State-of-Art in Innate Immunity
The innate immune system is the first line of defense against bacterial and viral infections and sterile inflammation through the recognition of pathogen-associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs) resulting in the production of proinflammatory and antiviral cytokines and chemokines. Several damage-associated molecular patterns (DAMPs), which were released by passive or active mechanisms under sterile conditions, are additionally recognized by PRRs and can cause or even aggravate the inflammatory response.In this special issue many aspects of innate immunity are summarized. Mechanisms of different DAMPs to induce pro- and anti-inflammatory activities, functions of different immune cells, as well as the crosstalk between coagulation and innate immunity were described. Furthermore, aspects of autoinflammatory diseases, types of programmed cell death pathways, and insect immunity are covered. Finally, therapeutic options for the treatment of diseases related to autoimmunity or infections are suggested. Overall, this special issue presents a broad overview of activities related to sterile inflammation and defense mechanisms of innate immunity.
Methods for Preclinical Research in Addiction
This volume presents a wide array of animal models that are used in the study of the individual and environmental factors involved in the development of addiction, the consequences of chronic drug exposure, and recently developed behavioral and biological procedures for the treatment of addictive disorders. The chapters in this book are organized into three sections that cover the aforementioned aspects in relation to different drugs of abuse and pathological gambling. The first section of the book focuses on the individual variables that affect vulnerability to addiction to nicotine, alcohol, cocaine, psychostimulants, and gambling. Section Two looks at the environmental variables that contribute to the vulnerability to addiction. Section Three explores the consequences of chronic drug consumption and new approaches to the treatment of addiction. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successfulresults in your laboratory. Cutting-edge and comprehensive, Methods for Preclinical Research in Addiction is a valuable resource that helps researchers and scientists understand the neurobiological mechanisms that underlie the influence of individual and environmental variables on the risk for addiction, and assists them in developing new behavioral and pharmacological strategies to prevent and treat addictive disorders.
Landmarks Medical and Surgical
This Book "Landmarks Medical and Surgical" has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation
Tumor-associated macrophages (TAMs) accumulate in the solid tumor microenvironment (TME) and have been shown to promote tumor growth and dampen antitumor immune responses. TAM-mediated suppression of T-cell antitumor reactivity is considered to be a major obstacle for many immunotherapies, including immune checkpoint blockade and adoptive T/CAR-T-cell therapies. An ex vivo culture system closely mimicking the TME can greatly facilitate the study of cancer immunotherapies. Here, we report the development of a 3D TME-mimicry culture that is comprised of the three major components of a human TME, including human tumor cells, TAMs, and tumor antigen-specific T cells. This TME-mimicry culture can readout the TAM-mediated suppression of T-cell antitumor reactivity, and therefore can be used to study TAM modulation of T-cell-based cancer immunotherapy. As a proof-of-principle, the studies of a PD-1/PD-L1 blockade therapy and a MAO-A blockade therapy were performed and validated.
Invariant Natural Killer T-Cells
1. Genetic Analysis of iNKT Cell Development and Function Julie Sahler, Orchi Anannya, Candice Limper, Brian Imbiakha, Tim Pierpont, and Avery August 2. Genetic Studies of Natural Glycosphingolipid Ligands for NKT Cells Dapeng Zhou, Chengfeng Xia, Peng G. Wang, Zhiyuan Li, Wenpeng Zhang, Guanghui Ni, and Jiaxi Cheng 3. Retroviral Transduction of NKT Hybridoma Cells Ke Wang, Rong Jin, and Qing Ge 4. Methods for Studying Mouse and Human Invariant Natural Killer T-Cells Yang Zhou, Yan-Ruide Li, Samuel Zeng, and Lili Yang 5. Isolation and Detection of Murine iNKT Cells in Different Organs Mengqing Cong, Xiang Li, Haopeng Fang, Li Bai, Xucai Zheng, and Bofeng Li 6. Identifying, Isolation, and Functional Use of Human Liver iNKT Cells Wenjing He, Dongmei Ye, and Yifang Gao 7. Isolation and Characterization Methods of Human Invariant NKT Cells Rui Liu and Hua Wang 8. Detection of Mouse Type I NKT (iNKT) Cells by Flow Cytometry Vibhuti Joshi and Masaki Terabe 9. Identification of Rare Thymic NKT Cell Precursors by Multiparameter Flow Cytometry Jihene Klibi and Kamel Benlagha 10. iNKT Cell Transfer: The Use of Cell Sorting Combined with Flow Cytometry Validation Approach Marcella Cipelli, Theresa Ramalho, Cristhiane Favero de Aguiar, and Niels Olsen Saraiva Camara 11. Expansion of Human iNKT Cells Ex Vivo Jing Wang, Chen Zhao, and Jianqing Xu 12. The Expansion and Cytotoxicity Detection of Human iNKT Cells Xue Cheng, Xiaosheng Tan, Rui Dou, Xiongwen Wu, and Xiufang Weng 13. Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood Natasha K. Khatwani, Kelly J. Andrews, and Asha B. Pillai 14. Intravital Microscopy Imaging of Invariant Natural Killer T-Cell Dynamics in the Liver Using CXCR6-eGFP Transgenic Mice Zhou Hong, Zeng Zhutian, and Wang Fei 15. In Vivo Cytotoxicity by α-GalCer-Transactivated NK Cells Patrick T. Rudak and S.M. Mansour Haeryfar 16. Redirecting iNKT Cell Anti-Tumor Immunity with αGalCer/CD1d-scFv Fusion Proteins Lianjun Zhang and Alena Donda 17. Investigating the Dynamic Changes in iNKT Cell Metabolic Profiles during Development Jana L. Raynor and Hongbo Chi
Dr. Schuessler's Biochemistry
The Theory and Practical Applications of Schuessler's Twelve Biochemic Remedies discovered over one century ago by German physician, Dr. Wilhelm Heinrich Schuessler. This is an Unabridged, Digitally Enlarged Printing of 'A Medical Book for the Home, ' with Repertory, to include a Comprehensive Index at book's end.
