Genomic Structural Variants in Nervous System Disorders
This volume covers the detection of structural variants (SVs), which require different strategies than the ones used for single nucleotide variants (SNVs). This book aims to provide readers with a combination of the latest "wet lab" methods and computational pipelines that target all SV classes. The chapters in this book cover topics such as detection of transposable elements (TEs) from short read data; long read sequencing used for multiple variable number tandem repeat analysis; genomic mosaicism in the nervous system; and optical genome mapping. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Genomic Structural Variants in Nervous System Disorders is a valuable resource for scientists and researchers interested in learning more about this important field.
The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences
Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade.
Social Behavior as Resource Exchange
This book takes the reader on an exciting journey presenting the development of resource theory of social exchange originated from Uriel G. Foa and Edna B. Foa. This groundbreaking theory has inspired and generated a tremendous amount of basic and applied research in various disciplines of psychology, sociology, management, economics, marketing, and political science. This book, edited by Kjell T繹rnblom and Ali Kazemi, two prominent and leading scholars in this field, complements and deepens the Foas' pioneering work from 1974. Within these covers the reader will find an abbreviated version of the Foas' out-of-print original, which is increasingly referred to by current researchers, alongside new chapters on current issues, developments, and applications written by eleven scholars. The book has a simple and clear-cut message: resource theory is not an exercise in academic hair-splitting but has far-reaching societal implications in that it can provide interesting solutions to a wide range of social issues.
Interpretation of Computed Tomography
A comprehensive textbook on the interpretation of the normal anatomy of the oral and maxillofacial region with the help of computed tomography. High quality computed tomography images and elaborate description of the oral and maxillofacial region in a simple style for faster and easier understanding. Aimed to bring about a thorough understanding to interpret your radiographs accurately for the most effective diagnosis and patient care.
The Filth Disease
Shows how the investigation of local outbreaks of typhoid fever in Victorian Britain led to the emergence of the modern discipline of epidemiology as the leading science of public health Typhoid fever is a food- and water-borne infectious disease that was insidious and omnipresent in Victorian Britain. It was one of the most prolific diseases of the Industrial Revolution. There was a palpable public anxiety aboutthe disease in the Victorian era, no doubt fueled by media coverage of major outbreaks across the nation, but also because Queen Victoria's husband, Prince Albert, died of the disease in 1861. Their son and heir, Prince Albert Edward, contracted and nearly succumbed to typhoid a decade later in 1871. The Filth Disease shows that typhoid was at the center of a number of critical debates about health, science, and governance. Victorian public health reformers, the book argues, working in central and local government, framed typhoid as the most pressing public health problem in order to persuade local officials to implement sanitary infrastructure to prevent the spread of disease. In this period British epidemiologists uncovered how typhoid is spread via food and water supplies, disrupting the longstanding idea that typhoid was spread via filth. In the process the modern disciple of epidemiology emerged as the chief science of public health. Typhoid was as much a social and political problem as it was a scientific one, and The Filth Disease provides a striking reminder of the cultural context in which infectious diseases strike populations and how scientists study them.
Antimicrobial Effects of Allium Sativum (Garlic) and Zinger Officinale (Ginger) on Pathogenic Bacteria
Bachelor Thesis from the year 2022 in the subject Biology - Micro- and Molecular Biology, grade: 4.27, University Of Abuja (FACULTY OF SCIENCE), course: MICROBIOLOGY, language: English, abstract: This study on the antimicrobial effects of Allium sativum (garlic) and Zinger officinale (ginger) on pathogenic bacteria was conducted. The result of zone of inhibitions of Ethanolic extracts of the Allium sativum (garlic) and Zinger officinale (ginger) as described in the material and methods is presented. The zone diameter of inhibition in millimeter of Ethanolic extracts of Allium sativum (garlic) and Zinger officinale (ginger) at concentration of 500 mg/ml against Staphylococcus aureus shows that Allium sativum (garlic) and Zinger officinale (ginger) met the standard of the antibiotic used as the positive control (chloramphenicol) with 25.0簣1.0 mm each. Meanwhile Salmonella typhi had significant zone diameter of inhibition (21mm, 22 and 24mm against Zinger officinale (ginger) and Allium sativum (garlic) respectively at concentration of 500mg/ml. Two of the extracts which include Allium sativum (garlic) and Zinger officinale (ginger) had the minimum inhibition concentration (MIC) of 125 mg/ml against Staphylococcus aureus and which correlate with the control (Cloramphenicol). Meanwhile Zinger officinale (ginger) had MIC of 250 mg/ml against Salmonella typhi respectively. The Minimum bactericidal concentration of the extracts shows that only Allium sativum (garlic) have the least value of 250 mg/ml which correlates with the standard antibiotic (chloramphenicol) used as control against Salmonella typhi while the rest of the other plant extracts which include Zinger officinale (ginger) had 500 mg/ml each as MBC against Salmonella typhi. Similarly, both Allium sativum (garlic) and Zinger officinale (ginger) had MBC of 250 mg/ml which also correlates with the standard antibiotics drug (Cloramphenicol).
