then used to explore questions about evolution, the origin of life, and the possibility of extraterrestrial life. The authors also consider human evolution, intelligence, and the extent to which our species can be regarded as biologically unique. About Life makes modern cell biology comprehensible to the non-specialist. Non-technical language is used throughout and all scientific terms are clearly explained when they are introduced. The novel approach taken by this book to issues in biology will interest both the general reader as well as students and specialists in the field.
Revolve
Artificial intelligence, nanotechnology, implantable chips, and life extension. These and many other technologies are being promoted as the way for humanity to become something radically different. The transhumanist movement claims that by applying them to our biology, we will become posthuman. A new religion for a new age is being born, and it centers around Man's scientific attainment of eternal life. The Philosopher's Stone of the alchemists now appears to be within reach. Revolve takes you beyond the typical Singularity sales pitch to bring you face to face with something far more profound, disturbing, and ancient.
The Brain and the Voice in Speech and Song
This book has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
Aromatics and the Soul
This book has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
The Covid-19 Response
The COVID-19 Response: The Vital Role of the Public Health Professional explores population health during a pandemic and how is it different than clinical medicine. Other sections cover federal, state and local responses to COVID-19, testing for COVID-19, the implementation of public health control measures, the use of public health emergency powers, health equity, the resignation and firing of public health leaders, vaccination planning, and the future of public health post COVID-19. Leaders and practitioners working in public health practice and academia, as well as students in public health undergraduate and graduate level programs will find this book extremely useful.
Benzimidazole Chemistry and Applications
A heterocyclic aromatic organic compound that is produced by fusing benzene and imidazole is referred to as benzimidazole. It is a colorless solid and is often bioactive. Many anthelmintic drugs such as albendazole, mebendazole, triclabendazole belong to the benzimidazole class of compounds. Benzimidazole fungicides act by binding to the fungal microtubules and stopping hyphal growth. Omeprazole, lansoprazole, pantoprazole, rabeprazole, and tenatoprazole comprise a benzimidazole group. Benzimidazole can be used as an organic solderability preservative in printed circuit board manufacturing. Several dyes are extracted from benzimidazoles. This book presents the complex chemistry of benzimidazole in the most comprehensible and easy-to-understand language. It elucidates the concepts and innovative models around prospective developments in the application of benzimidazole. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts.
Outbreaks, Epidemics, and Health Security
Outbreaks, Epidemics, and Health Security: Ensuring Future Preparedness for Small Island Nations and the World reviews the many lessons learned from the COVID-19 pandemic. Topics include epidemic preparedness, the politics of epidemics, health security, anti-vaccine campaigns, vaccine preparedness, the need for detailed information sharing and infection tracking versus protected health information, the effects on international relations, the need for intelligence assets to contribute to global health, and the development of biodefense shields.
The Genesis Conspiracy
Did the early Church of Rome conspire with the pagan Emperor Constantine to create a new religion for the West, superseding Judaism and displacing the Children of Israel as God's First Born Son (Exodus 4:22)? Catholic scholar, Bernard Lee observed: "Most Christological interpretation has been 'supersessionist', that is, it has interpreted Jesus as initiating a new Covenant that supersedes Judaism. Historically, it is quite improbable that Jesus had any such thing in mind." Similarly, "There is little likelihood that Jesus had any conscious intention of founding a new religious institution, either superseding Judaism or alongside it." The obvious question is: If that was not in the mind of Jesus, on whose life and teachings Christianity is said to be based, in whose mind was it? This study examines the wealth of evidence that has convinced the author that in truth, Christianity is a centuries-old conspiracy with significant anti-Jewish undercurrents.
The Genesis Conspiracy
Did the early Church of Rome conspire with the pagan Emperor Constantine to create a new religion for the West, superseding Judaism and displacing the Children of Israel as God's First Born Son (Exodus 4:22)? Catholic scholar, Bernard Lee observed: "Most Christological interpretation has been 'supersessionist', that is, it has interpreted Jesus as initiating a new Covenant that supersedes Judaism. Historically, it is quite improbable that Jesus had any such thing in mind." Similarly, "There is little likelihood that Jesus had any conscious intention of founding a new religious institution, either superseding Judaism or alongside it." The obvious question is: If that was not in the mind of Jesus, on whose life and teachings Christianity is said to be based, in whose mind was it? This study examines the wealth of evidence that has convinced the author that in truth, Christianity is a centuries-old conspiracy with significant anti-Jewish undercurrents.
