Diagnosis and Treatment algorithm for patients with Chronic Heart failure
Practical Control of Mosquito Disease Vectors
Disease vector control is rapidly changing, both because of the emergence of resistance to conventional methods and the development of new and potentially game-changing techniques. This book reviews several current and future measures for controlling mosquito vectors of disease, with an emphasis on malaria vectors.Beginning with an introduction to the topic of mosquito ecology and sampling methods, the book then covers several vector-borne disease control methods. The emphasis in many of these methods is for the sufferers of the diseases to take charge of their monitoring and control. Tackling the problems facing mosquito control, the authors review the important issues of education, economic considerations and climate change before concluding with a consideration of the politics and practicalities of method choice and implementation. This book is a thought-provoking concise and practical resource for anyone interested in primary healthcare and tackling or studying mosquito disease vectors.
Frequency of occurrence and risk factors for the development of Chronic Kidney disease in women of fertile age
Kiss Your Dentist Goodbye, Second Edition
You can brush, floss, be mindful of your diet and follow all the traditional oral hygiene advice, yet still find yourself needing fillings and ongoing dental cleanings. Dr. Ellie Phillips challenges this conventional dental instruction to "brush and floss," arguing it can be both ineffective and potentially harmful. In her groundbreaking book, Kiss Your Dentist Goodbye, she unveils the secrets to achieving and maintaining a truly healthy mouth. In this book, Dr. Phillips explains the importance of bacterial balance for oral health, highlighting how it will never be attained through excessive flossing, aggressive cleanings, or the indiscriminate killing of mouth bacteria. She exposes the detrimental effects of certain dental procedures and products, including tooth whitening, bleaching, dental sealants, and certain fluorides. By adopting her practical do-it-yourself daily routine, you can effortlessly reduce plaque buildup, strengthen your teeth, heal and even reverse small cavities, cure periodontal disease, and eliminate tooth sensitivity.The book is divided into two parts. Part 1 examines the underlying causes of cavities and gum disease-as well as how teeth and gums can naturally heal themselves. It provides a clear picture of why we must rethink our fundamental beliefs about oral care if we want to avoid dental problems and sidestep all the chronic health conditions that are so closely associated with poor oral health. Part 2 provides details of a complete program that has the power to stop, prevent, and even reverse dental problems.Isn't it time to bid farewell to cavities, gum disease, and the general health dangers from poor oral health? With Kiss Your Dentist Goodbye as your guide, you will be empowered to take rapid action and dramatically enhance the look, feel, and health of your teeth-at any stage of life, and with the confidence that it is never too late to begin.
Dixon and Stein's Encounters with Children
Building on the legacy of Drs. Suzanne D. Dixon and Martin T. Stein, Dixon and Stein's Encounters with Children, Fifth Edition, offers a unique, how-to approach to understanding the developmental stages of childhood, providing practical strategies for today's clinicians who interact with children and families. Unlike pathology-focused pediatrics texts, this compact volume examines typical child development and offers expert guidance on childhood stages, developmental challenges, family wellbeing, and social determinants of health. From the neonatal visit and newborn exam through the late adolescent years, this highly regarded reference provides thorough, evidence-based guidance with an emphasis on relationships as central to a child's wellbeing. Content is aligned with the well-child visit schedule, making it highly relevant to new and experienced clinicians alike. Now under the expert guidance of new editors, Drs. Jenny Radesky and Caroline Kistin, this edition: Brings the child's perspective into focus through the use of numerous children's drawings and quotesContains a new chapter on the juvenile justice system and school-to-prison pipeline, as well as updates to topics and language that are inclusive of BIPOC families, LGBT families, those experiencing poverty and related material insecurities, children experiencing foster care, and community partnerships to help families under stressDraws upon the knowledge and experience of experts in the field and includes new guidance on addressing social determinants of health, promoting parent-child attachment, promoting equitable school readiness, and supporting families through traumatic experiencesProvides Observational, Interview, and Examination points for each age, and presents a "Heads Up" section in each chapter, alerting clinicians to certain behaviors that may be presentDiscusses key topics such as childhood depression, digital and social media, educational opportunity, community violence, bullying, learning disabilities, and much moreIncludes data gathering sections at the end of each chapter that demonstrate how to apply information in clinical settings by using age-appropriate interview techniques and activitiesAn eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Multiple Sclerosis for Dummies
Everyone's MS is different--learn the best way to manage yours Multiple sclerosis (MS) is a chronic, unpredictable autoimmune disease that affects millions of people worldwide. It poses unique challenges for people with MS and their care partners because the symptoms (many of which are invisible to others) are so variable from day to day and month to month. Multiple Sclerosis For Dummies helps you and your loved ones understand the importance of early treatment and become familiar with all of the latest treatment options and therapies. You aren't alone--this compassionate guide includes resources for connecting with the right MS care provider, building a care team, managing your emotions and stress, and getting the support you need. Plus, you'll get tips for making lifestyle choices that help you along your MS path. Discover information on the latest diagnostic information, treatments, and symptom management strategies Learn why it's so important to take care of your mental health and emotional wellbeing as you treat your MS Get pointers for talking to MS care providers and your loved ones, advocating for yourself, and making decisions alongside your care team Find trustworthy books, websites, and community resources to expand your knowledge and improve your health Multiple Sclerosis For Dummies is a great starting point for anyone facing a new MS diagnosis or looking for updated information. Partners and family members will also learn how to care for themselves while caring for the person they love.