Nanorobot
A robot is widely used in a different field because it deals with the layout, manufacture, and control of nanorobots using computers or other sensors. Physics, chemistry, biology, medicine, pharmaceutical sciences, engineering, biotechnology, and health sciences are multidisciplinary fields that require special planning on the part of research and engineering departments. These days the healthcare establishment goals, in addition, to enhance the satisfaction of scientific treatments via growing minimally invasive diagnostic techniques which include helping new advances in nanotechnology. Nanorobot uses in cancer treatment, blood clot removal, atherosclerosis treatment and parasite removal etc.
Expressive Origins
Have you or a family member struggled to lose weight despite years of dieting? Do you struggle with a chronic disease that won't resolve? Are you reaching an age where menopause symptoms are affecting your lifestyle? Or do you just need a decent night's sleep and less brain fog?By combining breakthrough science in epigenetics with unique genetic blueprints, the authors in this book demonstrate how you can find the true path for you and your body toward health. With practical examples of how to take your health and longevity into your own hands, this book provides real-life stories of practitioners and clients who have changed their health, wellness, and longevity by applying precision health practices unique to their genetic blueprint.Traditional approaches to weight loss, menopause, and other chronic health conditions will have us believe that a cookie-cutter approach will work and that we are all very much the same. The truth is: one size fits none.
Medical Ethics
This book provides the knowledge needed to understand who has the right to healthcare, the justice of clinical practice, what autonomy means for a patient giving consent, who is going to make any surrogate decisions and more.
Modelling Survival Data in Medical Research
Fourth edition has new chapters on Bayesian survival analysis and use of the R software. Chapters extensively revised, expanded to add new material on topics that include methods for assessing predictive ability of a model, joint models for longitudinal and survival data, modern methods for the analysis of interval-censored survival data.
Signal Detection for Medical Scientists
Signal Detection for Medical Scientists: Likelihood Ratio Based Test-Based Methodology presents the data mining techniques with focus on likelihood ratio test (LRT) based methods for signal detection. It emphasizes computational aspect of LRT methodology and is pertinent for first-time researchers and graduate students venturing into this interesting field. The book is written as a reference book for professionals in pharmaceutical industry, manufactures of medical devices, and regulatory agencies. The book deals with the signal detection in drug/device evaluation, which is important in the post-market evaluation of medical products, and in the pre-market signal detection during clinical trials for monitoring procedures. It should also appeal to academic researchers, and faculty members in mathematics, statistics, biostatistics, data science, pharmacology, engineering, epidemiology, and public health. Therefore, this book is well suited for both research and teaching. Key Features: Includes a balanced discussion of art of data structure, issues in signal detection, statistical methods and analytics, and implementation of the methods Provides a comprehensive summary of the LRT methods for signal detection including the basic theory and extensions for varying datasets that may be large post-market data or pre-market clinical trial data Contains details of scientific background, statistical methods, and associated algorithms that a reader can quickly master the materials and apply methods in the book on one's own problems
Type 2 diabetes and high blood pressure
An epidemiological, cross-sectional, descriptive and analytical study of 150 women aged 18 to 85 years, residing in Berkane, was conducted. The data collected from a questionnaire including sociodemographic, anthropometric, and biological characteristics were processed and analyzed. Our study population had an average age of 50.3 years (standard deviation = 12.02 years), BMI of 30.36 kg.m-2 (簣7.3), the incidence of diabetes was 25% with only 45% of diabetics being on treatment, and 24% having a balanced hba1c. The incidence of overall hypertension was 54%, with 39% of hypertensives undergoing treatment for hypertension. Multivariate analysis showed significant associations (P
Modern Survival Analysis in Clinical Research
An important novel menu for Survival Analysis entitled Accelerated Failure Time (AFT) models has been published by IBM (international Businesss Machines) in its SPSS statistical software update of 2023. Unlike the traditional Cox regressions that work with hazards, which are the ratio of deaths and non-deaths in a sample, it works with risk of death, which is the proportion of deaths in the same sample. The latter approach may provide better sensitivity of testing, but has been seldom applied, because with computers risks are tricky and hazards because they are odds are fine. This was underscored in 1997 by Keiding and colleague statisticians from Copenhagen University who showed better-sensitive goodness of fit and null-hypothesis tests with AFT than with Cox survival tests.So far, a controlled study of a representative sample of clinical Kaplan Meier assessments, where the sensitivity of Cox regression is systematically tested against that of AFT modeling, hasnot been accomplished. This edition is the first textbook and tutorial of AFT modeling both for medical and healthcare students and for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional Cox regressions. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern data analysis methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 25 years and their research can be characterized asa continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics.
