Stem Cell-Derived Exosomes and Microvesicles
This book is an essential resource on the technologies and applications of exosomes and extracellular microvesicles derived from stem cells. Divided into three parts, the book covers the biology of stem cell-derived extracellular vesicles; isolation, characterization, and manufacture of exosomes and extracellular vesicles from stem cells; and exosomes and extracellular vesicle therapy. Taken as a whole, readers will learn how exosomes and extracellular vesicles are produced for clinical use. This is an ideal book for clinical researchers, cell and stem cell scientists, corporate leaders, and scientific entrepreneurs, as well as undergraduate and graduate students studying medicine, the biological sciences, and biotechnology.
Principles of Bioinspired and Biomimetic Regenerative Medicine
Nature has developed a diverse of materials, structures, and processes that are highly optimized for various functions. Through the field of biomimicry and bioinspiration, engineers are enhancing their understanding of natural design principles and applying these insights to create complex engineering models across different scales. These innovative approaches are particularly appropriate to address challenges in tissue engineering and regenerative medicine. Natural materials and systems exhibit a diverse array of functions, including but not limited to structural support, signal transduction, charge transfer, self-assembly, self-organization, and self-replication. Consequently, nature's "solution manual" is remarkably comprehensive. Despite significant advancements, the reconstruction of nature-inspired designs using synthetic materials presents ongoing challenges. As a result, nature and bioinspired materials and architectures have emerged as a paradigm shift within the realm of tissue engineering and regenerative medicine. This comprehensive guide aims to provide scientists with inspiration to address a variety of critical challenges in tissue regeneration by directly applying established design principles. A key focus of this volume is the utilization of bioinspired architectures in tissue engineering. It also emphasizes the development of nature-inspired structures through the integration of novel biological macromolecules, bioinspired polymers and hydrogels, as well as biomimetic ceramics. Furthermore, the text concentrates on the biochemical and biophysical dimensions of bioinspired surface engineering. Both dry-lab and wet-lab methodologies for characterizing nature and bio-inspired materials and structures are also addressed. The publication seeks to promote the development of high-level translational knowledge among both established and emerging scientists.
Peptide Synthesis
This fully updated second edition provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is important for successful synthesis. Chapters explore techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Peptide Synthesis: Methods and Protocols, Second Edition aims to be comprehensive guide for researchers in the field.
Cold Spring Harbor Monograph Series, Volumes 1-7
Papers From The Biological Laboratory, Issue 40
Cold Spring Harbor Monograph Series, Volumes 1-7
Polymers
The second edition of Macromolecular Chemistry broadens into two areas: biomacromolecules, Volume 1 and polymers, Volume 2. Polymers covers polymer history, polymerization reactions, polymer morphology, technology, characterization and testing, processing, and recycling. The book discusses the building blocks of synthetic polymers, comparison of macromolecules and polymers, polymer classification, and illustration of polymer chemical structures. Polymerization reactions such as step-growth polymerization and chain-growth polymerization are extensively discussed. It then presents tacticity, molecular interactions and polymer crystals. Biodegradable polymers, biomedical polymers, conducting polymers, electroluminescent polymers, water-soluble polymers, additives, adhesives, fibres, and coatings are described. The next section explores inorganic polymers such as polysilanes, polysiloxanes, and polyphosphazenes. The book then delves into polymer characterization and testing, including Infrared Spectroscopy, Raman Spectroscopy, NMR, X-ray Spectroscopy, and Electron Microscopy, and the last section addresses selected polymer processing techniques such as moulding, casting, extrusion, coatings, and foaming.
Dynamics of Bacteria-Mucus Interactions
This volume details the importance of bacteria in and around the human body, highlighting the bacteria that is harmless and pathogenic bacteria. Chapters guide readers through protocols on different bacteria's providing a better understand on they operate and how people can protect ourselves. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Dynamics of Bacteria-Mucus Interactions aims to be comprehensive guide for researchers in the field.
Resilient Forest Management
Global forest management is now grappling with ways to address the many dimensions of global change, including a warming climate and increasing forest disturbance from fires and pest outbreaks, along with changes in public values. However, the dominant forest management paradigms still assume a constant and predictable world in which command-and-control (i.e., treating long-lived forests much like short-lived agricultural crops) and single-value (i.e., timber) optimization still prevail. This novel text argues for new approaches to forest management that focus on resilience and embracing adaptability to the changing socio-ecological environment as it unfolds. Resilience is the ability of a system to maintain its essential attributes (in the form of composition, structure, and/or function) in response to stress, disruption, or disturbance. Managing a system for resilience places an emphasis on persistence rather than growth, efficiency, or profitability, which can be fulfilled by enhancing the capacity to resist change (i.e., robustness) or by enhancing the capacity to incorporate change in desirable directions (i.e., flexibility), or a combination of the two. Resilient Forest Management develops many of the same resilience-enhancing strategies for protected areas, multi-purpose forests, and timber production lands, but with different degrees of emphasis. Featured prominently are practices that enhance diversity, connectivity in space and time, and adaptive management as informed by vulnerability analysis and broad stakeholder consultation. In so doing, Resilient Forest Management builds on foundational concepts of ecological forestry and our understanding of complex adaptive systems and takes sustainable forest management to the next level. Resilient Forest Management will be suitable as a primary or supplementary text in forest policy and management. It will appeal to graduate-level students and researchers in the fields of forestry and conservation along with active policymakers in government, the forest industry, and environmental non-governmental organizations. While focused on forestry, parks managers, agriculturists, and urban planners too will find much useful insight and many creative solutions to sustainable development in a changing world.