Toxicity Assessment
1. The Single Cell Gel Electrophoresis Genotoxin Sensitivity Assay Franziska Ferk, Miroslav Mis穩k, Halh Al-Serori, Armen Nersesyan, Georg Wultsch, and Siegfried Knasmueller 2. Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay Emanuela Corsini, Sue Gibbs, Erwin Roggen, Ian Kimber, and David A. Basketter 3. Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation Tatiana do Nascimento Pedrosa, Carolina Motter Catarino, Paula Comune Pennacchi, Silvia Berlanga de Moraes Barros, and Silvya Stuchi Maria-Engler 4. Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System, Vessel Rheology, and Xenobiotic Distribution Cristina Bichels Hebeda, ?ric Diego Barioni, and Sandra Helena Poliselli Farsky 5. Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment Moritoshi Sato and Yoshio Umezawa 6. In Vitro Contraction of Isolated Cauda Epididymal Duct Smooth Muscle as a Complimentary Approach to Physiological, Pathological, Toxicological, and Pharmacological Studies on Epididymal Function Cibele S. Borges, Luiz Ricardo A. Kiguti, Andr矇 S. Pupo, and Wilma G. Kempinas 7. Early Life Stage Assays in Zebrafish Flavia Renata Abe, Klaus Alvaro Guerrieri Accoroni, Carlos Gravato, and Danielle Palma de Oliveira 8. Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ Thania Rios Rossi Lima, Bianca Camargo Penteado Sales, and Shadia Muhammad Ihlaseh Catalano 9. Evaluation of Development of the Rat Uterus as a Toxicity Biomarker Marlise Guerrero Schimpf, Mar穩a M. Milesi, Enrique H. Luque, and Jorgelina Varayoud 10. Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish Carlos Gravato, Fl獺via R. Abe, Danielle P. Oliveira, Amadeu M.V.M. Soares, and In礙s Domingues 11. Ecotoxicity Assays Using Freshwater Planarians Jo瓊o Lu穩s Teixeira Pestana and Pearl Ugochi Ofoegbu 12. Toxicogenomic Analysis Taisa Magnani Dinamarco, Paula Fagundes de Gouv礙a, Emerson de Souza Santos, and Lucas Oliveira Sousa 13. Strategy Combining Non-Animal Methods for Ocular Toxicity Evaluation Marize Campos Valadares, Gisele Augusto Rodrigues de Oliveira, Renato Ivan de ?vila, and Artur Christian Garcia da Silva 14. Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads Raul Ghiraldelli Miranda, Elisa Raquel Anast獺cio Ferraz, Lilian Cristina Pereira, and Daniel Junqueira Dorta 15. Oxygen Consumption
Eosinophils
1. Molecular Biology of Eosinophils: Introduction Paige Lacy, Helene F. Rosenberg, and Garry M. Walsh 2. Functionally Active Eosinophil Purification from Peripheral Blood Kiho Son, Paige Lacy, and Manali Mukherjee 3. Eosinophil Purification from Peripheral Blood of Rhesus Monkeys Fanny Legrand 4. Generation of Mouse Eosinophils in Tissue Culture from Unselected Bone Marrow Progenitors Eric Mai, Ajinkya R. Limkar, Caroline M. Percopo, and Helene F. Rosenberg 5. Detection of Mouse Eosinophils in Tissue by Flow Cytometry and Isolation by Fluorescence-Activated Cell Sorting (FACS) Caroline M. Percopo, Ajinkya R. Limkar, Albert C. Sek, and Helene F. Rosenberg 6. Mutant Mice and Animal Models of Airway Allergic Disease Julyanne Brassard, David Marsolais, and Marie-Renee Blanchet 7. Eosinophils in Asthma Models to House Dust Mite for Drug Development Fran癟ois Daubeuf and Nelly Frossard 8. Analysis of Mouse Eosinophil Migration and Killing of Tumor Cells Sharon Grisaru, Michal Itan, and Ariel Munitz 9. Murine Models of Eosinophil Function in Fungal and Viral Infections Meenakshi Tiwary, Kim S. LeMessurier, and Amali E. Samarasinghe 10. Assays of Eosinophil Apoptosis and Phagocytic Uptake Naomi N. Gachanja, David A. Dorward, Adriano G. Rossi, and Christopher D. Lucas 11. In Vivo Eosinophil Expansion Using Gene Transfer by Electroporation Emi Hamaguchi-Tsuru, Masataka Korenaga, and Fabrizio Bruschi 12. Observation and Quantification of Eosinophil Motility Karina T. Barretto, Deane F. Mosher, Nizar N. Jarjour, Colleen S. Curran, Stephane