Beyond Results
Your Guide to Understanding Pregnancy Blood Chemistry for Better Maternity OutcomesAs a practitioner, you understand the importance of ensuring the best outcomes for your clients. However, traditional maternity care often overlooks in-depth education on lab analysis, leaving practitioners ill-equipped. Beyond Results: The Practitioner's Guide to Functional Lab Analysis in Pregnancy decodes critical nutritional and functional lab patterns often missed in traditional maternity care. This practical guide draws from current and emerging research to give practitioners the skills to feel confident in their understanding of maternal physiology and its effects on blood chemistry. Inside these pages, you'll learn how to...Identify underlying nutritional deficiencies and functional etiologies of common lab patterns.Implement evidence-based treatment protocols based on diet and lifestyle modifications.Utilize comprehensive insights from blood work to make informed clinical decisions and improve patient care.Differentiate your practice by offering advanced functional medicine approaches that address the root causes of maternity health issues.Improve your clinical outcomes throughout all stages of your patients' childbearing years.From understanding the effects of maternal physiology on reference ranges to developing treatment plans centered on diet and lifestyle, this book will help you transform your practice and bridge the gap between conventional and functional medicine in patient care.
A Fighting Chance
This book is a motivating and empowering peek into real-life events that offer hope, assurance, and a fighting spirit during trauma. I invite you to take a glimpse into the journey of determination, endurance, mindfulness, faith, and resilience of a woman to regain her quality of life.A Fighting Chance: How to Rise Against Severe Trauma is a memoir describing Shannon's journey of survival. This is the survival story of a middle-aged woman shot in the back of the head and suffering a stroke, which led to unforeseen physical, mental, and legal issues while also dealing with a traumatic brain injury (TBI).You are invited to take a glimpse into Shannon's real-life trials and victories as she continues to fight, determined to never give up. This is a journey of strength, inspiration, and faith from a middle-aged professional woman who learned how to use several coping strategies to rise again and fight for a new life after severe brain trauma.Regrouping and fighting after any type of severe trauma in life is a journey with many twists and turns. You may have a few roadblocks in life, but if you stumble or get knocked down, don't quit and never lose hope. Therefore, never give up, because you still have a fighting chance.This book was written to encourage and inspire anyone who has experienced any type of trauma, which can include, but is not limited to a mental, physical, or emotional ordeal, or anything that has profoundly affected your life-changed your way of thinking and negatively impacted your life. As you journey with me through my story, take a moment to reflect on the questions provided at the end of each chapter. Within this book, I hope you find a spark of inspiration that will light up your life and set you on fire with flames of encouragement to keep fighting and never give up.
Acupuncture and Osteopathy to Treat Musculoskeletal Pain of the Extremities
Clear instructions explain how to use the fundamental methods of acupuncture techniques and osteopathic maneuvers to treat musculoskeletal painStep-by-step videos in the enhanced ebook, included with print purchase, demonstrate how acupuncture and osteopathy can be combined for effective treatment of musculoskeletal pain of the extremitiesWritten by an expert in acupuncture, osteopathy, physiotherapy, rehabilitation, and sports medicine, along with co-authors who are experts in acupunctureCoverage of Western medicine concepts and red flags prepares you to manage emergency conditionsAn enhanced ebook, included with print purchase, provides access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud
50 Pharmacotherapy Studies Every Palliative Practitioner Should Know
50 Phamarcotherapy Studies Every Palliative Practitioner Should Know is a compilation of key pharmacotherapy studies that form the foundation of evidence-based practice. The studies cover topics including: agitation and delirium, fatigue, nausea and vomiting, pain, anorexia and cachexia, ALS, seizure, dyspnea, anxiety, pruritis, symptom clusters, COPD, cancer, and more. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. Brief information on other relevant studies is provided, and an illustrative clinical case offers readers the opportunity to conceptualize findings. As with all books in the "50 Studies" series, each study was selected using an objective selection criterion that included citations per year, high levels of evidence, clinical studies and trials, and a 3-stage Delphi review by international experts in the field. This book is a must-read for palliative practitioners, pharmacists, advance practice nurses, and physician assistants, and anyone who wants to learn more about the data behind clinical practice.
