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Current Insights on Lipid-Based Nanosystems
Lipid-based nanosystems, including solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), cationic lipid nanoparticles, nanoemulsions, and liposomes, have been extensively studied to improve drug delivery through different administration routes. The main advantages of these systems are their ability to protect, transport, and control the release of lipophilic and hydrophilic molecules (either small-molecular-weight molecules or macromolecules); the use of generally recognized as safe (GRAS) excipients that minimize the toxicity of the formulations; and the possibility to modulate pharmacokinetics and enable the site-specific delivery of encapsulated payloads. In addition, the versatility of lipid-based nanosystems has further been demonstrated for the delivery of vaccines, the protection of active cosmetic ingredients, and the improvement of moisturizing properties of cosmetic formulations.Lipid-based nanosystems are well established and there are already different commercially approved formulations for various human disorders. This success has paved the way for the diversification of the pipeline of development, to address unmet medical needs for several indications, such as cancer, neurological disorders, and autoimmune, genetic, and infectious diseases.This Special Issue aims to update readers on the latest research on lipid-based nanosystems, both at the preclinical and clinical levels. A series of 15 articles (six reviews and nine studies) is presented, with authors from 12 different countries, showing the globality of the investigations that are being carried out in this area.
Heterocyclic Compounds from Marine Organisms
Marine drugs have drawn considerable attention due to their significant biological and pharmacological properties, such as antimicrobial or antibacterial activities and antitumor effects, among others. The frequent occurrence of heterocyclic motifs in the structure of many of these targets has revealed the key role of these units as promising pharmacophores. In this Special Issue we have gathered several original papers which highlight the isolation, structural elucidation and biological essays of newly isolated heterocyclic marine drugs, as well as reviews which give an overview of the isolation, synthesis and pharmacological activities of different classes of marine heterocycles.
Pediatric and Adolescent Nephrology Facing the Future
The Special Issue entitled "Pediatric and adolescent nephrology facing the future: diagnostic advances and prognostic biomarkers in everyday practice" contains articles written in the era when COVID-19 had not yet been a major clinical problem in children. Now that we know its multifaceted clinical course, complications concerning the kidneys, and childhood-specific post-COVID pediatric inflammatory multisystem syndrome (PIMS), the value of diagnostic and prognostic biomarkers in the pediatric area should be appreciated, and their importance ought to increase.
Endocrine and Neuroendocrine Cancers
Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available.This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives.
The No Breakfast Plan and the Fasting-Cure
The No Breakfast Plan and the Fasting-Cure, has been regarded as significant work throughout human history, and in order to ensure that this work is never lost, we have taken steps to ensure its preservation by republishing this book in a contemporary format for both current and future generations. This entire book has been retyped, redesigned, and reformatted. Since these books are not made from scanned copies, the text is readable and clear.
Biomedical and Pharmacological Applications of Marine Collagen
Biomimetic polymers and materials have been widely used in a variety of biomedical and pharmacological applications. Particularly, collagen-based biomaterials have been extensively applied in various biomedical fields, such as scaffolds in tissue engineering. However, there are many challenges associated with the use of mammalian collagen, including the issues of religious constrains, allergic or autoimmune reactions, and the spread of animal diseases. Over the past few decades, marine collagen (MC) has emerged as a promising biomaterial for biomedical and pharmacological applications. Marine organisms are a rich source of structurally novel and biologically active compounds, and to date, many biological components have been isolated from various marine resources. MC offers advantages over mammalian collagen due to its water solubility, low immunogenicity, safety, biocompatibility, antimicrobial activity, functionality, and low production costs. Due to its characteristics and physicobiochemical properties, it has tremendous potential for use as a scaffold biomaterial in tissue engineering and regenerative medicine, in drug delivery systems, and as a therapeutic.In this Special Issue, we encourage submissions related to the recent developments, advancements, trends, challenges, and future perspectives in this new research field. We expect to receive contributions from different areas of multidisciplinary research, including-but not restricted to-extraction, purification, characterization, fabrication, and experimentation of MC, with a particular focus on their biotechnological, biomedical and pharmacological uses.
