Traditional and Indigenous Knowledge for the Modern Era
While there is talk of the Fourth Industrial Revolution, old and new challenges bedevil the world - climate change, nutrition, and health poverty being at the top of the list. In seeking solutions to these and other problems which afflict the modern era, it is worthwhile to look into our collective past, to the traditions and knowledges of our ancestors. Such knowledge continues to exist in many parts of the world, though now marginalized by homogenous, Eurocentric ontolology and epistemology. This book presents a compilation of reviews, case studies, and primary research attempting to locate the utility of traditional and Indigenous Knowledges in an increasingly complex world. It assembles chapter authors from across the world to tackle topics ranging from traditional knowledge-based innovations and commercialization, traditional medicine systems as practiced around the world, ethnoveterinary practices, and food innovation to traditional governance and leadership systems, among others. This book is an important resource for policymakers; scholars and researchers of cultural studies, leadership, governance, ethnobotany, anthropology, plant genetic resources and technology innovation; and readers interested in the history of knowledge and culture, as well as cultural activists and political scientists.Features: Unique combination of social science and anthropological aspects with natural science perspectives Includes summaries aimed at policymakers to immediately see what would be relevant to their work Combines case studies illuminating important lessons learned with reviews and primary data Multidisciplinary in the scope of the topics tackled and assemblage of contributors Global footprint with contributions from Africa, Europe, North America, Asia, and the West Indies David R. Katerere, Department of Pharmaceutical Sciences, Tshwane University of Technology, South AfricaWendy Applequist, William L. Brown Center, Missouri Botanical Garden, St Louis, MissouriOluwaseyi M. Aboyade, Department of Pharmaceutical Sciences, Tshwane University of Technology, South Africa and Nutritica SA, The Innovation Hub, Pretoria, South AfricaChamunorwa Togo, The Innovation Hub, Pretoria, South Africa
Biocontrol of Plant Diseases by Bacillus Subtilis
Plant diseases are a serious threat to food production. This unique volume provides the fundamental knowledge and practical use of B.subtilis as a promising biocontrol agent.
Quantitative Structure - Activity Relationship
Quantitative structure-activity relationship (QSAR) is a computational approach for mathematically connecting structural features of compounds to their biological activities. This unique volume provides the essence of QSAR analysis in a practical manner. It illustrates the basic principles essential for assisting readers in performing analyses.
Pharmaco-Complexity
Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic "Pharmaco-complexity: Non-linear Phenomena and Drug Product Development".
Antioxidants in Foods
Antioxidants in food have a dual role; on the one hand, they preserve the quality and shelf life of food products; on the other hand, they function as an external aid, helping to defend our living cells from the threat of oxidative stress. Therefore, foods rich in antioxidants are a useful tool to reduce morbidity and prevent degenerative diseases. Consequently, research related to antioxidants is continually growing. This book brings together 21 articles regarding the latest advances in the most relevant fields of food antioxidant research; from the identification and characterization of new active components, to their molecular mechanisms and the scientific evidence of their clinical use and effectiveness.
Cutting-Edge Topics in Dry Eye Disease
This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.
Embedded Pharmacists in Primary Care
As healthcare delivery moves from a provider-centric approach to a more patient-centric approach, systems and payers need to reimagine how care and team-based care is delivered to patients and reimbursed. Thus, the goal should be to see the right patient, by the right provider, in the right place, for the right price, and where appropriate, with the use of the right pharmaceutical(s) - "5 P's". There continues to be a reduction in physicians that are pursuing primary care roles in the United States, thus exacerbating the ability to meet patient demand. Most patient encounters begin with or end with the prescribing of medication. Thus, a future where pharmacists are embedded in primary care settings allows these pharmacists to collaborate at the point-of-prescribing (i.e., in-clinic) and provides tremendous benefits to providers and patients. The pharmacist workforce is educated at the doctoral level, yet vastly underutilized and can assist in a collaborative approach in primary care. The collection of articles in the Special Issue "Embedded Pharmacists in Primary Care" highlight examples of models that have included pharmacists in the ambulatory setting providing services in chronic disease management, comprehensive medication management, and care of specific conditions such as diabetes.
