Microneedles
The microneedle field has been expanding exponentially with innovative designs and various applications, thus capturing the interest of academic industry and regulatory sectors.Microneedles: The Future of Drug Delivery equips readers with a comprehensive understanding of microneedles: from percutaneous absorption to microneedles production, characterization, applications in drug delivery and diagnosis, to practical perspectives on the development, manufacturing, regulatory issues, and commercialization of microneedles. This book is written by a single author and thus provides complex information in a simple, elegant, and cohesive style.The book is intended for graduate students, researchers, scientists, and engineers working in the pharmaceutical, medical, cosmeceutical, and biotechnology industry.
Comprehensive Review of Headache Medicine
Originally designed as a resource for those preparing for board certification in headache medicine, the first edition of this book became a staple in training programs across the United States and worldwide. Building on this success, the second edition of Comprehensive Review of Headache Medicine serves as a versatile text designed for both learners and experienced practitioners who treat patients with various types of head pain, namely doctors, nurses, dentists, and therapists. Dr Morris Levin serves, once again, as the editor of this multi-authored work to ensure a useful and coherent reading experience, with current information and recommendations. The second edition begins with chapters on the anatomic and physiological foundations of head pain, followed by detailed sections on diagnosing primary and secondary headache conditions. Subsequent chapters cover the treatment of headache disorders, including special populations and complementary therapies. Expert authors have focused their chapters on the practical needs of medical, dental, and other healthcare providers. Instead of exhaustive referencing, each chapter includes a list of recommended readings and self-assessment questions, totaling around 260 throughout the book. The content has been thoroughly updated to reflect recent advances in our understanding of headache medicine and covers all required information from the headache medicine board exam.
Pharmacological Evaluation of Solanum Viarum Dunal Leaves Extract
Kumar & Clark's Cases in Clinical Medicine
This award-winning book provides a comprehensive collection of over 200 real-life clinical cases designed to support clinical reasoning and enhance diagnostic and management skills through case-based learning. The cases cover a wide range of acute symptoms and conditions encountered in medicine, with clear and concise advice on diagnosis and management. The level of detail is ideal for exam revision as well as to support junior doctors and other healthcare professionals on the wards. Now in its fifth edition, this latest Kumar & Clark has been fully updated by new editors who bring a wealth of clinical experience as well as a recent junior doctor perspective to this highly useful book.More than 200 clinical cases covering various acute symptoms and conditionsIncludes the most common MLA conditionsConcise, relevant, and fully updated with evidence-based information and the latest guidelinesClear advice on immediate and further management, complications, differential diagnoses, history-taking, tips, pitfalls, alerts, investigations, and prioritisationKey points reinforced through 'Remember', 'Investigations' and 'Information' boxesHigh-quality diagrams, tables, and photographs throughoutAn enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloudNew sections on palliative care, ophthalmology, and metabolic bone diseasesExpanded dermatology chapterFully updated and aligned to latest guidelines
Advanced Materials for Oral Application (Volume II)
This is a reprint of the Special Issue titled "Advanced Materials for Oral Application (Volume 2)" from the journal Materials and consists of twenty-four original research articles, two review papers, and an editorial. It is focused on exploring the recent advances in the field of dental materials for prevention, direct and indirect restorations, endodontic use, and dental implants, as well as their properties and interactions with the oral environment. A scoping review on 3D bioprinting technologies, biomaterials, and cells used for dental applications is also included. The aim of this reprint is to inform the readers of the current challenges and future directions in the field of materials for oral application.
