Theory and Design of Fermentation Processes
This book covers the kinetics and design of fermentation processes, defined in the broader sense as any industrial processes that use living microorganisms or cells, both under aerobic and anaerobic conditions. It starts with a concise introduction to microbes and their metabolism, followed by rate equations, stoichiometry, derivation and use of mass balances for the design processes. It covers oxygen transfer and mass balances, heat transfer and design and scale-up/scale-down of fermentation processes. It further includes industrially relevant process examples, over 100 solved examples, questions and problems, and solutions of differential equations and systems of equations in Excel. Features Uses chemical engineering principles for the study of fermentation processes Provides detailed coverage of stoichiometry and kinetics of fermentation processes Discusses pertinent oxygen transfer theory and its applications Concisely covers microorganism biochemistry and metabolism Includes solved examples and problems with solutions This book is designed as a textbook for undergraduate students in chemical engineering; however, it is also suitable for postgraduate students and for process engineers interested in these topics.
Emotion and Attention Recognition Based on Biological Signals and Images
Emotion, stress, and attention recognition are the most important aspects in neuropsychology, cognitive science, neuroscience, and engineering. Biological signals and images processing such as galvanic skin response (GSR), electrocardiography (ECG), heart rate variability (HRV), electromyography (EMG), electroencephalography (EEG), event-related potentials (ERP), eye tracking, functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) have a great help in understanding the mentioned cognitive processes. Emotion, stress, and attention recognition systems based on different soft computing approaches have many engineering and medical applications. The book Emotion and Attention Recognition Based on Biological Signals and Images attempts to introduce the different soft computing approaches and technologies for recognition of emotion, stress, and attention, from a historical development, focusing particularly on the recent development of the field and its specialization within neuropsychology, cognitive science, neuroscience, and engineering. The basic idea is to present a common framework for the neuroscientists from diverse backgrounds in the cognitive neuroscience to illustrate their theoretical and applied research findings in emotion, stress, and attention.
Dynamics of Blood Cell Suspensions in Microflows
Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine.Features: The first book to provide a physical perspective of blood microcirculationDraws attention to the potential of this physical approach for novel applications in medicineEdited by specialists in this field, with chapter contributions from subject area specialists
Biocomposites and Hybrid Biomaterials of Calcium Orthophosphates with Polymers
This title gives an overview of composites and biocomposites. It discusses the history of CaPO4/ /polymer biocomposites and hybrid biomaterials, as well as analyzing the latest developments in the field. It also covers bioactivity and biodegradation of CaPO4-based biomaterials.
Innovation, Commercialization, and Start-Ups in Life Sciences
Innovation is a translation of a new method, idea, or product into reality and profit. It is a process of connected steps that accumulates into a brand reputation required for success. Unlike Fortune 500 companies, whose projects are self-funded, a start-up must simultaneously have a value proposition that attracts a customer (for revenue), investors (for capital), and acquirers (for a liquidity event or IPO). A high percentage of start-ups fail before attaining positive cashflow, due to a variety of reasons that are detailed in this book. Avoiding the pitfalls and wrong turns are the goals of this book. Innovation, Commercialization, and Start-Ups in Life Sciences details the methodologies necessary to create a successful life science start-up from initiation to exit. Written by an expert who has worked with more nearly 500 life science start-ups, this book discusses specific processes and investor milestones that must be navigated to align customer, funder, and acquirer needs. Successful commercialization requires attention to multiple constituents, such as investors, regulators, and customers. Investors require liquidity for their return, which is achieved through selling their stock in a public or private sale. The reader will gain an appreciation for the necessary data, partnerships, and skills needed to create a competitive and sustainable company. The author discusses such specific issues as customer problems, demonstrating sales access, and ensuring intellectual property is impervious to competitive advancement. This book is intended to be suitable for entrepreneurs, venture capitalists, and investors in both business and academic settings. These organizations have specific departments, such as R&D, operations, business development, legal, regulatory, and marketing, that would also benefit from this book. FEATURES Focuses specifically on life science start-ups Examines how to determine a company valuation and future "fundable milestones" Explores how to align regulatory and clinical strategies Discusses intellectual property derived from a university or individual through formation to exit. Reviews how start‐ups must simultaneously meet the needs of multiple constituencies at once: investors, regulators, customers and exit candidates James F. Jordan is an author, consultant, and speaker. He is a Distinguished Service Professor of Healthcare & Biotechnology Management, a former Fortune 100 executive, and a managing director of a venture fund. Access the Support Material: https: //healthcaredata.center/ Cover design by Sarah Mailhott.
Childhood Seized
To date, little research has been conducted to the effects of epilepsy on cognitive and language issues. This study is a response to this knowledge gap. A careful matched-subject, mixed-factors description, designed to identify cognitive decline during the process and treatment of this illness. The research is focused on description and exploration, of linguistic considerations in Rolandic epilepsy. Rolandic epilepsy, is also known as Benign focal epilepsy with centrotemporal spikes (BECS). The intention is to shed light from a neurolinguistic perspective, on reasons that might underline cognitive and behavioral complications, in children with epilepsy. This study has been approached corroborating 'structural connectivity', which defines language network in the brain. The rational derives from research of neurological data, from prestigious neurological and scientific international journals, on the topic that illustrates our case. Conclusions are based upon careful evaluation on how epilepsy affects cognitive skills, and language issues upon observations drawn on results. Deficits in language patterns have been associated to different brain areas, in patients who suffer from different pathologies. Degenerative illnesses have opened a milestone in the study on reasons leading to cognitive decline, in children affected from "Benign childhood epilepsy". Medical history has been well documented to current day. Lack of consistent information internationally recognized on cognitive issues toughen consensus on best medical procedure to follow, in best interest of the child. Our research confronted this shortage of information, in the light of the new literature coming through. Overall, the results indicate that when working with language skills in people with epilepsy or with degenerative diseases, clinicians should account for the presence of anti-epileptic medication or amalgamation of medications as possible cause of cognitive decline.