Esnault, and Mats W. Johansson 13. Isolation and Functional Aspects of Eosinophil-Derived Exosomes Jos矇 Antonio Ca簽as, Jos矇 Manuel Rodrigo-Mu簽oz, and Victoria del Pozo 14. Interactions of Eosinophils with Nerves Matthew G. Drake, Becky J. Proskocil, and Zhenying Nie 15. Measurement of Eosinophil Kinetics In Vivo Neda Farahi, Daniel Gillett, Chrystalla Loutsios, A. Michael Peters, Charlotte Summers, and Edwin R. Chilvers 16. Detection of Eosinophil Extracellular DNA Traps Marina Valente Barroso and Josiane S. Neves 17. Eosinophil Shape Change and Secretion Sergei I. Ochkur, Elizabeth A. Jacobsen, and Paige Lacy
Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy
This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.
Mitochondrial Gene Expression
This volume details the most recent advancements in the field of mitochondrial gene expression. Chapters guide readers through methods and protocols on mtDNA replication, transcription, and translation to membrane insertion of the mtDNA-encoded protein products. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mitochondrial Gene Expression: Methods and Protocols aims to provide complementary approaches and practical guidelines. Chapter 7 is available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Phenolic Compounds
Interest has grown regarding natural plant extracts in food and beverage applications, their vital role in the food industry, and their therapeutic use against diseases. The protective effects of healthy diets are partially due to the variety of plant metabolites, particularly phenolic compounds, which are considered the most important class of compounds that originates from plant-derived metabolites. Phenolics are well renowned for their possession of a wide array of remarkable biological properties. This Special Issue (SI) aims to gather the most recent contributions concerning their chemistry, extraction methods, and analytical techniques, applications, and biological activities. This Special Issue of Processes, entitled "Phenolic Compounds: Extraction, Optimization, Identification and Applications in Food Industry", gathers the recent work of leading researchers in a single collection, covering a variety of theoretical studies and experimental applications and focusing on the extraction, identification, and industrial applications. The advances presented in the contributions in this SI have significantly helped to accomplish this target. In addition to research articles, the Special Issue features two reviews that cover a range of topics highlighting the versatility of the area. The topics covered in this SI include advanced methodologies for the isolation, purification, and analysis of phenolics from food, food waste, and medicinal plants; biological activities and mechanisms of action; health benefits from in vivo evaluation; and the development of novel phenolics-based nutraceuticals and functional ingredients.
Patterns of Parental Behavior
Modern neuroscience has presented new opportunities for exploring the molecular and neural mechanisms controlling specific social responses. This book reviews insights into the neural circuits underlying a particularly fascinating form of social interaction, parental behavior. This book presents a detailed review of maternal and paternal behavior of particular mammalian species. It offer neuroscientists a spectrum of specific mammals that can be used as experimental models to explore particular topics on the functions of the nervous system. It shows that results coming from the laboratory can be translated into useful information for raising mammals on the farm, and it stimulates biologists to gain insights into the underpinnings of the complex mechanisms governing mammalian behavior in the wild. It also discusses the implications of this research for human parental behavior.
