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Formulation and Development of Bilayer Floating Tablets of Nifedipine
The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
Use of Lidocaine for preventing Propofol induced pain
Propofol (2, 6-di-isopropylphenol) is a popular intra venous (IV) anaesthetic induction drug associated with smooth induction and rapid recovery. It is the most widely used IV induction agent for a large variety of purposes like induction of general anaesthesia, total intravenous anaesthesia, sedation, anticonvulsant and as an anti- emetic.However, pain on injection, is a clinical disadvantage of the drug, which, according to quantitative systematic reviews, has been reported in up to 70% of patients. Some patients recall the pain on injection as the most uncomfortable experience during surgery .Many interventions have been been developed and studied example, injection sites, infusion rate, temperature, microfiltration, venous occlusion and bacteriostatic saline. Objective of the current research was to assess and compare the efficacy of intravenous lidocaine with different concentrations in reducing the incidence and severity of propofol injection pain.
Nanotubes de carbone ? parois multiples portant de l'art矇sunate pour le paludisme c矇r矇bral
Le paludisme est l'un des principaux probl癡mes de sant矇 caus矇s par un protozoaire appartenant au genre plasmodium. Le paludisme c矇r矇bral comprend les reflets cliniques du paludisme ? plasmodium falciparum qui provoque des alt矇rations de l'矇tat mental et parfois, le coma. Il s'agit d'une maladie intense du cerveau, provoquant des l矇sions annulaires dans le cerveau, accompagn矇es de fi癡vre. Le patient doit 礙tre trait矇 le plus t繫t possible, car la malaria c矇r矇brale est fatale dans les 24 ? 72 heures. Ainsi, les f-MWCNTS constituent une meilleure plateforme pour prot矇ger le bioactif de la d矇gradation dans le milieu endosomal, ce qui permet d'obtenir une meilleure efficacit矇 bioactive intracellulaire. La fonctionnalisation des MWCNT am矇liore leur efficacit矇, en raison de leur capacit矇 d'internalisation accrue ou d'une absorption intracellulaire efficace, tout en augmentant leur dispersibilit矇. L'art矇sunate a pu 礙tre charg矇 avec succ癡s dans les MWCNT purifi矇s ainsi que dans divers MWCNT fonctionnalis矇s. Les MWCNT conjugu矇s au mannose pr矇sentent la plus grande efficacit矇 de pi矇geage et une lib矇ration prolong矇e. La mannosylation a am矇lior矇 la dispersibilit矇 des MWCNT dans les solvants aqueux et ceux-ci peuvent 礙tre d矇velopp矇s pour l'administration de diff矇rents bioactifs ainsi que pour le ciblage du tissu c矇r矇bral ? l'aide d'un ligand actif (mannose).
Fungal Infections Complicating COVID-19
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread globally to pandemic proportions. Although the majority of cases have asymptomatic or mild infections, a significant proportion of cases progress to severe pneumonia and acute respiratory distress syndrome requiring critical care. Opportunistic infections following severe respiratory viral infections have been recognized since the 1918 influenza pandemic. Among critically ill patients with COVID-19, secondary fungal infections caused by Aspergillus and Candida spp. are increasingly described, affecting up to 30% of COVID-19 patients requiring intensive care treatment. This collection of manuscripts focuses on fungal infections complicating COVID-19, including immunological mechanisms and pathogenesis, diagnosis, and treatment.
Disaster Planning
As disasters become more frequent and severe worldwide, disaster planning as a human endeavor is more important than ever, with the potential to save millions of lives globally. In this important new book, the author offers a practical, step-by-step guide for writing, implementing, and measuring the quality of your own disaster plan to address any threat with an approach that has been tested in public health and medical settings worldwide. Filling a significant gap in the existing literature, this book offers a comprehensive reference for both the principles and the practice of disaster planning. Access to a 25-lecture training course provides ancillary teaching materials for college level courses, offering added value for academic readers. An essential resource for public health graduates and anyone responsible for the management of disasters, primarily public health professionals, emergency physicians, first responders, and emergency managers.
Rare Disease Drug Development
This book provides a broad overview of rare disease drug development. It offers unique insights from various perspectives, including third-party capital providers, caregivers, patient advocacy groups, drug development professionals, marketing and commercial experts, and patients. A unique reference, the book begins with narratives on the many challenges faced by rare disease patient and their caregivers. Subsequent chapters underscore the critical, multidimensional role of patient advocacy groups and the novel approaches to related clinical trials, investment decisions, and the optimization of rare disease registries. The book addresses various rare disease drug development processes by disciplines such as oncology, hematology, pediatrics, and gene therapy. Chapters then address the operational aspects of drug development, including approval processes, development accelerations, and market access strategies. The book concludes with reflections on the authors' case forreal-world data and evidence generation in orphan medicinal drug development. Rare Disease Drug Development is an expertly written text optimized for biopharmaceutical R&D experts, commercial experts, third-party capital providers, patient advocacy groups, patients, and caregivers.