Herbal Medicine for Rare Diseases
Many rare diseases are genetic and lack effective cures. Herbal medicine, developed by ancient healers without the benefit of modern cell biology knowledge, focuses on alleviating symptoms associated with uncommon conditions. Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations adopts an herbal medicine approach to addressing signs and symptoms of rare diseases.Each herb possesses a multitude of compounds that allow it to treat various conditions, while a single condition can often be addressed by several different herbs, illustrating complex relationships that artificial intelligence (AI) excels at deciphering. The herbal prescriptions in this book are generated using AI models, trained on a decade's worth of medical insurance data from Taiwan, featuring the use of Good Manufacturing Practice (GMP)-certified traditional Chinese medicine (TCM) products. The connection between deep learning and big data ensures that the trained AI model represents the collective wisdom of 5,000 herbal medical doctors in Taiwan who contributed to the training data.Features Prescribes granulated herbal products sourced from GMP-certified manufacturers to ensure quality and safety Provides precise dosage information for the GMP herbal products in every prescription Includes a wealth of common and alternative herbal prescriptions tailored for specific conditions or combinations thereof Cites evidence from preclinical and clinical studies of the herb and formula to offer insights into their efficacy and mechanisms In each section Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations, AI-generated prescriptions are meticulously annotated with evidence from modern pharmacological and phytochemical studies of the herbs and multi-herb formulas included in the prescriptions. This book is beneficial for health professionals and practitioners, particularly those who specialise in complementary, alternative, and herbal medicine.
Synthetic Organic Chemistry and the Nobel Prize, Volume 3
The Nobel Prize is the highest award in science, as is the case with nonscience fields too, and it is, therefore, arguably the most internationally recognized award in the world. This unique set of volumes focuses on summarizing the Nobel Prize within organic chemistry, as well as the specializations within this specialty. Any reader researching the history of the field of organic chemistry will be interested in this work. Furthermore, it serves as an outstanding resource for providing a better understanding of the circumstances that led to these amazing discoveries and what has happened as a result, in the years since.
Method Development and Validation for Voriconazole Estimation
A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 ? 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the λmax determined to be 223 nm. The method exhibited linearity over a concentration range of 5-30 繕g/mL. Validation parameters, including linearity, range, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ), were assessed and met the required standards.
Clinical Pharmacy Practice
This book equips students with foundational knowledge and practical skills necessary for pharmacy practice, focusing on delivering pharmaceutical care in clinical settings. Upon completion, students are expected to understand and provide comprehensive patient care, interpret laboratory results to support clinical diagnoses, and offer well-analyzed medicine and poison information to healthcare professionals for effective patient management.
Biological Activities and Potential Applications of Phytotoxins
This reprint focuses on the isolation and characterization of some phytotoxins and the evaluation of their biological activities for potential application in different fields. Plants and microbes are able to produce several specialized (secondary) metabolites belonging to different classes of natural compounds. Among them, phytotoxins are substances that are poisonous or toxic to plants. They seem to play an important role in plant-pathogen interactions when produced by phytopathogenic fungi or bacteria, while plant-produced phytotoxins-including allelochemicals-seem to be involved in plant-plant interactions. Thus, the determination of their chemical structure and their identification are fundamental for chemical ecology and for understanding their function. However, most of these compounds have already shown other interesting biological activities and potential applications in fields such as agriculture or medicine. In fact, some phytotoxins have already been proposed for the development of biopesticides, cosmetics, and drugs.
Development of Clotrimazole Emulgel
Clotrimazole is an imidazole derivative with a broad spectrum of anti-mycotic activity. The Present investigation is the design and characterization of Novel Emulgel of Clotrimazole. Nine different formulations of Emulgel were prepared by the proposed method of preparation by Mohammad et.al (2004), varying with different 2 different polymers of gelling agent such as Carbopol 934 and HPMC K15 M and their combinations in different ratios. All the Formulations were characterized for physical evaluation, drug content, Viscosity, spreadability, extrudability, and In-vitro Drug release studies. Stability studies were revealed with marginal differenceswith a good stability. Also this study refers to the kinetic data of the drug release studies.
Fundamentals of Gastroretentive Drug Delivery Systems
This book provides basic concepts related to gastroretentive drug delivery systems This book covers the aspects of anatomy & physiology of the GIT, approaches for gastric retention. This book also emphasizes on formulation aspects with detailed information and the evaluation aspects including the in vitro and in vivo parameters, applications and the research work done on gastroretentive systems This book will serve for under graduate students.
Anti-Retroviral Therapy (ART) in HIV/AIDS patients
It was found that patients receiving ZLN show significant increase in levels of Triglycerides, Indirect Bilirubin serum creatinine and shows slight increase in levels of Total Bilirubin, and SGPT and show significant decrease in HB levels. Patients receiving TLE drug combination shows significant increase in levels of SGPT, Indirect Bilirubin, serum creatinine and shows slight increase in levels of Total cholesterol, CD4 count and slight decrease in levels of RBC, VLDL. So, the systems that were mostly affected due to ART therapy were found to be hepatic and renal systems along with significant alterations in the lipid profile. In order to slow down the deterioration process, drug use must be optimized along with the periodic monitoring of the systems.
Salbutamol Drug Delivery by Core in Cup Device
Core and cup tablet of Salbutamol sulphate for chronotherapeutic delivery was prepared to increase the effectiveness of drug by using optimization technique.The formulation contains three components a core tablet, impermeable layer and soluble hydrophilic polymer layer. The core tablet contains salbutamol sulphate drug and other excipients, impermeable layer is made up of Ethyl cellulose (EC), and the polymer layer is made of HPMC 15cps and HPMC 50cps. In this work the key ingredients like HPMC 15cps and HPMC 50cps were optimized by using 32 Factorial designing in this various proportions of HPMC 15cps and HPMC 50cps (polymers) were used in different levels in the preparation of core in cup tablet.