Simple Medicine
In Simple Medicine, the most common medical conditions, complaints, screening, medications, and medical testing are described in layman terms and very easy to understand, helping patients take control of their own health care and challenge their doctor to do the right thing.
Principles of Forensic Toxicology
The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner's offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
Clinical Biomechanics and Its Implications on Diabetic Foot
This book presents essential information on biomechanical features of the diabetic foot, which could help to minimize the risk of future diabetic foot problems. India has recently been classified as the 'diabetic capital' of the world. Type 2 diabetes mellitus has become a serious concern for Indian society, where the prevalence rate is increasing exponentially. Similarly, the comorbidities and foot complications of type 2 diabetes mellitus are worsening day by day. Of all complications, diabetes peripheral neuropathy is the most common, and leads to foot deformities, pain, altered sensation, loss of foot arch, etc. The ultimate fate can even be gangrene and amputation. Accordingly, foot complications of diabetes represent a pressing medical issue. Sharing insights into diabetic foot syndrome, its causative factors, prevention and management, this book offers a valuable resource for medical and paramedical students, researchers, podiatrists, surgeons, and physicians alike.
Pharmacy Practice Research Methods
This book presents a contemporary view of pharmacy practice research covering theories, methodologies, models and techniques that are applicable. It has thirteen chapters covering the range of quantitative, qualitative, action research and mixed methods as well as management theories underpinning change in pharmacy practice. "Pharmacy Practice Research Methods" examines the evidence and impact as well as explores the future. Pharmacy practice is rapidly transforming and as such it is to be adaptable as student and academic researchers and to not only understand techniques and methodologies, but as champions to nurture the field. There is a literature in this area but few integrated texts which cover the wide range of pharmacy practice including methodologies, evidence, practice and policy. This book provides a solid foundation for exploring these phenomenon further, and is expected to serve as a valuable resource for academics, students, policy makers and professional organisations.
Nanoparticles and Their Biomedical Applications
Nanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.
Emergency Management of the Hi-Tech Patient in Acute and Critical Care
EMERGENCY MANAGEMENT OF THE HI-TECH PATIENT IN ACUTE AND CRITICAL CARE Emergency Management of the Hi-Tech Patient in Acute and Critical Care helps practitioners stabilize and care for pediatric and adult patients who have specialized medical devices such as prosthetic valves, cochlear transplants, insulin pumps, orthopedic hardware, and ventriculoperitoneal (VP) shunts. Using a step-by-step approach to acute presentations of patients with clinical hardware, this concise yet comprehensive guide provides specific instructions for the initial evaluation and management of numerous clinical scenarios including device malfunctions, infections, trauma, surgical complications, and more. Encompassing management of both the patient and the device, the guide enables emergency and critical care clinicians to rapidly make appropriate treatment decisions without the immediate need for extensive research, extended discussions with subspecialists, or recalling complex diagnostic and therapeutic algorithms. Clear, concise, and easy-to-follow chapters--written by a panel of highly experienced experts across specialties--include numerous algorithms, figures, tables, diagrams, and color illustrations and clinical images. An invaluable resource for improving the quality of care for the unique hi-tech patient population, this advanced practical manual: Provides algorithms for the most common clinical scenarios of device malfunction and related complicationsCovers management of patients who have undergone major operations such as organ transplantation or complex congenital heart disease repairPresents detailed management plans for a wide range of hardware types and medical conditionsOffers expert guidance to practitioners in settings where not all specialties are readily available, such as rural and remote areas or community hospitalsFeatures contributions from a team of experts in various areas of adult and pediatric emergency and critical care medicineEmergency Management of the Hi-Tech Patient in Acute and Critical Care is a must-have clinical reference and guide for pediatric and adult emergency medicine physicians, general pediatricians, internists, general practitioners, critical care specialists, and allied health practitioners.
What in the World is Insulin?
When you hear the word insulin, you may think of high blood sugar or diabetes. While insulin is involved in these conditions, the dangers of uncontrolled levels of insulin show to be more life-threatening. Insulin is a hormone that plays an essential role in digestion and metabolism because it allows glucose to enter the body's cells to provide energy. It is also responsible for regulating the storage of excess glucose in the liver, muscles and fat cells. Driven by Canadian inventiveness in 1921 and carried across the globe, insulin is widely recognized as one of medicine's greatest achievements. In this book, you will learn the story of insulin, including its discovery, development and continued innovation.
