Molecular deregulation in prostate cancer
Detailed analysis of gene and epigenetic expression in prostate cancer patients reveals specific molecular abnormalities associated with this pathology. These alterations are responsible for the deregulation of cell growth and resistance to programmed cell death, essential features of cancer. The discovery of unique molecular profiles in patients opens up prospects for the development of personalized treatments.
BI-RADS mammography glossary
The BI-RADS classification was first published in 1993 by the American College of Radiology (ACR) for mammography, and updated in 2013. The aim of the BI-RADS (Breast Imaging Reporting and Data System) lexicon is to facilitate communication by homogenizing vocabulary; to standardize reading by proposing a framework for reports, in order to reduce confusion in the interpretation of breast abnormalities; and to classify breast abnormalities according to their probability of malignancy and propose appropriate management.This clear, educational book provides a detailed description of the BI-RADS mammographic lexicon, richly illustrated with demonstrative diagrams. This book will be of interest to all practicing physicians.
Liver System
This book seeks to provide knowledge of the hepatic system, both its importance and its diagnosis, in order to lead to safe and effective treatment. To help with your studies in the field or in your laboratory or clinic. We hope to provide you with the knowledge you need to make your diagnosis and treatment as efficient as possible and thus improve your health more and more through the constant search for knowledge. Happy reading!
Effects of Radiofrequency on skin wound healing
In view of the number of plastic surgeries in Brazil and the search for better aesthetic and functional results, research is needed to find ways of improving healing and scars. It can be affirmed that radiofrequency has an influence on the inflammatory process, showing that in the rats that received radiofrequency, the square remained ulcerated. Radiofrequency reduces scar contraction in excisional wounds.
Nigeria in Focus
Kemdi Chino Opara was born in Nigeria, in West Africa. As a native of Mbaitoli Local Government Area of Imo State, Nigeria. Opara graduated from Government Secondary School in Owerri. To further his education, Opara came to the United States in 1979 and began to acquire scores of graduate and postgraduate degrees. Opara went on to attain a Bachelor of Science in Industrial Engineering from The College of New Jersey, in Trenton, New Jersey. Opara holds a Doctorate in Education, and received two master's degrees in Business Administration, all from Morgan State University in Baltimore, Maryland. After holding various positions in the New State Government, Opara has become a very successful entrepreneur in real estate development, and as a consultant in Urban Education Leadership programs. Kemdi is currently the Chief Executive/Partner of 1 Heart Home Health Care, LLC in Philadelphia, Pennsylvania; A Place of Hope Home Health Care, LLC in Trenton, New Jersey; And The Lotuscure LLC - a health and wellness center in Trenton, New Jersey. Opara believes strongly in charity work which led him to establish- Kemdi Chino Opara Foundation resident in Nigeria and that society must help to uplift the down trodden as well as the less privileged. Opara has four children by his wife Angela. His son, Kemdi Jr, and daughters Chibuzo, Chinwendu and Ugochinyere are all graduates of Howard University in Washington, DC. Kemdi jr and Chibuzo both have master's degrees. Kemdi jr received his from LIM College in New York while Chibuzo received hers from John Hopkins University, in Maryland. Chibuzo is now in Medical School at Howard University, in DC. Kemdi has also published another book titled, The Man and His Destiny.
Service Before Self
Responding to the 2014-2016 Ebola Crisis"Throughout our long and proud history, the Commissioned Corps of the U.S. Public Health Service has led on many notable public health achievements and saved countless lives by eradicating disease and responding to disasters. However, the Corps' effort to stem the Ebola outbreak is the most visible and widely recognized global health response in our history." -VADM Vivek H. Murthy "The United States Public Health Service (USPHS) Commissioned Corps is one of eight Uniformed Services protecting the Nation-along with the Army, Navy, Air Force, Marine Corps, Coast Guard, Space Force, and National Oceanic and Atmospheric Administration Commissioned Corps (10 USC 禮 101(a)(5)). The USPHS Commissioned Corps is the only uniformed service in the world dedicated to public health, authorized by Congress, commissioned by the President and deployed by the Secretary of U.S. Department of Health and Human Services (HHS), as a unique, adaptable, mobile, and deployable force that stands ready to meet the public health (including clinical) needs and demands of our Nation and the world. Health Services Officers are one of eleven professional categories of the USPHS Commissioned Corps of the U.S. Public Health Service. Corps assets were the the only U.S. Government asset to provide direct patient care to healthcare providers with Ebola in West Africa." -RADM Epi Elizondo "We are in West Africa to offer help, healing, and hope - continuing the legacy of our Corps and our country. When our neighbors need us most, we Americans open our hearts and extend our hand - regardless of whether they live in places near or far. In this sense we are there to be "hope multipliers." . . . To save lives, we need safe facilities and safe equipment, and most importantly, we need to keep the people safe who are doing the saving." -LCDR Kate Migliaccio
Vitamin D Status in Asthmatic Children
Asthma in children is the most common respiratory disease worldwide. It is a major cause of morbidity and mortality. An accurate assessment of its prevalence has been hampered by the heterogeneity of asthma definitions. It has been described that vitamin D possesses an immunomodulatory effect via its receptor (VDR) and 1-alpha-hydroxylase, which are present in T and B lymphocytes, macrophages and antigen-presenting cells. Thus, 25 hydroxy-vitamin D (25 OH D) reduces the proliferation of T lymphocytes (particularly Thelper-1 [Th1] and Th17 lymphocytes) and the production of certain "pro-inflammatory" cytokines (particularly Il-2, Il-6 and IFN-γ), and it has also been described that the vitamin reduces mainly viral respiratory infections and improves lung function. The interaction between asthma and vitamin D has been studied over the past two decades. This interaction is multi-faceted and has potential clinical implications for asthmatic patients, affecting disease severity, control and prognosis.