Scorpion Venom
This book provides a comprehensive overview of scorpion biology and the medical implications of their venoms. It presents the taxonomic classification, anatomy, morphology, and natural habitats of scorpions, detailing their reproductive processes. It further explores the chemical nature of scorpion venom, discussing its composition, toxicity, and physiological effects, as well as its varied functions and mechanisms of action on ion channels. The chapter also focuses on scorpionism, presenting comprehensive epidemiological data and clinical insights from across the globe and reviewing the origin, evolution, and intricate composition of scorpion venom, framing its functional complexity and evolutionary significance. The book also covers the preventative measures and current treatment strategies for scorpion envenomation. It also addresses the limitations of existing antivenom therapies and examines innovative approaches, including the use of pharmaceuticals to enhance treatment protocols. The final chapter provides the promising biomedical applications of scorpion venom toxins across various medical fields. It discusses the therapeutic potential of these toxins in treating a range of human diseases, from cancer and cardiovascular diseases to autoimmune disorders and diabetes. This book is intended for researchers, clinicians, and students of toxicology, pharmacology, and arachnology.
Orally Disintegrating Tablets of Amlodipine Besylate
In the present study, orally disintegrating tablets (ODTs) of amlodipine besylate was prepared by using two types of natural super disintegrants in different ratios by direct compression method. The basic approach followed in this study was to achieve rapid disintegration. The evaluation of ODTs of amlodipine was performed for general appearance, physical parameters such as hardness, friability, wetting time, weight variation, uniformity of drug content, in vitro disintegration, in vitro dissolution studies. The above-mentioned tests were performed using the official procedures and with modified testing procedures collected from various research articles. Further the ODT formulations were subjected to further evaluation testing.
Over the Counter Medicines for Winter Illnesses
"Over-the-Counter Medicines for Winter Illnesses" is a comprehensive guide that delves into the world of self-care and medication for a variety of ailments commonly encountered during the winter season. This book is an invaluable resource for anyone seeking to understand and manage the health challenges posed by the colder months.Winter brings a unique set of health issues, from the common cold and flu to more serious conditions like pneumonia and heart attacks. This guide covers a wide range of over-the-counter (OTC) treatments for these illnesses, offering practical advice on selecting and using medications effectively and safely. The book is structured to provide an in-depth look at each condition, exploring its nature, symptoms, and the best OTC remedies available.The initial chapters focus on familiar winter woes like the common cold, flu, and bronchitis, discussing the effectiveness of various OTC options for symptom relief, from nasal decongestants to cough suppressants. It also addresses less common but equally important issues like norovirus infection, strep throat, and seasonal affective disorder (SAD), guiding readers through the myriad of OTC supplements and remedies that can help alleviate symptoms.A particularly noteworthy aspect of this book is its emphasis on understanding the illnesses themselves. It helps readers differentiate between similar symptoms and choose the most appropriate treatment. For example, the chapters on bronchitis and pneumonia highlight the importance of recognizing the severity of symptoms and when to seek professional medical attention.The book also goes beyond physical illnesses. It addresses mental health challenges like SAD, offering insights into the impact of seasonal changes and how OTC supplements and lifestyle modifications can help manage these symptoms.Chapters dedicated to conditions like asthma, heart attacks, and skin issues like eczema and dry skin, often exacerbated by cold weather, provide a holistic view of winter health. They emphasize the importance of preventive measures and understanding the role of environmental factors in these conditions.Moreover, the book doesn't shy away from exploring alternative remedies. It dedicates entire chapters to herbal and natural solutions, providing evidence-based information on how these can complement traditional OTC treatments.In its final sections, the guide emphasizes empowerment and preparedness, encouraging readers to take control of their winter health. It provides resources for creating a personalized wellness plan and staying informed about winter health management.Written in simple, accessible language, "Over-the-Counter Medicines for Winter Illnesses" is a must-have for anyone looking to navigate the challenges of winter health with confidence and knowledge. It's not just a book; it's a resource for maintaining wellness during the toughest months of the year. Whether you're a parent managing a household, a senior seeking to stay healthy, or simply someone who wants to be prepared for the winter, this book offers the guidance you need.