How to Save Your Loved Ones From COVID
EARLY TREATMENT IS THE KEYAre you or a loved one vulnerable to COVID-19? Are you unable (or unwilling) to take the vaccines? Do you live in fear of this disease?This is knowledge about the prevention and treatment of Covid that may make you and your loved ones much safer.Inside this book you will learn: The Four Key Supplements for preventing COVID-19.The inexpensive, incredibly effective prescription medicine that usually stops COVID-19 in its tracks.How to know exactly when to go to the hospital. (If you go too soon, they just send you home.)The reason people don't know all of this. (Hint: Follow the Money.)
Phytochemistry of Plants of Genus Ocimum
This book describes an efficient and accurate UPLC-ESI-QqQLIT-MS/MS method for quality control of O. Sanctum derived formulations which was validated for simultaneous determination of twenty-three bioactive markers including phenolic acids, flavonoids, propenyl phenol and terpenoid in the leaf extract.
Phytochemistry of Plants of Genus Phyllanthus
This book deals with the importance of separation techniques in screening of major lignans, flavonoids and terpenoids in Phyllanthus species using HPLC/UPLC coupled with mass spectrometric techniques.
Phytochemistry of Plants of Genus Piper
This book describes ultra-performance liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry in multiple reactions monitoring (MRM) mode with continuous polarity switching in the species to study the quantitative variation of thirteen bioactive markers in different plant parts of ten Piper species.
Sustainable Agriculture Reviews 43
Preface; Ankit Saneja, Amulya K. Panda and Eric Lichtfouse 1. Pharmaceutical technology for improving the of bioavailability of natural products; Shweta Paroha, Rikeshwer P. Dewangan and Pravat K. Sahoo 2. Solubility Enhancement Techniques for Natural Product Delivery; Harsha Jain and Naveen Chella 3. Delivery of natural products using polymeric particles for cancer chemotherapeutics; Rahul Ahuja, Neha Panwar, Hairam Meena, Debi P. Sarkar and Amulya K. Panda 4. Chemistry, pharmacology and therapeutic delivery of major tea constituents; Ajay Rana and Sanjay Kumar 5. Current approaches and recent advances in Galantamine Delivery for Alzheimer's; Shweta Sharma 6. Overview of Paclitaxel Delivery Systems; A. Prabakaran, Kar Sourav, K. Vignesh and Ujwal Kolhe 7. Phytosomes as an emerging nanotechnology for herbal drug delivery; Dinesh Kumar, Nitin Vats, Kamal Saroha and Avtar Chand Rana 8. Albumin as natural versatile drug carrier and various diseases treatment; Hitesh Kumar Dewangan
Hereditary Hemorrhagic Telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.
The Immunology and Biology of Brain Tumors
Immunotherapy has become a viable treatment modality for a variety of cancers (and referred to as Science Magazine's "Breakthrough of the Year" in 2013, as well as ASCO's "Advance of the Year" in both 2016 and 2017). This Special Issue is focused on the relevance of immunobiology in brain tumors, touching on elements of immune suppression, immune stimulation, and the immune microenvironment, with culminations in translational immunotherapy.
Rehabilitation from COVID-19
This book contains basic knowledge about COVID-19, including its etiology, pathogenesis and treatment both in traditional Chinese medicine and western medicine. It includes relative assessment and rehabilitation targeting residual dysfunctions due to COVID-19, such as pulmonary dysfunction, mental disorders, and malnutrition, among others.