Imaging breast anatomy
Mammography, ultrasound and MRI are essential imaging examinations in the exploration of the mammary gland. By correlating anatomical, histological and physiological data with imaging data, we can better understand the image produced and, consequently, facilitate the detection of abnormal images within a glandular structure.This pedagogical book is clear and didactic, and richly illustrated. It is intended for radiology interns and practicing physicians wishing to learn about breast imaging.
Financial, Staffing and Societal Sustainability of Dutch Health Care
This open access book analyzes how sound choices can be made in Dutch health care policies, and shows why they are necessary, urgent, and even inevitable. Analyzing the current functioning and funding of the Dutch health care system, this book shows how three dimensions of sustainability - financial, staffing and societal - are under increasing pressure. This study explores priority setting in health care and calls for well-informed, clear and sometimes uncompromising choices in the allocation of means and personnel. This is necessary in order to maintain accessible and high-quality care for all, and to improve public health. Making balanced choices in health care is of particular importance to vulnerable groups whose voices may not be heard as readily or effectively in the public debate, and whose interests are more easily crowded out. Prioritizing in the domain of public health care is first and foremost a political responsibility, but also one for health care providers across the system and ultimately also for citizens. While this work focuses on the Netherlands, similar processes are at play across the developed economies, making it broadly relevant to policy makers, health care professionals and health care (policy) researchers grappling with the questions surrounding the sustainability of public health care.
Understanding and Addressing Brain Injury and Repair Mechanisms After Intracerebral Hemorrhage
This comprehensive document delves into the intricate realm of ""Understanding and Addressing Brain Injury and Repair Mechanisms After Intracerebral Hemorrhage."" Exploring the complex interplay between intracerebral hemorrhage and the body's innate repair mechanisms, this work offers a profound analysis of the challenges posed by intracerebral hemorrhage. Readers will be guided through the latest advancements in neuroscience, shedding light on the multifaceted aspects of brain injury and the intricate repair processes that follow. From the molecular and cellular levels to clinical implications, the document navigates through cutting-edge research, providing a nuanced understanding of the mechanisms involved. Whether you are a medical professional, researcher, or simply intrigued by the mysteries of the human brain, this document serves as a valuable resource, bridging the gap between scientific inquiry and practical insights. Gain profound insights into the complexities of intracerebral hemorrhage and discover the potential avenues for therapeutic interventions in the evolving landscape of neurology and brain health.
Immunity
This book explores the essence of immunity. Philosophical reflection with reference to Spinoza and Canguilhem suggests immunity is part of the essence of life - and the essence of immunity embraces elements with normativity. This book demonstrates the potential of this approach and contributes to a richer understanding of nature.
The Double Pandemic
"The Double Pandemic" tackles the twin threats we faced in recent times: COVID-19 itself and the rampant spread of misinformation surrounding it. This book delves into the challenges of navigating a real health crisis while also combating a flood of false information online. It explores how social media and online communication played a significant role in spreading misinformation about the virus, hindering public health efforts. The book analyzes the different types of misinformation that emerged, the factors that fueled its spread, and the impact it had on public health decisions. "The Double Pandemic" doesn't just diagnose the problem; it offers solutions. It explores strategies for identifying and debunking misinformation, promoting media literacy, and fostering trust in reliable sources of information. This book is a call to action for a healthier information environment in the digital age, crucial for tackling future public health challenges.
Behind the Scenes of a COVID-19 Test
The COVID-19 pandemic has brought the world of medical testing to the forefront. Millions of people have undergone swabs, gargled for samples, and waited anxiously for results. But what happens behind the scenes after that swab leaves your hand? This article delves into the fascinating journey of a COVID-19 test, revealing the intricate steps that lead to a positive or negative result. The Initial Steps: Collection and Transport The journey begins with the collection of a sample. The most common method utilizes a nasal swab, gently inserted into the nasal cavity to collect respiratory secretions where the virus might reside. Some tests use an oropharyngeal swab, reaching further back into the throat. Less frequently, saliva samples may be collected.