Graphic illustrations of abortion and the diseases of menstruation; Consisting of Twelve Plates from Drawings Engraved on Stone, and Coloured by Mr. J. Perry, and Two Copper-plates from the Philosophi
The book "" Graphic illustrations of abortion and the diseases of menstruation; Consisting of Twelve Plates from Drawings Engraved on Stone, and Coloured by Mr. J. Perry, and Two Copper-plates from the Philosophical Transactions, Coloured by the Same Artist. the Whole Representing Forty-five Specimens of Aborted Ova and Adventitious Productions of the Uterus, With Preliminary Observations, Explanations of the Figures and Remarks, Anatomical and Physiological. "" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
Habits that Handicap
The book "" Habits that Handicap: The Menace of Opium, Alcohol, and Tobacco, and the Remedy "" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
An Authentick Account of the Measures and Precautions Used at Venice; By the Magistrate of the Office of Health, for the Preservation of Publick Health
The book "" An Authentick Account of the Measures and Precautions Used at Venice; By the Magistrate of the Office of Health, for the Preservation of Publick Health "" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
The Cure of Rupture by Paraffin Injections
The book "" The Cure of Rupture by Paraffin Injections "" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
Carec Health Strategy 2030
The study reviewed the health sector challenges and progress in the CAREC region and recommends establishing a regional health coordination mechanism and developing a regional health strategy and investment framework. The strategy aims to enhance health security through regional cooperation. It has four main pillars: (i) leadership and human resource capacity, (ii) technical preparedness, (iii) surge demands and access to supplies, and (iv) vulnerable population groups and border health. It is intended as a tool to guide CAREC health cooperation, dialogue and knowledge exchange, programming and mobilize new project financing.
Advanced Statistics for Health Research
Advanced Statistics for Health Research provides a rigorous geometric understanding of models used in the analysis of health data, including linear and non-linear regression models, and supervised machine learning models. Models drawn from the health literature include: ordinary least squares, two-stage least squares, probits, logits, Cox regressions, duration modeling, quantile regression and random forest regression. Causal inference techniques from the health literature are presented including randomization, matching and propensity score matching, differences-in-differences, instrumental variables, regression discontinuity, and fixed effects analysis. Codes for the respective statistical techniques presented are given for STATA, SAS and R.
Curiosities of Medical Experience
The book "" Curiosities of Medical Experience "" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
A Practitioner's Guide To Erectile Dysfunction
Erectile Dysfunction (ED) is one of the most prevalent and complex problems that we see in the field of sexual medicine. Practically every man irrespective of his age, race, nationality, health or financial status experiences it sometime or the other in his life. Starting from adolescent boys to men in their 60s, 70s and 80s, I have seen the entire spectrum of men struggling with this problem with the widest possible range of causes (etiology), from psychogenic to organic to iatrogenic. Each of these cases needs an individual and specific analysis, diagnosis and treatment. I haven't found a single book that encompasses all aspects, approaches and options concerning the diagnosis and management of ED. All the information concerning ED is scattered and randomly spread across the sexology literature. I have put it all together in a systematic and easy-to-unfold manner in this book, to guide every qualified medical practitioner practicing with integrity, irrespective of his specialization or experience.
Covid-19 Pandemic
"Dr Amitav Banerjee has a knack of conveying seemingly complex public health messages in a lucid manner, understandable and appealing to experts as well as to the layperson. His writings are gripping, like a story, while at the same time educating the reader on subtle issues with apt analogies. This collection of his writings is a treatise for posterity and essential reading if we are not to repeat the mistakes of the past." Dr Bhaskaran Raman, Professor, Indian Institute of Technology, Bombay. It is indeed refreshing to go through the well-written essays, enriched with wits and humour from an erudite and distinguished personality who enjoys a robust experience on the nuances of public health in our country. He has rightly drawn our attention to the 'politicisation, corruption and suppression of science' by the big pharma and tech companies, thus making us forget the golden principles of 'evolutionary biology'. The readers will certainly realise that clarity and perception arise when the 'third eye' opens up, for it symbolises a state of enlightenment. Dr Amitav Banerjee is a rare bird to see in our modern medical parlour who can dispel the illusion of control with his lucid writings and fascinating evidence. He has also exposed the 'cracks in our public health and regulatory systems' so eloquently that one will realise how not to meddle with a socio-medical issue. Dr Sthabir Dasgupta, a Kolkata-based cancer practitioner and writer.
Natural Products Chemistry
Natural Products Chemistry: Biomedical and Pharmaceutical Phytochemistryfocuses on the development of biochemical, biomedical and their applications. It highlights the importance of accomplishing an integration of engineering with biology and medicine to understand and manage the scientific, industrial, and clinical aspects.