Sustainable Agriculture Reviews 44
Preface; Ankit Saneja, Amulya K. Panda and Eric Lichtfouse 01. Nanotechnology applications for natural products delivery; Anna Rita Bilia, Vieri Piazzini and Maria Camilla Bergonzi 02. Nanotechnology-inspired bionanosystems for valorization of natural origin extracts; Ana Catarina Sousa Gon癟alves, Ana Sofia Mendes Ferreita, Alberto Dias, Marisa P. S獺rria and Andreia Castro Gomes 03. Nanocarriers as tools for delivery of nature derived compounds and extracts with therapeutic activity; Raja Saka and Naveen Chella 04. Nanoemulsions as optimized vehicles for essential oils; Tha穩s N. Barradas and K. Gyselle de Holanda e Silva 05. Lipid Nanoarchitectonics for Natural Products Delivery in Cancer Therapy; Vishal Chaudhari, Prakash Kishore Hazam and Subham Banerjee 06. Inorganic particles for delivering natural products; Jairam Meena, Anuradha Gupta, Rahul Ahuja, Amulya K. Panda and Sangeeta Bhaskar 07. Nanotechnology based targeting strategies for the delivery of camptothecin; Santwana Padhi and Anindita Behera
CAH Screening
The aim of this Special Issue of the International Journal of Neonatal Screening on Newborn Screening for Congenital Adrenal Hyperplasia (CAH) is to describe the current state of CAH newborn screening around the world, with a focus on efforts to find solutions to obstacles and on successful strategies to improve the efficiency of CAH screening. It provides insight into the dilemma of optimal timing for specimen collection, successful strategies to reduce the relatively high screening false positive rate, as well as strategies to address limitations in clinical follow-up and the availability of treatment.
Sulfur-Containing Marine Bioactives
Sulfur is an essential element for all living organisms and is required by algae, plants, fungi, animals, and humans for growth and development. It is present in a variety of biomolecules involved in many biological functions, including the maintenance of cell redox homeostasis, defense, and detoxifying processes. The alteration of sulfur compound metabolism may lead to human diseases as well as to plant and animal pathologies. The marine environment, which is characterized by a high biodiversity of species and a great chemical diversity, represents a great potential source of bioactive sulfur molecules. A broad range of biologically active sulfur compounds with unique structures and pharmacological properties have been reported to occur in marine organisms, from amino acids to different sulfated derivatives. Great attention is also focused on sulfur metabolites in the marine microbial world in relation to the global sulfur cycle. The aim of this Special Issue is to present existing knowledge and recent studies on sulfur-containing marine bioactive compounds in different biological systems. Attention is also focused on metabolites active at the ecological level.
Formulation and Evaluation of Transdermal Patches of Ibuprofen
In the present study, Transdermal drug delivery of Ibuprofen was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of Transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as Permeation enhancer and Plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters, In-vitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.5% drug release in 12 hours. For F6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that they were no interactions.
Interventional Pain Procedure Templates
About this book⚠ Documentation is an integral part of clinical practice but is often neglected as it is time-consuming. This book will help you get a head start with templates that contain all the basics you need.♥ The book begins with a section on general considerations. Subsequent sections discuss commonly performed procedures on spine, knee, hip, abdomen & pelvis, chest & shoulder, & head, face & neck. Many techniques & approaches exist for each procedure. Sincere efforts have been made to include all the routinely performed ones. Alternative therapies are included, which make the book comprehensive. The last section provides useful information about consent forms, resuscitation, & emergency care of anaphylaxis.◆ This book is written to provide a practical guide to write procedure-notes & to serve as a 'quick revision' before performing interventional pain procedures.★ With more than 60 chapters across nine sections & an easy-to-follow presentation, this book is a useful resource for all interventional pain physicians, whether they are just embarking on training or are well established in their career.
Molecular Biomarkers In Cardiology
ear Colleagues, The approach to diseases is facing novel frontiers: targeting gene and improving person-centered medicine able to easily and specifically detect early stages of pathologies. The present book includes the most futuristic approaches to the identification of cardiac diseases by means of the most recent discoveries in molecular and genetic diagnosis. The articles will give you the opportunity to think of cardiac diseases as adverse conditions which can be more easily detected by means of technologies and the research spirit of us, physicians dedicated to humans' care. Please enjoy this reading.