Emergence of in Vitro 3D Systems to Model Human Malaria
This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for liver-stage malaria, including principles, protocols, applications for disease modeling and drug screening, and their limitations. The initial chapter describes the basis of stem cells in liver generation during development and in adults. The subsequent chapters highlight recent and emerging advances in liver organoid and liver-on-a-chip in modeling malaria. The book presents current protocols and methods to generate liver organoid and liver-on-a-chip together with their advantages and limitations. Toward the end, the book examines the humanized mouse model of liver-stage malaria using ectopic artificial livers regarding novel readout modalities. The recent advancement and challenges in combining liver-on-a-chip technology with biosensors are highlighted for assessing hepatocyte development viability and functions. The book elucidates the potential of these 3D models to understand the biological complexity of cellular and molecular mechanisms involved in Plasmodium development in the liver, toolboxes to investigate parasite deployment in the 3D models, and to implement in drug discovery. Finally, the book discusses the future directions and challenges in the applications of liver organoids and liver on-chip in the biology of live-stage malaria. This book is helpful for researchers and scientists in the field of parasitology, cell biology, tissue engineering, and pharmacology.​
Chemotaxis Modeling of Autoimmune Inflammation
This book is directed to the computer-based modeling of chemotaxis inflammation, typically resulting from an infection by a pathogen (e.g., bacteria, viruses). The book has particular relevance to the coronavirus pandemic since long-Covid neurological impairment may be the result of brain inflammation.
Digitizing Diagnosis
A fascinating history of the first attempts to computerize medical diagnosis. Beginning in the 1950s, interdisciplinary teams of physicians, engineers, mathematicians, and philosophers began to explore the possible application of a new digital technology to one of the most central, and vexed, tasks of medicine: diagnosis. In Digitizing Diagnosis, Andrew Lea examines these efforts--and the larger questions, debates, and transformations that emerged in their wake. While surveying the continuities spanning the analog and digital worlds of medicine, Lea uncovers how the introduction of the computer to medical diagnosis reconfigured the identities of patients, diseases, and physicians. Debates about how and whether to apply computers to the problem of diagnosis, he demonstrates, were animated by larger concerns about the nature of medical reasoning, the definitions of disease, and the authority and identity of physicians and patients.In their attempts to digitize diagnosis, these interdisciplinary groups of researchers repeatedly came up against fundamental moral and philosophical questions. How should doctors classify diseases? Could humans understand, and come to trust, the opaque decision-making processes of machines? And how might computerized systems circumvent--or calcify--bias? As medical algorithms become more deeply integrated into clinical care, researchers, clinicians, and caregivers continue to grapple with these questions today.
An Accidental Advocate
An Accidental Advocate is an engrossing Erin-Brockovich style memoir with Lembi Buchanan fighting for fair tax treatment, not only for her husband Jim who lives with bipolar disorder, but also for thousands of Canadians with disabilities who have been discriminated against by a government that views chronic and persistent mental illness as being less disabling as physical impairments. Lembi takes on the Canada Revenue Agency in the Tax Court of Canada and wins big time, with a case that is upheld by the Federal Court of Appeal. An Accidental Advocate is also a deeply poignant personal story, about the power of love when their marriage is threatened by an unforgiving mental illness, time and time again. Lembi captivates her readers with honesty, humour and humility as she shares a love affair that has endured for more than 50 years. She counters the antipsychiatry movement that denies the existence of severe mental illness and denigrates their biological treatment because she and her husband chose science over unfounded theories that have no basis in medicine. In her remarkable memoir, Lembi shares the intimate details of a love story destined to last forever. Their story will resonate with families searching for answers and understanding, providing them with hope for better days ahead.This is a must read for everyone because mental illness has no boundaries and shows no discretion. Anyone can be affected at anytime.
The benefits of music therapy for palliative care patients in hospice
Research Paper (undergraduate) from the year 2023 in the subject Nursing Science - Palliative Care, grade: A, language: English, abstract: Music therapy has emerged as a valuable adjunctive intervention in palliative care settings, specifically within hospice care. This systematic review aims to explore and summarize the benefits of music therapy. 6 relevant studies were identified and included in this review. The study discusses the potential benefits of music therapy for individuals receiving palliative care due to life-limiting illnesses. It highlights how music therapy can enhance the quality of life, manage symptoms, reduce stress and anxiety, and deliver palliative care. The study draws on existing research and emphasizes the potential of music therapy as a valuable form of supportive care for patients in hospice. Music therapy is an evidence-based approach that has been shown to provide a range of benefits for palliative care patients in hospice. Research has demonstrated the effectiveness of music therapy in hospice care, and it is increasingly being recognized as a valuable form of supportive care for patients with life-limiting illnesses.
Glaucoma
The manual is intended for teachers of medical universities on technology training for practical training of students of medical and preventive medicine faculty on the subject of ophthalmology "Glaucoma". This textbook is written according to the educational standard and syllabus of the specialty 5510300 - prophylactic medicine.Along with the general methodical instructions, which should be followed when presenting theoretical material and teaching practical skills, this manual sets out the goals and objectives of the practical session, the necessary knowledge and skills of the student, the techno map of the session, situational tasks, tests, control questions, topics of independent works, handout material and used literature.
