Epitome of the Pharmacopeia of the United States and the National Formulary
Apis Mellifica; or, The Poison of the Honey-Bee, Considered as a Therapeutic Agent
Coca And Cocaine
Unlock the secrets of a bygone era with "Coca and Cocaine: Their History, Medical and Economic Uses, and Medicinal Preparations" by William Martindale. This captivating work, out of print for decades, has been meticulously restored and republished by Alpha Editions, offering a rare glimpse into the fascinating world of coca and cocaine. Dive into the pages of this cultural treasure, where Martindale expertly weaves history, science, and economics, revealing the profound impact of these substances on society. From their ancient origins to their medical applications and economic significance, this book provides an unparalleled exploration of coca and cocaine's dual nature as both remedy and vice. Whether you're a casual reader intrigued by the past or a collector of classic literature, this edition is more than just a reprint it's a beautifully restored collector's item, a testament to the enduring allure of historical knowledge. Experience the timeless relevance of Martindale's insights, preserved for today's and future generations. Don't miss the chance to own a piece of history that continues to resonate in our modern world.
Antibody-Drug Conjugates
The field of antibody-drug conjugates (ADCs) has undergone remarkable advancements in recent years, marked by significant progress in both drug approvals and ongoing clinical development. Since the approval of the first ADC in 2010 (gemtuzumab ozogamicin, Mylotarg(R)), the landscape has expanded dramatically. Today, there are 11 FDA-approved ADCs, targeting a variety of cancers across multiple indications. The approved ADCs include a range of payloads, linkers, and antibodies, each optimized for a variety of specific therapeutic targets. The increasing diversity of ADCs reflects the growing potential of these innovative treatments to address a wide array of malignancies, from hematologic cancers to solid tumors. This book aims to provide a comprehensive overview of the current state of the ADC field including the latest developments, challenges, and emerging trends, comprising expertise from a broad range of disciplines from basic research, industry, clinical practice and regulatory affairs. We explore not only the scientific and technical aspects of ADC design--such as payloads, linkers, and antibody selection--but also the developmental hurdles and regulatory complexities that influence the success of ADCs in clinical practice. Real-world examples of ADCs that have made it from the lab to the clinic offer invaluable insights into the trials and triumphs that shape this dynamic field. It is our hope that this book will serve as both a valuable resource for experts in the field and an accessible introduction for those new to the exciting world of ADCs.
Tcm Tongue Diagnosis Explained
This is a practical guide for any TCM practitioner to arrive at a clear, logical and rational TCM diagnosis with the help of tongue pictures and the patients' histories. It is a bridge between TCM and scientific, allopathic medicine. Each change of the tongue is explained from the point of view of TCM and allopathic medicine.From this comprehensive guide, the reader will be able to follow the step-by-step directions to see and understand all significant tongue changes, and thus able to arrive at an effective diagnosis and rational therapy for any patient.
Primeros Auxilios En Lugares Remotos Atenci籀n de Emergencia En La Naturaleza, Sexta Edici籀n
Microneedles
This book equips readers with a comprehensive understanding of microneedles; from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles.
Comprehensive Review of Headache Medicine
Originally designed as a resource for those preparing for board certification in headache medicine, the first edition of this book became a staple in training programs across the United States and worldwide. Building on this success, the second edition of Comprehensive Review of Headache Medicine serves as a versatile text designed for both learners and experienced practitioners who treat patients with various types of head pain, namely doctors, nurses, dentists, and therapists. Dr Morris Levin serves, once again, as the editor of this multi-authored work to ensure a useful and coherent reading experience, with current information and recommendations. The second edition begins with chapters on the anatomic and physiological foundations of head pain, followed by detailed sections on diagnosing primary and secondary headache conditions. Subsequent chapters cover the treatment of headache disorders, including special populations and complementary therapies. Expert authors have focused their chapters on the practical needs of medical, dental, and other healthcare providers. Instead of exhaustive referencing, each chapter includes a list of recommended readings and self-assessment questions, totaling around 260 throughout the book. The content has been thoroughly updated to reflect recent advances in our understanding of headache medicine and covers all required information from the headache medicine board exam.