Operational Research Approaches
Operational research is a collection of modelling techniques used to structure, analyse, and solve problems related to the design and operation of complex human systems. While many argue that operational research should play a key role in improving healthcare services, staff may be largely unaware of its potential applications. This Element explores operational research's wartime origins and introduce several approaches that operational researchers use to help healthcare organisations: address well-defined decision problems; account for multiple stakeholder perspectives; and describe how system performance may be impacted by changing the configuration or operation of services. The authors draw on examples that illustrate the valuable perspective that operational research brings to improvement initiatives and the challenges of implementing and scaling operational research solutions. They discuss how operational researchers are working to surmount these problems and suggest further research to help operational researchers have greater beneficial impact in healthcare improvement. This title is also available as Open Access on Cambridge Core.
Mitochondrial Medicine
This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
Mitochondrial Medicine
This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional' mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be acomprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
Ethics for Bioengineers
Increasingly, biomedical scientists and engineers are involved in projects, design, or research and development that involve humans or animals. The book presents general concepts on professionalism and the regulation of the profession of engineering, including a discussion on what is ethics and moral conduct, ethical theories and the codes of ethics that are most relevant for engineers. An ethical decision-making process is suggested. Other issues such as conflicts of interest, plagiarism, intellectual property, confidentiality, privacy, fraud, and corruption are presented. General guidelines, the process for obtaining ethics approval from Ethics Review Boards, and the importance of obtaining informed consent from volunteers recruited for studies are presented. A discussion on research with animals is included. Ethical dilemmas focus on reproductive technologies, stem cells, cloning, genetic testing, and designer babies. The book includes a discussion on ethics and the technologies ofbody enhancement and of regeneration. The importance of assessing the impact of technology on people, society, and on our planet is stressed. Particular attention is given to nanotechnologies, the environment, and issues that pertain to developing countries. Ideas on gender, culture, and ethics focus on how research and access to medical services have, at times, been discriminatory towards women. The cultural aspects focus on organ transplantation in Japan, and a case study of an Aboriginal child in Canada; both examples show the impact that culture can have on how care is provided or accepted. The final section of the book discusses data collection and analysis and offers a guideline for honest reporting of results, avoiding fraud, or unethical approaches. The appendix presents a few case studies where fraud and/or unethical research have occurred. Table of Contents: Introduction to Ethics / Experiments with Human Subjects or Animals / Examples of Ethical Dilemmas in Biomedical Research / Technology and Society / Gender, Culture, and Ethics / Data Collection and Analysis
Cytotoxic T-Cells
This new edition explores lab protocols describing new techniques to study cytotoxic T-cells (CTLs), as well as chapters of a more general discursive nature, all with an emphasis on the use of systems biology in immunology. Beginning with phenotypical characterization of CTL populations, the volume continues with in vitro and in vivo cytotoxicity assays, methods to detect senescent T cells, in vivo and in vitro models to understand immune and bone cells cross-talk, microscopy and in vivo imaging, as well as "Omics" approaches and molecular methods, concluding with chapters on CTL involvement in transplantation and link microbiota-immunity. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detail and key implementation advice for best results in the lab. Authoritative and up-to-date, Cytotoxic T-Cells: Methods and Protocols, Second Edition serves as an ideal guide for researchers working with these vital cells.
The Making of a Doctor Part 2
Introduction. Query results listed in tables for results of queries that list all consultations from the 22nd to the end of: (a) April 2000 to April 2015 (b) May 1997 to May 2015 (c) June 1997 to June 2015 (d) July 1997 to July 2015 (e) August 1997 to August 2014
The Making of a Doctor Part 2
Introduction. Query results listed in tables for results of queries that list all consultations from the 22nd to the end of: (a) April 2000 to April 2015 (b) May 1997 to May 2015 (c) June 1997 to June 2015 (d) July 1997 to July 2015 (e) August 1997 to August 2014
Organ Transplants and Ethics
Originally published in 1990, this study of the moral problems bound up with transplant therapy addresses a finely balanced distinction between ethical issues relating to its experimental nature on the one hand and those which arise when transplantation is routine on the other.