Determinants of pregnancy desire in HIV-positive women
This work concerns the determinants of the desire for pregnancy among HIV positive women under antiretroviral treatment in the District of Rwamagana. It is a post-graduate research paper for a Master's degree in Public Health. You will find the analysis of the problems, the methodology used for data collection and the main results, and finally the conclusion and the different recommendations.
The Enigma of COVID-19
Patients infected with SARS-CoV-2 show a wide spectrum of clinical manifestations ranging from mild febrile illness and cough up to acute respiratory distress syndrome, multiple organ failure and death. Data from patients with severe clinical manifestations compared to patients with mild symptoms indicate that highly dysregulated exuberant inflammatory responses correlate with severity of disease and lethality. Epithelial-immune cell interactions and elevated cytokine and chemokine levels, i.e. cytokine storm, play a central role in severity and lethality in COVID-19. Recognition by innate Pattern-recognition receptors (PPRs) and activation of central cellular signal transduction pathways were shown to play a central role in the pathophysiology of COVID-19. The impact and interplay of different additional factors, such as age, comorbidities, endemic infections with the underlying immune pathological mechanisms for COVID-19 are discussed and provide a better understanding of the disease and the development of new targets for more efficient treatment strategies. Importantly, different SARS-CoV-2 variants were found to differ in their engagement of various signalling pathways correlating with differences in their cellular tropism and pathologies. Finally, by using selected parts of the virus for immunization various very rare vaccination-associated side effects can imitate the picture of a limited COVID-19 pathological pattern. The present collection provides an excellent integrated overview on central cellular and molecular mechanisms involved in COVID-19 as well as in rare vaccination-associated side effects.
Concomitant Tuberculosis Infection in HIV-positive Patients
Document from the year 2015 in the subject Biology - Micro- and Molecular Biology, grade: A, course: Dept. of Microbiology, MLB Medical college, Jhansi, language: English, abstract: Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are two major public health problems in many parts of the world, particularly in many developing countries. TB is the most common opportunistic disease and cause of the death for those infected with HIV. Diagnosis of TB in HIV infected patients may be delayed because of atypical clinical presentation and involvement of inaccessible sites and low sputum smear positivity. Further, there has been an increase in rates of drug resistant tuberculosis, including multi-drug (MDR-TB) and extensively drug resistant TB (XDR-TB), which are difficult to treat and contribute to increased morbidity and mortality. TB is the most common serious opportunistic infection in HIV positive patients and is the manifestation of AIDS in more than 50% of cases in developing countries. TB shortens the survival of patients afflicted with HIV infection, may accelerate the progression of HIV, and is the cause of death in one third of people with AIDS worldwide. While HIV and TB can individually be the major causes for public health threats, the combination of the two has proven to have a far greater impact on the epidemiologic progression and consequently on the global health scene. Although the increased access to highly active antiretroviral therapy (HAART) has led to a reduction in HIV-associated opportunistic infections and hence mortality, but the concurrent management of HIV/TB co-infection remains a serious challenge to the health care delivery system. Discussion on the mechanisms produced by infectious cofactors with impact on disease pathology could shed light on how to design potential interventions that could decelerate disease progression. It is the need of the hour to design strategies against HIV-TB co-infection. Thi
Practical manual of videonystagmography
The development of new techniques for exploring vertigo has considerably facilitated its diagnostic and therapeutic approaches. Among these new techniques, videonystagmography (VNG) occupies a place of choice. It allows the vestibular system to be studied in real time by observing the eye. The results are presented in the form of graphs and numerical values provided automatically. The interpretation is based on the analysis of all the results. Thus, these results associated with the clinical data make it possible to have an etiological orientation in front of any vertigo. In conclusion, any practitioner who wants to be a specialist in vertigo should acquire a VNG. But, a first knowledge of the anatomophysiological bases is essential in order to know how to direct and interpret the tests.
Structural and Functional Characterization of Staphylococcus aureus Enolase
Doctoral Thesis / Dissertation from the year 2022 in the subject Biology - Micro- and Molecular Biology, grade: 9.5, course: PhD, language: English, abstract: The presence of metabolic enzymes like enolase on the surface of S. aureus has sparked considerable scientific debate. Enolase (rSaeno) is found in S. aureus as a fragile octamer and a robust dimer. The catalytic octamer resides in the cytoplasm and engages in energy metabolism, metal interchangeability, and averting the host's massive metal exploitation. In contrast, the membrane-bound dimer possesses a high affinity for host plasminogen and is involved in binding and immobilizing the host plasminogen on the S. aureus. The interaction of host plasminogen and rSaeno on the bacterial surface mediates the adherence of S. aureus to the host and subsequently arbitrates plasminogen activator-mediated activation of plasminogen. The binding of dimeric rSaeno to the kringle domain of plasminogen prevents α2-antiplasmin-mediated inhibition of plasmin. Enolase is a moonlighting protein that serves two unrelated functions in two separate cell compartments using two oligomeric conformations. Moonlighting proteins for pathogenicity saves a great deal of energy for the pathogen and allows the bacterial invasion system to remain incognito to the host. The pathogen develops an endless supply of host protease and disguises the host immune system by targeting copious host plasminogen. Although enolase is conserved across species, prominent structural variations can be utilized as potential competitive drug targets. As S. aureus employs numerous multifunctional proteins for pathological invasion, targeting enolase and other moonlighting proteins engaged in various steps of pathological invasion may serve as a potential means by which the pathological invasion of antibiotic-resistant S. aureus can be prevented.