Development, Characterization, and Application of Bioactive Peptides, Diagnostic Biomarkers, and Pharmaceutical Proteins
As proteins and peptides are the most abundant and versatile biomolecules, playing many critical roles in nearly every life process, many proteins/peptides are also strongly associated with human health and diseases. Various protein/peptide molecules have been proposed as biomarkers with potential diagnostic or prognostic value, and renewed interests in exploring peptides/proteins as crucial targets for therapeutic purposes have arisen. Bioactive proteins/peptides including various enzymes, antibodies, and peptide hormones have been developed and serve as biopharmaceuticals for clinical use. In addition, the advances in protein/peptide technology include the development of pharmaceutical molecular platforms such as peptide nanoparticles and drug delivery systems.This Special Issue aimed to present research articles that address the topic of biopharmaceutical proteins/peptides. Studies that contribute to advancing the molecular engineering and production process of biopharmaceutical peptides/proteins, as well as papers providing novel application-oriented perspectives, were also included.
Community Pharmacy: Symptoms, Diagnosis and Treatment
Community Pharmacy: Symptoms, Diagnosis and Treatment, Sixth Edition is the ideal book to support pharmacists in identifying, diagnosing, treating or referring the illnesses and conditions they will commonly encounter in the community. A logical structure covers the full range of common presentations, including respiratory, ear, eye, gastroenterological and skin conditions. Clear pictures, referral criteria and summaries of treatment options support clinical reasoning, differential diagnosis and selection of appropriate products. Suitable for both pharmacy students and qualified pharmacists, the sixth edition has been fully updated to align with changes to the pharmacy curriculum and the rapidly expanding scope of pharmacists working in primary care and community pharmacy.Logically and clearly structured by body system - easy to use and followCovers most conditions commonly encountered in community pharmacyIncludes information on differential diagnosis, practical prescribing and product selectionFully illustrated throughout - helps the reader to recognise common conditions and illnessesIncludes red flags indicating the need for referral as well as hints and tipsSelf-assessment questions at the end of each chapter, with answer explanationsCase studies using a clinical reasoning approach to diagnosisAn enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customise your content, make notes and highlights, and have content read aloud
Neurodegenerative Disease
This Special Issue addresses the problem of treating neurodegenerative diseases from a variety of perspectives, from basic research into the molecular mechanisms responsible for a disease to reviews of the most advanced therapies available. This topic can provide exciting insights into new therapeutic approaches for various neurodegenerative disorders, expanding our knowledge on the biological basis and clinical research, as well as new challenges and future perspectives in neurodegeneration.
Minimally Invasive Heart Surgery
Special Issue on Minimally Invasive Cardiac Surgery-guest edited by Prof. Dr. Manuel Wilbring from the "Center of Minimally Invasive Cardiac Surgery" at the University Heart Center Dresden (Dresden, Germany).
Latest Research in Post-COVID (Long COVID)
Coronavirus disease 2019 (COVID-19) has undeniably led to the worst worldwide healthcare outbreak of the twenty-first century. Our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus), the agent that causes COVID-19, has dramatically improved over the past several years. Currently, healthcare systems are facing another COVID-19 outbreak in the form of long COVID or post-COVID-19 syndrome-that is, the development and presence of long-lasting symptoms after an acute SARs-CoV-2 infection. To date, more than 100 potential long-lasting post-COVID symptoms have been attributed to SARS-COV-2. This Special Issue, which is entitled "Latest Research in Post-COVID (Long-COVID): Pathological and Treatment Studies of Sequelae and Complications" as part of the journal Biomedicines, focuses on potential gaps regarding the identification, timeframe, mechanisms, and treatment strategies associated with the management of this post-COVID-19 condition. The issue includes fourteen published papers covering the following topics: (1) treatment of this post-COVID-19 condition; (2) neonatal repercussions of SARS-CoV-2 infection; (3) risk factors of severe COVID-19; (3) phenotyping of post-COVID pain; and (5) other topics.
Molecular Advances in Abiotic Stress Signaling in Plants
Plant reactions to abiotic stresses are extraordinarily complex. They take place at various levels of plant organization, starting from changes in biochemical processes, such as respiration, photosynthesis, and transpiration, and ending during morphological and anatomical changes in plant organs. However, these above-mentioned changes are preceded by the activation of efficient molecular signaling machinery, which ensures that plants tune in to external abiotic stimuli.