Stem Cell Biology and Regenerative Medicine, Second edition
The study of stem cell biology is under intensive investigation. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell and gene therapy.The aim of this book is to provide readers and researchers with timely and accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on conferences given by recognized scientists involved in the international master course on stem cell biology at Sorbonne Universit矇 in Paris.
The Narrate of Innovation Theories and Methods of Cancer Treatment Volume 3
In this book, is a summary of the new things and our past work together in the detail, especially emphasizes the medications for cancer treatment.
The Narrate of Innovation Theories and Methods of Cancer Treatment Volume 2
In this book, is a summary of the new things and our past work together in the detail, especially emphasizes the medications for cancer treatment.
The Narrate of Innovation Theories and Methods of Cancer Treatment
In this book, is a summary of the new things and our past work together in the detail, especially emphasizes the medications for cancer treatment.
The Art is Long
The Art Is Long: Primary Texts on Medicine and the Humanities gathers introductory texts in the growing field of medical humanities. This unique volume presents a lens with which to examine the intersection of literature and medicine with diverse selections that span time and the globe. With authors from Sushruta to Hippocrates, Margery Kempe to John Donne, and Susie King Taylor to Sigmund Freud, the volume also highlights the voices of women, people of color, and those who have been overlooked or marginalized by the medical establishment.The Art Is Long aims to expand the medical humanities canon. In addition to more traditional works, readers will find snippets of literary and narrative encounters with medicine by writers who are neither doctors nor nurses, including professional caretakers and people who might be labelled "quacks" today but whose contributions represent a part of medical history.This anthology also includes medical reportage and philosophy, fiction and nonfiction, image and poetry. The shifts in genre, style, and perspective provide a wealth of opportunities to reflect on medical history and literary techniques, focusing on narratives that highlight a personal context for medical subjects in a single volume.
Mathematics, Physics, and Engineering in Medicine
Diagnosed with Type II diabetes at the height of his career as a Silicon Valley CEO, Gerald Hsu spent the next decade relying on prescribed medication to control his condition. Unfortunately, his health continued to deteriorate as he suffered from problems with his heart, kidney, bladder, thyroid, vision, and extremities. Refusing to succumb to a life of insulin injections and dialysis treatments, Gerald took it upon himself to study and research chronic diseases and food nutrition. Having spent half his life studying and learning ten different academic disciplines, Gerald had a unique perspective on how to approach his medical research despite lack of formal training in biology and chemistry. He relied on mathematics, physics, computer science, and engineering, to conduct his medical research work. Utilizing an AI-based computer system he developed for his research, Gerald was able to reverse much of the damage done to his health and reduce the dosages of his medications until he ceased taking them completely. This book is a collection of approximately ten percent of his published research papers across multiple medical journals. It reflects what he has learned in his personal health journey and his hope to share his knowledge with the medical community and the world.
A-Z of First Trimester Sonography Atlas & Illustration
The use of high-frequency resolution ultrasound machines in the clinical practice and, particularly, high-frequency transvaginal probes, has permitted the study of the initial phases of the morphological development of the embryo and to detect possible pathologies. The diagnostic potential of TVS ultrasound is very high in the first weeks of embryonic development, but the operator needs a good knowledge of the processes of embryonic morphogenesis and the varying ultrasound findings that can be found in the first weeks of pregnancy. An ultrasound examination in the first trimester can also provide useful information in order to predict the risk of miscarriage. The elements on which such a prognosis is based are many. So I decided to clarify the above problems related to early pregnancy up to 14wks as: - Guidelines for first Trimester pregnancy assessment: Minimum Standard for the first Trimester pregnancy.- Implantation & its problems.- Sonoembryology- Biometry: importance of early GA establishment.- Sonography of First Trimester pregnancy: normal & abnormal- Pseudo pathology of Embryo- Gestational Sac (GS) Amniotic cavity & extra embryonic celom.- Yolk sac (YS)- Anembryonic Pregnancy: Blighted Ovum.- Chorionic frundosum & placenta; Bumps, Hydatid Mole / Gestational Trophoblastic Disease (GTD)- Sub chorionic Hematoma- Incomplete Abortion & missed Abortion- First trimester anomalies scan (FTAS)- NT & Nasal bone (first trimester aneuploidy screening: FTS)- Early foetal cardiac echo by TVS- Ectopic pregnancy & pregnancy of unknown location(PUL): tubal, cervical, cs scar ectopic & other.- Chorionic villous sampling: overview.- Multifetal pregnancy: chronicity, early disparity & MFPR About the Author: Dr. B. I. Patel is an Obstetrician and Gynecologist, specializing in Fetal medicine over the last 25 years at Gynob Sono Scan Center, Shachi Women's Hospital, Ahmedabad. He is an alumnus of the well-known B J Medical College, Ahmedabad from where he pursued MBBS, diploma and master degree. He was awarded Diploma in Fetal Medicine by NSU, Singapore in 1992, was awarded the Fellowship of IFMUB 1996 and was awarded Diploma of 3D and 4D Ultrasonography at Austria by Dr. Kratochwil in 1999.Dr. Patel has been a pioneer in Conventional and Advanced Sonography, Transvaginal Sonography, 3D, 4D, Doppler and Interventional Sonography and is credited for introducing 3D and 4D USG for the first time in the state of Gujarat in 1999. Dr. Patel has attended many workshops and conferences, trained around 700 Gynecologists in Sonography at his FOGSI accredited training center. He was felicitated by Ahmedabad Medical Association (AMA) for Excellence in the Medical field in 2000 and received the Outstanding Contribution Award by FOGSI Committee in the same year. He was felicitated by the Red Cross Society and Government of Gujarat for his outstanding contribution in Chorionic Villus Sampling in Thalassemia patients. Dr. Patel is the Hon. Secretary of Gujarat Medical Journal (GMJ) for the last 20 years, and the founder President of Society of Fetal Medicine (SEM), Gujarat, Chapter.
Today's Curiosity Is Tomorrow's Cure
Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)
Randomised Clinical Trials
Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.