3D Innovations in Personalized Surgery
Current practice involves the use of 3D surgical planning and patient-specific solutions in multiple surgical areas of expertise. Patient-specific solutions have been endorsed for several years in numerous publications due to their associated benefits around accuracy, safety, and predictability of surgical outcome. The basis of 3D surgical planning is the use of high-quality medical images (e.g., CT, MRI, or PET-scans). The translation from 3D digital planning toward surgical applications was developed hand in hand with a rise in 3D printing applications of multiple biocompatible materials. These technical aspects of medical care require engineers' or technical physicians' expertise for optimal safe and effective implementation in daily clinical routines.The aim and scope of this Special Issue is high-tech solutions in personalized surgery, based on 3D technology and, more specifically, bone-related surgery. Full-papers or highly innovative technical notes or (systematic) reviews that relate to innovative personalized surgery are invited. This can include optimization of imaging for 3D VSP, optimization of 3D VSP workflow and its translation toward the surgical procedure, or optimization of personalized implants or devices in relation to bone surgery.
Current Challenges and Advances in Cataract Surgery
This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed.
Adaptive Design Methods in Clinical Trials
This second edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology. This edition significantly updates the chapters on p
I know you try
"Psoriasi, dermatite atopica, cefalea, celiachia e allergie sono spesso causate da intolleranze alimentari. La malattia di mio figlio mi ha spinto a cercare e percorrendo strade diverse ho risolto una malattia considerata incurabile. Scoprendo le cause si possono migliorare le condizioni di salute senza ricorrere a medicinali. In questo romanzo documento il mio lavoro e tanta ricerca." (L'autore)
Outcomes and Therapeutic Management of Thyroid Carcinoma
Globally, the impact of differentiated thyroid cancers has significantly increased in the last decade, resulting in growth of public health spending. Many international scientific societies are actively involved in the difficult process of building updated guidelines in response to scientific research, especially in the genetic and immunohistochemistry fields.The watch, wait, and see policy has added a new possibility for patients in selected cases.Considering the recognized international interest in this disease, this Special Issue aims to analyze the most recent acquisitions in terms of the diagnosis and therapy of differentiated thyroid cancer.It will offer the reader an updated point of view of the most illustrious endocrinology and endocrine-surgery international schools.
Stabilization and Resuscitation of Newborns
The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the "Stabilization and Resuscitation of Newborns", aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes.
Chinese Medicine Explained
Traditional Chinese Medicine has been around for the last 3,000 years! It has many complementary and alternative features that cannot be replicated in today's modern medicine even with the combination of advanced technologies. TCM's fundamentals are based from abstract theories like the yin and the yang as well as the 5 elements. It is a rational medical system that can be used not just in treatment but also in diagnosis, prognosis and even prevention of certain diseases. It can be an alternative method to treat all kinds of diseases that people encounter today. This book will teach you the basic theories of Chinese Medicine, the fundamentals, herbal medicines, acupuncture, and how the system can be applied and act as an aid to the many forms of diseases nowadays. This book will guide you on how this ancient system has stand the test of time and why it is now being practiced more than ever today.Chinese Medicine Overview, Theories, Philosophies, History, Western Medicine Comparison, Acupuncture, Herbal Medicines, Methods, Patterns of Disharmony and Much More!
Nutrition, Diet Quality, Aging and Frailty
In the last century, the average life expectancy at birth increased from roughly 45 years in the early 1900s to more than 80 years of age at present. However, living longer is often related to different levels of frailty. There is no curative treatment for frailty-the interventions that have been described as effective to slow or delay the onset of frailty are physical activity and nutritional interventions. Maintaining adequate nutrition status is important to reduce the risk of chronic diseases, many of which are age-related. On the other hand, frailty itself may have a negative effect on eating and, thus, on the nutritional status.This Special Issue, "Nutrition, Diet Quality, Aging and Frailty", addresses the existing knowledge on nutrition regarding the causative factors of frailty and disease due to aging, i.e., strategies for delaying the pathological effects of aging. It consists of twelve peer-reviewed papers covering original research, protocol development, methodological studies, narrative or systematic reviews, and meta-analyses, to better understand these complex relationships.