The Weight of Scrubs
Moman et al. (2020) revealed that in a study conducted by the United States Veterans Health Administration, through distributing surveys at a pain management conference, providers reported that 41% of assaults on healthcare workers occur in inpatient psychiatric units, yet 59% of assaults occur elsewhere within healthcare institutions. Kiymaz and Ko癟 (2023) used a mixed-methods study to research WPV among emergency department (ED) nurses and how WPV correlated to occupational commitment and intention to resign. Kiymaz and Ko癟 determined that emotional commitment to the nursing profession might decrease, and nurses' intention to resign may rise as exposure to aggression and violence increases.
Building a United Front
The global health landscape demands a united front. "Building a United Front: The Critical Role of Global Health Diplomacy" emphasizes the importance of collaboration in safeguarding health worldwide. This piece delves into the concept of global health diplomacy, the bridge between nations when it comes to health issues. It explores how coordinated efforts, like the eradication of smallpox, showcase the power of international cooperation. However, "Building a United Front" acknowledges past challenges. We'll examine the fragmented responses and inequities exposed by COVID-19, highlighting the need for a more unified approach. This title underscores the urgency for a stronger global health architecture. The focus is on solutions. We'll explore strategies for fostering stronger communication channels between nations. This includes investing in robust health surveillance systems and promoting equitable access to resources and technologies. By building a united front through global health diplomacy, nations can navigate future health threats more effectively. This collaborative approach, built on shared responsibility and proactive preparedness, safeguards global health and well-being for all.
The Silent Healers
For millennia, archaeology has painted a largely homogenous picture of the past. While skeletal remains and artifacts offer invaluable insights into ancient societies, they often overlook a crucial segment of the population - disabled and/or impaired individuals. Historically relegated to the fringes of historical narratives, these individuals have been categorized as "liminal" figures (Doat, 2017), existing on the margins and receiving scant attention (Metzler, 2013). When disability is acknowledged in the archaeological record, it's often framed through a lens of pity, focusing on suffering and despair (Metzler, 2013). This narrow perspective leads to a skewed understanding of past societies, omitting the rich tapestry of experiences woven by those navigating disability. This exclusion has significant consequences. By neglecting disabled individuals, we create an incomplete picture of the past. Archaeology, with its focus on past lifeways, has the potential to reveal a more nuanced understanding of how societies cared for their members. This necessitates a shift in perspective, moving beyond the traditional focus on pathology and impairment towards a recognition of the complex social dynamics surrounding disability.
Pedagogical Manual
This teaching manual for nursing students covers the safe and effective administration of medicines and the management of therapeutic regimens. With a focus on best practices, the manual details techniques for administering drugs intramuscularly, intravenously, subcutaneously, among others, and emphasizes the importance of accurate dosing and the correct selection of injection sites. Enriched with evidence-based guidelines and case studies, the manual also highlights effective communication with patients and the application of Virginia Henderson's principles for patient-centered care. This resource is essential for students seeking excellence in clinical practice and compassionate, informed care.
Swallowing sounds in cerebral palsy using Doppler sonar
Dysphagia is a very common symptom in children with cerebral palsy and may be associated with aspiration, leading to chronic lung problems and recurrent pneumonia. Our challenge was to study and compare swallowing sounds in children with and without cerebral palsy using Doppler sonar simultaneously with videofluoroscopy, analysing possible differences between the variables frequency, intensity and time.
Surgery for intramedullary tumors
Due to the rarity of TIMs, their clinical presentations and histological varieties, these lesions remain a current subject to which several questions must have consensus answers, especially with regard to the attitude towards asymptomatic TIMs, the extent of excision in relation to infiltrating gliomas and the real place of radiotherapy and chemotherapy in the therapeutic arsenal. TIMs develop slowly and insidiously, and are often benign, but localized in one of the densest functional areas of the nervous system. They can have relatively clear boundaries like ependymomas or grow infiltratively like astrocytomas. The first-line treatment is surgical. The latter imposes the highest technical requirements on neurosurgeons; specific surgical procedures and intraoperative functional monitoring tools. The primary objective of microsurgery is to preserve functions while achieving the widest possible resection (ependymoma, cavernoma, hemangioblastoma) or maximum reduction (astrocytoma) of the tumor.