Interdisciplinary Pediatric Palliative Care
Palliative care is one of the main rights of children with life-limiting diseases and their families. Despite this importance, many of these children and their families around the world are deprived of this service and do not receive these services. Among the reasons for not providing palliative care in many countries of the world according to literatures, we can mention the lack of knowledge of the health care team about the principles of palliative care and the lack of necessary infrastructure. This book will be written with the aim of improving the knowledge and empowerment of the treatment team in the field of the basics of supportive and palliative care for children, and by increasing their knowledge, it can help in providing these services.
Global One Health and Infectious Diseases
While many terms relate to One Health, the idea remains the same: to think outside a chosen area of specialty and work collaboratively as part of a team to improve health status around the world. This involves the collective effort of physicians, veterinarians, public health practitioners, ecologists, anthropologists, social workers, economists, and many others. Collectively, these are the Global One Health practitioners.Through the lens of infectious disease, this book brings together the diverse range of topics necessary to be an effective global health practitioner at the intersection of human and animal health, particularly in developing countries. It explores what an aspiring or mid-career practitioner should be aware of when working with infectious diseases, including technical skills, cultural competency, capacity building, big data, and understanding the landscape and history of global health. Each chapter focuses on a specific area of necessary knowledge with background information, case examples, and resources to use moving forward.An important reference for upper-level undergraduate students, graduate students, and early practitioners in human, animal, and public health, this text highlights the competencies rather than focusing on the problems in Global One Health. It provides a blueprint of areas that the reader should pay attention to, particularly in the realm of infectious diseases.Chapter 13 of this book is freely available as a downloadable Open Access PDF at at https: //www.taylorfrancis.com/books/9781032140674 under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
Current Practice Guidelines in Primary Care 2025-2026
The authoritative guidelines primary care clinicians need to diagnose and treat the most common outpatient conditions--compiled, distilled, and updated for easy referencing Striking the perfect balance between brevity and clinical necessity, this annual resource presents all the latest evidence-based guidelines clinicians need to treat the most common outpatient conditions. The most thorough print compendium of guidelines for primary care practice, the book features content drawn from government agencies, expert panels, medical specialty organizations, and other professional and scientific authorities.CURRENT Practice Guidelines in Primary Care 2025-2026 converts lengthy and cumbersome text into a practical, relevant collection of available options for busy clinicians. Each topic is carefully selected for relevance to the office practice of ambulatory medicine and the text is presented in a convenient, easy-to-navigate outline and tabular format. The system-based organization makes information retrieval fast, easy, and logical.- Content is drawn from a wide array of recommendations from government agencies, expert panels, medical specialty organizations, and other professional and scientific authorities- NEW: Updates reflecting the review of more than 150 guidelines- Guideline Discordance Tables highlight when major guidelines do not mirror each other- Topics are carefully selected for relevance to the office practice of ambulatory medicine, and the text is enhanced by a convenient outline and tabular format- Screening and prevention of conditions have been combined to enhance clinician use
Commonsense Childrearing
Can we raise healthy children in a toxic world?Yes, we can!Modern life, with its conveniences and technologies, has had mixed results. With great gains come also losses. For better or for worse, as certain types of knowledge have increased, others, which were not perhaps knowledge in the modern sense, but rather types of wisdom, which were once innate, have grown faint.Just as the wisdom of traditional diets faded and gave way to a haphazard, increasingly toxic, industrialized, "modern" diet--the hazardous results of which many are now waking up to--so, too, did older, likely innate wisdom for guiding a growing human being from birth through childhood and adolescence into adulthood all but vanish, with predictable results.It falls to those who are willing to step outside the box of today's widely unquestioned orthodoxies to honestly assess where we've come from, where we are, and how to go forward in ways that not only restore sanity (though that's a necessary first step), but also reclaim something of the wisdom of being human, but in new ways.While it's true that we can't go back to how things once were, wisdom is also possible going forward. A living, contemporary, and conscious approach to raising children, born of both commonsense and love, is both achievable and necessary. This is the path that Dr. Cowan outlines in this book.With friendly humor and out of his keen observation of children through the years, as a physician, a parent, grandparent, and friend, Dr. Cowan offers hope and guidance for the parents of today's youngest generation, that they may raise up a cohort of free, healthy, happy, caring human beings.While rearing children in the twenty-first century entails facing certain challenges that were either unknown or insignificant even a generation ago, Dr. Cowan demonstrates that the door is wide open to meet these challenges with new thinking and a renewed commitment to the sacredness of the growing human being.
