Environmentally-Friendly Pest Control Approaches for Invasive Insects
This reprint aims to present innovative and sustainable strategies to manage invasive insect species, while minimizing ecological disruption. This collection emphasizes biological control, genetic insights, and novel biochemical interventions. It also showcases recent advances in sustainable strategies to mitigate the impact of invasive insect species. Emphasizing ecological safety and specificity, the contributions focus on biological control agents, host plant resistance, molecular targets, and sublethal effects of pesticides as alternatives to conventional chemical control. Control methods demonstrated here show the potential for precision pest management that reduces non-target effects and environmental contamination. Looking ahead, the development of genetic and behavioral control strategies, combined with ecological modeling and biotechnology, will be essential for designing robust, environmentally sound management programs. This reprint provides a valuable foundation for future interdisciplinary approaches in invasive insect control.
Genomics-Guided Natural Products Discovery
Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, "genome-mining" tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more. Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.
Narcolepsy
Narcolepsy: Integrating Basic and Clinical Knowledge provides comprehensive coverage of narcolepsy-related topics. The book offers updated, deep coverage of its diagnosis, treatment, and impact on mental health based on the latest research findings and clinical practices. Its interdisciplinary approach brings together experts from different specialties, such as sleep medicine, psychology, and neurology to offer a more holistic understanding. This allows for a more nuanced discussion of how narcolepsy interacts with various aspects of health and well-being. Researchers and clinicians will find within this book novel information on pathophysiology and neurobiology, as well as behavioral and psychosocial considerations. Users will find this to be a resource that takes a deep dive into narcolepsy, introducing topics never before discussed in books on the topic, including COVID-19 and sleep, as well as immunotherapy and gene therapy. It's the cutting-edge medical volume professionals need, whether narcolepsy specialists or more casual readers.
The Mastery of Bile Duct Injury
The Mastery of Bile Duct Injury is a comprehensive medical reference that explores various aspects of biliary injuries, encompassing anatomy, causes, classifications, clinical management, and surgical procedures, with a particular focus on complications arising from laparoscopic cholecystectomy. It not only provides a meticulous dissection of biliary injuries but also navigates through the labyrinth of diagnostic modalities and therapeutic approaches, illuminating a path towards enhanced patient care, surgical precision, and the future of research. Through its detailed examination, this authoritative reference serves as an invaluable resource for the complexities of biliary pathology empowering readers to navigate the challenges inherent in hepatobiliary surgery. Beginning with the historical evolution of cholelithiasis and extending to the impact of laparoscopic cholecystectomy, the book provides detailed insights into the intrahepatic and extrahepatic biliary systems, offering a foundation for understanding the complexities of biliary injuries encountered during surgical procedures. By addressing classification, management, and prevention strategies, the book serves as an invaluable resource for optimizing patient outcomes and minimizing complications in hepatobiliary surgeries.
Computational Genomics and Structural Bioinformatics in Microbial Science
Computational Genomics and Structural Bioinformatics in Microbial Science: Microbial Genomics (Volume 2) covers different aspects of microbial genomics, metagenomics, and functional studies of microbes through informative illustrations of current trends in computational tools and bioinformatics approach in environmental microbiology and clinical diagnosis. This book aims to provide readers with an overview of the microbial genome, computational genomics, and structural bioinformatics in microbial science, as well as the most recent developments in these fields. This book covers a range of topics, including the challenges and opportunities of computational epigenomics, bioinformatics tools for assessing metagenomic data, as well as computed comparative genomics and computational phenotyping of microorganisms relevant to agriculture. Microbial Genomics: Host Adaptation, virulence, and Evolution is a valuable resource for faculty members, researchers, and undergraduate and postgraduate students at universities, medical research labs, that are interested in microbial science specifically related to the microbial genome, computing genomics, and bioinformatics.
The Cardiovascular System
The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Cardiovascular System: From Bench to Bedside, Volume 6 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the cardiovascular system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compoundscreening paradigms, genetically engineered mice, and stem cell transplantation to treat cardiovascular system disorders and diseases. The volume is written for researchers and scientists in stem celltherapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.