Toxic Sexual Politics
A bold expos矇 of how the very foundation of toxicology has been contaminated by sexist and racist ideologies The first critical understanding of the field of toxicology from a feminist and antiracist perspective, Toxic Sexual Politics asserts that the science of toxicants must be held accountable for the uneven distribution of toxic pollution along racial and sexual lines. Drawing upon in-depth interviews and extensive ethnographic and archival research, including participant observations in toxicology classrooms, conferences, and laboratories, Melina Packer urges environmental health advocates to place toxicant science within its masculinist, militarist, and eugenicist history. Toxic Sexual Politics shows how the founding fathers of U.S. toxicology were ideologically aligned with the chemical industry, inventing a science that could "make chemicals safe," as opposed to one that could adequately protect planetary health from toxicants' hazards. While many toxicologists today are critical of the chemical industry, they continue to rely on the highly limited tools of toxicology as accurate measures of toxicity, as do government regulators, the courts, and environmental advocates. Unlike most critiques of the chemical industry and narratives of environmental health movements, Toxic Sexual Politics refuses to take the science at face value. By focusing on the sexist, racist, and ableist biases reinforced by toxicology, Packer powerfully argues that this scientific discipline reproduces the very same white supremacist and heterosexist logics that generated environmental injustices in the first place. The field of toxicology can explicitly confront chemical corporate power by building from queer, feminist, anti-ableist, and antiracist movements for environmental and reproductive justice.
Phytochemical Screening & Activity of M.sapientum & P.dactylifera Leaf
The plants, Musa sapientum and Phoenix dactylifera, have been selected on the basis of its presence in Ayurveda as well as having its many traditional uses whereas not properly and scientifically explored or reported so far. Traditionally, the plants are used against diarrhea, diabetes and menorrhagia, otalgia, haemoptysis and also used as an anthelmintic etc. Impetuses have been given on the leaves of those plants for the benefits of researchers and manufacturers of formulations made from it. Further future work may be done on the leaves of those plants on other aspects, our findings say so. The anti-ulcer activity was studied and found to be new compounds (from the point of scientific evaluation) have been reported first time even though the plants (Musa sapientum and Phoenix dactylifera). Isolation and structure elucidation of certain compounds from the leaves of those plants have been done successfully, in two of the cases at least. Present work has covered all the above aspects, which have been presented in 10 chapters in a logical sequence with relevant references annexed to each chapter. In the conclusion, all the observations and findings have been placed.
My Leper Friends
NEW PRINT WITH PROFESSIONAL TYPE-SET IN CONTRAST TO SCANNED PRINTS OFFERED BY OTHERS My Leper Friends: An Account Of Personal Work Among Lepers, And Of Their Daily Life In India With A Chapter On Leprosy, By Surgeon-Major G. G. Maclaren, M.D. This book is a result of an effort made by us towards making a contribution to the preservation and repair of original classic literature. In an attempt to preserve, improve and recreate the original content, we have worked towards: 1. Type-setting & Reformatting: The complete work has been re-designed via professional layout, formatting and type-setting tools to re-create the same edition with rich typography, graphics, high quality images, and table elements, giving our readers the feel of holding a fresh and newly reprinted and/or revised edition, as opposed to other scanned & printed (Optical Character Recognition - OCR) reproductions. 2. Correction of imperfections: As the work was re-created from the scratch, therefore, it was vetted to rectify certain conventional norms with regard to typographical mistakes, hyphenations, punctuations, blurred images, missing content/pages, and/or other related subject matters, upon our consideration. Every attempt was made to rectify the imperfections related to omitted constructs in the original edition via other references. However, a few of such imperfections which could not be rectified due to intentional\unintentional omission of content in the original edition, were inherited and preserved from the original work to maintain the authenticity and construct, relevant to the work.
The effect of COVID-19 on Mental Health
The Corona virus Disease 2019 (COVID-19) is a pandemic that emerged for the first time in Wuhan, China, and spreads all over the world between December 2019 and early 2020. The state of lock-down in many parts of the world, which are contributing largely to the global economy has led to the halting of services and products. Along with the economy impacts, the ever-increasing morbidity and mortality due to COVID-19 is the biggest setback. The prevalence of epidemics accentuates or creates new stressors. The aim of our study is to determine the effect of the COVID-19 pandemic on mental health in the Indian population and their coping strategies. We found out anxiety as the prevalent problem among the participants and being female and under medical stream were associated with anxiety. Women need special attention as they were more vulnerable than evil. Finally, policymakers also need to care for younger adults, mostly students and individuals under the medical stream.
Toxic Sexual Politics
A bold expos矇 of how the very foundation of toxicology has been contaminated by sexist and racist ideologies The first critical understanding of the field of toxicology from a feminist and antiracist perspective, Toxic Sexual Politics asserts that the science of toxicants must be held accountable for the uneven distribution of toxic pollution along racial and sexual lines. Drawing upon in-depth interviews and extensive ethnographic and archival research, including participant observations in toxicology classrooms, conferences, and laboratories, Melina Packer urges environmental health advocates to place toxicant science within its masculinist, militarist, and eugenicist history. Toxic Sexual Politics shows how the founding fathers of U.S. toxicology were ideologically aligned with the chemical industry, inventing a science that could "make chemicals safe," as opposed to one that could adequately protect planetary health from toxicants' hazards. While many toxicologists today are critical of the chemical industry, they continue to rely on the highly limited tools of toxicology as accurate measures of toxicity, as do government regulators, the courts, and environmental advocates. Unlike most critiques of the chemical industry and narratives of environmental health movements, Toxic Sexual Politics refuses to take the science at face value. By focusing on the sexist, racist, and ableist biases reinforced by toxicology, Packer powerfully argues that this scientific discipline reproduces the very same white supremacist and heterosexist logics that generated environmental injustices in the first place. The field of toxicology can explicitly confront chemical corporate power by building from queer, feminist, anti-ableist, and antiracist movements for environmental and reproductive justice.