Death, Brain Death and Ethics
Originally published in 1985, this book examines the concept of death against the background of dramatic changes in medical technology. The book argues that 'brain death' can be precisely defined and that a biological concept of death such as 'brain death' can be philosophically well-grounded.
'I Follow Aristotle': How William Harvey Discovered the Circulation of the Blood
This book presents a new interpretation of how and why the discovery of the circulation of the blood in animals was made.
Postures and Movement Patterns of the Human Hand
Think of the complexity of ordinary hand activity and how to describe it all, both precisely and concisely. The author, a noted occupational therapist in Japan, offers a disciplined approach to doing just that. Whereas research has heretofore been limited mainly to how the hand grips, the methodology here is set up to account for grips, non-grip postures, and movement patterns, based on thousands of laboratory observations. This approach can provide hand experts with specific ways to conceptualize and study hand disabilities, artificial hands, and robotic hands. The author first surveys research over the past 100 years on forms that the hand normally assumes, noting the preponderance of studies on hand grips, with less attention having been paid to what the hand looks like when in non-grip postures and when moving its thumb and fingers. She then presents, in separate studies, the development of taxonomies to comprehensively account for grips, non-grip forms, and thumb and finger movements. Movements of the thumb and fingers appear as patterns readily distinguishable via an "XYZ notation" developed by the author. When combined into a single framework, the three taxonomies can describe the vast repertoire of ordinary activity performed by the normal hand. This book should be useful for hand experts in such fields as biomedical and robotic engineering, prosthetics and orthotics, occupational therapy, hand therapy, orthopedic surgery, kinesiology, and physical anthropology. Through this book, the reader can obtain a broad image of hand activity and learn to observe and record it in fine detail. WORDS OF PRAISEPart history, part technical manual, this book is a gem that is no longer hidden for anyone interested in hand function. --Sydney Schaefer, PhD, Biomedical Engineering, Arizona State University
Guidance for Healthcare Ethics Committees
Every accredited American hospital is required to have a process for handling ethical concerns within the institution. For the most part, hospitals satisfy this requirement by constituting an institutional healthcare ethics committee (HEC). However, many of these individuals, while well intentioned, have neither the training in ethics, nor the tools at their disposal to address properly the ethical considerations brought to them. Yet healthcare providers and patients turn to these committee members for ethical insight. This book focuses on HEC member education by providing definitive and comprehensive learning content for members of HECs. This second edition is fully updated throughout and adds new chapters that reflect the evolving nature of health care. Chapters are written by internationally recognized experts in bioethics and are directed specifically at members of HECs. Each chapter includes learning objectives, case presentations, and discussion questions to facilitate committee conversation.
Metabotropic Glutamate Receptor Technologies
This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and practical, Metabotropic Glutamate Receptor Technologies provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful.
Diagnosis and Management of Heart Failure
Heart failure prevalence continues to rise globally. Regardless of the underlying etiology, heart failure remains a progressive disease, largely irreversible and end-stage heart failure requires transplantation. Book focuses on the challenges and recent advances of diagnosis, treatment and prevention of heart failure with or without associated comorbidities. We hope that readers will appreciate the wide breadth of topics and clinical utility of the articles and reviews included to this book collection.
Thomas Percival's Medical Ethics and the Invention of Medical Professionalism
This book provides the first comprehensive, historically based, philosophical interpretations of two texts of Thomas Percival's professional ethics in medicine set in the context of his intellectual biography. Preceded by his privately published and circulated Medical Jurisprudence of 1794, Thomas Percival (1740-1804) published Medical Ethics in 1803, the first book thus titled in the global histories of medicine and medical ethics. From his days as a student at the Warrington Academy and the medical schools of the universities of Edinburgh and Leyden, Percival steeped himself in the scientific method of Francis Bacon (1561-1626). McCullough shows how Percival became a Baconian moral scientist committed to Baconian deism and Dissent. Percival also drew on and significantly expanded the work of his predecessor in professional ethics in medicine, John Gregory (1724-1773). The result is that Percival should be credited with co-inventing professionalism in medicine with Gregory. To aid and encourage future scholarship, this book brings together the first time three essential Percival texts, Medical Jurisprudence, Medical Ethics, and Extracts from the Medical Ethics of Dr. Percival of 1823, the bridge from Medical Ethics to the 1847 Code of Medical Ethics on the American Medical Association. To support comparative reading, this book provides concordances of Medical Jurisprudence to Medical Ethics and of Medical Ethics to Extracts. Finally, this book includes the first Chronology of Percival's life and works.