Fungal Macromolecule Applications in Life Sciences
Fungal Macromolecule Applications in Life Sciences: Biological Activity and Medical, Industrial, and Agricultural Applications provides a comprehensive guide to the diverse applications of fungal macromolecules, such as proteins, lipid carbohydrates, and nucleic acids. Chapters include an introduction to the background and importance of fungal macromolecules in various life science fields followed by a detailed overview of the methods for isolating, characterizing, and assessing the structural and functional characteristics of fungal macromolecules. The book also explores the practical applications of fungal macromolecules in the biomedical, agricultural, and industry sectors. In addition, the book explores potential uses of fungal macromolecules as pharmaceuticals, anti-cancer agents, and inhibitors of bacterial biofilm formation as well as in plant disease management, crop development, enzyme production, biosurfactants, and sustainable and functional food production. The book also examines the antimicrobial properties of fungal macromolecules and their role in managing disease and stimulating human immunology.
Contrasts in Scientific Style
Recounts the various styles of leadership shown by several prominent German chemists and biochemists during the period 1830 to 1914. Featured particularly are chemists Liebig, Baeyer and Emil Fischer and biochemists Hoppe-Seyler, Kuhne and Hofmeister. In a final chapter, Fruton considers the relevance of the conclusions drawn from the style of these 19th- and early 20th-centuy men to the styles of more recent research groups in the chemical and biochemical sciences. Special emphasis is placed on their influence on their scientific progenies in Germany, and in England, Russia, and the U.S. Attention is given to the individual contributions of the junior members of these scientific groups to the growth of knowledge within their disciplines.
Systematics and Evolution of the Moinidae
This is a print on demand edition of an important, hard-to-find publication.
Studies on the Marine Pleistocene
This is a print on demand edition of an important, hard-to-find publication. Over 50 illustrations.
Henrik Kroyer's Publication on Pelagic Marine Copepoda
This is a print on demand edition of a hard to find publication.
Studies on Chromosomes and Nuclear Division
This is a print on demand edition of an important, hard-to-find publication. Illustrations.
Whole Life Cycle of Chromosomes and Their Coiling Systems
Chromosomes play so important a role in heredity & development that it is desirable to know their entire life cycle since this knowledge will provide a basis for better understanding of their behavior. Contents of this study: Introduction; The genus "Holomastigotoides"; Species of "Holomastigotoides" in "Prorhinotermes"; "Holomastigotoides tusitala" species novum; "Holomastigotoides diversa" species novum; Centrioles & achromatic figure; Relation of chromosomes to nucleoli; Relation of chromosomes to nuclear membrane; Single chromatids; Double chromatids; Discussion; Summary; & References. 35 plates. This is a print on demand edition of an important, hard-to-find publication.
Autobiographical Ana of Robley Dunglison, M.D.
This is a print on demand edition of an important, hard-to-find publication. 14 plates.
Chromosomes in the Spermatogenesis of the Hemiptera Heteroptera
This is a print on demand edition of an important, hard-to-find publication.
F. A. Smitt, Marine Bryozoa, and the Introduction of Darwin Into Sweden
This is a print on demand edition of an important, hard-to-find publication.
Arbidol
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
Risk of Thrombosis during and after COVID Infection
The novel coronavirus known as SARS-CoV-2 is a respiratory virus that presents with symptoms such as a non-productive cough (60-80%), fever (90%) and shortness of breath (19-40%) and is responsible for the 2019-2020 global coronavirus disease (COVID-19) pandemic. Although most patients experience mild or no symptoms, severe disease is associated with thromboembolic complications and respiratory failure. There is an observed rise in the clinical manifestations of the disease 7 to 14 days after initial symptom onset and also associated with thrombotic complications. Understanding the thrombotic manifestations of the virus is important for patient management.