Neural Control Engineering
How powerful new methods in nonlinear control engineering can be applied to neuroscience, from fundamental model formulation to advanced medical applications. Over the past sixty years, powerful methods of model-based control engineering have been responsible for such dramatic advances in engineering systems as autolanding aircraft, autonomous vehicles, and even weather forecasting. Over those same decades, our models of the nervous system have evolved from single-cell membranes to neuronal networks to large-scale models of the human brain. Yet until recently control theory was completely inapplicable to the types of nonlinear models being developed in neuroscience. The revolution in nonlinear control engineering in the late 1990s has made the intersection of control theory and neuroscience possible. In Neural Control Engineering, Steven Schiff seeks to bridge the two fields, examining the application of new methods in nonlinear control engineering to neuroscience. After presenting extensive material on formulating computational neuroscience models in a control environment--including some fundamentals of the algorithms helpful in crossing the divide from intuition to effective application--Schiff examines a range of applications, including brain-machine interfaces and neural stimulation. He reports on research that he and his colleagues have undertaken showing that nonlinear control theory methods can be applied to models of single cells, small neuronal networks, and large-scale networks in disease states of Parkinson's disease and epilepsy. With Neural Control Engineering the reader acquires a working knowledge of the fundamentals of control theory and computational neuroscience sufficient not only to understand the literature in this trandisciplinary area but also to begin working to advance the field. The book will serve as an essential guide for scientists in either biology or engineering and for physicians who wish to gain expertise in these areas.
Stem Cell Transplantations Between Siblings as Social Phenomena
This open access book offers insights in short- and long-term experiences from families with bone marrow transplantations between minor siblings. It is based on the first extended qualitative study with 17 families about experiences with recent transplants and experiences with transplants up to 20 years in the past. It covers reflections of donors, recipients and other family members, as well as family interactions. Transplantation of bone marrow from one sibling to another who is ill with a blood cancer (such as Leukemia) is a life-saving therapy. Young children however are not in a position to give consent themselves. How should they be adequately included, depending to their age? Which ethical questions are raised for the parents both at the time of treatment and afterwards, and for the medical professionals in clinical and regulatory contexts? For an in-depth discussion of the findings the books brings together a group of leading scholars from the fields of bioethics, family sociology and philosophy of medicine.
Stem Cell Transplantations Between Siblings as Social Phenomena
This open access book offers insights in short- and long-term experiences from families with bone marrow transplantations between minor siblings. It is based on the first extended qualitative study with 17 families about experiences with recent transplants and experiences with transplants up to 20 years in the past. It covers reflections of donors, recipients and other family members, as well as family interactions. Transplantation of bone marrow from one sibling to another who is ill with a blood cancer (such as Leukemia) is a life-saving therapy. Young children however are not in a position to give consent themselves. How should they be adequately included, depending to their age? Which ethical questions are raised for the parents both at the time of treatment and afterwards, and for the medical professionals in clinical and regulatory contexts? For an in-depth discussion of the findings the books brings together a group of leading scholars from the fields of bioethics, family sociology and philosophy of medicine.