Evidence for Occupational Therapy in Parkinson's Disease
Evidence-based medicine (EBM) is the explicit and judicious use of the most efficient evidence in making decisions about the care of individual patients. EBM does not work on the basis of intuition, it says that through clinical experience and pathophysiology concrete clinical decisions can be made, emphasizing the value of clinical examinations and scientific evidence provided for clinical research. In pathologies such as Parkinson's disease, where not only the occupational performance of the person is affected, but also his or her immediate environment. Offering treatment to people and their families, with the greatest possible certainty and efficacy, is fundamental and the MBE is the one who facilitates it.
Nutrition and Oral Health
Nutrition and oral health are interrelated. Nutrition and diet can affect overall health and well-being as well as the development and integrity of the oral cavity and the progression of oral diseases. Likewise, oral disease impacts the ability to eat and nutrition status. Thus, the purpose of this book is to focus on the nutritional aspects, which may cause both positive and negative effects on oral health and its role on oral health for the prevention and control of dental and oral diseases.
Lymphatic Drainage System
Learn about all things lymphatic health with this handy guide packed with information, advice, and strategies to increasing longevity, mastering lymphatic drainage massage, and maintaining total-body health.The lymphatic system functions as a maintenance department for the body. It controls the fluid levels in our tissues, plays an important role in the optimal performance of immune responses, and aids the production of cells and antibodies that protects us from viruses and diseases. In this Book You will learn..Eliminate inflammationIncrease energyMaintain a healthy glowImprove immune healthStep-by-step lymphatic drainage massage techniques and their benefitsSimple, healthy recipesAnd much more!This book is intended to provide information on the value of the lymphatic system to the overall body conditions. Learn about ways to optimize your health and energy by keeping your lymphatic system healthy!
War on Ivermectin
Big Pharma and health agencies cry, "Don't take ivermectin!" A media storm follows. Why then, does the science say the opposite?" Ivermectin is a dirty word in the media. It doesn't work. It's a deadly horse dewormer. Prescribe or promote it and you'll be called a right-wing quack, be banned from social media, or lose your license to practice medicine. And yet, entire countries wiped out the virus with it, and more than ninety-five studies now show it to be unequivocally effective in preventing and treating Covid-19. If it didn't work, why was there a coordinated global campaign to cancel it? What's the truth about this decades-old, Nobel Prize-winning medication? The War on Ivermectin is the personal and professional narrative of Dr. Pierre Kory and his crusade to recommend a safe, inexpensive, generic medicine as the key to ending the pandemic. Written with Jenna McCarthy, Dr. Kory's story chronicles the personal attacks, professional setbacks, and nefarious efforts of the world's major health agencies and medical journals to dismiss and deny ivermectin's efficacy. Part personal narrative, part scathing expose, The War on Ivermectin highlights the catastrophic impacts of the mass media censorship and relentless propaganda that led to the greatest humanitarian crisis in history. Although numerous studies and epidemiologic data have shown that millions of lives were saved globally with the systematic use of ivermectin, many more millions perished. This carnage was the direct result of what Dr. Kory eventually discovered to be the pharmaceutical industry's silent but deadly war on generic medicines and the corrupt, captured medical and media systems that allow it to continue. For anyone who thought Covid-19 was the enemy, Dr. Kory's book will leave no doubt that the true adversary in this war is a collective cabal of power-hungry elites who put profits over people and will stop at nothing in their quest for control. The War on Ivermectin is published through ICAN PRESS, an imprint of Skyhorse Publishing. ICAN (Informed Consent Action Network) is a nonprofit organization investigating the safety of medical procedures, pharmaceutical drugs, and vaccines while advocating for people's right to informed consent.
From Biological to Artificial Consciousness
How does consciousness emerge from a brain that consists only of physical matter and electrical / chemical reactions? The deep mysteries of consciousness have plagued philosophers and scientists for thousands of years. This book approaches the problem through scientific studies that shed light on the neural mechanism of consciousness, and furthermore, delves into the possibility of artificial consciousness, a phenomenon that may ultimately solve the mystery. Finally, two key suggestions made in the book, namely, a method to test machine consciousness and a theory hypothesizing that consciousness emerges from a neural algorithm, reveal a novel and credible pathway to mind-uploading.The original Japanese version of this book has become a best-seller in popular neuroscience and has even led to a neurotech startup for mind-uploading.
African Swine Fever Virus
This volume provides a compilation of methods that will aid researchers studying virology, immunology, and vaccinology of this devastating disease of swine. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, African Swine Fever Virus: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.
