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Next-Generation Drug Delivery
This book explores advanced drug delivery systems developed through emulsification and solvent evaporation techniques, focusing on enhancing drug stability and prolonging therapeutic activity without compromising efficacy. It highlights the importance of preclinical studies to assess in vivo behavior, including organ distribution, metabolism, and pharmacokinetics. The content also addresses dosage optimization and the need for detailed kinetic studies before clinical application. With practical insights and case studies, the book serves as a guide for researchers aiming to develop stable, sustained-release formulations for improved therapeutic outcomes.
Bone and Cartilage Conduction
Sound can be transmitted to the inner ear not only through the typical air conduction pathway but also through other pathways such as bone conduction and cartilage conduction. In recent years, the development of devices utilizing these pathways has progressed, and they are now being used in clinical settings. This Special Issue covers basic research related to bone conduction, cartilage conduction, and studies on devices utilizing these methods.
From Pharmaceuticals to Biotechnolog
Gene therapy is revolutionizing medicine, offering new hope for treating genetic disorders, cancer, and other incurable diseases. From Pharmaceuticals to Biotechnology explores the cutting-edge science behind cell-penetrating peptides (CPPs)-a breakthrough in non-viral gene delivery.This book provides information about CPPs, their mechanisms, and their transformative role in modern biotechnology. Covering everything from gene therapy applications to vaccine development and CRISPR-based genome editing, this book is an essential resource for researchers, clinicians, and anyone interested in the future of medicine.Focusing on innovation and real-world applications, this book highlights how CPPs are shaping next-generation therapies. Whether you're a scientist, biotech professional, or a student, this book will guide you through one of the most exciting frontiers in biotechnology.
Capsule
In this comprehensive text, Dr. Dharmendra Kumar explores the science, technology, and practical aspects behind one of the most commonly used pharmaceutical dosage forms: capsules. The book provides a detailed overview of both hard gelatin and soft gelatin capsules, examining their composition, formulation strategies, manufacturing techniques, and quality control considerations. The author begins by introducing the fundamental types of capsules, including their advantages over other dosage forms such as tablets. Special emphasis is placed on formulation development, highlighting the selection of appropriate excipients, fill materials, and capsule shell ingredients based on drug properties and intended therapeutic outcomes. A core section of the book is devoted to the manufacturing process, covering stages like blending, encapsulation, drying, polishing, and packaging. For softgel production, Dr. Kumar outlines the rotary die process, the role of plasticizers, and factors affecting shell integrity and stability.
Impurity profiling in pharmaceuticals
Impurity profiling in pharmaceuticals refers to the process of identifying, characterizing, and quantifying any unwanted substances (impurities) present in a drug substance or drug product, which is crucial for ensuring safety and efficacy by monitoring and controlling their levels within acceptable regulatory limits; this involves using advanced analytical techniques to detect and analyze the structure of these impurities to assess potential toxicological risks.
Management of Parkinson ’s Disease
Parkinson's disease is a neurodegenerative illness that is frequently associated with motor symptoms such as bradykinesia, stiffness, resting tremor, and postural instability. Based on clinical characteristics and the patient's reaction to dopamine medication, it is usually diagnosed in the sixth or seventh decade of life. Although the precise etiology is still unknown, it is most likely the result of a genetic and environmental cocktail that kills dopamine-producing neurons in the substantia nigra.
In-Silico Selection of Syringic Acid Derivatives as Mao Inhibitors
Monoamine oxidase (MAO) inhibitors play a vital role in the treatment of various neurological and psychiatric disorders, such as depression, Parkinson's disease, and Alzheimer's disease. The identification of novel MAO inhibitors with high specificity and reduced side effects is a critical goal in drug discovery. Traditional experimental approaches, though effective, are often time-consuming and resource-intensive.This book focuses on the application of in silico screening techniques, leveraging computational tools to predict the MAO inhibitory activity of chemical compounds. By combining molecular docking, virtual screening, and structure-activity relationship (SAR) analysis, this approach offers a rapid and cost-efficient pathway to identify promising candidates for further experimental validation.The integration of in silico methodologies not only enhances the efficiency of drug discovery but also contributes to a deeper understanding of the interactions between potential inhibitors and MAO enzymes. This work aims to serve as a foundation for future research and development in this field, advancing both scientific knowledge and therapeutic innovation.