Coronary Spasm
Coronary heart disease is one of the most common cardiovascular diseases affecting the world's population. It is the leading cause of death in both developed and developing countries. Its basic pathophysiological mechanism is straightforward: a mismatch between myocardial oxygen supply and demand leads to more or less extensive ischemia, manifesting itself as stable or unstable angina, myocardial infarction or sudden cardiac death. Once considered an exclusively atherosclerotic disease, where cardiovascular risk factors such as: tobacco, diabetes, dyslipidemia... an accumulation of cholesterol in the coronary arterial wall (atherosclerotic plaque) reduces the internal lumen, causing imbalance and symptoms. In addition, thromboembolic phenomena associated with plaque rupture exacerbate the imbalance, precipitating acute coronary syndromes (ACS).
All you need to know about breast calcifications
Microcalcifications are an indirect sign of the mammary pathological process. They need to be studied in detail, together with other mammographic findings, before they can be classified. Their analysis includes a description of their morphology, number and distribution, the presence or absence of associated signs, and their evolution over time. They are then classified according to the context and the patient's history. Suspected microcalcifications should always be biopsy-checked under imaging before any therapeutic decision is taken. The occurrence of postoperative calcifications may pose problems of differential diagnosis between cytosteatonecrosis and recurrence.This clear, didactic book, richly illustrated with demonstrative diagrams, is intended for radiologists.
Determining factors in the outcome of surgical recovery procedures
Gingival recession is the apical migration of the gingival margin from its original position at or within a millimetre of the cemento-enamel junction, which exposes the root surface to the oral environment. Its etiology is multifactorial, and the most frequent complaints of patients suffering from this condition are dental hypersensitivity and poor aesthetics. Periodontal treatment of gingival recession includes surgical and non-surgical means, with the most effective therapy being provided by the field of periodontal plastic surgery.
Can myocardial infarction be predicted in cardiac emergencies?
Myocardial infarction (MI) is a cardiological emergency whose diagnosis in the emergency department remains a clinical problem. In this book, an artificial neural network (ANN) was used and compared to logistic regression in the prediction of MI in patients consulting the emergency department for chest pain. Patient data were randomized into training and test series. Neural network and logistic regression models were built on the basis of the training data and tested on observations from the test group. The models were compared by analyzing their ROC (Receiver Operating Curve) curves.
Antibiotic prescribing in pediatrics
Introduction: Antibiotics (ATBs) account for a large proportion of drug prescriptions in children. Aim: To assess the quality of antibiotic prescribing in children under 5 years of age in the pediatric wards of 6 health services in Bamako. Method: This was a descriptive cross-sectional study designed to assess the quality of antibiotic prescribing in children under 5 years of age over a two-week period in each department. Our study took place in 6 pediatric units in Bamako (Mali) and involved 481 prescriptions. Results: In this study, 54% of patients were male, with a sex ratio of 1.17. Of the 481 prescriptions, the majority bore the prescriber's name and stamp (96.6%). General practitioners were the prescribers in 28% of cases. Ceftriaxone was the most prescribed antibiotic overall, with 37.6%, followed by Amoxicillin with 28% and gentamicin with 21.6%.
Hyaline membrane disease in term newborns
Hyaline membrane disease (HMD) is a respiratory pathology due to pulmonary surfactant deficiency, commonly encountered in premature newborns, but still poorly understood in full-term newborns (FTNs). Our study examined the clinical and evolutionary profile of MMH in NNATs, and identified predisposing factors.The results show that the frequency of MMH was 12.5%. The mean gestational age at birth was 38.12 weeks' amenorrhea. The main risk factors were caesarean section outside labour and gestational age.Conclusion: NNAT MMH is a real entity in NNATs. It is essential to consider this diagnosis to avoid any delay in management, with obstetric-paediatric collaboration recommended to ensure a better prognosis.
Breaking the Chains
The HIV epidemic has cast a long shadow for decades, impacting millions of lives worldwide. While advancements in treatment have transformed HIV from a terminal illness to a manageable condition, a significant barrier remains: stigma. This pervasive negativity surrounding HIV isolates individuals, discourages testing and treatment, and fuels the epidemic's persistence. To truly end HIV, we must break the chains of stigma and foster a world of understanding, empathy, and support. The Grip of Stigma Stigma thrives on fear and misinformation. Misconceptions about transmission fuel anxieties, leading to social isolation and discrimination. People living with HIV (PLWH) may face rejection from loved ones, difficulties in employment, housing, and healthcare access. This fear of rejection can prevent people from getting tested, delaying critical treatment and increasing the risk of transmitting the virus unknowingly.