Ethics in Everyday Places
An exploration of moral stress, distress, and injuries inherent in modern society through the maps that pervade academic and public communications worlds. In Ethics in Everyday Places, ethicist and geographer Tom Koch considers what happens when, as he puts it, "you do everything right but know you've done something wrong." The resulting moral stress and injury, he argues, are pervasive in modern Western society. Koch makes his argument "from the ground up," from the perspective of average persons, and through a revealing series of maps in which issues of ethics and morality are embedded. The book begins with a general grounding in both moral stress and mapping as a means of investigation. The author then examines the ethical dilemmas of mapmakers and others in the popular media and the sciences, including graphic artists, journalists, researchers, and social scientists. Koch expands from the particular to the general, from mapmaker and journalist to the readers of maps and news. He explores the moral stress and injury in educational funding, poverty, and income inequality ("Why aren't we angry that one in eight fellow citizens lives in federally certified poverty?"), transportation modeling (seen in the iconic map of the London transit system and the hidden realities of exclusion), and U.S. graft organ transplantation. This uniquely interdisciplinary work rewrites our understanding of the nature of moral stress, distress and injury, and ethics in modern life. Written accessibly and engagingly, it transforms how we think of ethics--personal and professional--amid the often conflicting moral injunctions across modern society. Copublished with Esri Press
Positive Spirituality in Health Care
"Positive Spirituality in Health Care" offers a fresh, holistic, and practical framework for the integration of spirituality in health care. Dr. Craigie proposes that excellent spiritual care arises from three arenas: the personal groundedness and spiritual well-being of clinicians, the clinical encouragement of patients' spiritual resources, and the organizational cultivation of spirited leadership and "soul." In an approachable and conversational tone, he presents case examples, interview transcripts, research perspectives, and pragmatic strategies that will enable readers to refine their skills in each of these three arenas. "Positive Spirituality in Health Care" will be a source of affirmation, refreshment, inspiration, and practical tools for all clinicians and health care leaders who are passionate about supporting patients' journeys toward healing and wholeness.
Neuroprosthetics and Brain-Computer Interfaces in Spinal Cord Injury
This book provides a comprehensive overview of the current state of the art of practical applications of neuroprosthesis based on functional electrical stimulation for restoration of motor functions lost by spinal cord injury and discusses the use of brain-computer interfaces for their control.The book covers numerous topics starting with basics about spinal cord injury, electrical stimulation, electrical brain signals and brain-computer interfaces. It continues with an overview of neuroprosthetic solutions for different purposes and non-invasive and invasive brain-computer interface implementations and presents clinical use cases and practical applications of BCIs. Finally, the authors give an outlook on cutting edge research with a high potential for clinical translation in the near future.All authors committed themselves to use easy-to-understand language and to avoid very specific information, focusing instead on the essential aspects. This makes this bookan ideal choice not only for researchers and clinicians at all stages of their education interested in the topic of brain-computer interface-controlled neuroprostheses, but also for end users and their caregivers who want to inform themselves about the current technological possibilities to improve paralyzed motor functions.
Iot and Big Data Technologies for Health Care
This two-volume set of LNICST 414 and 415 constitutes the refereed post-conference proceedings of the 2nd International Conference on IoT and Big Data Technologies for Health Care, IoTCARE 2021, which took place in October 2021. Due to COVID-19 pandemic the conference was held virtually. The 79 revised full papers were carefully reviewed and selected from 165 submissions. The papers are arranged thematically as follows: Integrating healthcare with IoT; Information fusion for the devices of IoT; AI-based internet of medical things.
Medical Biochemistry
Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today's latest developments. You'll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice. Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicineHighlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the "-omics," as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exerciseEmphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of diseaseContains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancerIncludes clear, colorful icons and illustrations that help you easily navigate the text and understand the materialProvides online features such as challenging "Active Learning" questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and moreEnhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
School Violence and Primary Prevention
Significant shifts in community violence have created a need for greater awareness of character development and violence prevention in schools. Since the first edition (2008), public concern generated by high-profile shootings and other violence in schools has only increased. Now more than ever, effective strategies for preventing violence, treating victims, and assessing at-risk children are needed. This new edition, an update of contemporary issues of school violence, is a compendium of theory, research, and applied models that addresses violence and critical ingredients in prevention interventions in the school setting. The book uniquely addresses psychiatric input on neurobiology of trauma and victimization of children who experience school violence. Authored by clinicians, counselors, educators, researchers, and other professionals, the volume has new approaches to primary prevention in schools and new contributors including a school superintendent, school safety officer, and specialists who treat relationship and dating violence. New topics include guidelines for school personnel that address exploitation of teenagers due to sex trafficking, and perspectives of parents whose children were victims of abuse and violence in schools. Among the topics explored: Developmental Issues in the Prevention of Aggression and Violence in SchoolUpdated Perspectives on Linking School Bullying and Related Youth Violence Research to Effective Prevention StrategiesThe Role of School District Superintendent in School Violence and Prevention: Softening Schools While Hardening BuildingsRole of Law Enforcement in School Violence Prevention Through Positive Intervention and Relationship-BuildingEmpowering Children to Prevent Violence School Violence and Primary Prevention is a critical and timely resource forschool, medical, and mental health professionals working with children. It is also useful for students in public health, education, social work, psychology, and counseling-focused education.