Biomaterials for Bone Tissue Engineering 2020
This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
Pediatric Fractures
This reprint contains original research and review chapters concerning the latest advancements in various topics related to pediatric fractures. Topics include fractures of the face, clavicle, shoulder, elbow, forearm, wrist, pelvis, femur, and tibia; special considerations focus on osteogenesis imperfecta patients; and consideration is also given to general pediatric fracture topics, such as the influence of the COVID-19 pandemic, mortality after pediatric trauma, the effects of NSAID and electronic cigarette use, and chapters on epidemiology and physical activity.
Indopathy for Neuroprotection
Degenerative nerve diseases are age-related, progressive and cause irreversible neurological loss that may lead too death. Chronic diseases like amylotrophic lateral sclerosis, Huntington's disease, Alzheimer's disease, and Parkinson's disease are associated with insoluble protein depositions and pose serious health challenges that may intensify in the coming decades. Current therapies only help to alleviate some of the physical or mental symptoms associated with neurodegenerative diseases, although there is currently no remedy for slow disease progression. In recent years, attempts have been made to discover a mechanism for neurodegenerative diseases and prospective treatment that may help mitigate aging effects and prevent these diseases. Natural products have been a constant source of new approaches for the treatment of neurodegenerative diseases, in particular plant alkaloids and polyphenolic compounds. Indopathy for Neuroprotection: Recent Advances highlights herbal treatments that are preferred over conventional treatments in some regions. Book chapters focus on the effects of various medicinal plants that have shown promise in reversing pathological symptoms of neurodegenerative disease and highlight the neuroprotective role of medicinal herbal phytochemicals and their mechanism of action. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.
Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers
Introduction.- State-of-the art and ongoing developments.- Clinical cases debate: neoadjuvant checkpoint inhibition vs standard chemotherapy.- Slideshow of tumor samples before and after checkpoint inhibition.- Ongoing trials and clinical trials endpoints debate: the role of pathological response as a surrogate of survival endpoints.- State-of-the-art and future role of molecular biomarkers for patient selection.- Background of immunotherapy trials in prostate cancer.- Clinical case debate: immunotherapy vs alternative therapies in the neoadjuvant and adjuvant setting of localized, high-risk prostate cancer.- Cytoreductive nephrectomy in the era of targeted therapy and immunotherapy.- Clinical cases debate: Neoadjuvant vs adjuvant immunotherapy in localized RCC.- Benchmark of surgical safety results.- What the scientific data tell us about predictive biomarkers of immunotherapy efficacy across the GU malignancies.- Clinical cases debate: biomarker-driven patient selection vs unselective perioperative strategies.
Flies in the Ointment
A carefully selected and edited compendium of the best of Dr. Mark Crislip (the Puswhisperer)'s blog posts from sciencebasedmedicine.org. The sections have been edited for redundancy, updated for 2017, and classified into themes.Supplements and Complementary and Alternative Medicine (SCAM) can be classified many ways; generally speaking, alternative remedies are: Possible: mostly botanicals and herbal remedies. There is nothing impossible that a given plant product will affect a given disease, although often the provenance of a given herbal treatment is suspect.Impossible: the rest of CAM. It will be equally impossible to cover every CAM practice, so just a few are treated in depth.The book is classified as follows: What's the Harm? A general discussion of why SCAM is bad for people, animals, and the environment.Alt-Facts: Why Scientific Thinking is Hard. A discussion of how and why our powers of logic are often powerless against SCAM.Counting to Ten: Statistics for the Rest of Us. A somewhat technical section about statistical errors and fallacies, and why interpreting the literature is difficult even for clinicians. A must-read for lovers of math.Realm of the Possible. A discussion of supplements, including the evolution of my thinking on probiotics.Rectum? Damn Near Killed 'Em. Probiotics and the Gut Microbiome Herbs and SupplementsEliminate the Impossible. Impossible treatments, their fallacies and risks. Chiropractic Homeopathy Acupuncture Miscellaneous Quack RemediesVaccines and Flu Woo. The fallacies behind anti-vaccination beliefs, and why you should always get your flu shot.