How Dancing Really Stops the Clock
This book is about the theoretical mechanics of how capillary and endothelial cells stay healthy or alternatively what causes them to get sick and die. When their infrastructures begin to lose gravitas from the loss of dance step rhythm counterbalance, the processes that evoke chronic interstitial space inflammation escalate. When this occurs, the end organ cell loses functional reserve and the interstitial space will populate disease consorts. This book goes into the mechanics of how this occurs and then how to prevent it from happening.
Benjamin Rush, Civic Health, and Human Illness in the Early American Republic
Benjamin Rush (1745-1813) casts a long shadow over American medicine as well as over the social and political history of the American republic. The Philadelphia physician involved himself in numerous social, political, and scientific projects while maintaining a busy practice and lecturing to thousands of students over his career. As a result, attempts by historians to make sense of Rush and his world have been complicated and contradictory. Nevertheless, it is within that mixed narrative of the social, medical, and political that Rush's story becomes its most compelling. At the end of the Revolutionary War, new American citizens found themselves in a new country. For Rush and his colleagues, that newness extended beyond a change in political structure. They believed that the physical challenges of growing cities and western expansion and the psychological challenges of new identities came together in ways that could help or hurt American health. From his vantage point at one of the nation's few medical schools, located in its intellectual capital, Rush developed a reputation as America's physician--while mixing social and scientific ideas for the "improvement" of the country as a whole. Putting Rush in this context, Benjamin Rush, Civic Health, and Human Illness in the Early American Republic goes beyond biography to explore his social and scientific networks and their role in the development of a distinctly American medical profession.
Health legislation and hospital management
The managerial practices in our Health Care Facilities call upon managers and lawyers to examine not only the actuality of legal texts but also the impact that health legislation could have on hospital management. The health legislation has necessarily an influence, whether positive or negative, on a health facility whether it is public or private and whatever its size and mission. A study conducted at the Yaound矇 University Hospital allowed us to analyze the influence that health legislation can have on the management of a health facility in general and that of the University Hospital in particular. This was a qualitative study during which 12 people responded to our interview on the different themes of our work. The data were collected using a semi-directive interview guide and a non-participant observation grid. They showed the existence of texts, although they need to be updated, applied by managers lacking competence. The need to update the legal texts applicable in the health field and a profound reform of the hospital system emerged.
How Dancing Really Stops the Clock
This book is about the theoretical mechanics of how capillary and endothelial cells stay healthy or alternatively what causes them to get sick and die. When their infrastructures begin to lose gravitas from the loss of dance step rhythm counterbalance, the processes that evoke chronic interstitial space inflammation escalate. When this occurs, the end organ cell loses functional reserve and the interstitial space will populate disease consorts. This book goes into the mechanics of how this occurs and then how to prevent it from happening.
BIOLOGY; Journey to Graduation Volume 1
Aristotle is known as the father of Biology. Lamarch and Treviranus gave the term Biology.Biology is a natural science concerned with studying life and living organisms and comprises many specialised disciplines that study living organisms' structure, function, growth, distribution, evolution, or other features. DNA, bacteria, trees, fish. Living things are known as organisms because of their respiration, sensitivity, growth, reproduction, waste release, and food consumption.This publication is over 400 pages and covers.Molecules, Hydrolysis, Water, Carbohydrates, Proteins, Lipids, Nucleic Acids. Protein structure and functions. Organic substances, cells, tissues, organs.Classification, biodiversity and conservation, Energy transfer in human chains, Genetic Variation and Interdependence, Transport and Exchange in various systems; respiratory, circulation, ect, arteries, Veins, capillaries, and plants. EctThe book covers syllabi from the "A" level or Senior High School and bachelor's Therefore recommended to students, doctors, nurses, healthcare professionals, lawyers, and curious people.Some qualities of organisms include;Cells are the basic unit of life. Genes are the basic units for passing traits from parent to offspring. There are different types of animal examples.Mammals, including Humans, belong to the most advanced group of organisms, animals-humans, chimpanzees or chips ( Pan Troglodytes). The most common characteristics associated with mammals include having hair or fur, giving live birth to offspring, producing milk via mammary glands, being warm-blooded, and having sweat glands.There are three types of fish; Bony, Cartilaginous and LampreysThere are more than 42 types of trees; include, including Ash trees (Fraxinus), Aspen trees, Birch trees, Cedar trees (Cedrus), Cherry trees, Conifer trees, Cottonwood trees (Populus deltoids), and Crabapple trees.