Exploratory Subgroup Analyses in Clinical Research
This essential guide on subgroup analyses in the emerging area of personalized medicine covers the issues of subgroup analyses from a practical and a theoretical/methodological point of view. The practical part introduces the issues using examples from the literature where subgroup analyses led to unexpected or difficult-to-interpret results, which have been interpreted differently by different stakeholders. On the technical side, the book addresses selection and selection bias variance reduction by borrowing information from the full population in estimating a subgroup effect. To this end, subgroup analysis will be linked to statistical modelling, and subgroup selection to model selection. This connection makes the techniques developed for model selection applicable to subgroup analysis. Beginning with a history of subgroup analysis, Exploratory Subgroup Analyses in Clinical Research offers chapters that cover: objectives and current practice of subgroup analyses; pitfalls of subgroup analyses; subgroup analysis and modeling; hierarchical models in subgroup analysis; and selection bias in regression. It also looks at the predicted individual treatment effect and offers an outlook of the topic in its final chapter. Focuses on the statistical aspects of subgroup analysis Filled with classroom and conference-workshop tested material Written by a leading expert in the field of subgroup analysis Complemented with a companion website featuring downloadable datasets and examples for teaching use Exploratory Subgroup Analyses in Clinical Research is an ideal book for medical statisticians and biostatisticians and will greatly benefit physicians and researchers interested in personalized medicine.
Dressings for Advanced Wound Care
Dressings for Advanced Wound Care focuses on helping the reader better understand advanced wound care and relevant technologies. It explains how different types of wounds may require different environments to heal and how dressings can help in creating the right environment. It gives an overview of the various dressing technologies that are available to help manage wounds that are difficult to heal. Finally, this book highlights the current trends that may be directing the future of the advanced wound dressing sector. FEATURES: Relates technologies with commercially available end-products, giving the reader a more specific overview of the advanced wound dressing sector Provides a realistic overview of the process of developing an advanced wound care dressing Summarises recent clinical evidence on advanced wound dressings Explains how dressings differ and what works best for which wound type Examines clinical evidence on technologies and on-market products Describes the requirements for launching a new advanced wound dressing This book is aimed at medical clinicians and professionals in the fields of biomedical engineering, textile science, and materials engineering.
Into Sanity
In this remarkable collection, 22 writers describe suicidal despair or mania--or coming to terms with a generational legacy of mental illness. Into Sanity includes personal essays by contributors from all over the United States and a preface by Mark Vonnegut, who judged the contest at Talking Writing magazine that sparked these true stories.The media has paid more attention to suicide risks and depression in recent years, especially after the death of well-loved celebrities. And yet, mental illness remains misunderstood. Into Sanity offers the lived reality. These writers underscore why the stigma makes mental illness so hard to talk about--and why it takes courage to speak up.
Statistics at Square One
STATISTICS AT SQUARE ONE The new edition of the popular introduction to the world of statistics for health care professionals and medical studentsFirst published nearly three decades ago, Statistics at Square One remains one of the most popular introductions to medical statistics. Now in its twelfth edition, this international bestseller continues to be a must-have resource for anyone in need of a thorough introduction to statistics in the health sciences. Clear and accessible chapters help students with no previous background in the subject understand fundamental topics including summary statistics for quantitative and binary data, diagnostic and screening tests, populations and samples, survival analysis, correlation and regression, study design, computer modeling, and more.This edition reflects contemporary understanding of medical statistics and emphasizes the importance of statistics in public health, including extensively updated coverage of diagnostic tests and new COVID-related examples. All figures and examples now include code to reproduce them in the R statistical software. New chapters cover the basics for understanding numbers and introduce the use of models in medical statistical analysis. Based on the author's many years of experience teaching medical and health science students, the latest edition of this classic textbook: Highlights the connections between different medical statistics methodsEmphasizes the proper use of p-values in testingFeatures practical examples from recent literatureContains end-of-chapter exercises with answers, some of which are based on the Royal College of General Practitioners (RCGP) Advanced Knowledge TestStatistics at Square One is required reading for all medical and health care practitioners and students wanting to understand the use and value of statistical analysis in the health sciences.
Crop Improvement
Crop Improvement: Biotechnological Advances - Biomedical Science The field of biotechnology is advancing at a fast pace. The availability of low-cost DNA/genome sequencing technologies has led to the discovery and functional characterization of myriad of genes imparting stress tolerance and quality traits. The 'omics' group of technologies including genomics, proteomics, transcriptomics and metabolomics has revolutionized the agricultural biotechnology sector. The Nobel Prize-winning technology, such as the genome editing technique, is being employed to edit various gene functions in plants aiding in crop improvement. This technology may be adopted very quickly by consumers compared with the transgenic technique because the genome-edited plants have no adverse effects on the genome of the plant itself and on the environment and related species/non-target organisms. In this book, authors have attempted to compile the latest techniques of agricultural biotechnology and their applications in crop improvement. Certain chapters have been dedicated to describe the use of nanotechnology, a fast emerging new technique in the agriculture sector. Features Development, potential and safety issues in biotechnology Advances in genomics, proteomics and transcriptomics in agriculture Protein bioinformatics and its applications Genetically modified (GM) technology and its implications Genome editing in crop improvement Marker-assisted selection (MAS) in crop improvement Mutation breeding Cryobiotechnology Nanotechnology and biosensors This book includes real-world examples and applications making it accessible to a broader interdisciplinary readership. We hope that it will serve as a reference book for researchers engaged in molecular biology and biotechnology and will act as a ready reckoner for postgraduate (PG) students in the biotechnology discipline.