Kratom
This book serves to be an unbiased guide so that you can understand all of the important information before you invest money or time into trying kratom.This book goes into the origins and history of mitragyna speciosa, how kratom works, the science behind it, the positive and negative effects of consuming kratom, the different ways to consume it, as well as the legality and dangers involved. By investing in this book, you can get a grasp of the topic so that you can make a solid decision about what you put into your body, or even help other people in your life. In this book you will learn about: Chemistry & pharmacologyResearch about kratomBenefits and potential healing propertiesLegality of kratomConsumption methods, dosages, subjective effectsToxicity and abuseSuccess storiesKratom a new drug of today. How it's used, what are the benefits and downsides of it, what does it consist of, is it dangerous? And how it will affect one's perception, and abilities are only some of the things covered in this book. There are also practical and real-life examples included for those who seek realism in the world full of false information. Want to learn more about kratom? Whether you are looking for more information regarding the substance itself or merely wanting to learn more and educate yourself on this matter, this read is perfect for you. You will get to know about the following essential things after reading this book.
Natural Feed Additives and Novel Approaches for Healthy Rabbit Breeding
This book focuses on the effect of natural substances, bioactive compounds and bacteriocins on rabbit production and reproduction, performance, gastrointestinal microbiota, health parameters, and metabolic processes in rabbits. Obtained information may help in the utilization of natural additives in human and veterinary healthcare without negative impact on environment and animal welfare. Finally, special attention is given to urgent need for more studies to understand the metabolic processes of natural compounds on a molecular level, to establish the beneficial dose.
The Great American Fraud
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The Natural Method of Healing
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The Care and Treatment of Mental Diseases and war Neuroses (shell Shock) in the British Army
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The Book of Pharmacopoeias and Unofficial Formularies
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A Hand-book of Skin Diseases, and Their Homoeopathic Treatment
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Coca Erythroxylon, Vin Mariani
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A Text-Book of Materia Medica
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A Dictionary of Practical Materia Medica; Volume 1
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A Hand-book of Skin Diseases, and Their Homoeopathic Treatment
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The Homoeopathic Vade Mecum of Modern Medicine and Surgery
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On the Temperature in Diseases
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The Dispensatory of the United States of America
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The Dispensatory of the United States of America
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The Lethal war Gases, Physiology and Experimental Treatment; an Investigation by the Section on Intermediary Metabolism of the Medical Division of the Chemical Warfare Service at Yale University
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Eating for Health and Strength
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The Book of Pharmacopoeias and Unofficial Formularies
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A Translation of the Pharmacopoeia of the Royal College of Physicians of London, 1836
A Primer of Materia Medica for Practitioners of Homoeopathy
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Organotherapy or Treatment by Means of Preparations of Various Organs
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The Lethal war Gases, Physiology and Experimental Treatment; an Investigation by the Section on Intermediary Metabolism of the Medical Division of the Chemical Warfare Service at Yale University
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Archives of Physical Medicine and Rehabilitation
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The Materia Medica of the Nosodes With Provings of the X-Ray
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Mesmerism in India, and Its Practical Application in Surgery and Medicine [Ed. by D. Esdaile]
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On the Temperature in Diseases
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Eating for Health and Strength
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New, Old, and Forgotten Remedies
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Gout and Rheumatic Gout
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