Environmental Epigenetics
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Caring and Responsibility
June S. Lowenberg examines the symbolic meanings underlying the larger holistic health movement, and locates those changes within the broad social and historical context. Her analysis helps us understand the strains, as well as the strengths, of the emerging, more holistic medical model.
The Future of Hiv-1 Therapeutics
This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
Continuous Pharmaceutical Processing
Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PAT) for continuous processing, process control strategies including new concepts of quality-by-control (QbC), real-time process management and plant optimization, business and supply chain considerations related to continuous manufacturing as well as safety guidelines related to continuous chemistry. A separate chapter is dedicated to discussing regulatory aspects of continuous manufacturing, with description of current regulatory environment quality/GMP aspects, as well as regulatory gaps and challenges.Our aim from publishing this book is to make it a valuable reference for readers interested in this topic, with a desire to gain a fundamental understanding of engineering principles and mechanistic studies utilized in understanding and developing continuous processes. In addition, our advanced readers and practitioners in this field will find that the technical content of Continuous Pharmaceutical Processing is at the forefront of recent technological advances, with coverage of future prospects and challenges for this technology.
Pharmacogenomics in Precision Medicine
Chapter 1. Introduction and Principles of Pharmacogenomics and Precision medicine.- Chapter 2. Pharmacogenomics in Cardiovascular Diseases.- Chapter 3. Pharmacogenomics of Antitumor Chemotherapeutic Agents.- Chapter 4. Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy.- Chapter 5. Pharmacogenomics of Immunosuppressant.- Chapter 6. Pharmacogenomics of Psychiatric drugs.- Chapter 7. Pharmacogenomics of Anti-Infective Agents.- Chapter 8. Pharmacogenomics of Antithrombotic drugs.- Chapter 9. Pharmacogenomics in Therapeutic Drug Monitoring.- Chapter 10. Pharmacomicrobiomics.- Chapter 11. Genotyping technology in Pharmacogenomics.- Chapter 12. The Ethical, Legal and Regulatory Issues Associated with Pharmacogenomics.- Chapter 13. Cost-effectiveness of pharmacogenetic-guided treatment.- Chapter 14. Application of pharmacogenomics in drug discovery and development.- Chapter 15. Barriers and Solutions in Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine.
Migraine Journal
A GAME CHANGERChronic migraines and headaches are a huge pain in the butt (well, head).Note: for the funny non-PG version (F*cking Migraines), click on Wellness Warrior Press under the title.What if you could pinpoint the cause of your migraines and determine which relief measures work? What if you could identify trends, or patterns, and put a stop to them?Our new migraine tracking journal was designed to do just that.Extremely detailed, this tracker will allow you to figure out what your triggers are so you can put a stop to them. The best part? The majority of the journal entries require checkmarks or encircling, so you don't have to worsen your migraine or headache by writing lines upon lines of information.Click on "Look inside" to get an idea of what this super compact and extremely detailed journal has to offer.A FUN, CREATIVE, AND INNOVATIVE DESIGNBeginning of journal: A two-page summary sheetA 1-year calendar with a blank legend (for you to identify or color-code your bad days)DAILY ENTRIESFirst page: *the first page is where you will log exactly how you're feelingDate, day of week, and entry numberType of migraine or headache (image to encircle)Pain level (1 - 10)Detailed description (you select from descriptive words, such as throbbing, pounding, etc.)Onset (slow, average, fast, sudden)Angled face sketches for you to encircle exactly where you're hurtingOther symptoms to select from (dizziness, light sensitivity, etc.)Your moodYour energy levelsYour mental clarityWhether or not you're feeling sick. If you select yes, you'll then have 8 common symptoms to choose from (including nausea), along with an area to write additional symptoms.Second page*this is where you will dive into possible triggers + relief measuresHours of sleep & quality (previous night)Weather (humidity, temperature, sunlight, barometric pressure, allergen levels)Stress levelsFood / drinksNon-relief medication / supplementsHormones (menstruation, menopause, PMS, N/A / other)Computer use / readingActivity levelsRelief measures & efficiencyNotesAdditional note space is available at the back of the journal*Pain tracking can be life changing. Whether you're looking to better understand your chronic pain or looking for a thoughtful gift for a friend, this journal is for you.Additional information: ✓ 6 x 9 matte paperback (great compact size that can easily be taken to the doctor's office)✓ 120 pages of tracking (60 days total)✓ Other covers & trackers available - click on Wellness Warrior Press
Frontiers in Anti-Infective Drug Discovery Volume
This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs
Generic Drug Development Project Management
This is the first book in the series of three. These three books will be based upon the idea to tailor PMI's Project Management methodologies to the typical pharmaceutical projects.This book includes generic drug development project in detail. It is specially designed for Project Managers, team members and pharmacy students. Format of book is purposely kept simple. This book includes various useful flow charts and templates that can be used during the project life cycle. Information provided in this book is obtained from highly authentic sources, and links of data sources is provided for reference. Surely this is the kind of book every pharmaceutical personnel will want to be on their shelf.