Kumar & Clark's Cases in Clinical Medicine
This award-winning book provides a comprehensive collection of over 200 real-life clinical cases designed to support clinical reasoning and enhance diagnostic and management skills through case-based learning. The cases cover a wide range of acute symptoms and conditions encountered in medicine, with clear and concise advice on diagnosis and management. The level of detail is ideal for exam revision as well as to support junior doctors and other healthcare professionals on the wards. Now in its fifth edition, this latest Kumar & Clark has been fully updated by new editors who bring a wealth of clinical experience as well as a recent junior doctor perspective to this highly useful book.More than 200 clinical cases covering various acute symptoms and conditionsIncludes the most common MLA conditionsConcise, relevant, and fully updated with evidence-based information and the latest guidelinesClear advice on immediate and further management, complications, differential diagnoses, history-taking, tips, pitfalls, alerts, investigations, and prioritisationKey points reinforced through 'Remember', 'Investigations' and 'Information' boxesHigh-quality diagrams, tables, and photographs throughoutAn enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloudNew sections on palliative care, ophthalmology, and metabolic bone diseasesExpanded dermatology chapterFully updated and aligned to latest guidelines
Study of pharmacological benefits of some fused heterocyclic compounds
Management of a Patient with a Venous Sinus Thrombosis with or without an Intracerebral Haematoma
Development, Characterization, and Application of Bioactive Peptides, Diagnostic Biomarkers, and Pharmaceutical Proteins
As proteins and peptides are the most abundant and versatile biomolecules, playing many critical roles in nearly every life process, many proteins/peptides are also strongly associated with human health and diseases. Various protein/peptide molecules have been proposed as biomarkers with potential diagnostic or prognostic value, and renewed interests in exploring peptides/proteins as crucial targets for therapeutic purposes have arisen. Bioactive proteins/peptides including various enzymes, antibodies, and peptide hormones have been developed and serve as biopharmaceuticals for clinical use. In addition, the advances in protein/peptide technology include the development of pharmaceutical molecular platforms such as peptide nanoparticles and drug delivery systems.This Special Issue aimed to present research articles that address the topic of biopharmaceutical proteins/peptides. Studies that contribute to advancing the molecular engineering and production process of biopharmaceutical peptides/proteins, as well as papers providing novel application-oriented perspectives, were also included.
Advanced Materials for Oral Application (Volume II)
This is a reprint of the Special Issue titled "Advanced Materials for Oral Application (Volume 2)" from the journal Materials and consists of twenty-four original research articles, two review papers, and an editorial. It is focused on exploring the recent advances in the field of dental materials for prevention, direct and indirect restorations, endodontic use, and dental implants, as well as their properties and interactions with the oral environment. A scoping review on 3D bioprinting technologies, biomaterials, and cells used for dental applications is also included. The aim of this reprint is to inform the readers of the current challenges and future directions in the field of materials for oral application.
Community Pharmacy: Symptoms, Diagnosis and Treatment
Community Pharmacy: Symptoms, Diagnosis and Treatment, Sixth Edition is the ideal book to support pharmacists in identifying, diagnosing, treating or referring the illnesses and conditions they will commonly encounter in the community. A logical structure covers the full range of common presentations, including respiratory, ear, eye, gastroenterological and skin conditions. Clear pictures, referral criteria and summaries of treatment options support clinical reasoning, differential diagnosis and selection of appropriate products. Suitable for both pharmacy students and qualified pharmacists, the sixth edition has been fully updated to align with changes to the pharmacy curriculum and the rapidly expanding scope of pharmacists working in primary care and community pharmacy.Logically and clearly structured by body system - easy to use and followCovers most conditions commonly encountered in community pharmacyIncludes information on differential diagnosis, practical prescribing and product selectionFully illustrated throughout - helps the reader to recognise common conditions and illnessesIncludes red flags indicating the need for referral as well as hints and tipsSelf-assessment questions at the end of each chapter, with answer explanationsCase studies using a clinical reasoning approach to diagnosisAn enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud
Minimally Invasive Heart Surgery
Special Issue on Minimally Invasive Cardiac Surgery-guest edited by Prof. Dr. Manuel Wilbring from the "Center of Minimally Invasive Cardiac Surgery" at the University Heart Center Dresden (Dresden, Germany).