Robotic Technologies in Biomedical and Healthcare Engineering
New prospects for biomedical and healthcare engineering are being created by the rapid development of Robotic and Artificial Intelligence techniques. Innovative technologies such as Artificial Intelligence, Deep Learning, Robotics, and IoT are currently under huge influence in today's modern world. For instance, a micro-nano robot allows us to study the fundamental problems at a cellular scale owing to its precise positioning and manipulation ability; the medical robot paves a new way for the low-invasive and high-efficient clinical operation, and rehabilitation robotics is able to improve the rehabilitative efficacy of patients. This book aims at exhibiting the latest research achievements, findings, and ideas in the field of robotics in biomedical and healthcare engineering, primarily focusing on the walking assistive robot, telerobotic surgery, upper/lower limb rehabilitation, and radiosurgery. As a result, a wide range of robots are being developed to serve a variety of roles within the medical environment. Robots specializing in human treatment include surgical robots and rehabilitation robots. The field of assistive and therapeutic robotic devices is also expanding rapidly. These include robots that help patients rehabilitate from severe conditions like strokes, empathic robots that assist in the care of older or physically/mentally challenged individuals, and industrial robots that take on a variety of routine tasks, such as sterilizing rooms and delivering medical supplies and equipment, including medications. The objectives of the book are in terms of advancing the state-of-the-art of robotic techniques and addressing the challenging problems in biomedical and healthcare engineering. This book Lays a good foundation for the core concepts and principles of robotics in biomedical and healthcare engineering, walking the reader through the fundamental ideas with expert ease. Progresses on the topics in a step-by-step manner and reinforces theory with a full-fledged pedagogy designed to enhance students' understanding and offer them a practical insight into the applications of it. Features chapters that introduce and cover novel ideas in healthcare engineering like Applications of Robots in Surgery, Microrobots and Nanorobots in Healthcare Practices, Intelligent Walker for Posture Monitoring, AI-Powered Robots in Biomedical and Hybrid Intelligent Systems for Medical Diagnosis, and so on. Deepak Gupta is an Assistant Professor at the Maharaja Agrasen Institute of Technology, GGSIPU, Delhi, India. Moolchand Sharma is an Assistant Professor at the Maharaja Agrasen Institute of Technology, GGSIPU, Delhi, India. Vikas Chaudhary is a Professor at the JIMS Engineering Management Technical Campus, GGSIPU, Greater Noida, India. Ashish Khanna currently works at the Maharaja Agrasen Institute of Technology, GGSIPU, Delhi, India.
Individual Participant Data Meta-Analysis
Individual Participant Data Meta-Analysis: A Handbook for Healthcare Research provides a comprehensive introduction to the fundamental principles and methods that healthcare researchers need when considering, conducting or using individual participant data (IPD) meta-analysis projects. Written and edited by researchers with substantial experience in the field, the book details key concepts and practical guidance for each stage of an IPD meta-analysis project, alongside illustrated examples and summary learning points. Split into five parts, the book chapters take the reader through the journey from initiating and planning IPD projects to obtaining, checking, and meta-analysing IPD, and appraising and reporting findings. The book initially focuses on the synthesis of IPD from randomised trials to evaluate treatment effects, including the evaluation of participant-level effect modifiers (treatment-covariate interactions). Detailed extension is then made to specialist topics such as diagnostic test accuracy, prognostic factors, risk prediction models, and advanced statistical topics such as multivariate and network meta-analysis, power calculations, and missing data. Intended for a broad audience, the book will enable the reader to: Understand the advantages of the IPD approach and decide when it is needed over a conventional systematic review Recognise the scope, resources and challenges of IPD meta-analysis projects Appreciate the importance of a multi-disciplinary project team and close collaboration with the original study investigators Understand how to obtain, check, manage and harmonise IPD from multiple studies Examine risk of bias (quality) of IPD and minimise potential biases throughout the project Understand fundamental statistical methods for IPD meta-analysis, including two-stage and one-stage approaches (and their differences), and statistical software to implement them Clearly report and disseminate IPD meta-analyses to inform policy, practice and future research Critically appraise existing IPD meta-analysis projects Address specialist topics such as effect modification, multiple correlated outcomes, multiple treatment comparisons, non-linear relationships, test accuracy at multiple thresholds, multiple imputation, and developing and validating clinical prediction models Detailed examples and case studies are provided throughout.
Stem Cells
"Stem cell therapy to reverse aging and cure cancer." I'm sure you have seen headlines similar to this circulating in newspapers and on TV many times. You've probably also wondered what stem cells are, exactly, and how they are going to cause all of these miraculous scientific feats. This book was written as an answer to all of these basic stem cell questions, touching on areas such as the history of stem cells, a deep-dive into regenerative therapies, and future directions of stem cell therapy. Read on to find out more!
Johns Hopkins Evidence-Based Practice for Nurses and Healthcare Professionals, Fourth Edition
Awarded third place in the 2021 AJN Book of the Year Awards in Professional Development!The dynamic and competitive US healthcare environment requires healthcare professionals who are accountable to provide efficient and effective care. New evidence is continually surfacing in nursing and medical environments. Consumer pressure and increased patient expectations place an even greater emphasis on the need for healthcare professionals to deliver true evidence-based care in their daily practice.Johns Hopkins Nursing is steadfastly dedicated to making it easy for frontline nurses, health professionals, and students to use best evidence in their everyday practice. With each edition, we revise based on the honest, frank, and generous feedback we receive from frontline users of the Johns Hopkins Evidence-Based Practice Model from across the globe. In this fourth edition, we are excited to be able to share these changes. The 2021 revised JHEBP Model underscores the need for organizations to cultivate both a spirit of inquiry and an environment of learning that encourages questioning and seeking best evidence and its implementation and adoption in practice. Although our model was developed, tested, and implemented by and for nurses, we have had numerous requests and feedback from other health professionals to use the Hopkins model. Thus, we introduce the fourth edition with a new title-Johns Hopkins Evidence-Based Practice for Nurses and Healthcare Professionals. This change reflects the growing evidence base of the importance for interprofessional collaboration and teamwork, particularly when addressing complex care issues such as those often tackled by EBP teams. In this edition, our overarching aim is to provide practical and pragmatic explanations, approaches, and tools to guide and support teams engaging in EBP projects: We explicitly reflected the interprofessional nature of the EBP process and its use by all disciplines who serve, interact with, and care for those who seek services.We revised the flow of the book chapters across the sections to reflect the progression of steps in the EBP process.We included a new introduction for the evidence section that includes background on the use of evidence hierarchies, tips for differentiating research from quality improvement, and further explanation of the summary and synthesis steps in the evidence process.We provided real-world examples for how to complete all tools using feedback from our global users as well as tried and tested helpful hints.We added a new chapter to expand and amplify strategies for dissemination that includes how to create a dissemination plan, audience-specific recommendations for internal and external dissemination venues, details of the pros and cons of different types of dissemination, guidance on submitting manuscripts for publication, and an overview of the journal review process.Chapter-specific enhancements: Chapter 3: Defines critical thinking and clinical reasoning and differentiates their use in the PET process.Chapter 4: Outlines stakeholder selection criteria and an algorithm to determine the need for an EBP project.Chapter 5: Includes new information on the literature screening process to navigate a large number of results Chapter 6: Provides useful clarifications of research approaches, designs, and methods with a focus on frontline staff as the target audienceChapter 8: Includes revised synthesis and translation steps; assesses risk prior to translation; prioritizes translation models accessible to frontline staff with a focus on the QI methodology and PDSA; and describes an expanded list of outcome measures to determine the success of an EPB project.