The Care of Children
This book was originally published in 1894, and remains a valuable resource for any person responsible for the care of children in any era. The book stresses the importance of a child's strong emotional and physical well-being and provides practical advice on achieving the critical balance between the two. Topics covered include hygiene, nutrition, sleep, exercise, praise and discipline, development of self-esteem, and education.Elizabeth Robinson Scovil (1849-1934) was a prominent nurse and writer. She is considered one of the early American advocates for the rights of nurses, mothers and children - and for a fair acknowledgement of the critical role each plays in the honorable duty of caring for children.Ms. Scovil's most influential books are The Care of Children and Preparation for Motherhood. Her writings "so changed women's lives that when she traveled by train in British Columbia to attend a meeting of the National Council of Women, groups of women gathered at station platforms, calling her name so they could thank her for the gift of knowledge." (Scovil Obituary, Meadowlands: A Chronical of the Scovil Family).This book was edited by Jonathan D. Savage, Esq. and Mikesch Muecke, Ph.D.
Current Diagnosis and Treatment Surgery, 16th Edition
The evidence-based, point-of-care information you need to master the full scope of diseases and disorders most often treated by surgeons Organized by organ system, Current Diagnosis and Treatment: Surgery begins with the relationship between surgeons and their patients, training and professionalism, preoperative care, postoperative care, and surgical complications. Subsequent chapters cover wound healing, inflammation, infection, antibiotics, fluid and electrolyte management, and surgical metabolism and nutrition. In addition to sections covering everything from head and neck tumors to hand surgery, this comprehensive resource offers expert coverage of pediatric surgery, oncology, weight management, organ transplantation, and more. Featuring 600+ photographs and illustrations, hundreds of chapter-ending multiple-choice review questions, and the latest the latest research and discoveries, Current Diagnosis and Treatment: Surgery is designed to help you find all the answers you need quickly and easily.
Causal Inference and the People's Health
An essential introduction to concepts of causation and causal inference that explores how our definitions of causes in epidemiology influence how we go about finding them and estimating their effects. A key goal of epidemiologic research is to uncover the causes of diseases and other health-related outcomes. But exactly what we mean by a "cause" and what types of phenomena qualify as causes, differ across historical periods, and is a contentious topic. The causal status of social phenomena has been, and continues to be, particularly precarious. In Causal Inference and the People's Health, Sharon Schwartz and Seth J. Prins offer both a synthesis of the dominant school of thought around causality and propose an approach that keeps causal concepts as an organizing principle without marginalizing social phenomena. The authors examine the implications of the "Causal Revolution,"--introduced in epidemiology as the Potential Outcomes framework--which initiated a paradigm shift across the social sciences. As the authors show, this shift influences the questions we ask, the methods we use, the narratives we construct about our study results, and thus the knowledge we use to fight for the people's health. The guiding principle of the Causal Revolution is simple but profound: researchers should specify if their goal is description, prediction, or causation. In other words, researchers should declare their causal goals even for observational studies. This principle not only produced important innovations, but it also reignited debates about the definition of causation, the causal status of important social constructs like class and gender, and the role of manipulation or intervention in causal inference. Interrogating these debates and embracing causal questions that identify and explain etiologic processes, Causal Inference and the People's Health offers a path forward that expands causal inference to include social forces as causes of the people's health, and therefore reinvigorates epidemiology's historical role in targeting systems and structures for change.
Greater Mekong Subregion Health Cooperation Strategy 2024-2030
Detailing the Greater Mekong Subregion (GMS) Health Cooperation Strategy 2024-2030, this publication aims to help strengthen health systems toward universal coverage and to promote greater regional health security. Noting significant health improvements in the past two decades, the publication explains how the strategy is designed to guide programming, foster innovation, and strengthen financing for the next seven years. It underscores how gender, climate change, and digital health cut across all core themes, and shows how the strategy can help countries tackle regional issues and reduce health inequalities to make the GMS healthier and more sustainable.
Concise Handbook of Epidemiology (Second Edition)
Concise Handbook of Epidemiology is an essential resource introducing readers to core principles, models, and research methods of modern epidemiology. This comprehensive guide covers foundational concepts like health and disease, disease occurrence, epidemiological models, and study designs. It also talks about disease surveillance, outbreak investigations, statistical methods, and advanced epidemiological techniques, including the impact of genomics and community-based epidemiology. Each chapter incorporates real-world case studies, offering readers practical insights and applications. Ethical considerations, innovative methods, and future directions in the field ensure readers are equipped with foundational knowledge and forward-looking perspectives. Key Features: - Foundational Overview: Covers health, disease occurrence, and key epidemiological frameworks.- Practical Tools: Offers research designs, statistical methods, and real-world case studies.- Advanced Topics: Explores genomics, statistical advances, and challenges in modern epidemiology.- Future Focus: Discusses ethics and evolving innovations shaping epidemiological practices.