Incurable and Increasing
Neurodegenerative diseases, like Alzheimer's and ALS, cast a long shadow, stealing minds and bodies with no current cure. "Incurable and Increasing: The Growing Challenge of Neurodegenerative Diseases" explores this pressing issue, highlighting the rise in these conditions and the urgent need for solutions. These diseases are characterized by the progressive loss of neurons, the brain's fundamental units. Currently, there's no way to reverse this damage, leaving patients and families grappling with a relentless decline. The situation is further compounded by the growing prevalence of these diseases: Aging Population: As life expectancy increases, the number of people at risk for neurodegeneration naturally rises. Environmental Factors: Exposure to toxins, pollution, and certain lifestyle choices may contribute to the development of these diseases. Limited Awareness: Early signs can be subtle, leading to delayed diagnosis and hindering the potential for early intervention. The consequences of this growing challenge are vast: Devastating Impact: Patients experience cognitive decline, physical limitations, and a loss of independence, placing a significant burden on families and healthcare systems. Economic Costs: The financial impact of caring for individuals with neurodegenerative diseases is substantial. Social and Emotional Toll: These diseases affect not just the individual but also their loved ones, creating a ripple effect of emotional strain. Despite the bleak picture, there is hope: Intensified Research: Increased funding and global collaboration are accelerating research efforts towards understanding the causes of these diseases and developing potential treatments. Technological Advancements: New tools like brain imaging and genetic testing are aiding in earlier diagnosis and personalized treatment approaches. Lifestyle Modifications: Research is exploring the potential of healthy diet, exercise, and cognitive stimulation in preventing or slowing the progressi
A Call to Action
"A Call to Action: Early Identification and Intervention for Autism in South Africa" sounds the alarm on the importance of early diagnosis and intervention for children with Autism Spectrum Disorder (ASD) in South Africa. This book highlights the critical window of opportunity in a child's development and the positive impact of early intervention strategies. The book delves into the challenges of identifying ASD in South Africa, including limited access to specialists and culturally insensitive diagnostic tools. It explores the impact of delayed diagnosis on both children and their families. "A Call to Action" doesn't stop there. It empowers readers with knowledge on evidence-based interventions that can significantly improve a child's development and quality of life. The book proposes practical solutions to improve access to diagnosis and intervention services, advocating for collaboration between healthcare professionals, educators, and communities. This compelling call to action equips readers to advocate for a future where all children with ASD in South Africa can receive the support they need to thrive
Handbook of Functional Neuroimaging of Cognition, second edition
A new edition of the essential resource on using functional neuroimaging techniques to study the neural basis of cognition, revised with the student in mind; thoroughly updated, with new chapters on fMRI physics, skill learning, emotion and social cognition, and other topics. This essential resource on neuroimaging provides an accessible and user-friendly introduction to the field written by leading researchers. The book describes theoretical and methodological developments in the use of functional neuroimaging techniques to study the neural basis of cognition, from early scientific efforts to link brain and behavior to the latest applications of fMRI and PET methods. The core of the book covers fMRI and PET studies in specific domains: attention, skill learning, semantic memory, language, episodic memory, working memory, and executive functions. By introducing a technique within the description of a domain, the book offers a clear explanation of the process while highlighting its biological context. The emphasis on readability makes Handbook of Functional Neuroimaging of Cognition ideal for classroom use in advanced undergraduate and graduate courses in cognitive neuroscience. This second edition has been completely updated to reflect new developments in the field, with existing chapters rewritten and new chapters added to each section. The section on history and methods now includes a chapter on the crucial topic of the physics of functional neuroimaging; the chapters on skill learning and executive functions are new to the domain section; and chapters on childhood development and emotion and social cognition have been added to the section on developmental, social, and clinical applications. The color insert has been increased in size, enhancing the visual display of representative findings. Contributors: Todd S. Braver, Jeffrey Browndyke, Roberto Cabeza, B.J. Casey, Jody Culham, Clayton E. Curtis, Mark D'Esposito, Sander Daselaar, Lila Davachi, Ian Dobbins, Karl J. Friston, Barry Giesbrecht, Todd C. Handy, Joseph B. Hopfinger, Scott A. Huettel, Irene P. Kan, Alan Kingstone, Eleni Kotsoni, Kevin S. LaBar, George R. Mangun, Gregory McCarthy, Uta Noppeney, Robyn T. Oliver, Elizabeth A. Phelps, Russel A. Poldrack, Cathy J. Price, Marcus E. Raichle, Hannes Ruge, Gaia Scerif, Allen W. Song, Sharon L. Thompson-Schill, Daniel T. Willingham, Richard J.S. Wise
Vaccines, Did You Know?