Energy Medicine
In this textbook, Dr Karl-Heinz Rauscher introduces Healing Voices Rainbow, a shamanic healing method which he has developed over the last 25 years and employs daily in his practice and online worldwide in combination with symptom constellations. Dr Rauscher has presented these healing methods in seminars and individual therapies in 16 countries and four continents, proving the effectiveness of treatment with Healing Voices Rainbow in combination with symptom constellations across different cultures. The book opens up two valuable and extremely effective healing methods in the field of energy medicine that usefully complement and enrich conventional medical treatments. As Dr Rauscher himself puts it, this book is his legacy as a doctor to the world. https: //www.dr-rauscher.de/en/buch-healing-voices-rainbow
Student’s Guide to Pharma Biochem
Welcome to Student's Guide to Pharma Biochem: Quick Tables & Memory Shortcuts, a dedicated resource for B.Pharm 2nd-semester students designed to make the study of biochemistry straightforward, visual, and easy to remember. This guide is a comprehensive yet concise collection of biochemical concepts presented in a highly accessible, student-friendly format. It is crafted specifically for students who seek an efficient and effective way to grasp the fundamentals of pharmaceutical biochemistry and prepare for exams with confidence.
Natural Compounds Applications in Drug Discovery and Development
Nature is a valuable source for the development and design of drug lead compounds that could significantly impact the treatment of serious diseases, enhancing health and wellbeing. Herbal systems play a fundamental role in healthcare, as 60% of chemotherapeutic agents are derived from natural sources. The emergence of cutting-edge technologies and methods that improve the drug design process has provided new ways of processing complex natural products, using their structures to develop new and innovative drug candidates with superior properties. Current drug discovery and development trends focus on the latest applications of natural products in the fight against some of the most difficult-to-treat diseases.In this light, the Special Issue covers a wide range of topics that provide new insights into exploring the vast array of natural products and underlines the recent advances and applications in the field. The articles of the Special Issue emphasize researchers' efforts to combat various cancers, inflammation, and diabetes by applying extraction, synthesis, and computational techniques in conjunction with experimental testing to deliver better therapeutic candidates with fewer side effects, ultimately leading to safer, more effective, and affordable treatments for patients. By integrating advanced scientific techniques with natural biodiversity exploration, it ensures that the potential of natural products is fully explored in an attempt to address unmet medical needs.
Foundations of Network Pharmacology
Network pharmacology is an interdisciplinary approach that integrates systems biology, bioinformatics, and pharmacology to study the interactions between drugs and biological networks. It emerged as a response to the limitations of traditional pharmacology, which often focuses on single targets and may not account for the complex interactions within biological systems. A new science called network pharmacology combines systems biology, bioinformatics, and pharmacology to comprehend the intricate relationships that exist between medications, targets, and illnesses. Network pharmacology adopts a comprehensive approach, taking into account the complex web of interactions within biological systems, in contrast to traditional pharmacology, which frequently concentrates on specific drug-target interactions.
Eacvi Handbook of Nuclear Cardiology
Part of the European Society of Cardiology portfolio of titles, the EACVI Handbook of Nuclear Cardiology serves as a user-friendly clinical guide to the field of nuclear cardiology. Covering all aspects of this ever-expanding area, it is an indispensable tool in the diagnosis and management of patients with heart failure (ischemic and non-ischemic), amyloid heart disease, endocarditis, myocarditis, and cardiac sarcoidosis.The handbook includes many images, tables, and bullet points that can be used daily in your busy practice to refresh your memory on various cardiac pathologies. The illustrations are derived from a typical clinical practice and the easy accessible format allows you as a reader to focus on the "typical findings" of various cardiac pathologies. Written by an international collection of experts this concise and practical handbook will appeal to students, trainees or advanced users; cardiologists, radiologists, cardiac surgeons or technicians, in their everyday practice.
Evaluation of Quality of Life in Knee Osteoarthritis Patients
Knee osteoarthritis related disability is high in the elderly population. Patients feel difficulty in walking/ jogging, an important and easy option to reduce the risk of cardiovascular disease. Stiffness, pain, other knee related symptoms may limit the patients' functional status and recreational activities. Thus, these individuals suffer from progressive impact on their activities of daily living and leads to loss in leisure, social life, sleeping quality and thus decrease in their quality of life. Worse QoL in patients with knee OA is also associated with severity of clinical manifestations and radiographic features. The QoL of knee OA patients was found to be significantly poorer than QoL compared to healthy patients (Non-OA patients).