Effects of Ionizing Radiation in Cancer Radiotherapy
For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly DNA, or from indirect damage through reactive oxygen species produced by water radiolysis. This "targeted effect" (TE) model has been questioned by numerous observations, in which cells, that were not directly irradiated, exhibited responses similar to those of directly irradiated cells. Therefore, it is now accepted that the detrimental effects of ionizing radiation are not restricted only to irradiated cells, but also to non-irradiated adjacent or distant cells.The non-targeted effects (NTEs) of ionizing radiation, which include genomic instability, radiation-induced bystander effects, and abscopal effects, are defined as the occurrence of biological effects in non-irradiated cells because of the irradiation of other cells in the population. In opposition with TE, that display a linear dose-response, NTEs exhibit a non-linear dose-response, with a marked effect at low doses of radiation. The related cellular and molecular mechanisms of NTEs are still not completely understood, as they are mainly dependent on the cell type and the radiation quality.I am pleased to share with you this Special Issue on the "Targeted and non-targeted effects of ionizing radiation in the context of cancer radiotherapy".
Molecular Recognition in Pharmacology
This unique volume traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.Features Presents the basics of thermodynamics and kinetics of complex formation between ligands and receptors Selected novel therapeutic concepts are tested and validated Provides a review of the pharmacophore approach and drug design methods By its nature, pharmacology is a multi-disciplinary science, hence, disciplinary areas include chemistry, biology and neuroscience Discusses hot topics including 3D structure determination techniques and in silico methods and neural networks The main theme of the book is the consideration of mechanisms created by nature to protect physiologically active substances from being stuck on nonspecific acceptors in the body. The book describes the materials that aid in the development of new medicinal substances. It is intended for researchers, as well as upper-level undergraduate and graduate students interested in the problems of molecular pharmacology and drug design.
Clitoria Ternatea
Aparajita, scientifically known as Clitoria ternatea, is a plant species with a long history of use in traditional medicine. This plant is recognized for its abundance of bioactive compounds, such as alkaloids, glycosides, and flavonoids, which are associated with a range of pharmacological properties. Research has demonstrated that Aparajita exhibits antioxidant, anti-inflammatory, antimicrobial, and antidiabetic effects, indicating its potential as a therapeutic agent for various health conditions.Phytochemical investigations of Aparajita have identified several bioactive constituents, including taraxerol, taraxasterol, and clitorienine. These compounds are noted for their diverse biological activities, particularly their antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, extracts from the plant have shown neuroprotective, hepatoprotective, and cardio protective effects, further underscoring its therapeutic promise.Historically, Aparajita has been utilized in traditional medicine systems, notably in Ayurveda and Unani, to address a variety of health issues such as fever, rheumatism, and digestive disorders.
Handbook of Medicinal Plants of the World for Aging
Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways provides an unprecedented comprehensive overview of more than 100 plants used globally as medicine with the potential to prevent premature aging. This handbook covers the pathophysiology of aging from the molecular and cellular to the organ levels, as well as the current state of knowledge about the modes of action of natural products from plants on the pathophysiological pathways related to the (i) cardiovascular system and metabolism, (ii) central nervous system, (iii) kidneys, (iv) bones, (v) skin and hair, and (vi) immune system.Medicinal plants are presented alphabetically. For each plant is indicated the botanical family, synonyms, and common names in English, French, German, Portuguese, Russian, and Spanish. For each plant, the reader will also □find the part used, active principles, medical history, contemporary medicinal uses, as well as pharmacological, clinical, and toxicological studies. The bibliographical references have been carefully selected for their relevance. This handbook is intended for medical doctors, nurses, pharmacists, dieticians, and nutritionists, as well as readers with interest in health food and herbs.FEATURES Alphabetical presentation of over 100 medicinal plants and the pharmacological rationales for their uses for aging Discusses the medical history, current medicinal uses, and potential candidates for the prevention of premature aging Introduces the molecular mechanism of natural products on the pathophysiology of aging Contains a selection of bibliographic references A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways presents comment sections that invite further research and reflection on the fascinating and timely subject of herbals for healthy aging. This is an ideal reference text for medicinal plant enthusiasts.