Microbes and the Microbe Killer
Dive into the late 19th century with William Radam's "Microbes and the Microbe Killer," a fascinating and controversial treatise on the nature of disease and its purported cure. Radam, a self-proclaimed medical innovator, details his theories about microbes as the root cause of all ailments and champions his own invention, "Radam's Microbe Killer," as the universal remedy. This book offers a unique window into the world of alternative medicine and patent remedies during a period of rapid scientific advancement and intense medical debate. Whether viewed as a groundbreaking discovery or a questionable elixir, Radam's work sparked considerable public interest and continues to intrigue those interested in the history of medicine, scientific controversies, and the enduring quest for health and wellness. "Microbes and the Microbe Killer" is a valuable historical document reflecting the beliefs and practices of its time.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Solving the Protein Structure Prediction Problem With Fast Messy Genetic Algorithms
The ability to accurately predict a polypeptide`s molecular structure given its amino acid sequence is important to numerous scientific, medical, and engineering applications. Studies have been conducted in the application of Genetic Algorithms (GAs) to this problem with promising initial results. In this thesis report, we use the fast messy Genetic Algorithm (fmGA) to attempt to find the minimization of an empirical CHARMM energy model and generation of the associated conformation. Previous work has shown that the fmGA provided favorable results, at least when applied to the pentapeptide [Met]-Enkephalin. We extend these results to a larger Polyalinine14 peptide by utilizing secondary structure information as both searching constraints and seeding the initial population. Additional efforts where conducted to improve the performance of the algorithm with respect to solving the Protein Structure Prediction (PSP) problem through a short-circuiting operator where complete evaluation of the fitness function is halted if initial results are not promising, and by conducting additional searches on faster machines in a heterogeneous environment. Results indicate that, on average, this localized search tends to produce better final solutions. Finally, the fmGA as applied to the PSP problem is analyzed and shown to have improved performance and effectiveness.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Biotechnology
The developmental trends in biological sciences indicate there is a plethora of possibilities concerning the study of microorganisms and its applicability in creating the next generation of biological warfare agents. Both historical and recent events show the potentially devastating effect of using biological warfare agents and the terror they cause among the populace. Even more alarming is that the exponential growth in biotechnology could transform the conventional biological warfare agents into a much more lethal bioweapon using genetically engineered pathogens. Nations, groups, and individuals that have the resources, capabilities, and knowledge to develop this biotechnology in the year 2035 will have the global arms race advantage.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
On Some New And Little Known Diatoms
"On Some New And Little Known Diatoms" by Per Teodor Cleve offers a detailed exploration into the world of diatoms, microscopic algae found in marine environments. This scientific work delves into the identification and classification of both newly discovered and less familiar diatom species. Cleve's research provides valuable insights into marine biology, oceanography, and paleontology. This book is an essential resource for scientists, researchers, and students interested in understanding the diversity and significance of diatoms in aquatic ecosystems and their historical record.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Exploring the Borderlands
This study reproduces one "Report of Meetings" & six "Bulletins" from the Committee on Common Problems of Genetics, Paleontology, & Systematics. This Committee operated as an administrative unit of the National Research Council, part of the U.S. Nat. Acad. of Science. It was launched in 1943, blossomed for two years, then served as a cornerstone for other cooperative projects. The Committee provided a crucial foothold for those seeking a synthetics view of evolution in 1940s America. These forgotten documents show the Committee at work: building coalitions, defining priorities, & negotiating a common vision. They also show factions within the Committee competing for the leadership of this emerging community. Photo.
The Mutation Theory; Experiments and Observations on the Origin of Species in the Vegetable Kingdom
"The Mutation Theory; Experiments and Observations on the Origin of Species in the Vegetable Kingdom, Volume 2" presents a detailed exploration of Hugo de Vries' groundbreaking work on mutation theory. This volume builds upon his experimental research and observations concerning the origin of new species within the plant kingdom. The work provides insights into the mechanisms of evolution and heredity, focusing on the role of mutations as a driving force. Authored by Hugo de Vries, with contributions from John Bretland Farmer and A. D. Darbishire, this book remains a valuable resource for botanists, geneticists, and anyone interested in the history of evolutionary thought. It offers a deep dive into the experimental evidence and theoretical framework that shaped early 20th-century understanding of species evolution.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Biotechnology
The developmental trends in biological sciences indicate there is a plethora of possibilities concerning the study of microorganisms and its applicability in creating the next generation of biological warfare agents. Both historical and recent events show the potentially devastating effect of using biological warfare agents and the terror they cause among the populace. Even more alarming is that the exponential growth in biotechnology could transform the conventional biological warfare agents into a much more lethal bioweapon using genetically engineered pathogens. Nations, groups, and individuals that have the resources, capabilities, and knowledge to develop this biotechnology in the year 2035 will have the global arms race advantage.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Electro-biology; or, The Doctrine of Impressions