ML for Target Identification & Validation in Drug Discovery
Machine Learning Approaches for Target Identification and Validation in Drug Discovery examines the transformative role of machine learning (ML) in enhancing the drug discovery process. The introduction highlights the importance of accurate target identification and validation, while subsequent sections delve into various ML algorithms for predicting potential drug targets based on biological data. Gene prioritization methods are discussed, showcasing how ML can effectively rank disease-associated genes. Additionally, the integration of ML with knowledge graphs is explored, illustrating how these tools enhance data connectivity and decision-making. Finally, the importance of information extraction through data mining and natural language processing is addressed, illustrating how these approaches help researchers extract valuable insights from large datasets, thereby advancing the field of drug discovery.
Pulse of Life
This book serves as a bridge between ancient Ayurvedic wisdom and contemporary wellness practices, focusing on Nadi Parikshan (pulse diagnosis). It highlights the timeless relevance of decoding bodily rhythms through the pulse to foster holistic health and well-being.Core Themes: Ancient Wisdom, Modern Context: The book traces the roots of Nadi Parikshan in classical Ayurvedic texts, illustrating its evolution as a sophisticated diagnostic tool. It argues for its importance in understanding not just physical ailments but also emotional and spiritual health.Science Behind the Art: Nadi Parikshan is both intuitive and analytical. The book unpacks its scientific underpinnings, exploring how pulse rhythms correlate with the Tridoshas (Vata, Pitta, Kapha), Prana (life force), and the body's physiological and psychological states.Techniques and Methodology: Detailed descriptions of pulse examination techniques are provided, highlighting: The practitioner's approach to feeling and interpreting the pulse.Variations in pulse based on doshas, dhatus and also the diseases.Subtle cues for identifying imbalances in doshas and dhatus (body tissues).Integration with Modern Medicine: The book emphasizes how traditional pulse analysis complements modern diagnostic tools. It envisions Nadi Parikshan as a non-invasive, personalized health assessment method that aligns with the growing emphasis on preventive healthcare.Decoding Rhythms for Holistic Wellness: The pulse is positioned as a window to the body's internal universe. By interpreting its rhythms, practitioners can decode patterns of health, imbalance, and vitality. The book also explores its application in stress management, chronic conditions, and mental health.Key Insights and Takeaways: Timeless Relevance: Nadi Parikshan is not an outdated practice but a vital diagnostic art for today's wellness revolution.Personalized Healing: It underscores Ayurveda's focus on individualized healthcare rather than a one-size-fits-all approach.Bridging Gaps: The book advocates for a synthesis of traditional diagnostics with modern wellness paradigms.
Oxford Clinical Guidelines: Newly Qualified Doctor and Oxford Handbook of Clinical Medicine Pack
Pharmacogenomics in Personalized Medicine
Pharmacogenomics in Personalized Medicine explores the relationship between an individual's genetic makeup and their response to medications. The book delves into how genetic variations influence drug metabolism, efficacy, and safety, paving the way for more personalized treatment approaches. It highlights the potential of pharmacogenomics to optimize drug therapy, reduce adverse drug reactions, and improve overall patient outcomes. The text also discusses challenges in implementing pharmacogenomics in clinical practice, such as the need for genetic testing, regulatory considerations, and integration with healthcare systems.
Clinical Utility of Optical Coherence Tomography in Ophthalmology
This Special Issue reprint compiles a series of articles focused on the latest advancements in optical coherence tomography (OCT) in ophthalmology. Initially developed to assess the posterior segment, particularly the macula and optic nerve, OCT has since expanded its applications to the anterior segment, enabling a detailed analysis of structures such as the cornea, anterior chamber, and iridocorneal angle. Recent innovations, such as intraoperative OCT, en face OCT, and wide-field OCT, have provided new insights into complex ocular structures such as the choroid, vitreous, lens, and ciliary muscle. These advancements have also improved surgical precision and postoperative evaluation in various ophthalmological subspecialties, including the retina, cornea, and glaucoma. This Special Issue reprint presents a collection of original research articles and reviews that discuss the current state of the art, address existing knowledge gaps, and highlight the clinical impact of OCT in enhancing the diagnosis, treatment, and management of a wide range of ophthalmic conditions.
