The Healing Root
This book presents a comprehensive investigation into the antioxidant and antidiabetic potential of Pimpinella tirupatiensis, an endemic medicinal plant, with a focus on its protective effects against streptozotocin (STZ)-induced diabetic nephropathy in albino rats. It explores the role of oxidative stress in diabetic kidney damage and evaluates the therapeutic efficacy of the plant through in vitro antioxidant assays, biochemical analyses of both enzymatic and non-enzymatic antioxidants, and detailed histopathological examinations. By integrating traditional knowledge with modern scientific approaches, the book highlights the plant's promising nephroprotective and antioxidative properties, offering valuable insights for researchers and practitioners in the fields of phytomedicine, pharmacology, and diabetes management.
Long Non-Coding RNAs - Function, Mechanisms, and Applications
Environmental Pollution and Cardiovascular Diseases
Environmental Pollution and Cardiovascular Diseases helps stakeholders enhance their knowledge about environmental pollution, weather conditions, climate change, and impacts on the cardiovascular system. The book further aims to ameliorate the global burden of cardiovascular deaths attributable to pollution by identifying trends in pollution-linked cardiovascular disease from the 1990s to present day. Overall, air pollution is estimated to cause about 34% of ischemic heart disease deaths. As these figures show no sign of declining, this book is a must-have for researchers, cardiologists, and others seeking to understand such an important etiological factor in so many cardiovascular illnesses.
Bradykinin
Bradykinin: From Vasodilation to Neuroinflammation, the latest release in the Molecular Mediators in Health and Disease series is a comprehensive guide to the multi-functional peptide bradykinin and its impact across the human body. The early chapters provide an overview of the biosynthesis and metabolism of bradykinin, understanding its receptors and signaling pathways, and the therapeutic value of agonists and antagonists for targeting these. This book explores the role of bradykinin in vascular, renal, and brain function, as well as its influence on various conditions and diseases, including inflammation, pain, cardiovascular disease, renal disease, obesity, ischemic stroke, and infectious diseases, including Covid-19. In addition to its foundational knowledge, the book includes extensive coverage of bradykinin biochemistry and molecular biology. It highlights the therapeutic potential of bradykinin, making it an ideal reference for researchers working in these fields. The book serves as an invaluable resource for understanding the complex roles of bradykinin and its applications in medical research and treatment.
Gene Expression and Its Regulation: An Evolutionary Perspective
The Mutation Theory; Experiments and Observations on the Origin of Species in the Vegetable Kingdom
Anti-Prostate Cancer Agents
Anti-Prostate Cancer Agents walks the readers through the anti-prostate cancer drug development pipeline from early discovery/design to clinical studies/applications. This book covers discovery/design, synthetic studies, preclinical evaluation, mechanism of action, structure-activity relationships, clinical studies/applications of anti-prostate cancer agents. This book provides insight on how the design and discovery process of anti-prostate cancer agents have evolved from androgen deprivation therapy to current androgen receptor antagonists/degraders. So far, no book focusing on the topic has been published.
Structural and Functional Relationships in Prokaryotes
This book on bacterial physiology takes a balanced view of physiology, discussing both bioenergetics and bacterial metabolism in a way that establishes general principles and concepts and emphasizes the information gained from model systems. It also covers some experimental design issues in order to give readers an appreciation of the practical aspects and consequences of bacterial metabolism. The author stimulates readers to think about future developments in the field by presenting discussions from five world-famous bacterial physiologists.
Environmentally-Friendly Pest Control Approaches for Invasive Insects
This reprint aims to present innovative and sustainable strategies to manage invasive insect species, while minimizing ecological disruption. This collection emphasizes biological control, genetic insights, and novel biochemical interventions. It also showcases recent advances in sustainable strategies to mitigate the impact of invasive insect species. Emphasizing ecological safety and specificity, the contributions focus on biological control agents, host plant resistance, molecular targets, and sublethal effects of pesticides as alternatives to conventional chemical control. Control methods demonstrated here show the potential for precision pest management that reduces non-target effects and environmental contamination. Looking ahead, the development of genetic and behavioral control strategies, combined with ecological modeling and biotechnology, will be essential for designing robust, environmentally sound management programs. This reprint provides a valuable foundation for future interdisciplinary approaches in invasive insect control.