Musculoskeletal Disorders and Diseases
This Special Issue addresses recent advances and applications in the prevention and understanding of musculoskeletal disorders and diseases. This volume includes 10 high-quality studies covering topics such as biomechanical modeling, the study of ergonomic risks and postures, MSD risks in sport, the development of technical or therapeutic solutions to reduce the effects of musculoskeletal injuries, and the consequences of gait asymmetry on the onset of MSDs. By integrating methodologies based on neural networks, a Bayesian approach, the notion of virtual controllers, movement analysis and ergonomic assessments techniques, these studies aim to improve our understanding of MSDs, diagnostic accuracy and personalized treatment planning.
Selected Papers from the 2nd Conference with International Participation ”Basic Research in Endocrinology
The 2nd all-Russia conference with international participation "Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine" was held in Novosibirsk on 24-25 November 2022. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of endocrine disorders among various relevant specialists. The conference was intended for practicing endocrinologists, primary care physicians, medical geneticists, pediatric endocrinologists, pediatricians, and physician-scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists, and the 2nd-in-Russia educational course for physicians: "Maturity Onset Diabetes of the Young (MODY): Molecular Genetic Determinants and a Personalized Approach to Patient Management."
The U.S. Healthcare Ecosystem: Payers, Providers, Producers, Second Edition
An Essential Guide to the Processes and Operational Complexities of the U.S. Healthcare System The U.S. Healthcare Ecosystem, Second Edition serves as an expert navigator through the complicated and often confusing environment where healthcare payers, healthcare providers, and producers of healthcare technologies all interact. This thorough, updated resource delivers expert analysis of employer-based health insurance, pharmacy benefits, the major professions, healthcare consolidation, drug discovery and development, biotechnology, and much more.The author, a seasoned professor of management at The Wharton School, provides insight into important themes, including how the goals of healthcare relate to the "the iron triangle" (cost, quality, and access) and "the triple aim" (per capita cost, population health, and patient experience). Chapters include brief but timely cases that inspire you to think more critically about the healthcare industry and make informed assessments.The U.S. Healthcare Ecosystem, Second Edition features: Coverage of often neglected topics impacting healthcare delivery such as employer-based health insurance, pharmacy benefits, healthcare consolidation, and biotechnologyThe most current statistics and industry developmentsHelpful diagrams, charts, and tablesChapter ending summaries and Questions to PonderA 160-page Instructor Manual containing answers for the Questions to Ponder, talking points for the critical thinking exercises, as well as ready-to-use PowerPoints of all tables and figures within the textInsights and feedback from 60+ professors
The 20th Anniversary of Pharmaceuticals - Multi-Targeted Natural Products as Therapeutics
This Special Issue summarizes the latest research findings on identifying natural products targeting multiple pathways and body functions that can successfully treat multifactorial diseases. Research articles presented in this issue may be of great interest to pharmacologists, pharmacists, and physicians interested in the complementary treatment of disease.
Biomechanical Analysis in Physical Activity and Sports
This reprint, published by the Journal of Functional Morphology and Kinesiology, presents a comprehensive collection of research focused on the role of biomechanics in athletic performance. Featuring contributions from leading experts in the field, this reprint explores advanced biomechanical analysis techniques and their practical applications in sports and physical activity. Topics range from sport-specific movement analysis to the development of innovative materials for athletic equipment, as well as injury prevention and performance optimization strategies. This interdisciplinary volume is an essential resource for researchers, coaches, athletes, and professionals seeking evidence-based insights into the science of human movement and sports performance.
Isokinetics
In this fully revised third edition of Isokinetics: Muscle Testing, Interpretation and Clinical Applications, a group of international experts cover the main developments that have taken place in the field of isokinetics in the last 20 years. Isokinetic dynamometry is well recognized as the standard in assessing muscular strength status and particularly its variation following intervention. Key features of this Third Edition; New chapter on multiple joint isokinetic testing New chapter on isokinetic reconditioning in the clinical setting New chapter on isokinetics in neurological disorders New chapter on isokinetics in neuromuscular diseases New chapter on isokinetic testing and training in the elderly New chapter on isokinetic testing in children Isokinetics Third Edition provides a wealth of essential information for those especially concerned with the assessment of muscle function due to disease or injury and its rehabilitation. This fully revised book is essential reading for orthopedic and sports physicians, neurologists, physical therapists, exercise physiologists and related professionals who will find the 3rd edition an important clinical reference for their effective practice.