The Art of Carbohydrate Analysis
List of abbreviationsPreface Introduction Chapter 1 The World of Carbohydrates Chapter 2 Basic Knowledge of Glycobiology 2.1 Monosaccharides 2.1.1 The Molecular Structure 2.1.2 D/L-forms of Monosaccharides 2.1.3 Specific Monosaccharides 2.2 Oligosaccharides 2.3 Polysaccharides 2.4 Glycoconjugates 2.4.1 Glycoproteins 2.4.1.1 N-glycans 2.4.1.2 O-glycans 2.4.1.3 Blood Group Determinants 2.4.1.4 Different Types of Glycosylation 2.4.1.5 Glycosides 2.4.2 Proteoglycans and Glycosaminoglycans 2.4.3 Glycolipids 2.4.4 Glycosylphosphatidyl-inositol Membrane Anchors 2.5 Intrinsic Complexity of Carbohydrates 2.6 Working in a Laboratory Chapter 3 Carbohydrates involved in Diseases Chapter 4 Detection of Carbohydrate by Colorimetric Methods 4.1 Introduction 4.2 Preparing Standard Sugar Solutions for Calibration Curves 4.3 General tests 4.3.1 Detection of Carbohydrate by a Spot Test 4.3.2 Phenol-Sulfuric Acid Assay 4.3.3 Anthrone Test 4.3.4 Molisch's Test 4.3.5 Fehling's Test 4.3.6 Benedict's Test 4.3.7 Barfoed's Test 4.4 Specific Tests 4.4.1 Seliwanoff's Test for Ketoses 4.4.2 Bial's Test for Pentoses 4.4.3 Colorimetric Analysis of (N-acetyl) Aminosugars 4.4.4 Colorimetric Analysis of Uronic Acids 4.4.5 Colorimetric Analysis of Sialic Acids 4.4.6 Iodine Test for Starch Chapter 5. Analytical Techniques to Study Carbohydrates 5.1 Structural Parameters 5.2 Glycosidic-bond Cleavage techniques  
Blacks in Medicine
Ancient History as a Backdrop to Black Medical History.- Beginning of Transoceanic Slave Transport.- Initiation of the Transatlantic Slave Trade Between Africa and America.- Poor Medical Treatment of Slaves and Its Consequences.- Emergence of the First Black Doctors Trained in Medical Schools.- Beginning of Black Medical Autonomy and Self-Determination.- Destructive Effects of Discrimination and Institutional Racism.- Extreme Medical Hardship Period.- Development of Social Welfare.- Development of Healthcare Reform.
Recent Advances in Plant-Based, Traditional, and Natural Medicines
The purpose of this book is to discuss several medicinal plants to find wider application in the domain of medicinal, clinical, and pharmaceutical treatment. Recent Advances in Plant-Based, Traditional, and Natural Medicines serves as a useful source of ideas and an inspiration for further cell and molecular biology research toward developing drugs and treatments from these traditional and plant-based remedies.The book covers a variety of topics and: - Considers the current state of research of traditional and plant-based medicines- Covers the current status of ethnomedicine and medicinal plant discovery- Presents the clinical applications of traditional and plant-based medicines
Dendrimers in Medical Science
This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.
Plant- And Marine- Based Phytochemicals for Human Health
This new book, Plant- and Marine- Based Phytochemicals for Human Health: Attributes, Potential, and Use, provides insight with scientific evidence on the use of medicinal plants in the treatment of certain diseases. It describes bioactive compounds of marine and plant origin that have been discovered to be advantageous for human health, shedding new light on the potential of phytochemicals on human health and contributing to the ocean of knowledge on phytochemistry and pharmaceutical biology. In addition, the role of plant-based pharmaceuticals is also discussed as an example of innovative uses of plant product. This book addresses the importance of phytochemicals from plants and marine life. It divided in four parts: Bioactive compounds in medicinal plants: status and potential Plant-based pharmaceuticals in human health: review Therapeutic attributes of mushroom, cereal grains, and legumes Innovative use of medicinal plants This compendium will be useful for the students and researchers as well as for industry professionals working in the food, nutraceuticals, and herbal industries.
Nanodispersions for Drug Delivery
This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems. The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves.Key features: - Provides an overview of nanoemulsions for drug delivery- Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems- Presents information relevant to specific routes of applications of nanoemulsions- Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration- Explores nanomicellar approaches for drug delivery- Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery
Everyday Environmental Toxins
This title includes a number of Open Access chapters.This collection of timely chapters presents a nuanced study of environmental toxins and the risks they pose to children's development. The book details the impact of a number of commonplace environmental toxins, focusing on everyday exposure to tobacco smoke, lead, pesticides, and flame retardants. There is growing recognition that the impact of the environment on children's health is of critical importance for both current and future generations. In the last half-century, thousands of chemicals have been introduced into the environment with limited-although growing-research on the consequences of exposure. It has been proven that children and adolescents are far more vulnerable than adults to these environmental toxins by virtue of children's behaviors, higher metabolic rate, greater skin area relative to their volume, and still developing organ systems. Increased number of ear infections, poor asthma control, and learning disabilities are just some of the adverse outcomes that have been noted.This well-researched book: - Presents detailed information on why children are more vulnerable to everyday toxins- Discusses why new approaches to medical care are necessary that take into account children's unique physiology and development - Offers well-defined research on tobacco smoking on prenatal development as well as children's exposure to tobacco smoke during their early years, particularly the evidence of asthma and asthma-like symptoms- Examines the possible health effects of children born to mothers living in areas of natural gas development - Looks at the health effects of childhood exposure to environmental lead, using GIS technology to study areas of potentially high lead concentrations- Discusses the possible effects of agricultural pesticides on children's health during gestation- Presents studies on prenatal and adolescent exposure to PBDEs used as flame retardants in many household and commercial products to prevent fireThis valuable book, edited by a pediatric clinician at Boston's Children's Hospital, provides a wealth of information on this important issue. The book concludes with an article by the World Health Organization, which offers a practical and comprehensive summary of a series of action steps. The book aims to create greater awareness to spur additional research, provide vital information to clinicians, and send a powerful message to government officials, putting pressure on them to develop policies that improve the quality of the environment and spare children the detrimental effects of such exposures.