Computer-Aided Glaucoma Diagnosis System
Glaucoma is the second leading cause of blindness globally. Early detection and treatment can prevent its progression to avoid total blindness. This book discusses and reviews current approaches for detection and examines new approaches for diagnosing glaucoma using CAD system. Computer-Aided Glaucoma Diagnosis System, Chapter 1 provides a brief introduction of the disease and current methodology used to diagnose it today. Chapter 2 presents a review of the medical background of the disease, followed by a theoretical and mathematical background used in fundus image processing. Chapter 3 is a literature review about segmentation and feature extraction. Chapter 4 describes the formulation of the proposed methodology. In Chapter 5, the results of optic disc and optic cup segmentation algorithm are presented, the feature extraction and selection method, experimental results and performance evaluations of the classifier are given. Chapter 6 presents the conclusions and discussion of the future potential for the diagnostic system. This book is intended for biomedical engineers, computer science students, ophthalmologists and radiologists looking to develop a reliable automated computer-aided diagnosis system (CAD) for detecting glaucoma and improve diagnosis of the disease. Key Features Discusses a reliable automated computer-aided diagnosis system (CAD) for detecting glaucoma and presents an algorithm that detects optic disc and optic cup Assists ophthalmologists and researchers to test a new diagnostic method that reduces the effort and time of the doctors and cost to the patients Discusses techniques to reduce human error and minimize the miss detection rate and facilitate early diagnosis and treatment Presents algorithms to detect cup and disc color, shape features and RNFL texture features Dr. Arwa Ahmed Gasm Elseid is an assistant professor, Department of Biomedical Engineering, Sudan University of Science and Technology, Khartoum, Sudan. Dr. Alnazier Osman Mohammed Hamza is professor of Medical Imaging, College of Engineering, Sudan University of Sciences and Technology, Khartoum, Sudan.　
Nanomedicine and Tissue Engineering
This book focuses on the recent advances in nanomedicine and tissue engineering. It outlines the basic tools and novel approaches that are becoming available in nanomedicine and tissue engineering and considers the full range of nanomedical applications which employ molecular nanotechnology inside the human body, from the perspective of a future practitioner in an era of widely available nanomedicine. Topics include: Health benefits of phytochemicals and application of superparamagnetic nanoparticles for hyperthermiaSilver nanoparticles in nanomedicineOptical diagnostic of molecules and cells using nanotechnologyNanoparticulate drug delivery system for antiviral drugsLiposomal drug delivery systems, nanoemulsifying drug delivery system (SNEDS)Functionalization of tissue engineering scaffolds Induction of angiogenesis in scaffoldsMany other recent achievementsWritten by some of the most innovative minds in medicine and tissue engineering, this book considers the full range of nanomedical applications which employ molecular nanotechnology inside the human body and will help professionals understand cutting-edge and futuristic areas of nanomedicine and tissue engineering research. Readers will find insightful discussions on nanostructured intelligent materials and devices that are considered technically feasible and that have a high potential to produce advances in medicine in the near future.
Natural-Based Polymers for Biomedical Applications
This new book presents the authors' biomedical studies of natural degradable biopolymers (polyhydroxyalkanoates [PHAs]) and discusses the demand for medical-grade materials and modern trends, focusing on the present status and future potential of PHAs. The authors present and summarize their most important results and findings obtained during the last few years in experimental studies and clinical trials of PHAs at the Institute of Biophysics Siberian Branch of Russian Academy of Science.
Successful Qualitative Health Research
A practical overview for health students and health professionals embarking on an applied research project using a qualitative approach. Successful Qualitative Health Research offers a thorough introduction to the field, written in a very clear and concise fashion. Emphasising the rigorous approach required in health research, it provides a step by step guide to designing a research project using qualitative methods, and to collecting, analysing and presenting different types of data. Hansen provides essential insights into the ideas and arguments underpinning different qualitative methods, and highlights the links between theory and practice. She also explains the importance of choosing the most appropriate form of data analysis. Each chapter features real life examples from experienced researchers from a wide range of health fields. These examples show how researchers have overcome common problems and offer inspiration and guidance. Applied qualitative research is increasingly being used to explore a range of issues in health, both on its own and as an adjunct to quantitative research. This book offers a clear, no-nonsense approach that will be invaluable to students and professionals in nursing, medicine, allied health and public health. 'I strongly recommend this book to all those looking to undertake ethical and rigorous qualitative research in the field of health and health care.' - Dr Jon Adams, Director, Qualitative Research Laboratory, Faculty of Health, University of Newcastle 'From thinking about theory to writing for publication, this text covers a massive amount of ground in a fresh and dynamic way. It will enthuse the beginner and refresh the old hand . . .' - Associate Professor Jane Gunn, Research Director, Department of General Practice, University of Melbourne
Nanoparticles in Polymer Systems for Biomedical Applications
The volume includes presentations of technological and research accomplishments along with novel approaches in nanomedicine and nanotechnology. It explores the different types of nanomedicinal drugs with their production and commercial significance. Other topics discussed are the use of natural and synthetic nanoparticles for the production of drugs, different types of nanoparticles systems, drug carriers, wound-healing antimicrobial activity, effects of natural materials in nanomedicine, and toxicity of nanoparticles. The valuable information presented in this volume will help to keep those in this field up to date on the key findings, observations, and fabrication of drugs related to nanomedicine and nanotechnology. With chapters written by prominent researchers from academia, industry, and government and private research laboratories across the world, the book will prove to be a rich resource.