Glaucoma
This Reprint showcases recent advancements in glaucoma diagnosis and treatment, featuring studies on deep learning for disease detection, genetic influences on progression, and links between systemic conditions like diabetes and glaucoma. It highlights the role of OCTA in assessing microvascular changes, immune responses in glaucoma, and outcomes of minimally invasive surgeries. Additionally, the articles within the Reprint explore the therapeutic potential of nicotinamide, novel structural biomarkers, and sensory disturbances related to glaucoma. This Reprint serves as a valuable resource for clinicians and researchers seeking the latest insights in glaucoma care.
Echinoderms Metabolites
The book largely reflect the structural diversity of echinoderm metabolites including triterpene glycosides and fucosylated chondroitin sulfates, as well as branched fatty acids, di- and triacylglycerols and other lipid classes from the sea cucumbers, polyhydroxysteroids from starfish and different classes of sphingolipids from sea cucumbers and starfish. Finally, the MS-based metabolomic approach, which is very helpful for the estimation of such diversity, is discussed. The materials from the Special Issue also illustrate the biomedical potential of the presented metabolites as cytotoxins and anticoagulants. The in silico approach broadens the possibilities to investigate the mechanisms of the action of membranolytic compounds.
The New Medical Astrology
The teaching of a "New Medical-Astrology" is an attempt to bring medicine and astrology closer together again. While medicine has continued to develop and gain new insights into the organs, classical astromedicine has hardly developed at all in the last 2000 years, since the doctrine that Aries begins with the head and Pisces ends with the feet. After 40 years of thorough research, the New Medical Astrology is now based on 12 vital organ systems within the head and torso, which correspond to the 12 signs of the zodiac. Unlike in Hippocrates time more than 2000 years ago, the arms and legs do not play a major role in the new classification, as they do not represent vital organs. This work is a new connection between the psychological astrology, human anatomy, psychosomatics and eye diagnosis. This textbook forms the basis for learning astrology, New Medical Astrology, and at the same time forms a bridge to the psychosomatic explanations of illnesses in relation to the individual zodiac signs. The intention was to write a textbook in an easily understandable way and to avoid confusing foreign or technical terms that too difficult to understand. This makes it equally suitable for learning, teaching or just exploring for both young and old explorers of astrology. This astrological textbook includes the following topics: The basics of astrology, planets and elements The astrological house system based on Placidus The beginnings of Astrological Medicine The basics of the New Medical Astrology The twelve zodiac signs and their anatomical assignments The strengths and weaknesses of each zodiac sign The psychosomatic meanings to most diseases.
More Case Studies in Emergency Medicine
Following the successful book Case Studies in Emergency Medicine, More Case Studies in Emergency Medicine is another book with real, exciting and instructive case studies. Emergency physicians with many years of experience describe often dramatic and humanly touching emergency scene calls with which they have been confronted in the course of their professional lives. Each case is discussed based on the current literature and finishes with a conclusion to help in future practice. It is aimed at all those who work in emergency medicine or the emergency medical service and want to learn from the experience of their colleagues. Emergency physicians and nurses, paramedics and emergency medical technicians receive valuable tips for their own future work.
Advanced Materials for Energy Applications
This Special Issue explores frontier advances in energy-related materials science, highlighting state-of-the-art research in functional materials for energy storage, environmental remediation, process optimization, and theoretical modeling. Contributions span from bio-derived battery separators and smart electrochemical sensors to atomic-level simulations of interfacial behavior. Integrating experimental breakthroughs with computational insights, the Special Issue showcases the strategic role of innovative materials in enabling sustainable energy technologies and circular economy principles. It is ideal for researchers and professionals in materials science, energy technology, and environmental engineering.