Selected Papers from the pHealth 2022 Conference, Oslo, Norway, 8-10 November 2022
This reprint addresses healthcare transformation towards personalized, participative, preventive, predictive, and precision medicine (5P Medicine) with the support of new technologies such as micro-, nano-, and bio-techniques, as well as artificial intelligence and learning systems. These technologies offer big opportunities, but also bear big challenges regarding ethics including security, privacy, and related policies to be managed. The resulting multidisciplinary, highly dynamic, and context-sensitive 5PM ecosystems shall enable consistent and comprehensive interoperability between all actors, domains, specifications, and work products based on the understanding of the real-world business system and its development process viewpoints. This requires the representation and management of knowledge from different domains and their actors, using their methodologies and languages, but also individual skills and experiences. The outcome is a system-oriented, architecture-centric, ontology-based, policy-driven approach allowing for the formal representation and management of health ecosystems, including their standardized integration and interoperability in ISO 23903 Interoperability and integration Reference Architecture. The reprint describes the principles, methodologies, and standards needed for successfully managing the transformation of health and social care, exemplified by practical projects and solutions. The reprint is based on papers published in the context of the pHealth 2022 Conference in Oslo, Norway, which have been strongly extended regarding their focus and size.
Advances in Geriatric Diseases
This special issue focuses on research on relevant topics in geriatric medicine, discussing the condition of cognitive and functional decline and age-related diseases as well as polypharmacy and risk stratification. New insights into modern medicine pertaining to the issue of aging are required in order to adequately treat older chronic patients with comorbidity and polypharmacy, who should undergo complex and minimally invasive treatments.
Advances in Skull Base Tumor Surgery
This reprint of the Special Issue "Advances in Skull Base Tumor Surgery: The Practical Pearls" from the Brain Sciences Journal presents a curated collection of articles that exemplify the most complex surgical procedures for skull base surgery. This reprint serves as an invaluable resource for novice and seasoned skull base surgeons.
Pearls in Biological and Molecular Tissue Repair Pathways
The field of biological and molecular tissue repair, regeneration, and wound healing techniques and treatment strategies is a promising and continually developing area of advanced healthcare activities. There is an unmet need to treat complex pathological tissue conditions, like chronic wounds and traumatized and degenerative tissue structures, in a multidisciplinary fashion at the point of care. Clinical practitioners encounter both young and elderly patients with these complex and diverse pathologies daily, with a significant negative impact on their quality of life. Many research papers and book chapters have been produced to address and describe a variety of treatment modalities to repair, or regenerate, damaged or lost tissue structures. However, biological and molecular approaches to restore tissue function use patients' own cells (e.g., platelet-rich plasma, mesenchymal stem cells, matrix preparations) in conjunction with medical device technologies (such as lasers and hydrogen technologies) through interventional and nonsurgical procedures are less frequently cited. It is important to note that these modern treatment methods differ significantly from traditional methods of health care, as they employ a wide range of medicinal options and surgical procedures. This book provides a comprehensive and up-to-date overview of the latest advances in the field of biological and molecular tissue repair, regeneration, and wound healing to help patients be treated effectively and safely in a timely and effective manner.
Traditional Folkcure Plants in the Indian System of Medicine
The Indian system of medicine, particularly Ayurveda, has a rich tradition of utilizing medicinal plants for healing and wellness. Traditional folk cures often draw from local flora, integrating plants into daily practices for both preventive and therapeutic purposes. Here are some key plants commonly used in folk medicine across India: Tulsi (Holy Basil): Revered as a sacred plant, Tulsi is known for its anti-inflammatory and antioxidant properties. It is often used in teas and decoctions to relieve respiratory ailments, reduce stress, and enhance immunity. Neem (Azadirachta indica): Known for its purifying properties, Neem is used to treat skin conditions, infections, and as a natural insect repellent. Its leaves, bark, and oil are commonly applied in various formulations to support detoxification and enhance overall health. Amla (Phyllanthus emblica): Amla is rich in vitamin C and antioxidants. It is traditionally used to boost immunity, improve digestion, and enhance skin health. Amla juice or powder is often consumed for its rejuvenating properties. Turmeric (Curcuma longa): Widely known for its anti-inflammatory and antimicrobial effects.
Treat Them Where They Lie
This long-awaited memoir of a trailblazing emergency physician (otherwise known as "Doc Hollywood") and a former Nova Scotia Minister of Health also tells the story of modern emergency medicine. When Ron Stewart--a coal miner's son from the east coast of Canada--took a residency in emergency medicine in Los Angeles in 1972, emergency care was still in its infancy. First responders--often dispatched from fire departments or funeral homes, with hearses serving as ambulances--could put on bandages and perform CPR, but that was about it. Stewart took on a dual role as emergency physician and advisor (earning the nickname "Doc Hollywood") on the popular TV series Emergency!--where the fictional accident victims had a better chance of surviving than his real-life patients. Stewart's life's work was closing that gap, a mission he advanced by training the first generation of paramedics in LA. After sixteen years of high-stakes trailblazing in the US emergency medical system, Stewart took on the Minister of Health job in his native Nova Scotia, where he battled long odds and fierce opposition to introduce a modern Emergency Health Services system. In Treat Them Where They Lie, Ron Stewart and co-author Jim Meek tell a captivating story of passion and determination while exploring the highs and lows of a life well lived. With fifteen color images, and forewords from prominent US physician and author Dr. Brian Zink and Canada's foremost medical journalist, Dr. Brian Goldman, this riveting memoir offers readers an unvarnished look at a man who played a key role in the development of modern emergency medicine.
