High Content Imaging in Drug Discovery
High content imaging is a foundational technology platform in pre-clinical drug discovery, supporting the generation of key decision-making data at most, if not all, points along the journey from target identification to the development of candidate therapeutics. The breadth of available technology and the biology to which it is applied is vast, and recent advances in the ability to generate and interpret huge datasets are a paradigm shift in how this technology can be used on a large scale in early drug discovery. This comprehensive resource covers state-of-the-art technologies, essential supporting infrastructure and data analysis approaches to support pre-clinical drug discovery. Chapters will describe key considerations and recommendations for establishing an assay for high content imaging microscopy platforms, what is required to support the use of such platforms, critical image handling infrastructure, and also how to apply high content imaging. Additionally, case studies and examples will provide a guide to the latest advances in the field, such as cell painting/morphological profiling, the inclusion of complex cellular and more advanced 3-dimensional cell models, and the use of traditionally low throughput techniques to support hit and target discovery. High Content Imaging in Drug Discovery brings together the many advances, challenges, and their solutions into a single essential resource for scientists and leaders working in high content imaging and seeking to establish capability within their drug discovery processes.
The Brigham Intensive Review of Internal Medicine
Based on the popular review course from Harvard Medical School's teaching affiliate, the Brigham and Women's Hospital, The Brigham Intensive Review of Internal Medicine, Fourth Edition, provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or recertification, this highly regarded, authoritative review tool keeps you up to date with tremendous changes in the field, incorporating detailed discussions in every chapter, essential learning points, more than 600 review questions, numerous tables and figures, and more.Organizes 100+ chapters into 10 broad sections, with one additional section devoted to board simulation. Each chapter includes a section of multiple-choice questionsShares the knowledge and expertise of leading authorities from senior faculty at Harvard Medical School, as well as former chief residents at Brigham and Women's Hospital, making this an excellent exam review tool as well as a general practice resourceIncludes new chapters on Cancer Immunotherapy and Sedation Agitation Sleep DeprivationFeatures a full-color design with clinical photos, line drawings and illustrations, radiographs, and algorithms throughoutProvides extensively revised information throughout, covering a broad range of the most common illnesses and diseases an internal medicine physician would expect to encounter in practiceOffers comprehensive coverage to reinforce existing knowledge for residents, physicians in internal medicine and family medicine, physician assistants, and nurse practitionersEnhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Additional digital ancillary content may publish up to 6 weeks following the publication date
Papillomavirus-Induced Oncogenesis
This Reprint, based on the Special Issue "Papillomavirus - Induced Oncogenesis: Current Insights and Future Directions" published in the journal Viruses, brings together a curated collection of cutting-edge research articles, reviews, and short communications that explore the diverse and complex roles of human papillomaviruses (HPVs) in cancer development.Covering a broad spectrum of topics-from viral immune evasion mechanisms and novel diagnostic biomarkers to global epidemiological trends and public health barriers-this volume provides a comprehensive overview of HPV-driven oncogenesis across multiple anatomical sites. Special attention is given to emerging research in molecular oncology, prevention strategies including vaccination, and implementation challenges in low- and middle-income settings.Edited by Dr. G. Hossein Ashrafi and Prof. Mustafa Ozdogan, with editorial support from Assistant Guest Editor Muharrem Okan Cakir, this Reprint is an essential resource for virologists, oncologists, molecular biologists, epidemiologists, and public health professionals. It serves both as a state-of-the-art reference and a catalyst for future interdisciplinary collaboration to combat HPV-related cancers worldwide.
Sport and Exercise for Health and Performance
This reprint aims to make a significant contribution to the field by exploring a broad spectrum of interconnected areas that can directly influence the safety and effectiveness of training regimens. Another key focus is the role of relational coordination between individuals, trainers, administrators, health personnel, clubs, and other stakeholders. Effective communication and coordination across these entities are critical to ensuring a safe environment for all participants.
Asian Cobras
This book provides a comprehensive analysis of Asian cobras, covering their evolution, venom composition, geographic distribution, and the clinical effects of envenomation. It discusses treatment strategies and the public health impact of cobra envenomation, making it valuable for researchers in toxinology and pharmaceutical sciences.
Breastfeeding
Successful breastfeeding has benefits for both mother and infant that extend the lifespan. Unfortunately, the health disparities in breastfeeding are striking, and the variable rate of breastfeeding across racial or ethnic groups and among individuals with different socioeconomic statuses is an under-appreciated public health crisis. Overall parity in breastfeeding rates through 6 months could substantially reduce the incidence of childhood infection and the devastation of sudden infant death syndrome. To improve public health and education, further data are needed regarding the short-term and long-term benefits of breastfeeding across diverse cohorts. For this Special Issue of Nutrients, we solicited contributions to better define and expand our shared understanding of the global benefits of breastfeeding to infants and mothers.
Remarks on the Uses of Some of the Bazaar Medicines and Common Medical Plants of India
Remarks on the Uses of Some of the Bazaar Medicines and Common Medical Plants of India
Epitome of the Pharmacopeia of the United States and the National Formulary
Epitome of the Pharmacopeia of the United States and the National Formulary