Chitosan
Significant advancements exploiting Chitosan have been made worldwide, in order to investigate these systems according to patient requirements, both in terms of therapeutic efficacy as well as patient compliance. Such systems precisely control the release rate of the target drug to a specific site. The present review paper is an attempt to provide new insights on various physicochemical and biological characteristics of chitosan, along with its potential applications in a wide array of biomedical approaches. Chitosan has been considered as a unique and efficacious agent possessing a broad spectrum of desired characteristics. It is emphasized that recent scientific advancements in the use of this excipient as a carrier will yield new generation drug delivery systems, with better therapeutic interventions. Further studies are required to unveil the hidden beneficial properties of chitosan and its derivatives, to obtain newer delivery systems which may hold tremendous prospects in the near future.
Imaging Diagnosis in Abdomen
This Special Issue, named Imaging Diagnosis in Abdomen, provides a comprehensive overview of the latest advancements in abdominal imaging techniques, offering valuable insights for improving diagnostic precision and patient outcomes.
Patient with Suspected Cauda Equina Syndrome
Cauda equina syndrome is the clinical syndrome seen when there is acute compression of the cauda equina nerve roots and is a rare neurosurgical emergency. The approximate incidence in patients presenting with low back pain is 0.27% but delays in investigation and treatment can result in life-changing permanent disability. The best practice for patients presenting with potential cauda equina syndrome is urgent MRI imaging at the presenting hospital to avoid delays in diagnosis. Patients with a positive finding of cauda equina compression should proceed to decompressive surgery to restore the diameter of the spinal canal urgently to reduce the risk of developing a permanent deficit.
Cytotoxicity - A Crucial Toxicity Test for In Vitro Experiments
Cytotoxicity experiments are performed in order to assess the possible toxic effects and safety profiles of chemical, physical and biological agents. There are several mechanisms by which a substance may lead to cellular toxicity, including impairment of cellular functions, disruption of the cellular membrane and/or cellular signalling pathways or inducing an immune response. Cytotoxicity testing involves both in vitro and in vivo methods. In vitro methods offer a rapid and cost-effective approach, while in vivo methods provide a more comprehensive assessment. Rigorous cytotoxicity testing is essential for meeting regulatory standards, enhancing user safety, and improving the product quality of drugs, cosmetics and medical devices. Ensuring the accuracy and reliability of data obtained from in vitro cytotoxicity studies is critical for evaluating the safety profiles of different agents. In the past years, many in vitro methods have been developed to evaluate the viability of cells, and each method has its advantages, disadvantages, strengths and limitations. There are different methods for determining cytotoxicity. They can be summarized as "Staining Methods", "Colorimetric Methods", "Fluorometric Methods", "Luminometric Methods" and "Other Methods". The researchers should choose the most appropriate method for their research by considering the cell type they will use, the dose and properties of the chemical, physical and biological agents, and the mechanism through which it causes cell death (such as apoptosis, necrosis, autophagy). This book mainly focuses on cytotoxicity determination as the primary and crucial step in evaluating toxicity. In this book, the readers will find traditional and new methods used to evaluate cytotoxicity. We believe that readers will get qualified scientific knowledge and a general overview of the importance of cytotoxicity testing.
Antibiotics in Orthopedic Infections
The management of orthopedic infections has continuously been gaining increasing interest in the past few years. Various developments of new techniques have enhanced pre- and intraoperative diagnostics, leading to an increased number of identified pathogen organisms in septic but also assumed aseptic revisions. In addition to surgical debridement, knowledge about the systemic and local antibiotic therapy of bone and joint infections is an indispensable premise for a successful outcome. This Special Issue deals with all these topics and more, and it includes research articles as well as a review.
Smart Materials for Drug Delivery
-It focuses on a specific aspect of smart materials for drug delivery and discusses the properties of liposomes and how they can be used to improve drug delivery.-It explains the protein and peptide drug delivery and discusses the different types of protein and peptide drugs and how they can be delivered using smart materials.-It describes the the use of smart drug-delivery systems in the treatment of rheumatoid arthritis, phospholipid-based nano drug delivery systems of phytoconstituents and discusses how these compounds can be delivered using smart materials.-It discusses strategies to develop cyclodextrin-based nanosponges for smart drug delivery, targeted nano-drug delivery systems to colon cancer and explains the use of smart materials to target drugs to specific areas of the body.-It also explores the use of artificial intelligence in healthcare and discusses the potential applications of AI in drug delivery and other aspects of healthcare.-It discusses the applications of statistical tools for optimization and development of smart drug delivery systems and also explores the use of statistical tools to improve drug delivery and optimize the use of smart materials.-The book is an essential resource for researchers and professionals working in the field of drug delivery and nanotechnology.