The debate over vaccines and their impact on people has been ongoing for many years. While some people believe that vaccines are necessary, others are strongly opposed to them. Unfortunately, many people lack the necessary information to make informed decisions about vaccines. Veronica Moore has written a book called "Vaccines, Did You Know?" to provide readers with comprehensive information on this topic. Veronica's interest in vaccines began when her son was diagnosed with Asperger's Syndrome. She spent several years researching the condition, which led her to discover information about vaccines, the science, the laws, and the misinformation surrounding them. Her book aims to provide readers with a detailed analysis of vaccines, including their ingredients and effects on children and adults. Veronica draws on peer-reviewed medical studies, and conversations with doctors, nurses, epidemiologists, virologists, and parents, to ensure that she covers many aspects of the vaccine debate. Additionally, she shares her personal experience with vaccines, offering a more realistic and personal approach to the conversation. Veronica believes that questioning and researching information about vaccines is essential to understanding what we put into our bodies. By writing this book, she hopes to encourage others to investigate vaccines more thoroughly, enabling everyone to make more informed choices about what is best for their family. Veronica Moore is a wife, mother, grandmother, homeschool teacher, and an Associate Real Estate Broker. She and her husband reside in New York State with their children.
Pitfalls in Family Medicine Clinical Practice
In recent years, the discipline of general practice has undergone significant development. A general practitioner requires a broad knowledge base and a wide range of skills to provide comprehensive care for their patients. Within the time constraints of a busy practice and limited consultation time, the general practitioner must do their best to address various patient complaints and determine the most appropriate management plan. Consultation is at the heart of general practice. We have constructed clinical case scenarios based on the real-life experiences of a group of senior family medicine and internal medicine physicians. Our cases are designed to be symptom-based, tackling the most common and important presenting symptoms encountered in our practice.
Medicare Made 123Easy
Choosing a Medicare plan doesn't have to be confusing. If you're feeling overwhelmed with where to start, you are not alone. Over the past twenty years, we have heard a story or two. Most of them start with folks trying to research through thousands of websites for answers, maybe watching a video, maybe attending a class... But, if you are reading this, you are likely just craving that silver bullet, something or someone to tell you what you need to do, when to do it, and how. While we might not have a magic wand, our award-winning process, led by our Certified Medicare Planners(R), has created a gold standard in this industry. We are here to help you sort through the Medicare maze, as we have for thousands of enrollees before you. This book will help you cut through all the gimmicks and sales pitches so you can outsmart those telesales people, out-research your neighbors, and ultimately find the plan that meets your needs without all the nonsense.
The Prognostic Value of Carotid Intima-Media Thickness
Atherosclerosis in the carotid arteries can determine a poor prognosis in individuals after the occurrence of acute coronary syndrome (ACS). Thus, we sought to assess mortality associated with carotid intima-media thickness (CIMT) in participants in the Acute Coronary Syndrome Registry Strategy (ACSR) study. CIMT was assessed by B-mode ultrasound to evaluate the risk of mortality at 180 days, 1, 2 and 3 years.We evaluated all-cause mortality, cardiovascular disease (CVD) and coronary artery disease (CAD) by tertiles of CIMT in crude, age- and sex-adjusted and multivariate-adjusted models. It also analyzed groups stratified by age (= 65 years). EMIC was mainly influenced by ageing and was not a good predictor of all-cause mortality, CVD or CAD in the ERICO study.
Anctea
The purpose of this book is to go beyond providing information on the aspects that permeate the nutritional care of children with Autism Spectrum Disorder (ASD).This book is based on the scarcity of similar material, as well as the limited knowledge and practice of health professionals at a Specialized Rehabilitation Centre (CER).Thus, this book was designed to help health professionals understand the need for nutritional assistance for children with ASD, both in terms of knowledge and clinical practice.It is hoped that this material will fill this gap in the knowledge and practice of nutritional care for children with ASD and may provoke other researchers to look into the subject.
Evaluation of blood gases in the postoperative period of abdominal trauma
Individuals undergoing upper abdominal surgery may experience some pulmonary repercussions caused by anesthesia and the surgical procedure itself. Both can accentuate the reduction in functional residual capacity (FRC), promoting early closure of the small airways, leading to a degree of hypoxemia and possible incidence of atelectasis, alterations in respiratory mechanics, gas exchange, breathing pattern and pulmonary defense mechanisms, leading to the appearance of postoperative pulmonary complications (PPC).