Cryo-Electron Tomography
Cryo-Electron Tomography: A Journey from Sample Preparation to Data Mining providing a holistic overview of this rapidly advancing field and equipping researchers with the knowledge and tools necessary to initiate their own investigations. The book begins with a section on advanced cryogenic sample preparation for in situ cellular tomography, covering a range of sample types including viruses, bacteria, eukaryotic cells, and perspectives for organoids and tissues. Specific chapters focus on essential approaches such as vitrification, sample thinning, and bimodal correlative techniques. The book then transitions to a section on data mining and validation.
Solving the Protein Structure Prediction Problem With Fast Messy Genetic Algorithms
Computational Genomics and Structural Bioinformatics in Microbial Science
Computational Genomics and Structural Bioinformatics in Microbial Science: Microbial Genomics (Volume 2) covers different aspects of microbial genomics, metagenomics, and functional studies of microbes through informative illustrations of current trends in computational tools and bioinformatics approach in environmental microbiology and clinical diagnosis. This book aims to provide readers with an overview of the microbial genome, computational genomics, and structural bioinformatics in microbial science, as well as the most recent developments in these fields. This book covers a range of topics, including the challenges and opportunities of computational epigenomics, bioinformatics tools for assessing metagenomic data, as well as computed comparative genomics and computational phenotyping of microorganisms relevant to agriculture. Microbial Genomics: Host Adaptation, virulence, and Evolution is a valuable resource for faculty members, researchers, and undergraduate and postgraduate students at universities, medical research labs, that are interested in microbial science specifically related to the microbial genome, computing genomics, and bioinformatics.
The Cardiovascular System
The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Cardiovascular System: From Bench to Bedside, Volume 6 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the cardiovascular system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compoundscreening paradigms, genetically engineered mice, and stem cell transplantation to treat cardiovascular system disorders and diseases. The volume is written for researchers and scientists in stem celltherapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.
F. A. Smitt, Marine Bryozoa, and the Introduction of Darwin Into Sweden
This is a print on demand edition of an important, hard-to-find publication.
Fungal Macromolecule Applications in Life Sciences
Fungal Macromolecule Applications in Life Sciences: Biological Activity and Medical, Industrial, and Agricultural Applications provides a comprehensive guide to the diverse applications of fungal macromolecules, such as proteins, lipid carbohydrates, and nucleic acids. Chapters include an introduction to the background and importance of fungal macromolecules in various life science fields followed by a detailed overview of the methods for isolating, characterizing, and assessing the structural and functional characteristics of fungal macromolecules. The book also explores the practical applications of fungal macromolecules in the biomedical, agricultural, and industry sectors. In addition, the book explores potential uses of fungal macromolecules as pharmaceuticals, anti-cancer agents, and inhibitors of bacterial biofilm formation as well as in plant disease management, crop development, enzyme production, biosurfactants, and sustainable and functional food production. The book also examines the antimicrobial properties of fungal macromolecules and their role in managing disease and stimulating human immunology.
Chromosomes in the Spermatogenesis of the Hemiptera Heteroptera
This is a print on demand edition of an important, hard-to-find publication.
Risk of Thrombosis during and after COVID Infection
The novel coronavirus known as SARS-CoV-2 is a respiratory virus that presents with symptoms such as a non-productive cough (60-80%), fever (90%) and shortness of breath (19-40%) and is responsible for the 2019-2020 global coronavirus disease (COVID-19) pandemic. Although most patients experience mild or no symptoms, severe disease is associated with thromboembolic complications and respiratory failure. There is an observed rise in the clinical manifestations of the disease 7 to 14 days after initial symptom onset and also associated with thrombotic complications. Understanding the thrombotic manifestations of the virus is important for patient management.
Autobiographical Ana of Robley Dunglison, M.D.
This is a print on demand edition of an important, hard-to-find publication. 14 plates.
Whole Life Cycle of Chromosomes and Their Coiling Systems
Chromosomes play so important a role in heredity & development that it is desirable to know their entire life cycle since this knowledge will provide a basis for better understanding of their behavior. Contents of this study: Introduction; The genus "Holomastigotoides"; Species of "Holomastigotoides" in "Prorhinotermes"; "Holomastigotoides tusitala" species novum; "Holomastigotoides diversa" species novum; Centrioles & achromatic figure; Relation of chromosomes to nucleoli; Relation of chromosomes to nuclear membrane; Single chromatids; Double chromatids; Discussion; Summary; & References. 35 plates. This is a print on demand edition of an important, hard-to-find publication.
Studies on Chromosomes and Nuclear Division
This is a print on demand edition of an important, hard-to-find publication. Illustrations.
Henrik Kroyer's Publication on Pelagic Marine Copepoda
This is a print on demand edition of a hard to find publication.