Nanocarriers for Brain Targeting
This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.
Plant Secondary Metabolites for Human Health
This new book deals with recent advanced research on natural products and health-promoting foods that work to reduce the risk of diseases while enhancing overall well-being. Plant-based functional foods are known to contain compounds (also referred to as phytochemicals) in the leaves, stems, flowers, and fruits of certain plants. These plant products are drawing the attention of researchers because of their demonstrated beneficial effects against disease, particularly diabetes, hypertension, cancer, neurodegenerative diseases, among others. The medicinal and nutritional use of plant secondary metabolites is a hot topic and has been receiving extensive attention from both health professionals and the public. This book presents new information on the extraction of bioactive compounds from plants, plant-based drugs, and the innovative use of plant-based drugs for human health.
State-Of-The-Art Technologies in Food Science
There has been a growing interest in the health benefits derived from fruits and vegetables and the food products based on them. Many foods contain various phytochemicals, flavonoids, fibers, macronutrients and micronutrients, minerals, etc. that are good for health and essential for keeping good health. This volume provides a global perspective of the current state of food and health research, innovation, and emerging trends. It focuses on topics of food for better health, including functional foods and nutraceutical foods.The book is divided into several sections, covering: - Foods for Human Health Promotion and Prevention of Diseases, which include fruits, vegetables, and grains: their peels and fiber for better human health, health prospects of bioactive peptides derived from seed storage proteins, mushrooms as a novel source of antihyperlipidemic agents, and emerging foodborne illnesses and their prevention.- Specific Fruits, Spices and Dairy-Based Functional Foods for Human Health, which looks at the functional medicinal values of fenugreek, fruits as functional foods, and functional fermented dairy products.- Issues, Challenges, and Specialty Topics in Food Science, which focuses mainly on the stability issues of whole wheat flour, physicochemical properties and quality of food lipids, methods for food analysis and quality control, and interventions of ohmic heating technology in foods.The volume will be of interest to health practitioners, food specialists, nutrition producers and suppliers, practicing food process engineers, food technologists, researchers, food industry professionals, and faculty and upper-level students in food science.
Sleep, Circadian Rhythms, and Metabolism
This title includes a number of Open Access chapters.Providing a nuanced study of the connections between sleep, circadian rhythms, and metabolis, this informative book examines how circadian actions affect the liver and adipose tissue, the brain, and metabolism. This important book introduces the reader to circadian rhythms in the body and the external cues that set them, discusses on a molecular and organ level how disrupting these clocks results in metabolic and sleep disorders, and looks at the clinical applications of circadian rhythms, with a focus on sleep.The book covers a variety of important research in the field, including: - The power of computational biology to uncover new nodes in the network of circadian rhythms- Circadian rhythms as they relates to obesity- How late-night shift conditions impair the body's ability to keep time and promote metabolic diseases and how this can be mitigated by strategic planning of feeding times- The relationship between the suprachiasmatic nuclei and orexin neurons, demonstrating the elegant interplay between our biological clocks and wakefulness- How sleep disorders can result from irregular circadian rhythms and potential ways to diagnose this in individuals- How sleeping behaviors can disturb the hypothalamic-pituitary-adrenal axis and the repercussions of this disruption on female reproduction- How disruption of sleep can be clinically beneficial for depressed patients- How mental state is influenced by circadian rhythm
Nanoconjugate Nanocarriers for Drug Delivery
This new volume presents a plethora of new research on the use of nanoconjugate nanocarriers in drug delivery. Nanotechnology as drug carriers has been observed to increase the level of sophistication through a variety of ways. It helps to alleviate some of the pitfalls of conventional dosage forms, such as few pitfalls such as non-specific drug delivery, dose dumping, poor patient compliance, toxicities linked with higher doses, etc.With chapters from highly skilled, experienced, and renowned scientists and researchers, Nanoconjugate Nanocarriers for Drug Delivery is divided into four sections, providing an introduction to nanocarriers for drug delivery, physicochemical features of nanocarriers, and specific applications dealing with drug delivery in particular. The materials used as well as formulation and characterization have been discussed in detail. The nanocarriers covered in the book include nanoparticles, vesicular carriers, carriers having carbon as the core constituent, dispersed systems, etc. The book also delves into the interaction and associations between drug delivery research and its therapeutic applications in practice.The book integrates a wide variety of case studies, research, and theories in an attempt to reveal the diversity and capture the novel approaches of nanoconjugate nanocarriers for drug delivery employed by developers and content experts in the field. This timely publication will be an essential reference and current awareness source, building on the available literature in the field of pharmacy and biomedical science, while also providing ideas for further research opportunities in this dynamic field.