Interventional Spine and Joint
A comprehensive atlas of fluoroscopy guided interventional spine and joint procedures to effectively improve painand function.Review hundreds of fluoroscopic images for the most commonly performed procedures in the field of Interventional Pain Medicine.Each image is displayed with the exact fluoroscopic angles used, along with a supporting explanation on the adjustments needed to obtain the ideal view.Most procedures are presented with multiple real-world examples each, in order to demonstrate varying anatomical presentations which may be frequently encountered.Additional discussion is provided for a deeper understanding of anatomy and fluoroscopic manipulation, along with real-world procedural pearls.Each unique procedure contains a thorough analysis of the cost of supplies, gross revenue, and gross profit margin from data taken from a real-world private practice office setting.
Emergency Care For Beginners
You'll feel safer because you'll know how to keep those around you alive and safe; there's no effort too big or expense too high to get that safety for you and your family.How would you handle insect or animal bites in an emergency? Would you do something different than you learned in First Aid-CPR? Have you ever taken one of those classes to learn how to help someone in an emergency? What if you were traveling outside the country to a place that has more dangerous animals or insects? Would you know what to do?Even dogs and cats can deliver a bite that can have lasting effects on a person's health. Understanding what to do in an emergency, whether it is an insect or animal bite is essential to your survival or someone else's. You never know what you might encounter.We've all seen someone with an orthopedic cast, and some of us have had the misfortune of living the experience of having a fractured bone. We all have a idea of what's a fracture is, but only a small percentage of the population is able to understand and treat a fracture correctly.If you're aware of the dangers of a fractured bone, and you're worried about how an accident could change the health of your family, and you want to do something about it, then this book is the right book for you. Everything that you need to know regarding the approach to a fracture is right here in this book.This book will teach you about identifying and treating fractures. You'll learn basic knowledge about anatomy, source of fractures, and how to get an injured person to a hospital. You'll understand the different types of fractures, how to treat them if the person is an adult or a child, and how to limit the damage to this person during the whole process.You can't put a price on your safety, and the safety of those around you. You have the power to turn a dangerous injury that could become a disability into a healed and normal limb. You can make a huge difference in the life of those around you, and all you need to learn in order to do what is written inside this book.If you're one of those people who spend your time worrying about hypothetical scenarios, you may have worried about what to do in the case of a gunshot wound. This is a realistic worry as firearms become easier to obtain, and mass shootings plague the media. What can you do to protect your family and those around you? What should you do to be prepared to treat someone with a gunshot wound? Where must you go to find out? If you spend your time thinking about this repeatedly, imagining possible solutions for these problems, you're one of those people who make everyone around them safer, and this book is perfect for you.All the knowledge in this book is up to date with the latest protocols and health guidelines. The information is reliable, precise, and safe to follow. The Marines developed the scheme of the treatment first approach to gunshot wounded patients used in this book and it has increased their survival rate just like it'll keep your family safe. The book's designed to be a beacon of clarity between a sea of confusing and conflicting information.Read this book from top to bottom, study it, practice the techniques described here, and prepare the best first aid kit you'll ever need to treat a gunshot wound by following the instructions. The imaginary scenarios in your head will stop getting blurry and dark because you'll know exactly what to expect and what to do. You'll feel safer because you'll know how to keep those around you alive and safe; there's no effort too big or expense too high to get that safety for you and your family. Grab your copy today for you, and everyone else out there who takes security seriously!