Studies on the Marine Pleistocene
This is a print on demand edition of an important, hard-to-find publication. Over 50 illustrations.
Systematics and Evolution of the Moinidae
This is a print on demand edition of an important, hard-to-find publication.
Narcolepsy
Narcolepsy: Integrating Basic and Clinical Knowledge provides comprehensive coverage of narcolepsy-related topics. The book offers updated, deep coverage of its diagnosis, treatment, and impact on mental health based on the latest research findings and clinical practices. Its interdisciplinary approach brings together experts from different specialties, such as sleep medicine, psychology, and neurology to offer a more holistic understanding. This allows for a more nuanced discussion of how narcolepsy interacts with various aspects of health and well-being. Researchers and clinicians will find within this book novel information on pathophysiology and neurobiology, as well as behavioral and psychosocial considerations. Users will find this to be a resource that takes a deep dive into narcolepsy, introducing topics never before discussed in books on the topic, including COVID-19 and sleep, as well as immunotherapy and gene therapy. It's the cutting-edge medical volume professionals need, whether narcolepsy specialists or more casual readers.
Solving the Protein Structure Prediction Problem With Fast Messy Genetic Algorithms
Genomics-Guided Natural Products Discovery
Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, "genome-mining" tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more. Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.
Arbidol
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
The Mastery of Bile Duct Injury
The Mastery of Bile Duct Injury is a comprehensive medical reference that explores various aspects of biliary injuries, encompassing anatomy, causes, classifications, clinical management, and surgical procedures, with a particular focus on complications arising from laparoscopic cholecystectomy. It not only provides a meticulous dissection of biliary injuries but also navigates through the labyrinth of diagnostic modalities and therapeutic approaches, illuminating a path towards enhanced patient care, surgical precision, and the future of research. Through its detailed examination, this authoritative reference serves as an invaluable resource for the complexities of biliary pathology empowering readers to navigate the challenges inherent in hepatobiliary surgery. Beginning with the historical evolution of cholelithiasis and extending to the impact of laparoscopic cholecystectomy, the book provides detailed insights into the intrahepatic and extrahepatic biliary systems, offering a foundation for understanding the complexities of biliary injuries encountered during surgical procedures. By addressing classification, management, and prevention strategies, the book serves as an invaluable resource for optimizing patient outcomes and minimizing complications in hepatobiliary surgeries.
Exploring the Borderlands
This study reproduces one "Report of Meetings" & six "Bulletins" from the Committee on Common Problems of Genetics, Paleontology, & Systematics. This Committee operated as an administrative unit of the National Research Council, part of the U.S. Nat. Acad. of Science. It was launched in 1943, blossomed for two years, then served as a cornerstone for other cooperative projects. The Committee provided a crucial foothold for those seeking a synthetics view of evolution in 1940s America. These forgotten documents show the Committee at work: building coalitions, defining priorities, & negotiating a common vision. They also show factions within the Committee competing for the leadership of this emerging community. Photo.
Fenugreek
Fenugreek is a miraculous medicinal herb that can be extremely potent for treating diabetes. It is also known for its medicinal properties that include relieving joint pain, lowering blood sugar level, restoring hair growth, as well as a dietary supplement for menstrual cramps and other conditions. Fenugreek is also a useful crop that helps fix nitrogen in the soil, an important nutrient for plant growth. Keeping in view the tremendous medicinal applications of fenugreek, this new book offers a comprehensive review of fenugreek, highlighting its nutritional and medicinal applications while also discussing methods for enhancing its yield and quality by improving the growth, physiological, and biochemical parameters of the plant.
Flavonoids' and Other Polyphenols' Pharmacological Activities for Phytopharmaceutical and Medicinal Applications
In today's era of modern phytopharmaceutical and medicinal product development, the interest of industrial sectors and consumers in natural plant products, consisting of the bioactive molecules of flavonoids and other polyphenols, has remarkably increased. Furthermore, a significant number of extracts from medicinal plants and several traditional medicines have been researched to discover their major bioactive molecules. This provides powerful potential pharmacological activities to develop phytopharmaceutical and medicinal products, including seed compounds for pharmaceuticals, as well as cosmeceuticals, cosmetics, nutricosmetics, supplements, and other plant-based products with healthy benefits. This reprint is a part of Special Issue "Flavonoids' and Other Polyphenols' Pharmacological Activities for Phytopharmaceutical and Medicinal Applications", which aims to explore the potential of natural plant products, especially the bioactive molecules of flavonoids and other polyphenols from interesting medicinal plants worldwide, as well as from several traditional medicines whose attractive efficacy for phytopharmaceutical and medicinal applications awaits discovery.