"Electro-Biology; or, The Doctrine of Impressions" explores the fascinating intersection of early scientific inquiry and the emerging field of psychology in the mid-19th century. Authored by John A. Wroe with contributions from John Reid, M. D., this volume delves into the principles of electro-biology, a precursor to hypnotism and the study of suggestion. The book examines the effects of mental impressions on the human body, reflecting a time when the boundaries between science, philosophy, and spirituality were more fluid. Readers interested in the history of psychology, mesmerism, and the evolution of scientific thought will find this work a compelling glimpse into the past. Discover the ideas that shaped early investigations into the power of the mind and its influence on physical well-being.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Solving the Protein Structure Prediction Problem With Fast Messy Genetic Algorithms
The ability to accurately predict a polypeptide`s molecular structure given its amino acid sequence is important to numerous scientific, medical, and engineering applications. Studies have been conducted in the application of Genetic Algorithms (GAs) to this problem with promising initial results. In this thesis report, we use the fast messy Genetic Algorithm (fmGA) to attempt to find the minimization of an empirical CHARMM energy model and generation of the associated conformation. Previous work has shown that the fmGA provided favorable results, at least when applied to the pentapeptide [Met]-Enkephalin. We extend these results to a larger Polyalinine14 peptide by utilizing secondary structure information as both searching constraints and seeding the initial population. Additional efforts where conducted to improve the performance of the algorithm with respect to solving the Protein Structure Prediction (PSP) problem through a short-circuiting operator where complete evaluation of the fitness function is halted if initial results are not promising, and by conducting additional searches on faster machines in a heterogeneous environment. Results indicate that, on average, this localized search tends to produce better final solutions. Finally, the fmGA as applied to the PSP problem is analyzed and shown to have improved performance and effectiveness.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Heterozygosis in Evolution and in Plant Breeding
"Heterozygosis in Evolution and Plant Breeding," Volume 243, explores the significance of heterozygosity in the fields of evolutionary biology and agricultural science. Authored by Edward M. East and Herbert Kendall Hayes, this work delves into the genetic principles underlying heterozygosis and its implications for both natural selection and crop improvement.The book examines how the genetic diversity arising from heterozygosity contributes to the adaptability and resilience of plant species. It also investigates the practical applications of these principles in plant breeding programs, offering insights into the development of higher-yielding and more robust crop varieties. This volume remains a valuable resource for geneticists, botanists, and agricultural scientists interested in the intersection of genetics, evolution, and plant breeding.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Biological Cell Identification by Integrating Micro-Fluidics, Electrical Impedance Spectroscopy and Stochastic Estimation
The integration of micro-fluidics, electrical impedance spectroscopy and stochastic estimation will lead to a device with enhanced detection capabilities. The goal of this thesis was to build a micro-fluidic electrical impedance measurement device that can be used in combination with a stochastic estimator to accurately identify living cells. A microdevice capable of making impedance measurements on individual living cells was designed and built using a series of standard microelectronic fabrication techniques. A microchannel was patterned in SU-8 photoresist between two gold microelectrodes on a two inch Pyrex 7740 wafer. The design process, the fabrication techniques for the microchannel, the fluid port fabrication and the cover slip bonding processes are described in detail. Small glass cover slips were bonded to the wafer using Loctite 3301 adhesive. Impedance measurements of single cells, in the microchannel device, were made using a HP4194A impedance analyzer. Preliminary analysis of the impedance data suggests that Jurkat cells have characteristic impedance signatures, corresponding to their cell type. The microdevice that was designed and built for this project should facilitate future work to implement a stochastic estimation algorithm capable of single cell identification.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Biological Cell Identification by Integrating Micro-Fluidics, Electrical Impedance Spectroscopy and Stochastic Estimation
The integration of micro-fluidics, electrical impedance spectroscopy and stochastic estimation will lead to a device with enhanced detection capabilities. The goal of this thesis was to build a micro-fluidic electrical impedance measurement device that can be used in combination with a stochastic estimator to accurately identify living cells. A microdevice capable of making impedance measurements on individual living cells was designed and built using a series of standard microelectronic fabrication techniques. A microchannel was patterned in SU-8 photoresist between two gold microelectrodes on a two inch Pyrex 7740 wafer. The design process, the fabrication techniques for the microchannel, the fluid port fabrication and the cover slip bonding processes are described in detail. Small glass cover slips were bonded to the wafer using Loctite 3301 adhesive. Impedance measurements of single cells, in the microchannel device, were made using a HP4194A impedance analyzer. Preliminary analysis of the impedance data suggests that Jurkat cells have characteristic impedance signatures, corresponding to their cell type. The microdevice that was designed and built for this project should facilitate future work to implement a stochastic estimation algorithm capable of single cell identification.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Viral Infections in Immunocompromised Hosts
This Special Issue comprises 11 manuscripts and 1 editorial. The manuscripts include 4 research papers and 7 reviews, with one correction to a review article. All contributions focus on viral infections in immunocompromised hosts.