Cardiovascular Disease
According to the most updated epidemiological studies, cardiovascular disease remains a leading cause of death; in fact, despite substantial advances in the care of patients, the incidence of cardiovascular disorders continues to increase. Therefore, the search for novel mechanisms and therapeutics is desperately needed, and translational studies represent the best strategy to uncover novel therapeutic targets, reduce mortality, and improve the quality of life. This book gathers original articles and systematic reviews that have both a strong basic research background and clear translational potential. All the studies have been peer reviewed by at least two experts in the field. These contributions provide an updated systematic overview that examines, in detail, the mechanisms of the main cardiovascular and metabolic disorders, including ischemic and non-ischemic heart failure, hypertension, thromboembolism, atherosclerosis, stroke, diabetes mellitus, dyslipidemia, metabolic syndrome, valvulopathies, peripheral artery disease. In the final chapter, the functional role of the endothelium in the systemic manifestations of COVID-19 is described.
Acute Pain Management
With a focus on practical acute pain management in adults in the hospital setting, this book provides health professionals with simple and practical information to help them manage patients with acute pain safely and effectively. - Combines evidence-based information with practical guidelines and protocols - Covers the pharmacology of opioids, local anesthetics, and nonopioid and adjuvant analgesic agents - Discusses management of acute pain in both surgical and nonsurgical acute pain settings including in patients with spinal cord or burns injuries and selected medical illnesses - Includes evidence-based information about management of acute pain in some specific patient groups, including the older patient, opioid-tolerant patients, and those with addiction disorders, pregnant or lactating patients and patients with obstructive sleep apnea or who have renal or hepatic impairment - Considers the role of acute pain management in the context of the current opioid epidemic and identifies possible strategies to minimise the risks. This resource will be helpful to a variety of professionals in assessing and managing acute pain.
Hypertension and the influence of the waist circumference and the body mass index
Doctoral Thesis / Dissertation from the year 2013 in the subject Pharmacology, grade: A, course: Pharm. D, language: English, abstract: This study was performed in the department of pharmacy practice clinical research centers of MGM hospitals; Warangal in 2013. The Study group includes 150 subjects of non-teaching staff members of government and private school of Warangal. There were 44 women and 106 men. At the point of entry into the study group of all the study subjects written informed consent from before stating of research work. Data was collected by trained Pharm D and M. Pharmacy paramedical students. The exclusion criterion was the co-existence of any other serious elements. A total number of 32 subjects were found to be normotensive in which 25 (17%) were men and 7 (5%) were women. Overall, 26 subjects were found to be pre-hypertensives whereas, 20 (13%) were men. A total number of 8 (5%) subject were found to be hypertensive of which 6(4%) men and 2 (1.3%) women. Our results highlighted that the waist circumference seems to have a strong association with the risk of hypertension, especially among men than women. In future studies should investigate lipid profile of study subjects to correlate hypertension management regardless of gender or age. Hypertension is a major public health problem world-wide and is one of the risk factors for coronary artery disease. The objective of the present study was to determine the relative role of abdominal fat accumulation on the relationship between excess body weight, and high blood pressure among men and women of non-teaching staff members of public school of Warangal.