Stereotactic Body Radiation and Stereotactic Ablative Radiotherapy Therapy for Cancers
Within the last decade, the radiation oncology community has witnessed increased adoption of hypo-fractionated, high-precision radiation therapy using stereotactic body radiation therapy (SBRT), also referred to as stereotactic ablative radiotherapy (SABR), across many disease sites in the thorax, abdomen, and pelvis on the basis of clinical evidence demonstrating both efficacy and safety. The indication of SBRT/SABR is poised to greatly expand in coming years especially for the management of oligometastatic and oligoprogressive disease. Technological advancements in precision patient alignment, in-room imaging, tumor motion management, and treatment machine deliveries have also expanded the feasibility of delivering ablative radiation doses while better sparing nearby critical organs, thus markedly enhancing the therapeutic ratio.Therefore, this Special Issue aims to include articles on all types of stereotactic modalities and treatments (SBRT, SABR, and others) using ultra-hypofractionated and hypofractionated high-dose-per-fraction regimens, including original research describing clinical outcomes and also describing novel treatment planning and delivery approaches.
Simultaneous Estimation Of Desoximetasone & Clotrimazole Cream BY HPLC
Estimation of active pharmaceutical ingredient is very important because it helps us to know the actual amount of drug present in formulation as per the label claim. It can be achieved by various spectroscopic, chromatographic and hyphenated techniques. Simultaneous estimation of two or more than two drugs in single formulation can be better, cost effective and less time consuming method as compared to analyze drugs individually. In simultaneous estimation, all the active drug materials are determined by using single solvent system, at one time, single equipment and by one analyst also. The main problem in simultaneous estimation is the overlapping of responses of the drug material which is very difficult to resolve by simple conventional techniques. So to overcome these type of problems, chemometric tools has been introduced which can be easily resolve and extract the information from the data obtained by using various univariate or multivariate calibration and validation methods.
High Content Imaging in Drug Discovery
High content imaging is a foundational technology platform in pre-clinical drug discovery, supporting the generation of key decision-making data at most, if not all, points along the journey from target identification to the development of candidate therapeutics. The breadth of available technology and the biology to which it is applied is vast, and recent advances in the ability to generate and interpret huge datasets are a paradigm shift in how this technology can be used on a large scale in early drug discovery. This comprehensive resource covers state-of-the-art technologies, essential supporting infrastructure and data analysis approaches to support pre-clinical drug discovery. Chapters will describe key considerations and recommendations for establishing an assay for high content imaging microscopy platforms, what is required to support the use of such platforms, critical image handling infrastructure, and also how to apply high content imaging. Additionally, case studies and examples will provide a guide to the latest advances in the field, such as cell painting/morphological profiling, the inclusion of complex cellular and more advanced 3-dimensional cell models, and the use of traditionally low throughput techniques to support hit and target discovery. High Content Imaging in Drug Discovery brings together the many advances, challenges, and their solutions into a single essential resource for scientists and leaders working in high content imaging and seeking to establish capability within their drug discovery processes.