Ruptured Supratentorial Cerebral Artery Aneurysm with Large Intracerebral Haematoma
The ruptured aneurysm with an intracerebral haematoma is a commonly encountered neurosurgical emergency. The options for management of this situation have evolved with the changes in neurovascular surgery training and widespread use of endovascular techniques for aneurysm occlusion. This Element will discuss the differences between subarachnoid haemorrhage with or without an intracerebral haematoma including presentation, imaging and outcomes. The authors present their preferred surgical strategy including practical guidance on how to handle difficult situations such as the intra-operative rupture.
Ruptured Supratentorial Cerebral Artery Aneurysm with Large Intracerebral Haematoma
The ruptured aneurysm with an intracerebral haematoma is a commonly encountered neurosurgical emergency. The options for management of this situation have evolved with the changes in neurovascular surgery training and widespread use of endovascular techniques for aneurysm occlusion. This Element will discuss the differences between subarachnoid haemorrhage with or without an intracerebral haematoma including presentation, imaging and outcomes. The authors present their preferred surgical strategy including practical guidance on how to handle difficult situations such as the intra-operative rupture.
Protocols of Actinomycetes
Many of the natural products have been isolated and characterized from the actinobacteria, for example polyketides, phenazines, peptides, indolocarbarbazoles, and sterols. To explore new antibiotics from actinobacteria, several bioinformatics and synthetic biology tools were developed. This book covers basics to recent protocols for drug discovery from actinobacteria.Features: Discusses the benefits of production of antibiotics and enzymes from actinomycetes in a large scale Covers the synthetic biology approach Describes the strain improvement of actinobacteria Gives information on basic isolation of actinobacteria and modern techniques Covers the applications and metabolic engineering strategies of actinomycetes This book will be helpful for the pharmaceutical industries and researchers to develop new antibiotics from actinobacteria and can be used in support of future research in drug discovery.
Study of the Dispensing of Anti-Cancer Drugs
An anti-cancer drug is designed to fight cancer, whatever its mechanism. It is designed to destroy or stop the growth of malignant cells, or to help the body get rid of them more effectively. Dispensing is the pharmaceutical act that combines the dispensing of drugs, the pharmaceutical analysis of the medical prescription and the provision of information and advice necessary for the proper use of drugs (37).To study the dispensing of anticancer drugs in the M'PEWO private pharmacy from August 2023 to July 2024.This was a cross-sectional study with a 6-month survey period from December 1, 2023 to May 31, 2024.The study involved 102 registered prescriptions belonging to 85 patients. Women were more frequent. The [46 - 60] age group accounted for 37.7%. The mean age was 48.86 簣 16.45 years. Breast and gastric cancer were the most common, each accounting for 14.1%. Almost all prescriptions were written by medical specialists. All were legible, and most were sealed and dated. Availability of anticancer molecules was 99%...
The Quintessence Tantras of Tibetan Medicine
The Quintessence Tantras of Tibetan Medicine is a thorough, detailed, and systematic analysis of the characteristics of healthy and diseased bodies. Discussed are the diagnostic techniques of pulse and urine analysis, principles of right diet, right lifestyle, and behavioral factors--and a treasury of knowledge about the beneficial applications of herbs, plants, spices, minerals, gems, etc. Also included are the subtle and psychological techniques of therapeutics, and the ethics and conduct required of a Tibetan physician--a warrior-like person equipped to overcome even the most formidable internal and external obstacles.
Research on bionanocomposites with therapeutic properties
Did you come across this book by accident?This book was developed, and redeveloped, between the years 2021 and 2024. More relevant, and more competent, with each new appearance.Bio-Nano-Composite materials are the most recent pharmaceutical discovery of this century, with all their beneficial therapeutic effects and healthy natures for humans and their ecosystems.A well-written book, to be read at least once in a lifetime, for pharmaceutical biotechnologists.
Isolation of verbascoside and validation of an analytical method
In this study, the phenylpropanoid verbascoside, identified by NMR, which has pharmacological activities such as antioxidant, analgesic, anti-inflammatory and gastroprotective, was isolated from the ethyl acetate fraction of the aerial parts of Buddleja stachyoides Cham. & Schltdl. The analytical method using high-performance liquid chromatography was developed and validated to quantify the verbascoside content present in the crude alcoholic extract of the aerial parts. It proved to be reliable, sensitive, precise, simple and low-cost, as well as meeting all the validation parameters required by ANVISA's RE No. 899 of May 29, 2003. A long-chain fatty acid, identified as triacontanoic acid, was also isolated from the hexane fraction of B. stachyoides roots. This book is aimed at health professionals and researchers and offers them a contribution to research, development and the production chain of herbal medicines and/or pharmaceutical products based on extracts from B. stachyoides, or any other plant species containing the substance verbascoside.