Flavonoids' and Other Polyphenols' Pharmacological Activities for Phytopharmaceutical and Medicinal Applications
In today's era of modern phytopharmaceutical and medicinal product development, the interest of industrial sectors and consumers in natural plant products, consisting of the bioactive molecules of flavonoids and other polyphenols, has remarkably increased. Furthermore, a significant number of extracts from medicinal plants and several traditional medicines have been researched to discover their major bioactive molecules. This provides powerful potential pharmacological activities to develop phytopharmaceutical and medicinal products, including seed compounds for pharmaceuticals, as well as cosmeceuticals, cosmetics, nutricosmetics, supplements, and other plant-based products with healthy benefits. This reprint is a part of Special Issue "Flavonoids' and Other Polyphenols' Pharmacological Activities for Phytopharmaceutical and Medicinal Applications", which aims to explore the potential of natural plant products, especially the bioactive molecules of flavonoids and other polyphenols from interesting medicinal plants worldwide, as well as from several traditional medicines whose attractive efficacy for phytopharmaceutical and medicinal applications awaits discovery.
Cellular Responses of Antioxidants Related to Degenerative Eye Disease Research
Oxidative stress is critical in degenerative retinal diseases. Antioxidants are considered to be potential therapeutics that can treat retinal diseases. Loss of retinal epithelium (RPE) is an important contributor to the degeneration of the retina. Dry AMD induces straight RPE cell degeneration, whereas the wet form causes neovascularization following RPE cell loss. Glaucoma induces progressive retinal ganglion cell (RGC) axon degeneration, resulting in RGC death and visual deficits. RPE cells are also important regulators in eye growth and thus are also susceptible to participating in retinal detachment in myopia. In diabetic retinopathy, the RPE barrier breaks, leading to vascular leakage. The retina is a thin layer in the posterior part of the eye that collects visual information and transfers it to the brain via the optic nerve. Retina consists of RPE cells, photoreceptor rods and cones, glial cells, and neuronal cells, including RGCs. RPE cells support homeostasis by performing a heterocycle of outer photoreceptor segments, enabling nutritional transport from the choroid and removing waste material into the choroid, for example. RPE degeneration leads to vision loss, and antioxidants could protect these cells against oxidative stress, mitochondrial dysfunction, and inflammation, all important contributors to retinal degeneration. This Special Issue is a collection of studies related to cellular responses to oxidative stress and antioxidants in pre-clinical degenerative retinal eye disease research. It includes articles about different aspects of oxidative stress and antioxidants in degenerative retinal diseases.
New Insights into Ethnobotany and Ethnoecology
This Reprint compiles thirteen peer-reviewed research papers that collectively explore the dynamic intersections of ethnobotany and ethnoecology in the context of a rapidly changing global environment. The contributions examine how climate change, globalization, and human migration reshape traditional ecological knowledge and influence the use of wild and cultivated plants, as well as non-cultivated edible mushrooms, in various societies. Geographically diverse, the studies span multiple continents-including Europe, Asia, Africa, and the Americas-highlighting a wide range of ecosystems and cultural settings. Thematically, the papers delve into traditional uses of edible and medicinal plants, the shifting roles of local agroecosystems, and the cultural significance of plant biodiversity. Several contributions focus on the resilience of folk knowledge and plant-based practices amid environmental and socio-political transformations, while others examine the integration of introduced species into local traditions due to climate-induced range expansions. Additionally, this Reprint addresses the preservation of biocultural diversity through the documentation of traditional plant varieties and seed systems, contributing to food security and cultural heritage. A number of papers also consider the impact of digital technologies on the transmission and evolution of ethnobotanical knowledge in the modern world. Overall, the collection offers a rich, comparative view of how plants remain central to human life, adaptation, and cultural continuity across diverse geographical and socio-ecological landscapes.
Agricultural Crops Subjected to Drought and Salinity Stress
Dear Colleagues, Agriculture has historically been vital to the prosperity of civilizations and has withstood environmental pressure and population growth thanks to genetic improvement and plant management. Most agricultural crops are subject to environmental stresses such as drought and salinity, and in many cases, these stresses act together, limiting crop productivity. From this perspective, innovative management strategies can improve the productivity of agricultural crops subjected to such unfavorable environmental conditions.This Special Issue focused on developing and evaluating management strategies for crops subjected to drought and salt stress, featuring interdisciplinary studies from research fields related to agriculture, including horticulture, genetics, plant ecophysiology, irrigation, soils, and plant nutrition. The featured research articles discussed various agricultural crops and solutions for growing them under drought and salt stress conditions.