Handbook of Settings-Based Health Promotion
This book's central focus is to provide academics, students, policy-makers, and practitioners with a unique insight into a wide variety of perspectives on settings-based health promotion. It offers clarity amidst different interpretations and ideological understandings of what applying a settings-based approach means. Emphasis is given to a salutogenic focus, exploring how the creation of wellbeing and fostering of potential in settings to best enable individuals and populations to flourish implies that the setting itself must be the entry point for health promotion. Building on this, the text explores how the settings approach to health promotion strives for changes in the structure and ethos of the setting - detailing how changes and developments in people's health and health behavior are easier to achieve if health promoters focus on settings rather than solely on individuals. The book comprises 15 chapters organized in three sections: In Part I, Evolution, Foundations and Key Principles of the Settings-Based Approach, the first four chapters present the determinants, theoretical basis, and generic commonalities that are consistent over various settings initiatives and formulate the grounds for the settings-based health promotion approach.In Part II, Applying the Settings-Based Approach to Key Settings, Chapters 5-13 introduce the key settings initiatives - both traditional and non-traditional (new and contemporary) - with their developments and specific features. In Part III, Gaia - The Ultimate Setting for Health Promotion, the last two chapters consider the settings approach in the context of future challenges and explore possible directions for further development.Handbook of Settings-Based Health Promotion has novel information and perspectives on the topic that provide readers with up-to-date specialist knowledge and application of global developments to develop and enhance a common understanding and generate new thinking in relation to contemporary settings. This timely tome will engage the academic community in the fields of health promotion and public health including students, teaching staff, and researchers. Additionally, it is a useful resource for policy-makers and practitioners in these fields.
Social and Affective Neuroscience of Everyday Human Interaction
Molecular imaging of the human emotion circuit.- The neurocognitive mechanisms of unconscious emotional responses.- Social and Affective Neuroscience of Embodiment.- The neuroscience of beauty.- Mirror Neurons ... in action: ERPs and neuroimaging evidence.- Sex differences in social cognition.- Development of morality and emotional processing.- Trust in Social Interaction: From Dyads to Civilizations.- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode.- Social Cognition development and socio affective dysfunction in childhood and adolescence.- Clinical neuroscience meets second-person neuropsychiatry.- EEG and ERPs in the study of Language and Social Knowledge.- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities.- Modulating the Social and Affective Brain with transcranial stimulation techniques.- What our eyes can tell us about our social and affective brain?.- Facial EMG - Investigating the interplay of facial muscles and emotions.
Social and Affective Neuroscience of Everyday Human Interaction
Molecular imaging of the human emotion circuit.- The neurocognitive mechanisms of unconscious emotional responses.- Social and Affective Neuroscience of Embodiment.- The neuroscience of beauty.- Mirror Neurons ... in action: ERPs and neuroimaging evidence.- Sex differences in social cognition.- Development of morality and emotional processing.- Trust in Social Interaction: From Dyads to Civilizations.- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode.- Social Cognition development and socio affective dysfunction in childhood and adolescence.- Clinical neuroscience meets second-person neuropsychiatry.- EEG and ERPs in the study of Language and Social Knowledge.- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities.- Modulating the Social and Affective Brain with transcranial stimulation techniques.- What our eyes can tell us about our social and affective brain?.- Facial EMG - Investigating the interplay of facial muscles and emotions.
Effective Public Health Policy in Organ Donation
This book shows how a successful public health policy designed to foster the culture of brain death diagnosis and improve the interaction between Organ Procurement Organizations and Intra-Hospital Organ and Tissue Donation Committees for Transplants led the Brazilian state of Paran獺 to reach one of the highest rates of effective organ donors per million population in the world. Brazil has the largest public transplant system in the world, and each of the country's 26 states is responsible for organizing its own transplant system. The state of Paran獺, with 11 million inhabitants, has stood out in this regard in the last decade. It reached 47.7 effective donors per million population (pmp), performing better than countries such as the United States (33.3/pmp), Canada (21.9/pmp), Portugal (33.6/pmp) and Croatia (41.2/pmp). The remodeling of Paran獺's transplant system, between 2011 and 2020, was based on the recognized Spanish model, but has some unique characteristics.This book seeks to describe all the steps of this remodeling, describing its characteristics and explaining how the new system was built. By presenting an in-depth analysis of a local successful case, Effective Public Health Policy in Organ Donation: Lessons from a Universal Public Health System in Brazil seeks to provide useful information to policy makers, health professionals and students from different fields within the health sciences interested in understanding how public health policies can improve organ donation rates, especially in developing countries.