Aging and the Brain
The aging brain is a battlefield. As we get older, neurodegenerative diseases like Alzheimer's and Parkinson's become a looming threat. "Aging and the Brain: Can microRNAs Unlock New Treatments for Neurodegenerative Diseases?" explores the exciting potential of microRNAs, tiny molecules with a big role to play in potentially combating these devastating conditions. Imagine a new weapon in the fight against neurodegeneration: microRNAs. These microscopic regulators within cells control gene expression, influencing various cellular processes. In the context of neurodegeneration, scientists believe abnormal microRNA activity may contribute to the disease process. The potential benefits of targeting microRNAs are intriguing: - Modulating Cellular Function: By regulating microRNAs, scientists hope to influence cellular processes gone awry in neurodegeneration, potentially promoting neuron health and survival. - Early Intervention: Identifying specific microRNA patterns associated with neurodegeneration could pave the way for earlier diagnosis and intervention, before significant damage occurs. - Targeted Therapeutics: Developing drugs that manipulate microRNA activity offers a potentially more targeted approach to treatment compared to traditional medications. However, challenges remain: - Delivery Methods: Delivering microRNA-based therapies to the brain effectively and safely is a hurdle that needs to be overcome. - Disease Complexity: Neurodegeneration likely involves multiple factors beyond microRNAs. A single therapeutic approach may not be sufficient. - Long-Term Effects: More research is needed to understand the long-term safety and efficacy of microRNA-based therapies. Despite these challenges, the potential of microRNAs is undeniable: - Specificity: MicroRNAs can target specific pathways involved in neurodegeneration, potentially leading to fewer side effects. - Biomarker Potential: Studying microRNA profiles may provide valuable biomarkers for early detection an
Psychosocial factors at work
The theme of psychosocial factors at work in the epidemiology of occupational hazards has gained considerable momentum in recent years. The Effort/Reward Imbalance model had enriched occupational stress models by proposing an approach based on the dissonance between high costs and low gains. The aim of our study was to describe psychosocial constraints at work based on Siegrist's Effort/Reward Imbalance model, and to identify the determinants associated with it. Of all the company's employees, 81 were covered by the present study. The average age of the workers was 42.49 +/- 11.34 years. The majority (87.7%) were male. An imbalance in the effort/reward balance (ratio > 1) affected 30.9% of those surveyed. Male gender, body mass index, level of education, alcoholism, smoking and active work were associated with effort/reward imbalance among workers. At the end of this study, a global prevention approach in companies aimed at reducing psychosocial factors is necessary.
Epidemiological profile of malaria
Malaria is a parasitic disease, a febrile, hemolytic erythrocytopathy caused by the development and multiplication in humans of hematzoa of the genus Plasmodium. The aim of this study was to assess malaria management in the M矇kin-Sikoro population in 2021. This was a cross-sectional study of the epidemiological profile of malaria in M矇kin-Sikoro in Commune I of Bamako district. Our study, based on consultation and laboratory registers from 2021 and an interview survey of 234 people of all ages, will be carried out in October 2022. At the end of the study, we observed a malaria frequency of 51.5% among CSCOM patients. This frequency varied from one season to another, with the highest number of cases during the rainy season (58.2%). Children aged 6 to 15 suffered more from malaria, at 57.4%. The most frequent clinical signs were fever %, headache %, vomiting % and chills %. Simple malaria was the most frequent phenotype 99.5% versus less than 1% severe malaria. Injectable antimalarial drugs were, however, the most widely prescribed, at 73.1%.
The Brain's Building Blocks
Dive deep into the intricate world of the brain with "The Brain's Building Blocks: Decoding the Secrets of Synaptic Ultrastructure." This book isn't a generic overview; it zooms in on the microscopic level, focusing on synapses, the fundamental connections between brain cells. Imagine synapses as the tiny handshake points where thoughts and information flow. "The Brain's Building Blocks" delves into the fascinating ultrastructure of these connections, exploring the complex machinery that makes them tick. The book delves into the composition of synapses, analyzing the proteins, lipids, and other molecules that orchestrate communication between neurons. It explores how these intricate structures influence memory, learning, and brain function. Readers will discover groundbreaking research that is unveiling the secrets of synaptic plasticity, the brain's ability to adapt and modify these connections throughout life. This knowledge is crucial for understanding how the brain learns, remembers, and even heals from injury. "The Brain's Building Blocks" is a captivating journey for anyone curious about the intricate workings of the mind. It unlocks a deeper appreciation for the brain's remarkable architecture and paves the way for future advancements in neuroscience and brain-related disorders.
Unraveling the Cancer Puzzle
"Unraveling the Cancer Puzzle" delves into the complexities of cancer, but with a hopeful twist. This book acknowledges the immense challenge cancer presents, a seemingly ever-evolving puzzle with countless pieces. However, it offers a compelling approach: understanding the fundamental properties that unify different cancers. Imagine cancer not as a monolithic disease, but as a collection of variations sharing core characteristics. "Unraveling the Cancer Puzzle" explores these fundamental properties, from abnormal cell growth to disrupted communication pathways. By focusing on these common threads, the book argues, we can develop more targeted and effective therapies. The book delves into groundbreaking research that analyzes cancer through the lens of physics, biology, and even engineering. Readers will discover how scientists are using this holistic approach to identify vulnerabilities across various cancer types. "Unraveling the Cancer Puzzle" doesn is a promise of a quick fix, but a roadmap towards a future of more effective cancer treatments. It's a must-read for anyone seeking a deeper understanding of this complex disease and the scientific advancements offering renewed hope.