Concussion. Brain on Pause. How to Hit Play.
Fast-track your Concussion recovery (a.k.a. mild Traumatic Brain Injury / mTBI) and Post Concussion Syndrome healing (a.k.a. PCS / PPCS), using the most up-to-date Neuroplasticity principles, the latest concussion treatments, and the safest return to activity protocols. With this book in hand, you'll be able to overcome the commonest symptoms of a concussion, including: Conquer your concussion and headaches. Relieve your concussion-related neck pain.Eliminate your eye pain and restore better vision.Overcome your dizziness and balance problems.Shut down your light and sound sensitivity.Awake feeling more energized and ready to go.A complete guide to concussion self-care with step-by-step instructions, illustrations, and exercises + video links. An easy read, with engaging motivational stories, delivered in straightforward language, and an injured-brain-friendly font. All wrapped up with a little humour to help the medicine go down. To feel like YOU again, you need this concussion book!This concussion book will teach you how hard & fast to push yourself at each stage of healing. You will also learn where your concussion symptoms come from, how long your concussion will likely last, and how do YOU treat a concussion. Importantly, you will find out in what situations you should NOT GO IT ALONE, and whom to consult.Once you are feeling improved, the book will guide you with the most up-to-date return to learn concussion protocols and concussion return to play protocols. Finally, you will learn how best to return to work after concussion and how to continue working with a concussion.As a bonus, all net royalties from this book will be donated to concussion research and / or prevention. By buying this book in order to help yourself, you will be helping others too.
The Badge of Distinction Volume 2
Volume 2 of a 2-volume set, The Badge of Distinction refers to the way we all hope to be judged by our patients and colleagues who observe our work over the years.Volume 1 presents a manuscript about everyday dental problems and solutions, with valuable contributions from some world-leading clinicians and researchers.Volume 2 is a description of the new directions in which our dental profession is moving. The days of drill, fill, and bill are numbered, and our profession is now recognized, at last, as playing a vital role in systemic health.The book deals with pain with a broad perspective, non-odontogenic oral pain, headaches, orofacial pain, temporomandibular disorders, myofascial pain and dysfunction, practical splint and orthotic design and use, ankyloglossia and tethered tissue diagnosis and management, myofunctional therapy, airway assessment, management and referral, sleep-disordered breathing, obstructive sleep apnoea, and the creation of a network of allied health professionals.We are the sentinels of the airway.This is my legacy to the dental profession and allied health professionals after over 50 years of practice. I hope it is of use to all levels of professional experience, and it represents my view that professional knowledge and experience needs to spread to the world for the benefit of all, and not taken to the grave.
The Badge of Distinction Volume 2
Volume 2 of a 2-volume set, The Badge of Distinction refers to the way we all hope to be judged by our patients and colleagues who observe our work over the years.Volume 1 presents a manuscript about everyday dental problems and solutions, with valuable contributions from some world-leading clinicians and researchers.Volume 2 is a description of the new directions in which our dental profession is moving. The days of drill, fill, and bill are numbered, and our profession is now recognized, at last, as playing a vital role in systemic health.The book deals with pain with a broad perspective, non-odontogenic oral pain, headaches, orofacial pain, temporomandibular disorders, myofascial pain and dysfunction, practical splint and orthotic design and use, ankyloglossia and tethered tissue diagnosis and management, myofunctional therapy, airway assessment, management and referral, sleep-disordered breathing, obstructive sleep apnoea, and the creation of a network of allied health professionals.We are the sentinels of the airway.This is my legacy to the dental profession and allied health professionals after over 50 years of practice. I hope it is of use to all levels of professional experience, and it represents my view that professional knowledge and experience needs to spread to the world for the benefit of all, and not taken to the grave.
Contemporary Islamic Perspectives in Public Health
Across the world, there are over two billion people practicing the religion of Islam. There is increasing evidence of the value and influence of cultural competency and transcultural health for medical professionals working with these communities. Here, the authors have developed and organized a nuanced approach to cultural competence, simultaneously promoting diversity and insight into the influence and value of Islamic beliefs and practices on positive health. Endorsing culturally competent information, behaviors, and interventions, topics covered include immunization, hygiene, fasting and dietary restrictions, and sexual and reproductive health. This is a definitive resource for public health practitioners operating within Muslim communities and countries as well as for academic courses at undergraduate and postgraduate levels in public health and health promotion, medicine, social work, and social policy and for continual professional development.