Neurodegenerative Disease
This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeutic approaches for various neurodegenerative disorders, expanding our knowledge on the biological basis and clinical research, as well as new challenges and future perspectives in neurodegeneration.
Latest Research in Post-COVID (Long COVID)
Coronavirus disease 2019 (COVID-19) has undeniably led to the worst worldwide healthcare outbreak of the twenty-first century. Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus), the agent that causes COVID-19, has dramatically improved over the past several years. Currently, healthcare systems are facing another COVID-19 outbreak in the form of long COVID or post-COVID-19 syndrome-that is, the development and presence of long-lasting symptoms after an acute SARs-CoV-2 infection. To date, more than 100 potential long-lasting post-COVID symptoms have been attributed to SARS-COV-2. This Special Issue, which is entitled "Latest Research in Post-COVID (Long-COVID): Pathological and Treatment Studies of Sequelae and Complications" as part of the journal Biomedicines, focuses on potential gaps regarding the identification, timeframe, mechanisms, and treatment strategies associated with the management of this post-COVID-19 condition. The issue includes fourteen published papers covering the following topics: (1) treatment of this post-COVID-19 condition; (2) neonatal repercussions of SARS-CoV-2 infection; (3) risk factors of severe COVID-19; (3) phenotyping of post-COVID pain; and (5) other topics.
Molecular Advances in Abiotic Stress Signaling in Plants
Plant reactions to abiotic stresses are extraordinarily complex. They take place at various levels of plant organization, starting from changes in biochemical processes, such as respiration, photosynthesis, and transpiration, and ending during morphological and anatomical changes in plant organs. However, these above-mentioned changes are preceded by the activation of efficient molecular signaling machinery, which ensures that plants tune in to external abiotic stimuli.
Pharmaceutical Manufacturing Deviation and Failure Investigations
Effects of Ionizing Radiation in Cancer Radiotherapy
For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This "targeted effect" (TE) model has been questioned by numerous observations, in which cells, that were not directly irradiated, exhibited responses similar to those of directly irradiated cells. Therefore, it is now accepted that the detrimental effects of ionizing radiation are not restricted only to irradiated cells, but also to non-irradiated adjacent or distant cells.The non-targeted effects (NTEs) of ionizing radiation, which include genomic instability, radiation-induced bystander effects, and abscopal effects, are defined as the occurrence of biological effects in non-irradiated cells because of the irradiation of other cells in the population. In opposition with TE, that display a linear dose-response, NTEs exhibit a non-linear dose-response, with a marked effect at low doses of radiation. The related cellular and molecular mechanisms of NTEs are still not completely understood, as they are mainly dependent on the cell type and the radiation quality.I am pleased to share with you this Special Issue on the "Targeted and non-targeted effects of ionizing radiation in the context of cancer radiotherapy".
Clitoria Ternatea
Aparajita, scientifically known as Clitoria ternatea, is a plant species with a long history of use in traditional medicine. This plant is recognized for its abundance of bioactive compounds, such as alkaloids, glycosides, and flavonoids, which are associated with a range of pharmacological properties. Research has demonstrated that Aparajita exhibits antioxidant, anti-inflammatory, antimicrobial, and antidiabetic effects, indicating its potential as a therapeutic agent for various health conditions.Phytochemical investigations of Aparajita have identified several bioactive constituents, including taraxerol, taraxasterol, and clitorienine. These compounds are noted for their diverse biological activities, particularly their antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, extracts from the plant have shown neuroprotective, hepatoprotective, and cardio protective effects, further underscoring its therapeutic promise.Historically, Aparajita has been utilized in traditional medicine systems, notably in Ayurveda and Unani, to address a variety of health issues such as fever, rheumatism, and digestive disorders.