A Roadmap to Successful Scientific Publishing
In the age of "publish or perish," this book provides everything one needs to know about conducting research and successfully publishing it in a scientific journal. The reader learns about the complete process of scientific publishing: from selecting the most appropriate research design, to obtaining permissions and funding, to resourcefully presenting the research results in a poster and oral presentation. Additionally, the practical tips provided here help the reader formulate a compelling scientific article and choose the most suitable journal (subscription vs. the various open access modalities) for their publication.This book also addresses "invisible aspects" of scholarly publishing that are nonetheless important and that everyone should know and understand: avoiding predatory journals, understanding the editor's perspective, and becoming familiar with the various research metrics (from author to journal) that can all determine success or failure of a publication. Written in an informal style in which the author shares personal perspectives and experiences, the book is easily accessible to the reader. The book offers early career scientists in biomedicine and medicine a unique perspective on publishing research articles and how this process can enhance the authors' "scientific value" within the scientific ecosystem as well as their personal CVs.
The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences
Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade.
The Hermeneutics of Medicine and the Phenomenology of Health
This is the first monograph to deal with medicine as a form of hermeneutics, now in a thoroughly revised and updated edition, including a whole new chapter on medical ethics. The book offers a comprehensive philosophical argument why good medical practice cannot be curtailed to scientific investigations of the body but is a form of clinical hermeneutics performed by health-care professionals in dialogue with their patients. Medical hermeneutics is rooted in a phenomenology of illness which acknowledges and proceeds from the ill party's bodily feelings, everyday life-world circumstances and self-understanding in aiming to restore health.The author shows how the works of classical phenomenologists and hermeneuticians - Martin Heidegger, Maurice Merleau-Ponty, Hans-Georg Gadamer and Paul Ricoeur - may be employed to understand how medical diagnosis is enveloped by professional empathy and clinical judgement and developed by scientific investigations of the patient's bodily condition. Health and illness are ultimately considered to be ways of feeling at home or not at home in the world, and such experiences are the starting point of medical hermeneutics when aiming to make best use of scientific knowledge. The book is aimed at researchers and teachers in philosophy of medicine and medical ethics, and at physicians, nurses and other health-care professionals meeting with patients in ethically complex and challenging situations. Phenomenology and hermeneutics, most often considered as methods belonging to the humanities, are shown to be of vital importance for the understanding of medical practice and ethical dilemmas of health care.
Advances in Microbiology, Infectious Diseases and Public Health
This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.The book series publishes review and original research contributions, short reports as well as guest edited thematic book volumes. All contributions will be published online first and collected in book volumes. There are no publication costs.Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2020 Impact Factor: 2.622. 5 Year Impact Factor: 3.049; Cite Score: 3.9;Eigenfactor Score: 0.03583; Article Influence Score: 0.602
Applied Multivariate Statistics with R
Now in its second edition, this book brings multivariate statistics to graduate-level practitioners, making these analytical methods accessible without lengthy mathematical derivations. Using the open source shareware program R, Dr. Zelterman demonstrates the process and outcomes for a wide array of multivariate statistical applications. Chapters cover graphical displays; linear algebra; univariate, bivariate and multivariate normal distributions; factor methods; linear regression; discrimination and classification; clustering; time series models; and additional methods. He uses practical examples from diverse disciplines, to welcome readers from a variety of academic specialties. Each chapter includes exercises, real data sets, and R implementations. The book avoids theoretical derivations beyond those needed to fully appreciate the methods. Prior experience with R is not necessary.New to this edition are chapters devoted to longitudinal studies and theclustering of large data. It is an excellent resource for students of multivariate statistics, as well as practitioners in the health and life sciences who are looking to integrate statistics into their work.
The Populist Radical Right and Health
This contributed volume is the first in-depth analysis of the health policies of populist radical right (PRR) parties worldwide and their actual involvement in health care. The prominence of authoritarian, nationalistic, and populist parties is expanding steadily. However, it is often difficult to discern what kind of policies they really stand for, particularly with regard to the welfare state and public health, where research remains sparse. This book fills this critical gap. The text connects PRR parties and leaders with actual health and social policy effects in Eastern and Western Europe as well as in the United States, Brazil, and the Philippines. The chapters highlight ten individual country case studies authored by young scholars and professors with political science and health experts: The Austrian Freedom Party in Government: A Threat to Public Health? The Alternative for Germany (AfD) and Health Policy: Normalization or Containment of Populist Radical Right Tendencies? Populist Radical Right Influence on Health Policy in the Netherlands: The Case of the Party for Freedom (PVV) The Evolution of the Populist Radical Right and Their Impact on Health in Italy The Populist Radical Right and Health in Hungary Is the Polish 'Law and Justice' (PiS) a Typical Populist Radical Right Party? A Health Policy Perspective The Case of the United Kingdom Independence Party (UKIP) Rhetoric and Reality in the United States of America: Trump, Populism, and Health Policy Ruling Through Chaos in Brazil: Bolsonaro's Authoritarian Agenda for Public Health An Authoritarian Reaction to COVID-19 in the Philippines: A Strong Commitment to Universal Health Care Combined with Violent Securitization The Populist Radical Right and Health is exceptionally timely and essential reading for political science and health colleagues researching and writing about PRR parties and leaders; students and faculty in public health, health and social policy, and political science; and anyone interested in learning more about this topic.