Course of lectures on normal physiology. Volume two
The second volume of lectures on physiology is a continuation of the first volume released in 2023. The sequence of presentation of materials corresponds to the plans of lectures given by the authors to medical university students. The authors have been lecturers and teachers at the Department of Normal Physiology of the Tajik State Medical University for more than 30 years. The second volume presents lectures on normal physiology of digestion, nervous regulation, physiology of sensory organs, and physiology of higher nervous activity. A total of 20 lectures are presented.
Physiology in Diagrams and Drawings
This textbook has been prepared for publication by the Head of the Department of Normal Physiology of the Tajik State Medical University named after Abuali ibni Sino, Doctor of Medical Sciences, Professor F.A. Shukurov and Doctor of Medical Sciences, Associate Professor F.T. Halimova. Explanations for each scheme are presented in an accessible language, which ensures the assimilation of material on the relevant issues of physiology. 50 years of pedagogical experience of Shukurov F.A. and 20 years of experience of Halimova F.T. allowed to present the materials of all sections systematically and in an accessible language, which contributes to better assimilation. The use of this textbook allows to study more deeply the mechanisms underlying the functions of all systems. The use of schemes of this manual and explanations to them will allow students to understand the issues of all levels set out in the "Notebook for laboratory classes and independent work on normal physiology".
Egg Freezing in the 21st Century
This edited volume covers the development of egg freezing over the last few decades since the pioneering work of Chen in 1986, addressing both the scientific breakthroughs that have occurred and the social and demographic changes that are currently driving an increased demand for 'social' egg freezing and a recognition of the important role of 'medical' egg freezing for women facing potentially sterilizing oncology therapy. It presents the latest research in egg vitrification, methodologies for optimizing laboratory performance and contemporary clinical management of patients seeking oocyte cryopreservation. Audited international data on access, take-up, use and birth outcomes for women undertaking egg freezing are included. The book also discusses the ethical issues related to access and funding and considers how different legal jurisdictions have approached matters such as storage duration, ownership, donation, anonymity and identification. Such wide-ranging contents will bridge the gap between the highly technical laboratory handbooks and the 'popular' tabloid accounts directed at young women considering egg freezing. Drawing on the different approaches to fertility preservation prevailing around the world, with chapters written by leading international experts and edited by Gillian Lockwood, a pioneer of the field whose clinic produced the UK's first 'frozen egg' baby in 2002, Egg Freezing in the 21st Century will have an authoritative and global appeal, and may hopefully encourage a change of attitude in some jurisdictions.
In the Shadow of Animals
This book explains how various animals have adapted to extreme conditions, and why humans need animals and should protect them.
Preeclampsia in Pregnant Women
Pre-eclampsia is a maternal pathology, specific to pregnancy, secondary to placental dysfunction occurring from the second trimester onwards, and specific to human gestation. The causes of this placental dysfunction are highly variable, making the experimental approach to this pathology highly complex. Placental dysfunction is responsible for the release into the maternal circulation of substances responsible for endothelial dysfunction, characterized by activation of endothelial cells and increased vascular permeability. It appears to be a two-stage disease, with an initial stage of placental syndrome followed by maternal syndrome. The maternal syndrome in preeclampsia corresponds to a state of generalized endothelial dysfunction secondary to an excess of circulating factors toxic to the endothelium which are released by the pathological placenta. Understanding the mechanisms leading to placental ischemia in pre-eclampsia should shed light on the pathogenesis of pre-eclampsia.
Anesthesia for obese patients
In recent years, obesity has become the number one non-communicable disease in history. It has risen sharply worldwide, including in developing countries. It is a major risk factor for cardiovascular disease, diabetes and cancer. Algeria is no exception to this rule. Consequently, this rise in the prevalence of obesity in our society systematically includes an increase in the number of obese patients requiring surgical intervention for various reasons. Managing these patients in anaesthesia is a special challenge, requiring technical resources and knowledge to optimize the results of preoperative, intraoperative and postoperative management.
The effect of dystocic childbirth on women's psychology
Introduction: Postpartum psychological disorders are common and may be exacerbated after dystocic childbirth. Our objectives were to evaluate factors associated with posttraumatic stress disorder (PTSD), postpartum depression (PPD) and relational aspects after dystocic delivery.Materials and methods: A descriptive and analytical cross-sectional study including 60 women with a dystocic delivery from July to December 2022 at the Hedi Chaker University Hospital in Sfax.Results: PTSD and PPD were noted in 41.7% and 46.7% of cases. Factors associated with these disorders were primiparity (p=0.03), urgent caesarean section (p=0.04), lack of support (p= 0.016), lack of information (p=0.04), obstetric violence (p=0.04), lack of analgesia (0.05) and maternal complications (p=0.04). Sexual problems were reported in 61.7% of cases, and the mother-baby relationship was satisfactory in 80% of cases. Conclusion: Psychological support for patients at risk of mental disorders after dystocic childbirth is necessary, as is birth preparation for pregnant women.