The Brain Revival Plan
In The Brain Revival Plan, Nicole Yeates shares a powerful guide to reclaiming and optimising your brain's health. Whether you've experienced a traumatic brain injury, cognitive decline, mental health issues, identify as neurodivergent or are simply looking to enhance your mental performance, this book offers a step-by-step approach to transforming your brain.Nicole's personal journey from a devastating prognosis of expected death or life in a vegetative state to thriving with purpose and potential forms the heart of this guide. Drawing from neuroscience, neuroplasticity, real-life examples of individuals who have exceeded their own expectations, and her own experiences, she equips readers with practical strategies to nurture and revive their minds, no matter where they are in life.If you're ready to enhance your cognitive abilities, improve your mood and focus, and unlock a future full of possibilities, The Brain Revival Plan is the roadmap you've been searching for.
Meditation for Pain Relief
Discover a Revolutionary Path to Pain ReliefAre you tired of living with chronic pain that seems to control your life? In Meditation for Pain Relief: A Holistic Approach to Managing Discomfort, celebrated wellness advocate Aria Blake invites you to explore the transformative power of meditation as a practical, science-backed tool for alleviating pain and reclaiming balance.This groundbreaking guide delves deep into: The science of pain and how meditation rewires your brain for resilience.Proven mind-body practices like mindfulness, breathwork, and body scan to reduce discomfort.Integrating meditation with conventional treatments for a comprehensive approach to healing.Step-by-step guidance for creating a personalized routine that works for your unique needs.Blending ancient wisdom with modern neuroscience, this book offers actionable techniques and compassionate insights for managing physical and emotional pain. Whether you're navigating chronic conditions or seeking to reduce stress and discomfort, this book empowers you to take control and live with greater ease, strength, and clarity.It's time to transform your relationship with pain-one mindful breath at a time.
SARS-CoV-2
FROM RESPECTED INVESTIGATIVE AUTHOR GREG FELTON comes a book so shocking, so earth-shaking that it is sure to be suppressed and censored by Amazon, Google, Facebook-and the U.S. government!SARS-CoV-2: Contagion, Collusion, Corruption uncovers the collusion among scientists, governments, and media to keep the world ignorant of the real origin of SARS-CoV-2 to the detriment of public health.From early attempts by Beijing to fabricate cover stories, to the inability of the WHO to act in the public interest, to genetic analysis of SARS-CoV-2, Felton separates fact from fiction, science from hysteria, to expose the mismanagement, incompetence, cover-ups, and dishonesty that obscure who is responsible for the deaths of hundreds of thousands of people.Through meticulous investigation, dedicated reporting, and exclusive sourcing of primary documents, SARS-CoV-2 unearths a more complex understanding of the rise, spread, and consequences of the first year of the pandemic than has yet been seen. The tragedy of SARS-CoV-2 is that it could have been prevented because it is merely a symptom of the toxic practice of genetically manipulating viruses, ostensibly to develop vaccines.Meticulously researched, Felton demonstrates with cold, hard facts the following: Scientists caught faking genomic data to make SARS-CoV-2 look like as if it had a natural origin.Gain of Function (GoF) experiments in Wuhan beginning soon after President Barack Obama issued a moratorium on U.S. based experiments for safety reasons.Continuing funding for China-based GoF experiments violates the spirit-if not the law-of the moratoriumSARS-CoV-2 showing signs of genetic manipulation and certain nucleotide sequences that are statistically implausible in nature.Prestigious journals like Nature perpetuating the false "natural origin theory."Rampant collusion between researchers and journalists to promote the natural origin theory has been documented.EcoHealth Alliance, a New York-based non-profit, leading the effort to sabotage the lab-origin theory.U.S. and Chinese high-security labs having a long history of accidental viral release and/or biosafety lapses.Strong evidence from multiple sources are cited that HIV was spliced into SARS-CoV virus to create SARS-CoV-2.GoF research violating U.S. law against creating biological weapons.
Vector Borne Diseases
This book provides a comprehensive exploration of vector-borne diseases, highlighting current trends, control strategies, and their public health implications. With contributions from experts, it informs readers about specific diseases caused by vectors such as mosquitoes and other zoonotic agents, presenting innovative approaches for prevention and management. The book begins with a focus on mosquito control strategies, emphasizing their significance in reducing the burden of vector-borne diseases. It further unravels the impact of Rickettsial infections, providing insights into these often-underdiagnosed diseases. Scrub typhus is explored through its co-infections with other vector-borne zoonotic diseases and analyzed using an integrated omics approach to better understand its pathogenesis and treatment. The final chapter sheds light on lymphatic filariasis, a neglected tropical disease, covering its endemic nature, clinical manifestations like elephantiasis and hydrocele, mass drug administration programs, and novel vector management techniques. This resource is ideal for public health professionals, researchers, and students, providing actionable insights into combating vector-borne diseases globally. Key Features: -Discusses innovative mosquito control strategies and integrated vector management.-Explores lesser-known diseases like scrub typhus and Rickettsial infections with advanced omics approaches.-Provides a detailed analysis of lymphatic filariasis, including treatment strategies like antifilarial drugs and mass drug administration.-Highlights the importance of public health interventions in combating neglected tropical diseases.