Alginates
This new volume explores the latest research on the use of alginate as a biopolymer in various biomedical applications and therapeutics. The uses of alginates and modified alginates discussed in this book include tissue regeneration, encapsulation and delivery of drugs, nucleic acid materials, proteins and peptides, genes, herbal therapeutic agents, nutraceuticals, and more. This book also describes the synthesis and characterizations of various alginate and modified alginate systems, such as hydrogels, gels, composites, nanoparticles, scaffolds, etc., used for the biomedical applications and therapeutics. Alginate, a biopolymer of natural origin, is of immense interest for its variety of applications in pharmaceuticals (as medical diagnostic aids) and in materials science. It is the one of the most abundant natural biopolymers and is considered an excellent excipient because of its non-toxic, stable, and biodegradable properties. Several research innovations have been made on applications of alginate in drug delivery and biomedicines. There needs to be a thorough understanding of the synthesis, purification, and characterization of alginates and its derivatives for their utility in healthcare fields, and this volume offers an abundance of information toward that end.
Herbal Hair colorants products - a novel approach
Cosmetic any substance or preparation intended to be placed in contact with the various parts of the human body (epidermis, hair system, nails, lips and external genital organs). Or with the teeth and mucous membranes of the oral cavity with a view exclusively or mainly to cleaning them, perfuming them or chaining their appearance and/ or correcting body odour and/ or protective them or keeping in good condition. In the 21st century, the winds of changes in the society are seen in all parts of the world in the application of cosmetic. The increase in environmental and health hazards in the manufacture of dyes and its use throughout the world is a major concern.
Geriatric Assessment
Some decades ago, comprehensive geriatric assessment was referred to as the "new technology of geriatrics", as research indicated many benefits of building models of care on assessment systems. Since those times, assessment-care technologies have proliferated, and in many countries have become reference standards. Work, however, continues to extend and expand geriatric assessment programs, as represented in the contents of this book.
Genetic Perspectives in Thyroid Cancer
Thyroid cancer is an uncommon type of cancer, but it is one of the most common endocrine malignancies. The etiology of thyroid cancer is multifactorial, and radiation is the best documented risk factor related to the disease. Further risk factors have been hypothesized; however, we have yet to gather a wide range of information that will help us better understand the genetic mechanisms of thyroid cancer. The influence of genetics in the clinic and in therapeutics has been improved based on retrospective and prospective studies published worldwide in the last few decades, but the development of high through-put approaches has also been crucial. The new advances in high through-put methodologies such as next generation sequencing will open the door to new genetic variants that will help to clarify genotype-phenotype correlations, new gene associations, new genetic targets useful as potential biomarkers, and so on. The new decade that is now beginning may provide new evidence for the disease. "Genetic Perspectives in Thyroid Cancer" is an issue that intends to cover several topics on thyroid cancer, aiming to reach new findings based on genetic evidence in thyroid cancer as expressed in case studies, molecular approaches, and hereditary evidences, clinical and therapeutic developments.
Exercise Under Hypoxia as an Effective Intervention for Athletic Performance and Health Promotion
This book contains original and review article performed in our lab (Physical Activity and Performance Institude, Konkuk University, Korea). This content explains the effectiveness of various exercise training and intervention under hypoxia for enhancing athletic performance and various cardiometabolic health including obesity. By reading this textbook, it is believed that many readers will better understand the effectiveness of hypoxic training and hypoxic therapy.
Bioactive Molecules from Extreme Environments
The papers included in this Special Issue "Bioactive Molecules from Extreme Environments" provide an overview of the growing interest in species biodiversity, highlighting the importance of marine extreme environments as sources of a unique marine chemical diversity of molecules. It is worth noting that six articles in this Special Issue are focused on molecules and enzymes isolated from Antarctica. This means that there is a growing interest in this habitat, most probably due to being perceived as an important source of drug discovery. In fact, the unique environment and ecological pressures of marine polar regions might be the major drivers of a selection of unique biological communities that are able to biosynthesize new compounds with diverse biological activities. It is expected that, in the near future, more marine molecules from polar regions, as well as from other extreme habitats, will find their way into biomedical and biotechnological applications.