Regulatory Aspects of Pharmaceutical Quality System
If you're a B. Pharm or M. Pharm student seeking a comprehensive yet concise guide to the regulatory aspects of pharmaceutical quality systems, look no further than Regulatory Aspects of Pharmaceutical Quality System - Brief Introduction. While other textbooks on quality assurance cover a variety of topics to varying degrees of depth, this book provides a unified approach that is both insightful and practical. Designed to meet the needs of modern students and instructors, this book covers the basic guidelines and principles of quality assurance as they relate specifically to drug design, development, and evaluation. You'll learn about the latest developments in the industry and how to apply these principles to the real-world challenges that you're likely to encounter. Whether you're a seasoned pharmaceutical professional or just starting out, you'll find this book to be an invaluable resource that you'll refer to time and time again.
MCQs in Pharmacology and Toxicology
"MCQs in Pharmacology and Toxicology" offers a deep dive into the world of pharmacology, providing an analysis and study of the subject based on many reputed books and paragraphs. The result is a vast collection of multiple-choice questions that cover important concepts and theories within pharmacology and toxicology. The book is designed to provide students with a systematic approach to studying the subject matter, and it encourages readers to follow the "MCQs in Pharmacology and Toxicology" book as a foundational resource. Additionally, all of the questions in the book align with theory lectures that are offered by Solution Pharmacy, India's top YouTube channel for pharmacy-related study materials. One of the unique features of this book is that it is designed in a partwise pattern that helps students develop a deep understanding of the subject matter. It also includes a comprehensive answer key with correct options and option names located at the end of each question set. Finally, students can take advantage of the offline and online MCQs available in the Solution Pharmacy mobile application. Whether you're prepping for a licensing exam or simply want to deepen your knowledge of pharmacology and toxicology. "MCQs in Pharmacology and Toxicology" is an essential resource for mastering pharmacology.
Emergency Medicine Thinker
'Emergency Medicine Thinker' is a practical pocketbook that provides important considerations for the practice of emergency medicine. Based on the popular website created by the authors, 'emDocs.net', it covers practical thinking rules that can be applied on an emergency medicine shift and provides approaches to common and life-threatening diseases in the ED that physicians see on a regular basis. Easy to read with quick access to information, and full of essential tips and pearls from experts on the emergency frontlines, this is a handbook that can be used at the bedside on shift. Part 1 of the book explores the EM decision-making process and why it's important from a myriad of central and talented emergency physicians. Part 2 features over 170 pearls for the frontline EM clinician. This book is a must-have for anyone working in emergency medicine.