From SARS-CoV to MARS-CoV
Genetic Diversity of Coronaviruses (Volume 1) provides a comprehensive analysis of the genetic mutations and host interactions across three major coronaviruses-SARS-CoV, MERS-CoV, and SARS-CoV-2. This volume explores the evolutionary history, mutations, and emerging variants of these viruses, with a focus on understanding how they adapt to different hosts. The book is organized into three parts: Part I covers SARS-CoV, detailing its genetic mutations, host genetic diversity, and new variants. Part II focuses on MERS-CoV, offering insights into mutations and host adaptations. Part III addresses SARS-CoV-2, discussing its evolving variants and the role of host proteins. The book also discusses the connections between coronaviruses and neurological, epigenetic, and AI-related issues. Key Features: - In-depth analysis of genetic mutations in coronaviruses.- Exploration of host genetic diversity and virus adaptation.- Insight into emerging variants of SARS-CoV, MERS-CoV, and SARS-CoV-2.- Examination of host proteins' role in viral infections.- Discussion on the impact of AI and epigenetics on coronavirus research.
Huntington
Huntington's disease is a rare inherited, progressive, incurable, and fatal neurodegenerative disorder of the central nervous system. It affects muscle function and further leads to cognitive decline and dementia. It can present at any time in people during their life span. Symptoms may vary from person to person and usually appear in people who are in their 30s or 40s, but also earlier in life and even in children younger than 10. Most symptoms can be classified under motor, behavioral, or cognitive categories. The disease is caused by a defective gene characterized by an excessive number of trinucleotide (Cystosine-Adenine-Guanine) repeats - a part of the DNA code. The gene produces a protein of unknown function named Huntingtin, which is involved in the functioning of the nerve cells in the brain (neurons). When defective, the gene produces an abnormal (or mutated) Huntingtin protein that is toxic and causes selective loss of neurons. The pathogenesis of the disease remains, however, largely unclear so that the exact cause of neuronal death is unknown. Since each patient may have a unique combination of symptoms, there is no standardized treatment so that medication is prescribed on a case-by-case basis. Pharmacotherapy includes chorea medication, antipsychotics, antidepressants, mood-stabilizing medication as well as non-drug therapies. Side effects from medications can also affect each patient differently. Notwithstanding such approved therapies for specific disease symptoms, there is currently no cure and there are no approved drugs that delay the onset or slow disease progression. Fortunately, there are also many new therapeutics currently undergoing clinical trials that target the disease at its origin by lowering the levels of the mutant Huntingtin protein. In this book, I discuss the disease at length in its multiple facets and address the issue of its prevention and prognosis. I also consider what can be done about it and list the several available support and research organizations. Lastly, I review the current research and latest research developments in this subject.
Huntington
Huntington's disease is a rare inherited, progressive, incurable, and fatal neurodegenerative disorder of the central nervous system. It affects muscle function and further leads to cognitive decline and dementia. It can present at any time in people during their life span. Symptoms may vary from person to person and usually appear in people who are in their 30s or 40s, but also earlier in life and even in children younger than 10. Most symptoms can be classified under motor, behavioral, or cognitive categories. The disease is caused by a defective gene characterized by an excessive number of trinucleotide (Cystosine-Adenine-Guanine) repeats - a part of the DNA code. The gene produces a protein of unknown function named Huntingtin, which is involved in the functioning of the nerve cells in the brain (neurons). When defective, the gene produces an abnormal (or mutated) Huntingtin protein that is toxic and causes selective loss of neurons. The pathogenesis of the disease remains, however, largely unclear so that the exact cause of neuronal death is unknown. Since each patient may have a unique combination of symptoms, there is no standardized treatment so that medication is prescribed on a case-by-case basis. Pharmacotherapy includes chorea medication, antipsychotics, antidepressants, mood-stabilizing medication as well as non-drug therapies. Side effects from medications can also affect each patient differently. Notwithstanding such approved therapies for specific disease symptoms, there is currently no cure and there are no approved drugs that delay the onset or slow disease progression. Fortunately, there are also many new therapeutics currently undergoing clinical trials that target the disease at its origin by lowering the levels of the mutant Huntingtin protein. In this book, I discuss the disease at length in its multiple facets and address the issue of its prevention and prognosis. I also consider what can be done about it and list the several available support and research organizations. Lastly, I review the current research and latest research developments in this subject.
A Man Of Few Words
In everyone's life there is a defining moment: for me it came with the birth of our son, Daniel. His Birthday wasn't a star-studded affair by any stretch of the imagination, though 'his coming' was - without a doubt - unforgettable for a different reason. Daniel's general conduct had been weighing heavily upon us and we were determined to resolve the enigma once and for all. I made an appointment with our local hospital to speak with his consultant.... "... Do you really want to know what's wrong with your son?"... your son, is XYY and no way can we turn back the clock, or for that matter take away an extra chromosome".