Algal Biomass Technology and Research
This new two-volume work describes the advances and emerging issues in the use of algal biomass and the prospects of micro- and macroalgae in biotechnology, microbiology, metabolic engineering, synthetic biology, biochemical engineering, and systems biology for the creation of algal cell factories. The books cover a broad spectrum of algal biomass technology for value-added products and for the recycling of environmental pollutants.Volume 2 focuses on sustainable biorefinery methods based on algae for the treatment of wastewater, for desalination, for bioenergy production, for lignocellulosic waste biomass utilization, and for environmental bioremediation. It also covers the connections between traditional and cutting-edge technologies, emphasizing the production of all types of algal biomass (including macro- and microalgae), with a focus on the bioengineering component. This volume places emphasis on two key areas: engineering implications and biological sciences implications.Volume 1 explores the impact of process parameters and phytohormones to improve algal biomass generation in various industries, providing consideration of the engineering, biological design, and applications of algal biomass along with relevant implementations.
Algal Biomass Technology and Research
This new two-volume work describes the advances and emerging issues in the use of algal biomass and the prospects of micro- and macroalgae in biotechnology, microbiology, metabolic engineering, synthetic biology, biochemical engineering, and systems biology for the creation of algal cell factories. The books cover a broad spectrum of algal biomass technology for value-added products and for the recycling of environmental pollutants.Volume 1 explores the impact of process parameters and phytohormones to improve algal biomass generation in the food, pharmaceutical, nutraceutical, and agriculture industries, providing consideration of the engineering, biological design, and applications of algal biomass along with relevant implementations. Chapters include a review of the potential aspects of algal biomass and its sustainable usage for food processing, nutraceutical production, pharmaceutical applications, and more.Volume 2 focuses on sustainable biorefinery methods based on algae for the treatment of wastewater, for desalination, for bioenergy production, for lignocellulosic waste biomass utilization, and for environmental bioremediation.
Essential Laboratory Techniques and Biochemical Analysis
This laboratory manual comprehensively reviews essential laboratory practices and different biochemistry protocols. The initial chapters of the book provide an overview of lab safety protocols, focusing on the importance of accuracy and precision in experimental procedures. It covers essential topics, such as laboratory setup, proper handling and maintenance of lab apparatus, and waste disposal. It provides a detailed exploration of spectrophotometry principles and assays, along with comprehensive cell biology techniques, including staining and microscopy. The book also addresses qualitative and quantitative analyses of carbohydrates, amino acids, proteins, and lipids, providing methods for extraction and characterization. It further details the extraction, purification, and characterization of enzymes and presents enzymatic assays and studies on enzyme kinetics, providing a comprehensive understanding of enzyme activity and regulation. The final section introduces hematology techniques, including blood smear preparation and various blood parameter determinations. It also covers forensic tests for blood detection and serum protein electrophoresis. This book is useful for graduate and postgraduate students of biochemistry, molecular biology, and microbiology.
Probiotics against Antimicrobial Resistance
This book provides an overview of antimicrobial resistance (AMR), including its underlying causes, mechanisms, global ramifications, and the potential of probiotics as a viable approach in combating AMR. It explores the potential of probiotics to counteract resistance by competing with pathogenic bacteria, modulating the immune system, and producing antimicrobial compounds. It also examines the applications of probiotics in biofilm-related infections, respiratory health, urinary tract infections, and oral health. Additionally, the book covers important considerations such as safety, regulatory frameworks, challenges, and risks associated with probiotics in AMR. It provides insights into the development of novel approaches, including engineering probiotics for enhanced antimicrobial activity and exploring synergistic approaches by combining probiotics with traditional antibiotics. Toward the end, the book explores future directions and potential applications of probiotics, including their role in neonatal care and personalized probiotic interventions. This book is primarily intended for healthcare professionals, researchers, and individuals working in the fields of microbiology, infectious diseases, and public health.Key features1) Discusses the mechanisms, impacts, and global concerns associated with antimicrobial resistance2) Highlights the various methods utilized by probiotics to effectively counter resistant pathogens3) Explores the potential of probiotics in enhancing human health and combating antimicrobial resistance4) Presents novel approaches, such as engineering probiotics for enhanced antimicrobial activity5) Focuses on personalized probiotics and their role in bridging the gap between antimicrobial resistance and nutritional precision6) Examines safety considerations and regulatory frameworks for probiotics in the context of antimicrobial resistance