Leukemia in Our School
Jonathan's world changed when his Great Grandmother was diagnosed with leukemia. He was inspired to write this book in an effort to better understand the disease she was battling. Once he started researching, he learned that another person he respected, his school resource officer, also had leukemia. Join Jonathan on his quest to learn about leukemia through firsthand accounts, conversations with doctors, and two years' worth of research. Any profits from the sale of this book go to the Hillman Cancer Center so they can continue their research, treatment, and support of patients.
Madness in the Family
To fend off American and European imperialism in the nineteenth century, Japan strove to strengthen itself by drawing on the most updated ideas and practices from around the world. By the 1880s, this included the introduction of Western-derived psychiatry and its ideas about mental illness. The first Japanese psychiatrists claimed that mental illnesses required medical treatment in specialized institutions rather than confinement at home, as had been common practice. Yet the state implemented no social welfare policies to make new medical services more accessible and affordable to the public. The family, especially women, thus continued to carry the burden of caring for those considered mad. Madness in the Family examines how the family in Japan came to be seen as the natural provider of care for those suffering from mental illnesses. It centers on the experiences of women and families, which have long been obscured by the voices of male psychiatrists, state officials, and lawmakers. H. Yumi Kim traces how women and families negotiated a dizzying array of claims about madness and its proper management across various settings. In the countryside, psychiatrists tried to refute the notion that fox spirits could cause madness, and the government regulated the use of cage-like structures inside homes. In cities, a booming medical marketplace spread ideas about feminized illnesses such as hysteria, and female defendants were evaluated for menstruation-induced disorders. As women and families navigated this shifting therapeutic landscape, they produced their own gendered approaches to madness that would take precedence over the claims of psychiatry, the law, and the state in everyday life. Decoupling the history of mental illness from the discipline and institutions of psychiatry, Madness in the Family reveals the power and fragilities of gender, kinship, and care in the creation of different modes of caring for and understanding mental illness that persist to this day.
Medico-Surgical Tributes to Harold Brunn
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1942.
Medico-Surgical Tributes to Harold Brunn
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1942.
Quantitative Decisions in Drug Development
This book focuses on important decision points and evidence needed for making decisions at these points during the development of a new drug. It takes a holistic approach towards drug development by incorporating explicitly knowledge learned from the earlier part of the development and available historical information into decisions at later stages. In addition, the book shares lessons learned from several select examples published in the literature since the publication of the first edition. The second edition reiterates the need for making evidence-based Go/No Go decisions in drug development discussed in the first edition. It substantially expands several topics that have seen great advances since the publication of the first edition. The most noticeable additions include three adaptive trials conducted in recent years that offer excellent learning opportunities, the use of historical data in the design and analysis of clinical trials, and extending decision criteria tothe cases when the primary endpoint is binary. The examples used to illustrate the additional materials all come from real trials with some post-trial reflections offered by the authors. The book begins with an overview of product development and regulatory approval pathways. It then discusses how to incorporate prior knowledge into study design and decision making at different stages of drug development. Prior knowledge includes information pertaining to historical controls. To assist decision making, the book discusses appropriate metrics and the formulation of go/no-go decisions for progressing a drug candidate to the next development stage. Using the concept of the positive predictive value in the field of diagnostics, the book leads readers to the assessment of the probability that an investigational product is effective given positive study outcomes. Lastly, the book points out common mistakes made by drug developers under the current drug-development paradigm. The book offers useful insights to statisticians, clinicians, regulatory affairs managers and decision-makers in the pharmaceutical industry who have a basic understanding of the drug-development process and the clinical trials conducted to support drug-marketing authorization. The authors provide software codes for select analytical approaches discussed in the book. The book includes enough technical details to allow statisticians to replicate the quantitative illustrations so that they can generate information to facilitate decision-making themselves.