Current Research in Pharmaceutical Technology
This title includes a number of Open Access chapters.Pharmaceutical technology deals with the discovery, production, processing, and safe and effective delivery of medications to patients. Technologies involved include computer modeling for research, bioengineering for research instrumentation, processes and methods for increasing production, and computing technology and biosystematics for the management and analysis of data. This new book covers a wide range of important topics on today's pharmaceutical technology, such as in vitro drug release and controlled drug delivery, the use of nanotechnology in pharmaceuticals, quantum dot imaging, assessment and efficacy of pharmaceuticals, and much more.
Evidence in Medicine P
High-quality evidence is the foundation for effective treatment in medicine. As the vast amount of published medical evidence continues to grow, concerns about the quality of many studies are increasing. Evidence in Medicine is a much-needed resource that addresses the 'medical misinformation mess' by assessing the flaws in the research environment. This authoritative text identifies and summarises the many factors that have produced the current problems in medical research, including bias in randomised controlled trials, questionable research practices, falsified data, manipulated findings, and more. This volume brings together the findings from meta-research studies and systematic reviews to explore the quality of clinical trials and other medical research, explaining the character and consequences of poor-quality medical evidence using clear language and a wealth of supporting references. The text suggests planning strategies to transform the research process and provides an extensive list of the actions that could be taken by researchers, regulators, and other key stakeholders to address defects in medical evidence. This timely volume: Enables readers to select reliable studies and recognise misleading research Highlights the main types of biased and wasted studies Discusses how incentives in the research environment influence the quality of evidence Identifies the problems researchers need to guard against in their work Describes the scale of poor-quality research and explores why the problems are widespread Includes a summary of key findings on poor-quality research and a listing of proposed initiatives to improve research evidence Contains extensive citations to references, reviews, commentaries, and landmark studies Evidence in Medicine is required reading for all researchers who create evidence, funders and publishers of medical research, students who conduct their own research studies, and healthcare practitioners wanting to deliver high-quality, evidence-based care.
Applications of Biophotonics and Nanobiomaterials in Biomedical Engineering
This book provides a link between different disciplines of nanophysics, biophotonics, nanobiomaterials & applications of nanobiophotonics in biomedical research and engineering. The fundamentals of light, matter, nanobiomaterials & nanophysics are discussed together, and relevant applications in biomedical engineering as well as other related factors influencing the interaction process are explicated. Theoretical and experimental research is combined, emphasizing the influence of crucial common factors on applications.
Theoretical Physics for Biological Systems
Quantum physics provides the concepts and their mathematical formalization that lend themselves to describe important properties of biological networks topology, such as vulnerability to external stress and their dynamic response to changing physiological conditions. A theory of networks enhanced with mathematical concepts and tools of quantum physics opens a new area of biological physics, the one of systems biological physics.
The Physiological Measurement Handbook
The Physiological Measurement Handbook presents an extensive range of topics that encompass the subject of measurement in all departments of medicine. The handbook describes the use of instruments and techniques for practical measurements required in medicine. It covers sensors, techniques, hardware, and software as well as information on processing systems, automatic data acquisition, reduction and analysis, and their incorporation for diagnosis.Suitable for both instrumentation designers and users, the handbook enables biomedical engineers, scientists, researchers, students, health care personnel, and those in the medical device industry to explore the different methods available for measuring a particular physiological variable. It helps readers select the most suitable method by comparing alternative methods and their advantages and disadvantages.In addition, the book provides equations for readers focused on discovering applications and solving diagnostic problems arising in medical fields not necessarily in their specialty. It also includes specialized information needed by readers who want to learn advanced applications of the subject, evaluative opinions, and possible areas for future study.
Advanced Radiation Protection Dosimetry
Although many radiation protection scientists and engineers use dose coefficients, few know the origin of those dose coefficients. This is the first book in over 40 years to address the topic of radiation protection dosimetry in intimate detail. Advanced Radiation Protection Dosimetry covers all methods used in radiation protection dosimetry, including advanced external and internal radiation dosimetry concepts and regulatory applications. This book is an ideal reference for both scientists and practitioners in radiation protection and students in graduate health physics and medical physics courses.Features: A much-needed book filling a gap in the market in a rapidly expanding areaContains the history, evolution, and the most up-to-date computational dosimetry modelsAuthored and edited by internationally recognized authorities and subject area specialistsInterrogates both the origins and methodologies of dose coefficient calculationIncorporates the latest international guidance for radiation dosimetry and protection
Microbial Biotechnology
The new volume takes an interdisciplinary look at current technical challenges and recent developmental trends in microbial biotechnology. It covers an avalanche of new information available through research by focusing on a broad spectrum of issues on different microorganisms and their recent applications and implications in agriculture, soil science and forestry, industry, and public health and medicine.Microbes present in our immediate environment have a direct or indirect influence leading to either a harmful or beneficial effect. Microbial Biotechnology: Technological Challenges and Developmental Trends is divided into four major sections that focus onPart I: Antimicrobial Agents: Role and Applications in Medicine and Health CarePart II: Role of Microorganisms in Agriculture and Plant BiotechnologyPart III: Microbial Enzymes and Their Potential Industrial ApplicationsPart IV: Microorganisms in Environment: Role and Industrial ApplicationsTopic include organic chemistry, biomass conversion, optimal production processes for different microbes, screening methods, and application of omics approaches such as (meta) genomics, proteomics, and metabolomics, or other biotechnology tools, to provide a deeper understanding of the microbial-based new and emerging products, trends, processes, and technologies. The chapters present unbiased original research results on microbes by incorporating case studies wherever appropriate. Providing research findings applicable to the development of new methodologies, applications, and technologies, the book will be a valuable resource for people working in various fields of microbiology.