Footprints of Toxicology of India
The book "Footprints of Toxicology in India" is a tribute to the untold journey of India in the field of Toxicology. The book would be the first of its kind to trace the historical growth of the discipline in India, its origin and development, highlighting significant innovative achievements, breakthroughs, lessons learnt and issues addressed which have revolutionized the discipline. Equipped with case histories, technical, but applied approach, informative tables and easy to comprehend language, this book could be an unparalleled reservoir of information for graduate and postgraduate students, Ph.D. scholars and scientists studying/working in different arenas of toxicology with a practical understanding of the discipline. Moreover, the book also aims to reach out to the common masses, the non-scientific fraternity, to advance their basic understanding of the subject with better relativity in the day to day life. Key Features - The book offers several unique features: - Comprehensive description of earliest historical aspects in the field of toxicology and its origin and development in India since its formal inception in 1960s - Work that has been undertaken aiming at the recognition, identification and control/mitigation of hazards encountered occupationally (agricultural fields, mines) and environmentally (air, water, food) - Comprehensive account of the studies encompassing the pathophysiology, diagnosis, treatment, management and prevention of clinical problems associated with acute poisoning, adverse drug events; drug abuse, addiction and withdrawal; chemicals and hazardous materials; venomous bites and stings; and environmental and workplace exposures - Concise coverage of the research on nanoparticles directed towards synthesis and detailed characterization, bioavailability, uptake, biodistribution and excretion profiles, investigation of interactions with biological systems (from whole organism to molecular level) - Work undertaken on identification and validation of various biomarkers, toxicogenomic effects and genes susceptibilities that have revolutionized the understanding of human occupational and environmental diseases - Overview of the major legislations that have shaped the regulatory framework in India in context of toxicology and significant contributions that underlie the basis of various regulatory decisions in the country - Provides comprehensive information on mechanistic basis of drug/chemical/xenobiotics induced toxicity on the different organs. Establishment of novel screening strategies, validation of new alternatives to animal models, in vitro approaches, computational modelling and microarray approaches have been subtly discussed - A concise coverage of the preventive/therapeutic avenues proposed to prevent/protect against chemical/drug/xenobiotics induced toxicity to different organs - Provides a quantitative analysis of the publication output of the country in the field of toxicology and its global impact from 1960s-2019
Textbook on the Bases of Pharmaceutical and Medicinal Chemistry of Antibiotics
The use of antibiotics is the major medicinal fragment in therapy. With the development of latest modern academic and research sector, it has become of vital importance to let the professionals be informed with the modern trends by which they can be in a drastic position to understand and deliver to other places of their interest. Pharmacists and Pharmacologists will surely avail this opportunity to grasp knowledge about the medicinal chemistry of antibiotics. This resource book is invaluable, essential for learning and covers uniquely almost all core materials of the subject in a versatile manner which is necessary to provide a greater understanding of the antibiotics. One should always cultivate a devotion to science, the scientific methodology as well as emerging technology to achieve meaningful goals with humanistic consequences. Consequently, this book is of particular interest who might be considering future carrier in academics, research and product development.
Textbook on the Bases of Pharmaceutical and Medicinal Chemistry of Antibiotics
The use of antibiotics is the major medicinal fragment in therapy. With the development of latest modern academic and research sector, it has become of vital importance to let the professionals be informed with the modern trends by which they can be in a drastic position to understand and deliver to other places of their interest. Pharmacists and Pharmacologists will surely avail this opportunity to grasp knowledge about the medicinal chemistry of antibiotics. This resource book is invaluable, essential for learning and covers uniquely almost all core materials of the subject in a versatile manner which is necessary to provide a greater understanding of the antibiotics. One should always cultivate a devotion to science, the scientific methodology as well as emerging technology to achieve meaningful goals with humanistic consequences. Consequently, this book is of particular interest who might be considering future carrier in academics, research and product development.
Mental Health in the Athlete
This unique book provides a practical framework for and coverage of a broad range of mental health concerns applicable to the care of athletes, including depression, suicide, mood disorders, substance abuse and risk-taking behaviors. To this end, it presents content relevant to the care of athletes, including doping and the use of performance-enhancing drugs, the mental health impact of concussion, bullying and hazing, the impact of social media and exercise addiction, among other pertinent topics. Current basic and translational research on behavioral health and the relationship of brain to behavior are reviewed, and current treatment approaches, both pharmacological and non-pharmacological (including mindfulness training), are considered. This practical resource targets the stigma of mental in athletes in order to overcome barriers to care by presenting a definitive perspective of current concepts in the mental health care of athletes, provided by experts in the field and targeting sports medicine providers, mental health providers and primary care physicians involved in the direct care of recreational and competitive athletes at all levels.
Making Healthcare Safe
This unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement's founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today's modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks tothe future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an "insider's" tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.
Making Healthcare Safe
This unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement's founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today's modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks tothe future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an "insider's" tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.