Pharmacovigilance
Written by multidisciplinary experts in the fields of pharmaceutical and patient safety, Pharmacovigilance: A Practical Approach, Second Edition, provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. From cover to cover, this concise resource offers essential information for physicians and other health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance.Presents vital, easy-to-read, cutting-edge information on patient safety, the pharmacology regulatory landscape, and the current and future use of digital technologiesProvides up-to-date coverage of hot topics in the field, including pharmacodynamic and safety precision medicine, immunogenicity, vaccine hesitancy and safety, genetic toxicology, and adverse eventsContains new chapters on pre-clinical safety assessment, pharmacogenetics, first-in human trials, product aggregate safety assessment, data monitoring committees, and moreOffers new and expanded coverage of pharmacovigilance in early pre-clinical drug development through post-marketing surveillance, as well as a blueprint for training future pharmacovigilance professionalsIncludes real-world case studies to ensure content is relevant and applicable to everyday practiceDiscusses a range of topics across disciplines and how they relate to pharmacovigilance, including behavioral science, patient perspectives, and risk communicationAn eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Case of Filaria loa
Unlock the Mysteries of a Medical Marvel: ""Case of Filaria loa"" by Douglas Argyll Robertson Dive into the captivating world of medical discovery with ""Case of Filaria loa,"" a groundbreaking work by the esteemed Douglas Argyll Robertson. This fascinating exploration of the Filaria loa parasite, a rare and intriguing nematode, offers readers a unique glimpse into the challenges and triumphs of 19th-century medical science. Once lost to the sands of time, this extraordinary book has been out of print for decades. Now, thanks to the dedicated efforts of Alpha Editions, it has been lovingly republished for the current and future generations. This is not just a book; it's a collector's edition-a treasure trove for enthusiasts of medical history and curious minds alike. With its compelling narrative and insightful observations, ""Case of Filaria loa"" invites you to journey alongside Robertson as he unravels the mysteries of this elusive parasite. Whether you're a medical professional, a history buff, or simply a lover of intriguing tales, this book promises to enlighten and inspire. Don't miss your chance to own a piece of medical history. Add this rare gem to your collection today and discover why ""Case of Filaria loa"" continues to captivate readers over a century later.
The anatomy of drunkenness
Unlock the Secrets of the Past with a Timeless Classic! Dive into the fascinating world of ""The Anatomy of Drunkenness"" by Robert Macnish, a captivating exploration of the human condition and its age-old relationship with alcohol. First published in the 19th century and out of print for decades, this remarkable work has been lovingly republished by Alpha Editions for the current and future generations. Macnish's insightful and often humorous examination of intoxication, its effects, and its cultural significance offers readers a unique glimpse into the past while remaining strikingly relevant today. Whether you're a history enthusiast, a psychology buff, or simply curious about the quirks of human behavior, this book is a must-have addition to your collection. More than just a book, this is a collector's edition-a rare gem that promises to enlighten, entertain, and provoke thought. Don't miss your chance to own a piece of literary history that continues to resonate through the ages. Grab your copy now and embark on a journey through the intoxicating pages of ""The Anatomy of Drunkenness""!
Chronicles of Pharmacy, Vol. 2
Discover the Fascinating World of Pharmacy Through the Ages! Step into the captivating realm of ""Chronicles of Pharmacy, Vol. 2"" by A. C. Wootton, a timeless treasure that has been out of print for decades and is now beautifully republished by Alpha Editions for the curious minds of today and tomorrow. This collector's edition is not just a book; it's a journey through the rich legacy of pharmaceutical history, unraveling the secrets and stories behind the evolution of medicine. From ancient potions to groundbreaking discoveries, Wootton's masterful narrative brings to life the pivotal moments and remarkable figures that have shaped the world of pharmacy. Whether you're a history enthusiast, a medical professional, or simply someone with a thirst for knowledge, this book offers a unique glimpse into the past, illuminating the path to modern medicine. Don't miss your chance to own a piece of history. Dive into ""Chronicles of Pharmacy, Vol. 2"" and let the adventure begin!
Prevention, Diagnosis and Treatments of Early-Stage NSCLC
The following Special Issue on the "Prevention, Diagnosis and Treatments of Early-Stage NSCLC: New Advances and Future Prospective" forms a collection of articles showcasing the latest scientific progress in this field, focusing particular attention on minimally invasive techniques such as video-assisted thoracic surgery (VATS) and robotic-assisted thoracic surgery (RATS) compared to open surgery both for early and long-term outcomes in addition to the role of sublobar resection for the treatment of early-stage NSCLC compared to lobectomy. Moreover, we also focus on the importance of recently identified potential biomarkers such as TLR expression to be used for future prognostic purposes in NSCLC and the importance of enhancing immune response in NSCLC patients with the use of the 13-valent pneumococcal conjugate vaccine (PCV13).