Probiotics against Antimicrobial Resistance
This book provides an overview of antimicrobial resistance (AMR), including its underlying causes, mechanisms, global ramifications, and potential as a viable approach to combating AMR. This book is useful for healthcare professionals, researchers, and individuals working in the fields of microbiology, infectious diseases, and public health.
Diatoms and Sustainable Agriculture
This book explores the role of diatoms in revolutionizing agriculture practices towards sustainability by serving as plant growth promoters, indicators of ecosystem health, wastewater bioremediation, biosensors and insect control agents. This book is for researchers and academicians in mycology, biotechnology, and agricultural sciences.
Essential Laboratory Techniques and Biochemical Analysis
This laboratory manual comprehensively reviews the essential laboratory practices and different biochemistry protocols. It provides a detailed exploration of spectrophotometry principles and assays, along comprehensive cell biology techniques, including staining and microscopy.
Algal Biomass Technology and Research
This new two-volume work describes the advances and emerging issues in the use of algal biomass and the prospects of micro- and macroalgae in biotechnology, microbiology, metabolic engineering, synthetic biology, biochemical engineering, and systems biology for the creation of algal cell factories. The books cover a broad spectrum of algal biomass technology for value-added products and for the recycling of environmental pollutants.Volume 1 explores the impact of process parameters and phytohormones to improve algal biomass generation in the food, pharmaceutical, nutraceutical, and agriculture industries, providing consideration of the engineering, biological design, and applications of algal biomass along with relevant implementations. Chapters include a review of the potential aspects of algal biomass and its sustainable usage for food processing, nutraceutical production, pharmaceutical applications, and more.Volume 2 focuses on sustainable biorefinery methods based on algae for the treatment of wastewater, for desalination, for bioenergy production, for lignocellulosic waste biomass utilization, and for environmental bioremediation.
Algal Biomass Technology and Research
This new two-volume work describes the advances and emerging issues in the use of algal biomass and the prospects of micro- and macroalgae in biotechnology, microbiology, metabolic engineering, synthetic biology, biochemical engineering, and systems biology for the creation of algal cell factories. The books cover a broad spectrum of algal biomass technology for value-added products and for the recycling of environmental pollutants.Volume 2 focuses on sustainable biorefinery methods based on algae for the treatment of wastewater, for desalination, for bioenergy production, for lignocellulosic waste biomass utilization, and for environmental bioremediation. It also covers the connections between traditional and cutting-edge technologies, emphasizing the production of all types of algal biomass (including macro- and microalgae), with a focus on the bioengineering component. This volume places emphasis on two key areas: engineering implications and biological sciences implications.Volume 1 explores the impact of process parameters and phytohormones to improve algal biomass generation in various industries, providing consideration of the engineering, biological design, and applications of algal biomass along with relevant implementations.
Fenugreek
Fenugreek is a miraculous medicinal herb that can be extremely potent for treating diabetes. It is also known for its medicinal properties that include relieving joint pain, lowering blood sugar level, restoring hair growth, as well as a dietary supplement for menstrual cramps and other conditions. Fenugreek is also a useful crop that helps fix nitrogen in the soil, an important nutrient for plant growth. Keeping in view the tremendous medicinal applications of fenugreek, this new book offers a comprehensive review of fenugreek, highlighting its nutritional and medicinal applications while also discussing methods for enhancing its yield and quality by improving the growth, physiological, and biochemical parameters of the plant.
Nucleic Acids Chemistry
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed. New: expands on DNA nanotechnology and presents the fundamentals and new development of RNA therapeutics including CRISPR/Cas9, RNA editing and mRNA vaccines. Novel backbones for therapeutic nucleic acids. Lipid-, peptide- and protein-oligonucleotide conjugates. Modified DNA nanostructures. Aptamers and DNA catalysts. RNA therapeutics.