Biodegradable Polymeric Nanocomposites
How Can Polymers Constructed From Living Organisms Help Eliminate the Disposal Issue? A unique category of materials called biodegradable polymers could help remedy a growing environmental concern. Biodegradable Polymeric Nanocomposites: Advances in Biomedical Applications considers the potential of biodegradable polymers for use in biomedical applications that include drug delivery, biosensors, and tissue engineering. Since biomaterials perform on a time-limited function and are designed to disappear from the body after use, the development of biopolymers could greatly reduce and eliminate the need for plastic products, most specifically those used in biomedical applications.Highlights Biomaterials and the Design and Application of BiomaterialsUtilizing expert research contributors from around the world, this book considers the benefits and limitations of a variety of biomaterials, such as biopolymers, ceramics, biodegradable nanocomposites, and natural products-based biomaterials. It explores the bio-nano-interface; the interaction between nanoparticles and biomaterials, explains the basic concepts and methods of biodegradable nanocomposites (BNCs), and highlights recent developments in polymer-based bionanocomposites. The book provides an overview of degradation properties and the mechanical properties of biodegradable polymers. It also breaks down the mechanical properties and biocompatibility of starch-based polymers, and outlines distinct advantages (biodegradability and nontoxicity) that make them suitable as medical polymer materials. In addition, it highlights the FDA-approved biodegradable polyester family and focuses on the state-of-the-art recent advancements in drug-delivery devices. Biodegradable Polymeric Nanocomposites: Advances in Biomedical Applications provides current knowledge on biopolymers, examines recent developments and trends, and considers future applications of polymers. Featuring the work of highly-qualified international researchers, this book addresses applications relevant to polymer and material science, as well as material, biomedical, and chemical engineering, and is of specific interest to polymer science engineers.
The Furtherance of Medical Research
The Director for the Medical Sciences at the Rockefeller Foundation tells in this book what medical research is, what the universities and foundations have done and should do about it, and of the kind of man who works at the frontiers of the unknown in order to push back the curtains of darkness at least a little in the endless search for truth. Dr. Gregg candidly discusses some of the shortcomings of the foundations and their methods, the obstacles to their and the universities' doing their job properly, the booby traps and temptations that like in their way. But here at firsthand is an account of the men of good will, with none of the sanctimoniousness that has often characterized philanthropic endeavors, of men who critically, earnestly, doggedly, and intelligently have labored in the heat of the day and from whose minds will come the advances of the future. "This short book is addressed to the entire medical profession, to the medical student, to the student who contemplates entering medicine, and to many in the allied and basic sciences. It should be read by any who evince or profess an interest in medical research."--Journal of the American Medical Association
Handbook of Medical Device Design
First published in 2001: This handbook has been written to give those professionals working in the development and use of medical devices practical knowledge about biomedical technology, regulations, and their relationship to quality health care.
BionanotechnologyConcepts and Applications
Connecting theory with real-life applications, this is the first ever textbook to equip students with a comprehensive knowledge of all the key concepts in bionanotechnology. By bridging the interdisciplinary gap from which bionanotechnology emerged, it provides a systematic introduction to the subject, accessible to students from a wide variety of backgrounds. Topics range from nanomaterial preparation, properties and biofunctionalisation, and analytical methods used in bionanotechnology, to bioinspired and DNA nanotechnology, and applications in biosensing, medicine and tissue engineering. Throughout the book, features such as 'Back to basics' and 'Research report' boxes enable students to build a strong theoretical knowledge and to link this to practical applications and up-to-date research. With over 200 detailed, full-colour illustrations and more than 100 end-of-chapter problems, this is an essential guide to bionanotechnology for any student studying this exciting, fast-developing and interdisciplinary field.
Optical Techniques in Regenerative Medicine
In regenerative medicine, tissue engineers largely rely on destructive and time-consuming techniques that do not allow in situ and spatial monitoring of tissue growth. Furthermore, once the therapy is implanted in the patient, clinicians are often unable to monitor what is happening in the body. To tackle these barriers, optical techniques have been developed to image and characterize many tissue properties, fabricate tissue engineering scaffolds, and characterize the properties of the scaffolds.Optical Techniques in Regenerative Medicine illustrates how to use optical imaging techniques and instrumentation for the fabrication, assessment, and longitudinal monitoring of regenerative medicine therapies. The book covers optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, bioluminescence, second harmonic generation microscopy, multi-photon microscopy, coherent anti-Stokes Raman scattering, fluorescence spectroscopy, and light scattering spectroscopy. Each chapter provides an overview of a particular technique, its advantages and limitations in terms of structural and functional information, and examples of applications in regenerative medicine. The future evolution of regenerative medicine from academic research to viable clinical alternatives to conventional treatments is dependent on the development of non-destructive analytical techniques that can elucidate the stages of tissue development both in vitro and in vivo as well as track the fate of cells following injection. This practical book demonstrates the vital role of optical techniques in the dynamic field of regenerative medicine. It guides regenerative medicine researchers toward finding the most appropriate technique for their applications and helps biophotonics researchers see where their technologies can be applied.
Omics Technologies and Crop Improvement
Increased world population, decreased water supply, and climate change all put stresses on the global food supply. An exploration of the challenges and possible solutions to improve yields of the main crops, such as cereals, roots, tubers, and grasses, Omics Technologies and Crop Improvement reviews data on food sciences and omics. The book covers modern omic technologies such as nutrigenomics and metagenomics. It provides a detailed examination of how omics can help crop science and horticulture and introduces the benefits of using these technologies to increase crop yields and other features such as resistance and nutritional values.The book highlights crop improvements such as increased yield, drought resistance, disease resistance, and value-added performance through a non-transgenic format. It explores how the different omics technologies, especially the most recent ones (proteomics, metabolomics, nutrigenomics, ionomics, and metagenomics) would be used to improve the quantitative and qualitative features of crop plants. Topics covered include: Advances in omics for improved fresh cropsTranscriptome analyses on the drought response using drought tolerant near isogenic linesMetabolite profiling that reveals different effects of nitrogen amendments on vegetablesOmics technology application to forage crops improvementSecondary metabolites and plant tissue cultureRNAi technology and crop improvementGene expression analysis methods with NGS dataWeb database resources and crops improvementGene Expression Networks (GEN) in cropsSpecific crop improvement (papaya, wheat, coffee, potato, and more)With contributions from pioneering researchers from twelve countries, the book presents a broad view of how omics would help crop science and horticulture meet the challenges of a shrinking global food
Our Animal Connection
This book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on the planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. The authors discuss the strengths and weaknesses of Homo sapiens, and how the study of animals can make us stronger and healthier. To deepen our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve human performance, we can study the animal kingdom's top performers and learn from their successes. Considering these important pointers, the authors review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance. Finally, they discuss the challenges associated with our animal connection: the history of pandemics caused by bacterial and viral pathogens demonstrates that there is a risk for transmission of diseases that can disrupt human societies. The recent COVID-19 outbreak is covered in detail as an example.