Textbook of Pharmacovigilance
The second edition of the textbook retains the similar style but with expanded contents. It deals with all aspects ranging from concept to practice of pharmacovigilance. It covers the historical background in the evolution of this emerging science, India's and global scenario, science of pharmacovigilance, and pharmacovigilance of Indian system of medicine. The outstanding features are: - Written in easy understandable style.- Updated India's PV Regulation- Case studies on drug withdrawal and causality analysis.- Key messages giving the gist of each chapter.In brief the book is all about learning, developing competencies, practicing and building career in safety monitoring of medicines.
Cellular and Molecular Pharmacology
Cellular and Molecular Pharmacology is the first book of this type in the market for the M Pharmacy students The book is divided into five units and 20 chapters. The book provides the key insight into topics including recombinant DNA technology, PCR, ELISA, Blotting, Gene therapy, Gene Sequencing, Autophagy, Apoptosis, Micro-Array Technique, Gel electrophoresis, Pharmacogenomics, Gene mapping, Genetic Variations, Proteomics. Genomics, Cell signaling pathways, lmmunotherapeutics, Biosimilars, Animal Cell Culture, Assays and Flow Cytometry. We hope the book will cater the needs of students as well as young faculty in understanding the basic of cellular and molecular pharmacology .
Pharmaceutical Statistics and Research Methodology
Books covering the complete application of Biostatistics in Pharmaceutical and clinical trails data analysis. This book is authored in a detailed and easy to understand in a manner incorporating the updated information containing the following features. - The application of Biostatistics in pharmaceutical calculation and Evaluation. - Prime importance is given to the application in pharmaceutical field.- Introduction of statistical software for analyzing the data.
Nootropics
Do you want to have more focus, motivation, and energy? Would you like to optimize the way your brain functions? Are increased concentration, enhanced memory, improved mood, and reduced anxiety what you're looking for? If you answered yes to any or all of these questions, then this book is definitely for you! Nootropics (sometimes called smart drugs or cognitive enhancers) are substances that improve focus, mood, memory, energy, and other aspects of mental function. Their popularity has exploded over the past few years and is sure to increase in the years to come.Leaders in business, politics, medicine, law, the arts, and other professions have been using these wonderful substances to boost productivity and increase creativity - and now so can you! By the time you're done reading this book, you'll know: What nootropics areHow smart drugs workThe different types of nootropicsHow to get the most out of themWhere to buy different nootropicsWhich ones "stack" well togetherThe benefits of over 20 of the most popular nootropics used today If you're new to the wonderful world of nootropics, you'll have all the information you need to start benefitting from these amazing substances by the time you finish this book. And even if you're already an experienced nootropic user, this book is packed with current info that you're sure to learn from. Are you ready to unlock your brain's full potential?
Marine Anti-inflammatory Agents 2020
This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.
SOLO Field Guide to Wilderness First Aid
The SOLO Field Guide to Wilderness First Aid, Beyond the Golden Hour, Fifth Edition, is the textbook that accompanies the two day course of the same name. The Wilderness First Aid (WFA) course was created out of the direct experience of the founders of SOLO, the famous outdoor school that teaches wilderness medicine all over the world, and is designed for the "outdoor enthusiast". Whether hiker, climber, skier, kayaker, canoeist, or sailor, this course is for the adventurous who may find themselves away from immediate help and may have to rely on their own skills to survive and thrive if an emergency should arise.First offered in 1974 under the name of the Mountain Rescue Seminar, the course became Backcountry Medicine, and eventually Wilderness First Aid. The course has continued to evolve over more than 40 years, through thousands of programs, and hundreds of thousands of students.This book is intended to be a true field guide that SOLO students can carry with them throughout their training and to use as a reference later. This book was designed specifically to compliment the instruction in the SOLO Wilderness First Aid course and is not intended for self-instruction.
The Unseen
The Unseen allows the reader to come to an understanding about exactly what unseen forces have been in play for them throughout their lives, The things that have encouraged every poor decision, failed relationship and Trauma. The Unseen leads you then on to an understanding of the needs of this world, and lastly to a place where you can peacefully coexist with this world having re-found your individual sovereignty
Simultaneous Estimations of Illaprazole and Domperidone
Chemistry is a science that deals with the composition structure and properties of substances and with the transformation that they undergo. Analytical chemistry is a branch of chemistry involved with the analysis of chemical substances. It encompasses the theory and practice of all means of acquiring information about the composition of matter. The analysis is used here in a broad sense to include identifying substances called qualitative analysis, determining the concentration or amount of substance called quantitative analysis and determining the structure of substances. Pharmaceutical analysis plays a very vital role in the Quality Assurance and quality control of Bulk Drugs. Here we developed and validated of illaprazole and domperidone by using RP-HPLC methods.