The Brigham Intensive Review of Internal Medicine
Based on the popular review course from Harvard Medical School's teaching affiliate, the Brigham and Women's Hospital, The Brigham Intensive Review of Internal Medicine, Fourth Edition, provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or recertification, this highly regarded, authoritative review tool keeps you up to date with tremendous changes in the field, incorporating detailed discussions in every chapter, essential learning points, more than 600 review questions, numerous tables and figures, and more.Organizes 100+ chapters into 10 broad sections, with one additional section devoted to board simulation. Each chapter includes a section of multiple-choice questionsShares the knowledge and expertise of leading authorities from senior faculty at Harvard Medical School, as well as former chief residents at Brigham and Women's Hospital, making this an excellent exam review tool as well as a general practice resourceIncludes new chapters on Cancer Immunotherapy and Sedation Agitation Sleep DeprivationFeatures a full-color design with clinical photos, line drawings and illustrations, radiographs, and algorithms throughoutProvides extensively revised information throughout, covering a broad range of the most common illnesses and diseases an internal medicine physician would expect to encounter in practiceOffers comprehensive coverage to reinforce existing knowledge for residents, physicians in internal medicine and family medicine, physician assistants, and nurse practitionersEnhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Additional digital ancillary content may publish up to 6 weeks following the publication date
Papillomavirus-Induced Oncogenesis
This Reprint, based on the Special Issue "Papillomavirus - Induced Oncogenesis: Current Insights and Future Directions" published in the journal Viruses, brings together a curated collection of cutting-edge research articles, reviews, and short communications that explore the diverse and complex roles of human papillomaviruses (HPVs) in cancer development.Covering a broad spectrum of topics-from viral immune evasion mechanisms and novel diagnostic biomarkers to global epidemiological trends and public health barriers-this volume provides a comprehensive overview of HPV-driven oncogenesis across multiple anatomical sites. Special attention is given to emerging research in molecular oncology, prevention strategies including vaccination, and implementation challenges in low- and middle-income settings.Edited by Dr. G. Hossein Ashrafi and Prof. Mustafa Ozdogan, with editorial support from Assistant Guest Editor Muharrem Okan Cakir, this Reprint is an essential resource for virologists, oncologists, molecular biologists, epidemiologists, and public health professionals. It serves both as a state-of-the-art reference and a catalyst for future interdisciplinary collaboration to combat HPV-related cancers worldwide.
Sport and Exercise for Health and Performance
This reprint aims to make a significant contribution to the field by exploring a broad spectrum of interconnected areas that can directly influence the safety and effectiveness of training regimens. Another key focus is the role of relational coordination between individuals, trainers, administrators, health personnel, clubs, and other stakeholders. Effective communication and coordination across these entities are critical to ensuring a safe environment for all participants.
Asian Cobras
This book comprehensively explores Asian Cobras, covering their evolutionary history, geographic distribution, venom characteristics, pathophysiology of envenomation, and treatment strategies. The introductory chapters focus on venomous snakes, placing particular emphasis on cobras and the substantial impact of snake envenomation in Asia, where it is recognized as a neglected tropical disease. The venom delivery system, including glands, dentition, and fangs, is explored in detail. The book also explores their appearance, behavior, habitat, feeding, and mating habits, along with their geographic distribution across Asia. Further, the chapters examine the venom composition of different cobra species, highlighting the variations within and between species as well as across geographic regions, supported by advanced biochemical and proteomic analyses. The medical consequences of cobra envenomation are examined, focusing on clinical manifestations such as neurotoxicity, cytotoxicity, and other serious complications, while emphasizing the role of venom variability in determining the severity of envenomation.Key Features: Offers an in-depth overview of the evolution, taxonomy, and ecology of Asiatic cobras Explores the variability in cobra venom composition across different species and geographic regions, supported by cutting-edge biochemical, proteomic, and transcriptomic research Highlights the clinical manifestations of cobra envenomation, including neurotoxicity and cytotoxicity, and emphasizes the pathophysiological differences among cobra species Reviews the latest approaches in treating cobra envenomation, including the use of antivenoms and drug therapies Stresses the importance of public education, government initiatives, and NGOs in addressing cobra envenomation as a neglected tropical disease This book is a valuable source for researchers of toxinology, biochemistry, biotechnology, and biomedical sciences.
Breastfeeding
Successful breastfeeding has benefits for both mother and infant that extend the lifespan. Unfortunately, the health disparities in breastfeeding are striking, and the variable rate of breastfeeding across racial or ethnic groups and among individuals with different socioeconomic statuses is an under-appreciated public health crisis. Overall parity in breastfeeding rates through 6 months could substantially reduce the incidence of childhood infection and the devastation of sudden infant death syndrome. To improve public health and education, further data are needed regarding the short-term and long-term benefits of breastfeeding across diverse cohorts. For this Special Issue of Nutrients, we solicited contributions to better define and expand our shared understanding of the global benefits of breastfeeding to infants and mothers.