Stranger than Fiction
In March 2020, society as we know it shut down.What transpired next was a series of unprecedented public health decisions which would fundamentally reshape the entire world. From the way we approach healthcare and infectious disease, to the way we interact with other human beings, to so many other aspects of our lives - an alarming heel turn was made in the name of a disease which today is officially acknowledged as having a greater than 99.9% case-survival rate for the majority of people.Utilizing an overwhelming campaign of fear, choices were made for people at the expense of representative governance and of traditionally respected human rights, in both eastern and western nations alike. Not even scientists or doctors were spared by the wrath of the censor, as free speech was fixed in the crosshairs of a well-coordinated tyranny.And this is the true story Stranger Than Fiction seeks to tell in exhaustive detail. A synthesis of history, science, economics, and societal consequences, it documents what a spirit of furious, narcissistic suppression sought to bury for at least two years' time."Stranger Than Fiction is citation after citation, organizing all the confusion, deception, and uncertainty into a precise and clear read."- Patrick Daly of the P.A.T. Life podcast
A Course of Elementary Practical Physiology and Histology
A Course of Elementary Practical Physiology and Histology is an unchanged, high-quality reprint of the original edition of 1888. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Lectures on Diseases of the Respiratory Organs, Heart and Kidneys
Lectures on Diseases of the Respiratory Organs, Heart and Kidneys is an unchanged, high-quality reprint of the original edition of 1882. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Computer Science Protecting Human Society Against Epidemics
This book constitutes the refereed post-conference proceedings of the First IFIP TC 5 International Conference on Computer Science Protecting Human Society Against Epidemics, ANTICOVID 2021, held virtually in June 2021.The 7 full and 4 short papers presented were carefully reviewed and selected from 20 submissions. The papers are concerned with a very large spectrum of problems, ranging from linguistics for automatic translation of medical terms, to a proposition for a worldwide system of fast reaction to emerging pandemic.
The Journal-Lancet, Vol. XXXV, No. 5, March 1, 1915; The Journal of the Minnesota State Medical Association and Official Organ of the North Dakota and South Dakota State Medical Associations
The Journal-Lancet, Vol. XXXV, No. 5, March 1, 1915; The Journal of the Minnesota State Medical Association and Official Organ of the North Dakota and South Dakota State Medical Associations, a classic since it was first published. Has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.
The Bridge Between Bioethics and Medical Practice
Part 1: Defining Medical Professionalism.- Chapter 1. Professionalism and Medical Practice - Introduction (Luis Vivanco).- Chapter 2. Medical Professionalism - A Developmental View from the Trenches (Renzo Pegoraro).- Chapter 3. The Need for a Common Set of Competencies as Ingredients for Medical Professionalism, Paired with a Common Program of Assessment (Aaron R. Douglas).- Part 2: Medical Professionalism from Broader Perspectives.- Chapter 4. Medical Professionalism - legal framework (Sunčana Roksandic).- Chapter 5. Medical Professionalism - Sociological Framework (Gordana Cerjan Letica).- Part 3: The Moral Foundations of Medical Professionalism.- Chapter 6. Medical Professionalism - Philosophical Framework (Marko Ćurkovic).- Chapter 7. Medical Professionalism from Virtue Ethics Perspective (Claudia Ruiz Sotomayor).- Part 4. Medical Professionalism - Interpersonal Views and Considerations.- Chapter 8. Interpersonal or Relational Professionalism (Marko Ćurkovic).- Chapter 9. The Physician Patient Relationship: a Philosophical Perspective on Medical Professionalism and Virtues (Roberto Dell'Oro).- Chapter 10. Physicians Towards Fellow Colleagues (Marko Ćurkovic).- Chapter 11. Physicians Towards Other Healthcare Professionals (and Vice Versa) (Marko Ćurkovic).- Chapter 12. Interdisciplinary Challenges to Interprofessional Practice (Jos V. M. Welie).- Part 5. Medical Professionalism - Unique Challenges and Duties.- Chapter 13. The Impact of Uncertainties on Physicians' Health and Wellbeing (Marko Ćurkovic).- Chapter 14. Physicians and Organization: For a Reflective Organizational Professionalism (Jean-Philippe Cobbaut).- Chapter 15. Victims or Actors? Can Professionalism Shape Physicians' Roles Inside the Health Care System? (Bernice Elger).- Chapter 16. What do Doctors and Society Owe Each Other? A Scanlonian Reflection on Medical Professionalism (Andrew Papanikitas).- Chapter 17. Physicians Towards Society (and Vice Versa) (Sabine Salloch).- Part 6: Medical Professionalism Across Contemporary and Cultural Landscapes.- Chapter 18. Professionalism and Medical Practice - Cultural Perspectives (Marko Ćurkovic).- Chapter 19. Physicians as Citizens of the World (Henk ten Have).- Chapter 20. Physicians as Agents in Evolving Knowledge Landscapes (Srecko Gajovic).- Chapter 21. Afterthoughts: Towards a Realpolitik of Professionalism (Nathan Emmerich).