My Life Rewired
On July 21, 2020, during the height of Covid-19, my life changed forever. I sustained a traumatic brain injury at the worst possible time. It took years to discover who I was and learn to live comfortably in my own skin again. I decided to write about my brain injury and how I learned to cope with this new way of life. As I began to prepare to write, I reflected on just how many traumas I have survived in my nearly 50 years on this earth. I was blown away at how far I have come, so I decided to write about the many traumas that lead up to and include my brain injury. Many things no one in my life knew about until I shared them in this book. The reason I decided to be open and transparent about all I have been through is that I hope whoever needs to hear this message will receive understanding that you can heal from those wounds. Life is a precious gift, and we can learn to love and give ourselves grace - no matter when we become brave enough to start.
Low Vision Matters
According to the Centers for Disease Control and Prevention (CDC), over seven million people in the US alone suffer from severe vision loss or blindness. In the past, low vision was truly a life-altering condition. Those seemingly everyday tasks that were once so simple instead became difficult--whether one had to work, cook, read, drive, go out to shop, or even turn on a light switch, one's world had been completely turned upside down. Today, however, things have begun to change. With the revolution of Artificial Intelligence (AI) already underway, many of the major barriers caused by diminished or fully lost vision have been lessened or completely eliminated. In Low Vision Matters, authors Laura Stevens and Thomas Blackman provide a comprehensive guide to all the aids and equipment now available--along with important practical advice--to those who are vision-challenged. The book is divided into two parts. Part One focuses on the day-to-day activities that low vision can affect--from safety in your home or traveling outside, to the handling of finances or one's home entertainment system. It discusses the latest technologies that can enable a person with eyesight problems to turn on a light, start a dishwasher, or even answer a phone through the use of oral commands--and that's just the tip of the iceberg. Part Two then provides a breakdown of the various kinds of helpful vision-aid products now available. Because the authors understand the costs involved in purchasing such equipment, they include the names of those organizations and associations in an extensive Resources section along with various other crucial contacts about which those with low vision and their loved ones and caretakers need to know. Times have changed. Low Vision Matters provides a wealth of information that can vastly improve the daily life of a person living with vision loss or blindness.
What You Really Want to Know about Working with Dementia
Dementia can add a layer of complexity to health and social care, as problems with communication and understanding can make it more difficult to diagnose and treat other conditions and illnesses. For many people living with dementia, generalist clinicians in primary care will be their first port of call. This FAQ guide examines issues experienced by these clinicians during their daily practice, and offers expert advice on how to support people living with dementia. Each section includes a case study to illustrate a common concern, followed by analysis of the underlying issues and suggested approaches or solutions from an experienced Admiral Nurse. Topics include distressed behaviours at home and in clinical settings, managing fall risk, supporting older carers or those with disabilities, and advance care planning. This evidence-based guide sets out skills and approaches for all health professionals to provide excellent person-centred care for people living with dementia.
Essentials Ophthalmolog (2nd Ed)
Written by a multi-disciplinary team from the Department of Ophthalmology at the National University Health System in Singapore, the 2nd Edition of Essentials of Ophthalmology: For Medical School and Beyond is a significantly improved version of the much appreciated first edition. The original purpose of this publication remains the same: to serve as a comprehensive reference book for medical undergraduates, residents, and family physicians, who are often the first line of eye care providers in the community.The book is designed to cover all the Entrusted Professional Activities (EPAs) mandated by the Undergraduate Ophthalmology curriculum in Singapore. The chapters have been thoroughly revised, with the addition of new clinical images and expanded coverage of ophthalmic conditions. This edition also introduces three new chapters: one on basic electrophysiology, which aims to clarify the complex electrical responses of the retina and visual pathway to light; another on biostatistics, intended to inspire students to engage in basic research; and a comprehensive chapter on the End of Posting Test (EOPT), featuring scenario-based questions and answers from every subspecialty in ophthalmology, which will be invaluable for students preparing for assessments.The original point format, including "learning objectives" and "take-home messages," has been preserved to facilitate easy reading and quick learning. With nearly 250 high-resolution clinical images, this book now serves as an even more practical guide to studying ocular diseases, along with the basic methods of investigation and treatment where applicable.Written by experts from every sub-specialty for undergraduate medical students, the book is concise and well-illustrated with high resolution clinical pictures, and distinguished by its point format and inclusion of learning objectives and take-home messages.