The Errors Of Evolution
In "The Errors Of Evolution," Robert Patterson presents a critical examination of foundational scientific theories. This meticulously researched work delves into the nebular theory, challenging its assumptions and exploring alternative explanations for the formation of celestial bodies. Patterson rigorously assesses the geological evolution of Earth, questioning prevailing timelines and processes.The book also addresses the complex subject of the origin of life, scrutinizing existing hypotheses and proposing alternative perspectives. A significant portion of the book is dedicated to a detailed analysis of Darwinism, probing its strengths and weaknesses. "The Errors Of Evolution" invites readers to reconsider established scientific narratives and engage in a deeper understanding of the natural world.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
The Secret Life of the Universe
One of the world's leading astrobiologists takes us on an awe-inspiring journey across the cosmos to investigate some of humanity's most profound questions: Are we alone in the universe? And how did life on Earth begin? We are in a golden age in astronomy, living on the cusp of breakthroughs that will revolutionize our understanding of our place in the cosmos. Yet a profound question remains: Are we alone in the universe? We have never been closer to answering this question. In The Secret Life of the Universe, celebrated astrobiologist and the director of the Carl Sagan Center at the SETI Institute Nathalie A. Cabrol takes us to the frontiers of the search for life. The book's odyssey begins by exploring how life began on Earth in order to understand what's necessary for its existence elsewhere. What role did our moon play? And could life on Mars have seeded life on Earth? Cabrol continues this dazzling interplanetary tour, illuminating the likeliest places for life in our neighborhood: While Mars and the icy moons of Jupiter and Saturn are among the top contenders, recent missions are redefining the limits of habitability to include unexpected worlds. Finally, we seek life beyond our solar system, becoming witness to a revolution in the night sky: the realization that there are as many planets as stars in our galaxy. With more than 300 million exoplanets in the habitable zone of their stars in the Milky Way alone, to think we are alone, or the only advanced intelligent civilization, may be little more than nonsense. The Secret Life of the Universe is a comprehensive and authoritative guide to the search for life--"a mind-altering and exhilarating read for anyone who has ever wondered: are we alone?" (Helen Macdonald, author of H Is for Hawk).
Breaking the Chains of Aging
Oxygen fuels our bodies with life-giving energy - but at a hidden cost: over time, it also slowly degrades the very systems it powers. Breathing oxygen generates a energy by burning our food but at the same time oxygen relentlessly wears out all parts of our biochemical machinery.Breaking the chains of aging explains how the most pernicious type of biological oxidative damage is lipid peroxidation (LPO), as it is the only example of the non-enzymatic chain reaction. The exponential nature of LPO, which once ignited generates multiple damage, makes antioxidants inefficient. The body does not invest enough into cleanup processes, so the waste products of LPO accumulate with time, accelerating the aging process. Lipid peroxidation affects multiple organs and cellular structures - including the brain, eyes, skin, and mitochondria - as well as key biological processes like sleep regulation, pain perception, inflammation, and aging. Drawing on 3 decades of experience in academia and commerce Mikhail Shchepinov provides an overview of the underlying biochemical processes, and describes a novel approach to mitigating the LPO-inflicted damage. Breaking the chains of aging will be of interest to all those with an interest in the process of aging.
Annual Report of the Laguna Marine Laboratory Volume 6th (1918)
Dive into the depths of early 20th-century marine research with the "Annual Report of the Laguna Marine Laboratory, Volume 6th (1918)." Compiled by the Laguna Marine Laboratory and the Department of Biology at Pomona College, this report offers a fascinating glimpse into the scientific investigations conducted on the California coast. This volume presents detailed findings, observations, and studies related to marine life and oceanic phenomena of the period. A valuable resource for historians of science, marine biologists, and anyone interested in the natural history of the Pacific coast, this report showcases the dedication and meticulous work of early researchers. Explore the baseline data and methodologies employed in a time when marine science was still in its formative stages. "Annual Report of the Laguna Marine Laboratory Volume 6th (1918)" is a vital addition to understanding the evolution of marine biology and the exploration of our oceans.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
RNA Analysis
This volume explores the latest technologies for RNA analysis, covering fundamental techniques and innovative approaches that expand our understanding of RNA biology. The chapters in this book are organized into four parts: reverse transcription and RNA capture methods; high-throughput sequencing methods; RNA maturation: splicing, polyadenylation, and epitranscriptomic modifications; and RNA surveillance: nonsense-mediated mRNA decay. These chapters aim to provide detailed protocols for select techniques used by molecular and computational biologists to isolate, amplify, detect, modify, and analyze RNA to gain insight into a wide range of cellular functions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNA Analysis: Methods and Protocols is a valuable resource for students, technicians, and senior scientists who want to learn more about this dynamic field of RNA research.