Process Development of Amlodipine and Olmesartan Medoxomil Tablets
The present study was focused on process development of amlodipine and olmesartan medoxomil tablet 10/40mg. Amlodipine and Olmesartan medoxomil is a combination of a calcium channel blocker and an angiotensin II receptor antagonist used to treat high blood pressure . The Content uniformity was found of both the drugs were performed. Release study was conducted in pH 6.8 buffer media. Furthermore, dissolution profile comparison was carried out using similarity factor (f2) and the similarity factor of Amlodipine and Olmesartan Medoxomil found to be 73. Other studies Like DSC and FTIR studies reported compatibility of Amlodipine besylate with excipients like Cross Carmel lose sodium was performed shows no chemical interaction between drug and excipients. Dissolution profile of Test and Reference standard found to be similar, Similarity factor (f2) is 73.
GMP/GACP - new standards for quality assurance of cannabis
In order to gain high quality of cannabis and cannabis products for medicinal use and to meet some quality standards that will guarantee consistency, traceability and continuous quality of the product, it is necessary to implement Quality Systems. Good quality system is ISO standard system but for cannabis for medicinal use, GACP, GMP and GLC standards are used more often. Production of cannabis for medicinal use consists of: process of cultivation where GACP standards are applicable, primary processing where GMP standards are the most important and quality control of final product regulated with GLP standard. This book will serve as a guide that will facilitate and enable the innovation of new medicinal products in the fight against serious diseases.
Solid Lipid Nanoparticles
This Book is a platform to convey essential concepts of Solid lipid nanoparticles, a colloidal nano drug delivery system. Solid Lipid nanoparticles, known as SLNs This promising drug carrier system is at the interface in the preexisting lipid systems (emulsions and liposomes) and polymeric nanoparticle systems. These concepts can be employed to develop advanced Solid lipid nanoparticles for a range of biomedical applications. This book explains the advantages, dis advantages preparation methods, characterization of SLNs. The applications of SLNs in various fields are explained. It also explains the targeted drug delivery through SLNs. The concept of PEG coating on SLN is also explained.This book has become an important reference source for scientists, teachers, doctors, research scholars, and university students, who are interested in the field.
Artemisia annua with Extraordinary Healing Power
Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention from scientists due to its potent antimalarial properties as secondary metabolites. Moreover, more attentions are focusing on the roles of artemisinin and its derivatives in treating obesity and metabolic diseases. They also have anti-bacterial, anti-inflammatory, anti-tumor, anti-protozoa, anti-helminthic, anti-fungal, anti-angiogenic and antiproliferation properties.
Isosorbide dinitrate - Sublingual Tablets
Sublingual drug delivery traditionally" involves systemic administration via mucosal membrane of floor of mouth or the ventral surface of tongue. The sublingual mucosa is relatively permeable due to the lipoidal nature of mucous membrane with a rich vasculature, which allows rapid absorption and has acceptable bioavailability. It is convenient, facilitates ease of administration and its ability to bypass hepatic first pass.This research elaborate about development Sublingual" tablets of ISBD NT(Isosorbide dinitrate). Compared to all "formulations ISDN4 showed high" % "drug release i.e., 97.15 % "in 8 min so it is considered as best formulation which contains Pullulan as super disintegrate in the concentration of 10 mg".
Neisseria gonorrhoeae Infections
Gonorrhea is a sexually transmitted infection caused by the obligate human pathogen"Neisseria gonorrhoeae". This Gram-negative diplococcus is highly infective due to its virulence factors: pili, Por proteins, Opa proteins, Rmp proteins, lipooligosaccharides and IgA protease. Despite existing guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issuesm such as the molecular mechanisms of the disease, diagnostic tests and different treatment strategies used to combat gonorrhea.
Formulation and Development of Bilayer Floating Tablets of Nifedipine
The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.