Microballoons of Ondansetron hydrochloride for effective treatment
Drug therapy is a dynamic process. Oral route of drug delivery is typically considered the preferred and the most patient-convenient means of drug administration. Among the drugs that are administered orally, solid oral dosage forms represents the preferred choice of class of product. Commonly used solid oral dosage forms are tablets and capsules; tablets are indeed the most popular solid dosage form for oral administration. In recent years a wide variety of newer oral drug delivery systems like controlled/ sustained release dosage forms are designed and evaluated in order to overcome the limitation of conventional therapy. These products are able to maintain steady drug plasma levels for extended periods of time as a result the variation of drug levels in the blood are prevented and minimized drug related side effects. Multiparticulate dosage forms are pharmaceutical formulations in which the active substance is present as a number of small independent subunits with diameter of 0.05-2.00 mm and widely accepted as a means to achieve oral and parenteral controlled release.
Use of Patented Traditional Chinese Medicine against COVID-19
COVID-19 is a severe and complex epidemic ravaging many countries. Traditional Chinese medicine (TCM) has accumulated rich experience and achieved outstanding effects in its struggle against epidemics for thousands of years. As an essential intervention means for prevention and control of COVID-19, TCM boasts significant effects in relieving fever symptoms, slowing down disease progression, preventing disease transformation, reducing hormone dosage, and alleviating complications. Establishing and improving the emergency supply service mode of Chinese medicine in response to public health emergencies, and scientifically managing and allocating Chinese medicine medical resources are conducive to establishing a green channel for the emergency supply of Chinese medicine in response to major public health emergencies.This book focuses on the four oral Chinese patent medicines used in the clinical treatment period based on the Guidelines for the Diagnosis and Treatment of COVID-19 by the National Health Commission and National Administration of Traditional Chinese Medicine of China.This work is not only an important part of the theoretical system of TCM treatment based on syndrome differentiation but also an effective way to promote an even deeper integration of clinical pharmaceutical service and clinical medical practice.
The Future of Pharmaceuticals
Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future.Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.
The Outcast Pharmacist
The Outcast Pharmacist: Desiring change in pharmacy education, professional standards, and bias in the healthcare industryAmber Goodman, PharmD, RPh, MPHAshley Goodman, PharmD, RPh, MPHFor much of the general public, the first thing that comes to mind when they hear "pharmacist" is medication. Many are unaware that pharmacists are doctors with years of training and expertise. Doctors Amber and Ashley Goodman are twin pharmacists who advocate for the equity and well-being of those in the profession. Although conventions of the field would have them confined to one arena, they have continually challenged the status quo. Their nuanced professional moves have led the Goodman twins to consider themselves outcasts. Yet, there are thousands of other outcasts among practicing pharmacists and students enrolled in pharmacy schools.Pharmacists are much more than the smiling faces behind drug store counters. While retail pharmacy is invaluable to society, there are several other paths that a pharmacist can take. However, most pharmacy education programs and professional standards have yet to respond adequately. To add to the lack of awareness surrounding pharmacy itself, the wider healthcare industry has contributed to the inequities that pharmacists experience. The Outcast Pharmacist gets to the heart of key issues in pharmacy education, professional standards, and bias in the healthcare industry.
The Practical Guide to Clinical Research and Publication
The Practical Guide to Clinical Research and Publication provides a comprehensive overview of the key foundations of epidemiology, statistics and epidemiological studies. This book presents the most important terms and knowledge in the field from a medical point-of-view. Sections contain numerous, clinically-oriented examples and drawings to facilitate understanding and clarify the relation to clinic and practice. The book contains many graphics and key points for easier understanding and is written using bullet points for ease of use and comprehension. It is ideal for physicians and clinical researchers who want to use it as guidance for clinical research or teaching.
The effect of Polyethylene glycol (PEG) on the physicochemical properties of Polycaprolactone (PCL) nanoparticles
Master's Thesis from the year 2013 in the subject Medicine - Pharmacology, Pharmacy, grade: 71.5, University of Ulster (school of pharmacy), course: pharmaceutical sciences, language: English, abstract: The aim of the current study is to design amphiphilic PCL/PEG nanoparticles having better physicochemical properties than the PCL nanoparticles. Here we show that increasing the MWt of PCL can increase the size, zeta potential, protein loading efficiency and protein release rate of the PCL nanoparticles while blending of PEG with PCL can increase the protein loading efficiency, increase the stability, decrease the size and enhance the protein release rate of PCL nanoparticles. The BSA loaded LPCL nanoparticles have higher protein loading efficiency, protein release rate, size and zeta potential than the SPCL and MPCL nanoparticles. All the LPCL/PEG blends produce nanoparticles with smaller sizes, narrower PDI(s), and higher protein release rates than the BSA loaded LPCL nanoparticles. LPCL/SPEG2.5% and LPCL/SPEG5% nanoparticles have higher protein loading efficiencies, smaller sizes, narrower PDI(s), and higher protein release rates than the BSA loaded LPCL nanoparticles. Oral route is the best route for drug administration because it avoids pain and infections associated with injections. Biodegradable polymeric nanoparticles are considered an attractive alternative to injections as a controlled oral release protein delivery system because they are highly stable in the gastrointestinal tract (GIT) and able to protect the loaded proteins from destruction in GIT. Polycaprolactone (PCL) is a hydrophobic polymer, compatible with various hydrophilic and amphiphilic polymers, and a good candidate from the pharmaceutical point of view to form nanoparticles because its physical, chemical, and mechanical properties can be easily modified by copolymerization or blending or grafting with other polymers.