Nanoparticles for Rational Vaccine Design
This book introduces nanoparticles as a powerful platform for vaccine design. Current challenges in vaccine development are discussed and the unique advantages nanoparticles provide in overcoming these challenges are explored. The authors offer fascinating insights into the immunological assets of using nanoparticles as delivery vehicles or adjuvants and present different materials that are being used in nanoparticle-based vaccine development, covering peptides, proteins, polymers, virus-like particles, and liposomes.Its contemporary research insights and practical examples for applications make this volume an inspiring read for researchers and clinicians in vaccinology and immunology. Chapter "Liposome Formulations as Adjuvants for Vaccines" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Pioneers in Cell Physiology: The Story of Warren and Margaret Lewis
This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives. This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.
The Puerperal Diseases
The Puerperal Diseases - Clinical Lectures Delivered at Bellevue Hospital is an unchanged, high-quality reprint of the original edition of 1874. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Diseases of the Chest, Throat, and Nasal Cavities
Diseases of the Chest, Throat, and Nasal Cavities is an unchanged, high-quality reprint of the original edition of 1894. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Practical Neurophysics
Practical Neurophysics: The Physics and Engineering of Neurology explores and explains the physical foundations of neurology with a principal focus on the technologies that we use for diagnosis and management. The physics of biologic systems is also discussed, in the context of interfacing with our technologies and the mechanisms behind abnormalities. With sections on ultrasound, advanced laboratory tests, and neurotherapeutics, this is a unique book that focuses on the science and engineering rather than on disease processes. This book is intended to give the reader an appreciation of the mechanisms behind our technology and how humans and machines interface. The spectrum of presented information ranges from basic atomic physics to electronics to mechanisms of abnormalities on MRI and EEG. With this book, the reader should have a better understanding of the mechanisms of the technologies we use as well as an understanding of how normal and pathological functioning produces findings we can record.
Cognitive Neuroscience of Language
Cognitive Neuroscience of Language provides an up-to-date, wide-ranging, and pedagogically practical survey of the most important developments in this exciting field. It guides students through all of the major areas of investigation, beginning with the fundamental aspects of brain structure and function and then following with key topics such as classic and progressive aphasia syndromes; speech perception and production; the meanings of object nouns, action verbs, and abstract words; the formulation and comprehension of complex expressions, including grammatically inflected words, complete sentences, and entire stories; and several other domains of neurolinguistic research, including reading and writing, sign language, and the bilingual brain. Drawing heavily on prominent theoretical models, the core chapters illustrate how such frameworks are supported, and sometimes challenged, by experiments employing diverse brain mapping techniques. This edition has been thoroughly updated throughout, and now includes a dedicated chapter on the neural substrates of bilingualism. Chapters have been revised to reflect the most salient developments in the field, and the book has undergone a thoughtful restructure to mirror course teaching. While the study of language can be challenging, the text has been written accessibly and requires no previous knowledge of either neuroscience or linguistics and includes definitions of technical terms and explanations of important principles from both disciplines along the way. Accompanied by online resources for students and instructors, it is an essential companion for graduate or upper-level undergraduate students.
Tuberculosis of Bones and Joints
Tuberculosis of Bones and Joints is an unchanged, high-quality reprint of the original edition of 1892. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Clinical Lectures on Certain Acute Diseases
Clinical Lectures on Certain Acute Diseases is an unchanged, high-quality reprint of the original edition of 1860. Hansebooks is editor of the literature on different topic areas such as research and science, travel and expeditions, cooking and nutrition, medicine, and other genres. As a publisher we focus on the preservation of historical literature. Many works of historical writers and scientists are available today as antiques only. Hansebooks newly publishes these books and contributes to the preservation of literature which has become rare and historical knowledge for the future.
Handover of Power - Health
Health rethought Do you sometimes worry about becoming seriously ill without knowing who or what can help you? And do you also wish for an environment that keeps you healthy? Which healthcare system can identify what makes you healthy and offer it at a reasonable price? This book tells us: ... how a link between environmental protection and health can make it possible to keep humans and nature healthy with measurements and measures. ... what a directory could look like in which all diseases, treatment methods and physicians can be retrieved and evaluated according to their prospects of success. ... which way health costs can go if there are health insurances for general accidents and illnesses, for immortality and for addictive substances. After 20 years of work on this book series, Andreas Seidl thus ventures a step towards founding a party. In doing so, he entertains his readers both intellectually and visionarily. If this work can give you hope, inspire you or move you to action, it has fulfilled its purpose. Available in German and English