The Role of Think Tanks in Combatting COVID-19 and Improving Pandemic Preparedness
Academic Paper from the year 2023 in the subject Health - Public Health, grade: 1,0, Free University of Berlin (Otto-Suhr-Institut f羹r Politikwissenschaft), course: Global Perspectives on Megatrends and the Role of Think Tanks in International Cooperation, language: English, abstract: When the COVID-19 pandemic started, Think Tanks were just as many other institutions forced to adapt to the new circumstances. Whereas some were not able to continue with there work, most of them managed to continue with their research and used their resources to support the global fight against the pandemic. To show in which way they have influenced the handling of the pandemic and which policy recommendations they did provide to improve pandemic preparedness is the key purpose of this paper. Like never before, think tanks had to measure up to their self-claim to provide independent, high-quality research and practical policy recommendations. At the same time, they were confronted with challenges many institutions and companies that used to rely on analogue work faced during the pandemic, among others increased stress and worries of their staff followed by decreasing productivity. For think tanks this problem was accompanied by a serious lack of new research funding as a study from On Think Tanks (OTT) about the COVID-19 impacts on the sector found. However, the same study showed that the respondents (from whom nearly 85 % worked either for a think tank or a policy research programme or department) were relatively optimistic regarding the pandemic effects on their research institutions. Only 16,4 % reported serious concern about the future of their institution whereas 44 % expected to be challenged but able to handle the situation well. 31 % did not even expect too many disrupting changes because their institutes had already established remote work before (idem. 6). Some answers even had a positive angle, as the study participants expected a modernisation towards digitalization, an
The Ancestral Diet Revolution
Could the diet of our ancestors prevent, treat, and reverse most cases of overweight, coronary heart disease (CHD), cancer, type 2 diabetes, metabolic syndrome, Alzheimer's disease, dementia, age-related macular degeneration (AMD), and autoimmune disease, including multiple sclerosis, rheumatoid arthritis, lupus, Crohn's disease, and ulcerative colitis, as well as most other chronic, degenerative diseases? And is this a diet plan that is simple, effective, and allows one to eat to their heart's content? The simple answers are yes, and yes! This book presents a vast body of published and original research that results in profound conclusions: Overweight, obesity, and most all chronic diseases can be prevented simply by the elimination of processed foods and vegetable oils from the diet. And while the science and evidence presented are immense, the tenets of the authors' advice are deceptively simple. We can prevent and reverse most chronic diseases by eliminating the major processed food components - including refined flour, sugars, and most vegetable oils. Simultaneously, excess weight drops effortlessly, and energy increases, while fatigue, brain fog, and a myriad of other mysterious symptoms generally disappear. The effects of aging are obviously delayed. Most people are shocked at their results, including the authors. And what is the single most important component of an ancestral diet? The answer is as simple as the elimination of vegetable oils - oils that are extremely high in omega-6 fats - which are highly pro-oxidative, pro-inflammatory, toxic, and nutrient deficient. Come witness for yourself... the evidence is beyond compelling... it even meets the Bradford Hill criteria of 'proof, ' as the authors have clearly demonstrated.
Post-Covid Public Health
After three years of lockdowns, masks, and uncertainty, it's time to ask the question: are we done now? Is it even possible for us to return to what we once considered normal? These are important questions, which this book hopes to answer, covering topics from the crumbling of the healthcare system to why everyone had a colloquial ennui. Welcome to the aftermath.
Until It Sleeps
Ted Messimer is a ghost tour guide in Key West, Florida. In late August of 2022 he was diagnosed with a level four malignant brain tumor. He was told that at best he would have maybe five years left to live. What happens when someone that talks about spirits every night is about to become one of the tales? This book will answer that question. Follow Ted on the first eight months of his battle with brain cancer. This is a book about brain cancer. If you are someone that is currently in this battle this book will let you know that you are not alone. If you are someone that is about to begin this journey this book will let you know what to expect. If you are by the side of a loved one in this battle this book will help you better understand what they deal with on a daily basis. There are many books available that talk of brain cancer. There are many books that share a person's battle with brain cancer. This one is Ted's. This one tells of his journey. The purpose of this book is to hopefully provide insight and inspiration. It will show cancer warriors that behind every dark cloud, there is some bright light.
Global Handbook of Health Promotion Research, Vol. 1
While research teams are producing relevant and valid knowledge for health promotion, there is not yet a structured manual and distinct field of health promotion research. This timely "state-of-the-art" handbook contributes to the structuring of such a field of research. This collection of original contributions explores the major epistemological, methodological, and ethical challenges facing health promotion research. It brings together experts from different "research traditions" that coexist in the field. The handbook covers the existing knowledge production and sharing practices to delineate the "discipline" and its agenda for future research. Ultimately, it contributes to the creation of a global community of health promotion researchers. The handbook is organized by four types of practices (what people actually do) studied in health promotion; the practices of: Individuals and populations in relation to their health and itsdeterminantsProfessionals who intervene to improve population healthPolicy-makers and institutions involved in the advocacy, design, and implementation of policies and programsResearchers and innovators (academic scholars and global agencies) through which investment in research and production of evidence-based guidelines are made. Global Handbook of Health Promotion Research, Vol. 1: Mapping Health Promotion Research is a highly relevant reference tool for researchers and graduate students in health promotion, public health, education and socio-health sciences; practitioners in health, medical, and social sectors; policy-makers; and health research administrators.
Heart failure
This book is intended for medical and paramedical personnel for their daily practice. It addresses in a synthetic manner, the epidemiology, pathophysiology, diagnosis and mandatory complementary examinations in case of heart failure as well as the management according to the latest international recommendations. The cardiovascular risk factors are well detailed to allow the reader to have a look and an understanding in the prevention of cardiovascular events.