Essentials Ophthalmolog (2nd Ed)
Written by a multi-disciplinary team from the Department of Ophthalmology at the National University Health System in Singapore, the 2nd Edition of Essentials of Ophthalmology: For Medical School and Beyond is a significantly improved version of the much appreciated first edition. The original purpose of this publication remains the same: to serve as a comprehensive reference book for medical undergraduates, residents, and family physicians, who are often the first line of eye care providers in the community.The book is designed to cover all the Entrusted Professional Activities (EPAs) mandated by the Undergraduate Ophthalmology curriculum in Singapore. The chapters have been thoroughly revised, with the addition of new clinical images and expanded coverage of ophthalmic conditions. This edition also introduces three new chapters: one on basic electrophysiology, which aims to clarify the complex electrical responses of the retina and visual pathway to light; another on biostatistics, intended to inspire students to engage in basic research; and a comprehensive chapter on the End of Posting Test (EOPT), featuring scenario-based questions and answers from every subspecialty in ophthalmology, which will be invaluable for students preparing for assessments.The original point format, including "learning objectives" and "take-home messages," has been preserved to facilitate easy reading and quick learning. With nearly 250 high-resolution clinical images, this book now serves as an even more practical guide to studying ocular diseases, along with the basic methods of investigation and treatment where applicable.Written by experts from every sub-specialty for undergraduate medical students, the book is concise and well-illustrated with high resolution clinical pictures, and distinguished by its point format and inclusion of learning objectives and take-home messages.
The Handbook of Fatigue Management in Transportation
In the world of transportation, fatigue is a silent killer that can affect us all. Understanding fatigue, including how to manage it to minimize safety risk, is of great importance. However, while it is one thing to recognize that fatigue is a critical safety issue, it is quite another to set up a successful, scientifically informed fatigue risk management programme. This book is here to help. It has been carefully designed as a comprehensive reference point, bringing together international expertise from leaders in fatigue science, and showcasing valuable insights from transportation industry practitioners. The 40 authored chapters are divided into six sections, to better understand fatigue science, the consequences of fatigue in transportation, contributors to fatigue, managing fatigue and promoting alertness, real world case studies of fatigue management in practice, and future perspectives. While it is possible to read each chapter in isolation, most will be gained by reading the book as a whole. Each chapter starts with an abstract overview and concludes with summary bullet points, creating a handy "quick check" for key points. This accessible text is for those who are interested in supporting alert and safe transportation operations. It is suitable for professionals, transport managers, government advisors, policy makers, students, academics, and anyone who wants to learn more. All transport modes (road, rail, maritime and aviation) are considered. For anyone waking up to the complex challenge of fatigue management, this handbook is a must.
Pediatric Collections: Digital Media: Part 1: Ecosystems
Pediatric Collections offers what you need to know - original, focused research in a snapshot approach. Digital ecosystems have an outsized impact on children's development and yet have received considerably less attention than individual behavioral approaches in digital media research (such as a child's "screen time"). The digital ecosystem includes the digital design patterns that influence children's media habits by funneling children toward endless scrolls, feeds, and nudges to keep watching. It includes the highly monetized patterns of advertisements and commercialization that are thinly veiled in popular content platforms. It includes the erosion of digital privacy with companies and third parties collecting personal information in covert and overt ways. Part 1 of this series on digital media is an important addition to the literature because it includes studies of how digital design increases children's risks from media, and how digital media use interacts with larger systemic structures and cultural forces at hand. This important review builds an evidence base justifying the reduction of commercialized content that is so popular in platforms.
Pediatric Collections: Digital Media: Part 2: Media Effects
Pediatric Collections offers what you need to know - original, focused research in a snapshot approach. Digital media companies are hurtling ahead in a race to capitalize on artificial intelligence (AI) technology, with commercial motives. The evolution of technology continues without enough voices from families and pediatricians to design the technology to suit children's needs. Indeed, families are adopting technologies at an exponentially more rapid clip with each new technology developed. Part 2 of this book series reflects on previous breakthroughs on the impact of digital media on child and adolescent outcomes, illuminating the ways that digital media can introduce risks through harmful content, displacement of other healthy behaviors, or contact from unwanted adults. This collection delves into how digital media intersects with physical health, such as sedentary behaviors and eating disorders; how digital media intersects with social determinants of health and mental health such as online victimization, problematic internet use, and academic performance. Additional risks identified in this collection explore amplification with artificial intelligence (AI), creating algorithms selecting commercialized content for children with surgical precision, creating sophisticated interactive designs to demand more and more timed play for young children, and widening the systemic and structural disparities that shape children and adolescent's daily lives and digital experiences.
Pediatric Collections: Digital Media: Part 3: Use of Media as a Tool
Pediatric Collections offers what you need to know - original, focused research in a snapshot approach. Technology can be leveraged as a tool to measure digital media use and eventually intervene, including a mobile app to track child smartphone and tablet use, which revealed insights about problematic content often accessed on devices. Future studies could use mobile apps and help families set limits and change design features, to support healthier relationships with media with tailored precision and accuracy. Part 3 of this collection reflects how well-designed technologies including artificial intelligence (AI) have the potential to expand the possibilities of play with imagination and envision a world where child-centered design can improve children's wellbeing. Digital media can be leveraged as a distraction tool to reduce pain in prehospital settings. As technology becomes more sophisticated and can integrate children's responses, there is the potential for it to contingently respond to children and act as a social partner. This may provide a more tailored and individualized approach to education and learning that meets children where they are developmentally.