Mitochondria-Targeted Drug Delivery
Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells' energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers.
Vagus Nerve
The vagus nerve is the most important nerve you probably didn't know you had. It is a long meandering bundle of motor and sensory fibers that links the brain stem to the heart, lungs, and gut. It also branches out to touch and interact with the liver, spleen, gallbladder, ureter, female fertility organs, neck, ears, tongue, and kidneys. Dr Justin Hoffman, a Santa Rosa, California, licensed naturopathic medical physician, says: "Without the vagus nerve, key functions that keep us alive would not be maintained." Nationally recognized sports nutritionist, strength, and conditioning coach Brandon Mentore elaborates: "The vagus nerve is extremely critical to your overall health and is intimately tied in with multiple organs and systems of the body." Vagus nerve dysfunction can result in a whole host of problems including obesity, bradycardia (abnormally slow heartbeat), difficulty swallowing, gastrointestinal diseases, fainting, mood disorders, B12 deficiency, chronic inflammation, impaired cough, and seizures. Meanwhile, the vagus nerve stimulation has been shown to improve conditions such as: - Anxiety disorder - Heart disease - Tinnitus - Obesity - Alcohol addiction - Migraines - Alzheimer's - Leaky gut - Bad blood circulation - Mood disorder - Cancer Your social nervous system increases your ability to respond effectively when you feel keyed up with anxiety or shut-down with depression. Your vagus nerve plays a key role in your overall wellbeing and performance. Whether you are feeling anxiety or depression, you can use tools to engage your social nervous system to re-establish higher order nervous system functions. Healing the nervous system can take time and requires patience. Put the polyvagal theory into action in you life to increase your sense of freedom in body and mind This book provides all the tools you need to understand and heal your vagus nerve.
The Making of a Doctor Part 2
Introduction. Query results listed in tables for results of queries that list all consultations in the third week of: (a) November 2002 to November 2015 (b) December 1998 to December 2015 Query results listed in tables for results of queries that list all consultations from the 22nd to the end of: (a) January 1997 to January 2015 (b) February 1997 to February 2015 (c) March 1997 to March 2015 (d) April 1997 to April 1999
The Making of a Doctor Part 2
Introduction. Query results listed in tables for results of queries that list all consultations in the third week of: (a) November 2002 to November 2015 (b) December 1998 to December 2015 Query results listed in tables for results of queries that list all consultations from the 22nd to the end of: (a) January 1997 to January 2015 (b) February 1997 to February 2015 (c) March 1997 to March 2015 (d) April 1997 to April 1999
Translational Methods for Multiple Sclerosis Research
This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.
Data Science in Healthcare
Data science is an interdisciplinary field that applies numerous techniques, such as machine learning, neural networks, and deep learning, to create value based on extracting knowledge and insights from available data. Advances in data science have a significant impact on healthcare. While advances in the sharing of medical information result in better and earlier diagnoses as well as more patient-tailored treatments, information management is also affected by trends such as increased patient centricity (with shared decision making), self-care (e.g., using wearables), and integrated care delivery. The delivery of health services is being revolutionized through the sharing and integration of health data across organizational boundaries. Via data science, researchers can deliver new approaches to merge, analyze, and process complex data and gain more actionable insights, understanding, and knowledge at the individual and population levels. This Special Issue focuses on how data science is used in healthcare (e.g., through predictive modeling) and on related topics, such as data sharing and data management.
An Evolutionary and Environmental Perspective of the Interaction of Nanomaterials with the Immune System-The Outcomes of the EU Project PANDORA
The book collects scientific contributions aiming at describing the common mechanism, across living species, by which innate immunity interacts with nanomaterials with the goal of harnessing such interactions for improving environmental and human safety and exploiting them for modulating immunity in vaccination strategies.