Retinal fundus images segmentation and analysis
The cup to disk ratio (CDR) is the key indicator of this disease for detecting Glaucoma. It is observed that the CDR for healthy subjects lies in 0.233-0.306 range and for Glaucoma patients it lies in the range of 0.355-0.503. These values are in accord with the gold standards. Similarly for DR, in the first stage, gray-scale image is extracted from the colored image using Principal Component Analysis (PCA) in the preprocessing step. The contrast enhancement by the Contrast Limited Adaptive Histogram Equalization (CLAHE) highlights the retinal blood vessels in the gray-scale image. These operations help in extracting retinal blood vessels in the disc and non- disc region of the image. The results are compared with state of art methods such as watershed transform.
Hair
Why is hair so news worthy? Historically, people believed in the power of hair rituals to transform an existing emotional state. Today, people are more skeptical. Certainly, responses to life crises do change over time, raising legitimate questions. In this study, I explore three current hair rituals that focus on this remarkable body part. By turning the lens, I discover how the symbolic use of hair to mourn is a rite of passage that marks real or symbolic death. In each case, a hair ritual is usefully reconfigured to meet the demands of a changing society while remaining connected to our vanished past through this stable conduit ― hair.
Yeast Functional Genomics
This second edition volume discusses the latest techniques and protocols used in the field that were not covered in the previous edition. The chapters in this book are organized into five parts. Part One looks at transcriptomic analyses and Part Two covers DNA replication and protein/DNA interactions. Part Three discusses translation dynamics, protein complexes, and proteomics. Part Four looks at genotypic screens and phenotypic profiling, and Part Five explores in silico integration of functional genomics data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Yeast Functional Genomics: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about the evolving field of yeast. Chapters 1, 9, 16, 20, 22, 24, and 25 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
"Covid" Compensation
The world was quietly going about its "normal business" when late in 2019 the entire global world of 195 countries, even China, was turned completely on its head by a fake "virus" and a fake "pandemic". However, the world was not to know at the time, and for the most part still does not know; until the publication of this book, that the entire chapter and verse of the "virus" paradigm called "SarsCov2", and its ensuing ailment "Covid19 and its "pandemic" were all total lies and fake. Lies and fake propagated by hidden persons and their nominated puppets in mostly unelected, globalist organisations beyond the reach of sovereign states: WHO, WEF, UN, World Bank etc who in reality control the world. Consequently, in early 2020 and the following months through to 2021 there was a world-wide 'nightmare' that no one seemed to fully understand or indeed understand at all. This nightmare was known variously as "Coronavirus" "Sars-Cov2" and "Covid19". Coronaviruses can cause mild disease similar to a common cold. "Sars-Cov2" - severe acute respiratory syndrome coronavirus 2 was claimed to be a "novel" (new) coronavirus and the illness "Covid19", was supposedly caused by "Sars-Cov2". Mass Induced Dystopian Nightmare The dystopian nightmare had only just begun and was to last almost two full years - 2020-2022. Horrible images appeared from China (not the most democratic country in the world) then from Italy and other countries until world-wide. Preposterous projections of not to happen global deaths based on very flawed computer models were bandied about to an unknowing mass of a very frightened and unfortunately deliberately ill-informed global population. Global mass media fanned the flames morning, day, and night for many months on end. Inappropriate quarantine measures were globally, in lockstep, imposed that restricted human movement to an inhuman level that people were not permitted to see their loved ones when their loved ones were dying in hospitals and care homes! The world was a surreal, dystopian horror story - police vans patrolling the street at night, complete lockdown and no one allowed outside except for one hours walk per day, no gatherings greater than six, empty streets, closed and boarded shops, empty parks, and empty beaches. Draconian civil rights restrictions were imposed. The Global economic and social life the world over were about to fall into total collapse. On what data were these extreme measures taken? Was the world really under such a massive threat that we had to close down global capitalism for 2 years? Had the benefits of these very severe measures been adequately assessed against the damage that they would also no doubt cause to the global economy and to individual person's lives throughout the world? No, they had not. They were simply imposed globally without recourse to any open debate or serious risk analysis. Medico-Totalitarianism strode the world like a Great Dictator with all debate and opposition silenced by the baying mob of puppet Mainstream Media. Until the publication of this book - "COVID" COMPENSATION - SHOCKING TRUTH REVEALED by the finest independent scientific, medical, and legal minds in the world.
Managing Risk During the Covid-19 Pandemic
The past 30 years have seen risk become a major field of study, most recently with the COVID-19 pandemic positioning it at the centre of public awareness, yet there is limited understanding of how risk can and should be used in policy making. This book provides an accessible guide to the key elements of risk in policy making, including its role in rhetoric to legitimise decisions and choices. Using risk as a framework, it examines how policy makers in a range of countries responded to the COVID-19 pandemic and explains why some were more successful than others.