The Regeneration Promise
The Regeneration Promise is a reader-friendly guide to the world of regenerative medicine and stem cell technology. It covers the history of stem cell technology as a general introduction to the subject and then continues with a description of the many known types of stem cells and how these can potentially be used to treat disease. The author explains the pros and cons of using stem cell technology to treat patients in simple and factual terms throughout the book while clarifying many stem cell myths. There is valuable advice for people considering undergoing stem cell therapy and also for those who are considering stem cell storage such as umbilical cord blood storage at the birth of a baby. The book also covers information on current research in stem cell technology and how this may be useful in the clinic, as promising regenerative medicine treatments emerge in the near future. The simple use of language with a clear explanation of scientific terms, where applicable, makes this book an accessible source of information for anyone interested in enhancing their general knowledge about regenerative medicine when considering such treatment options and understanding the debate surrounding stem cell technology and its use in disease therapy.
Biotechnology in China
In her quest for global leadership in science and technology, the People's Republic of China has attained top ranks in the number of scientific publications, "hot papers," or national and international patent applications. However, analysis of the underlying structures and mechanisms is hindered by the sheer flood of data, stringent government control of all media, and ambiguities inherent in translation from Chinese. This book overcomes these difficulties and provides a concise picture of biotechnology-related research and development in China. It begins with brief accounts of China's geography, people, political and administrational structure, economy, finance, infrastructure related to science and technology, and educational system. It presents succinct accounts on structures and developments in biomedicine, diagnostics, agriculture, fermented food, bioindustry, and environmental biotechnology, with reference to government, industry, and academia. Finally, it predicts the next steps in Chinese biotechnology for the national agenda and, in view of China's ambitious global development strategy, the Belt and Road Initiative.
Is Life Too Long?
Is Life Too Long? Essays about Life, Death, and other Trivial Matters is a collection of 18 selected essays and medical tales that were first published in The Mining Journal and in The Mining Gazette, the two leading newspapers of the Upper Peninsula of Michigan. Dr. Shahar Madjar tells the stories of doctors and their patients with empathy, philosophical flavor, and humor.Shahar Madjar, MD, MBA, is an Israeli-born urologist practicing in the remote, cold Upper Peninsula of Michigan (population 300,000). His medical training took him to different parts of the world: Tel Aviv, Israel; London, England; Miami, Florida; Cleveland, Ohio; Jackson, Mississippi; and Stony Brook, New York. Dr. Madjar is a former fellow at the University of Miami, Clinical Associate at the Cleveland Clinic, and Assistant Professor of Clinical Urology at the State University of New York, Stony Brook. He has published more than 50 articles in the medical literature and has presented his research internationally. For the past several years, Dr. Madjar has been writing a popular medical column for The Mining Journal, and for The Mining Gazette, the two leading daily newspaper of the Upper Peninsula of Michigan. He lives with his wife and three sons in Marquette, Michigan.
The Hcq Debate!
There is too much confusion about one pandemic drug, hydroxychloroquine. so much the US Government officials don't know what to tell you. Here are the facts with vivid descriptions of clinical trials and what researchers intentionally left out before speaking to the media. This is a review of over 25 important hydroxychloroquine clinical trials addressing the pandemic from around the world. Shocking truths that will get you thinking right again. What research was the EUA for hydroxychloroquine based on? What clinical trials were used by the NIH to formulate a non-treatment plan?
The Enlightened Guide To Methadone Maintenance Treatment
The dawn of a new era is upon us, and that is the era of medication assisted treatment (MAT) for opioid addiction as a first-line treatment. Ever since the first methadone clinics opened in the early 1970s in the U.S., nothing in medicine has been the subject of more stigma, controversy, misinformation, and downright mythology than methadone maintenance treatment (MMT.) The stigma against MMT is staggering and well-known, and it is the primary intent of this text to eliminate all of the false myths and fears surrounding MMT by providing accurate, if not always politically correct information in an easy to understand format.Do you, a loved one, friend, or family member suffer from severe opioid addiction? Tired of using the revolving door of abstinence-only-based treatment, only to constantly feel like a failure in spite of the fact that you want desperately to get better? Are you interested in the most researched, evidence-based, and most importantly, effective treatment modality for opioid addiction, one which has been considered the "Gold Standard" amongst addiction specialists for 50 years?If you are reading this, chances are that what you will discover between the covers of this book will astonish, shock, and possibly even anger you. Considering that abstinence-based treatment has been widely known to be ineffective for serious opioid addiction for at least a century, you may even have some questions of your own as to why such an effective treatment for opioid addiction has been hidden for so long from public-view, until now.This book has been designed to answer almost any serious question about Methadone Maintenance Treatment, and it does so in a manner which is groundbreaking: No more "conventional wisdom" or politically-correct B.S., this text cuts to the chase and, for the first time in publishing, tells the naked, unvarnished Truth about this vastly under-utilized, life-saving, indeed, life-changing treatment modality. Once you've read it, you'll never see methadone in the same tired and slanderous light ever again. Rigorously researched and cross-referenced over a period of five years, this book is the only serious text on the subject written for everyone from patients to treatment providers.