Feel It to Heal It
Caroline is a passionate, transformational leader. She is continually driven by the results of those that have learned the Total Release Experience (R). Privileged to have discovered the many mysteries of the body to heal itself with a simple, empowering, primitive practice, she was inspired to share many of the stories. 'They are powerful and inspiring. They are not mine to sit on. The time has come to encourage the world to change their mindset, find hope, and break the chains for their children.'
Fundamentals of Pharmacology
All registered nurses must have a thorough understanding and a strong knowledge of pharmacology, medicines administration, and the ability to recognise and react to the effects of medicines. Fundamentals of Pharmacology helps nursing and healthcare students develop the skills and confidence required to apply the fundamental principles of pharmacology and to offer safe, competent and compassionate care. Concentrating on the medicines that students are most likely to encounter in real-world practice, this textbook provides concise coverage of pharmacology, essential medicines management principles, legal and ethical issues, drug formulations, analgesics, immunisations, and much more. Clinically focused chapters feature defined learning outcomes, multiple-choice questions, practical examples, and full-colour illustrations to aid readers' comprehension of the complexities of pharmacology and care provision. The book utilises a straightforward, student-friendly approach to present 'must-have' information, with contributions from experienced clinicians and academics. Describes how to use pharmaceutical and prescribing reference guides Stresses the role and importance of compassionate care throughout Contains a full range of pedagogical tools which enhance learning and recall Aligns with current NMC Standards and Proficiencies for Registered Nurses and Nursing Associates Supplemented and supported by a wealth of online extras and resources Fundamentals of Pharmacology is essential reading for all nursing students, trainee nursing associates, post-registration nurses taking 'nurse prescribing' or 'non-medical prescribing' modules, and newly qualified nurses and nursing associates looking to better understand pharmacology.
Trends in Clinical Deep Brain Stimulation
This book covers the current trends in clinical deep brain stimulation (DBS) research. This collection of papers from experts in the field provides state of the art knowledge and future perspectives in clinical DBS research. A range of topics involved in DBS is presented, ranging from high resolution imaging, electrophysiology and personalized medicine, in a broad range of brain disorders.
Daily Pain & Symptom Tracker
A GAME CHANGER (WITH STYLE)Chronic pain can be a real pain in the butt, which is why figuring out potential triggers is so important. Sometimes, we don't realize what these triggers are until we track our day-to-day activities for an extended period of time.Is your pain linked to certain foods? The weather? Stress?That's where this journal comes in. Not only was it designed to support loved ones with chronic pain, but it has been upgraded to include even more tracking items requested by warriors of chronic pain from around the globe.A FUN, CREATIVE, AND SIMPLE DESIGNBeginning of journal: Your doctor / specialist information (name, address, contact)Daily medicationsSummary sheetDAILY ENTRIESFirst page: How you're feeling overallYour pain level (1 - 10)What your pain / symptoms feel likeWhere your pain is located (front and back figure) + a.m. vs. p.m.Your moodYour energy levelsYour mental clarityWhether or not you're feeling sick. If you select yes, you'll then have 8 common symptoms to choose from, along with an area to write additional symptomsSecond page: Hours of sleep & sleep qualityWeather (humidity, temperature, barometric pressure, allergen levels)Stress levelsFood / drinksMedication / supplementsDaily exercise / activityNotes / suspected triggers / improvementsPositivity area to include 1 thing you're grateful forAdditional note space is available at the back of the journal*Pain tracking can be life changing. Whether you're looking to better understand your chronic pain or looking for a thoughtful gift for a friend, this journal is for you.Additional information: ✓ 6 x 9 glossy paperback (great compact size that can easily be taken to the doctor's office)✓ 120 pages of tracking (60 days total)✓ Other covers & colors available - click on Wellness Warrior Press
