Contemporary Clinical Treatment Options and Outcomes of Aortic Valve Disease
Direct Aeromedical Evacuation From USCENTCOM to the Continental United States
Perspectives of Quorum Quenching in New Drug Development
Antibiotic resistance in pathogen microorganisms is a major global concern, especially the formation of biofilms. Quorum quenching has been practically used to control biofilm growth, and this indicates a promising hope for the development of new drugs for the control of biofilm-forming pathogens. This book provides a single source of information about two issues: the biology of quorum sensing and quorum quenching, and the perspectives of quorum quenching in new drug development. The text covers the latest literature from the last ten years and insights into quorum quenching and its need in medicine as an anti-virulence strategy.Features: Exclusively focuses on quorum quenching and its ability to be used as an alternative to antibiotics in the control of multidrug-resistant pathogens. Reviews the latest literature and case studies of the last ten years in the field of quorum sensing and quorum quenching. Promotes a new approach to the development of the next generation of antibacterial drugs. In the wake of rising antibiotic drug resistance, it is crucial to develop an alternative approach to control bacterial infection diseases and quorum quenching appears to be a promising strategy in the development of new medicines.
Innovations in Drug Discovery
This fascinating volume delves into the forefront of pharmaceutical research to shed light on the ground-breaking methodologies and technologies driving advancements in drug discovery today.
Advancements in Hybrid Excipients for Targeted Drug Delivery
"Advancements in Hybrid Excipients for Targeted Drug Delivery" explores the innovative use of hybrid excipients to enhance the precision, efficiency, and safety of drug delivery systems. Combining the benefits of natural and synthetic materials, these advanced carriers improve drug solubility, stability, and controlled release while enabling targeted delivery to specific tissues or cells. The book highlights recent breakthroughs, formulation strategies, and applications in treating diseases such as cancer, infections, and inflammatory disorders. It serves as a valuable resource for researchers, pharmaceutical scientists, and healthcare professionals involved in drug development and delivery system innovation.
Peptide Science
Understand the nature and applications of peptides with this clear and comprehensive guide Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. Peptide Science offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it's a must-own for anyone looking to understand a vital field of chemistry. Peptide Science readers will also find: Through coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs Detailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more A section dedicated to key challenges and future directions in peptide therapeutics Peptide Science is ideal for industry professionals and researchers in organic chemistry, peptide science/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences.
Historical Sketch of the Progress of Pharmacy in Great Britain, by J. Bell and T. Redwood
Molecular Mechanisms in Demyelinating Disorders of the Central Nervous System
This Special Issue reprint explores the molecular mechanisms driving myelin formation, maintenance, and breakdown within the central nervous system, offering a focused insight into demyelinating disorders such as multiple sclerosis. The article "Exploring Myelin Dynamics in Demyelinating Disorders at the Molecular Level" offers a curated overview of recent advances in oligodendrocyte biology, highlighting key regulatory pathways, transcription factors, and cellular interactions that govern myelin dynamics. Drawing from ten representative studies, it emphasizes the translational relevance of early developmental signals, the role of neural and immune system cross-talk, and promising regenerative strategies. Particular attention is given to how molecular and cellular processes contribute to disease progression and to how targeted interventions might reshape current therapeutic approaches. This reprint is especially valuable for researchers and clinicians interested in neuroregeneration, glial biology, and CNS pathophysiology, providing a concise yet comprehensive synthesis of current trends in demyelination research.
Simulations and Applications of Augmented and Virtual Reality
A Guide to Particulate Science in Pharmaceutical Product Development
Hazmat Med Life Support (2nd Ed)
The Hazmat Medical Life Support basic provider course book aims to equip medical responders to a hazmat incident - chemical, radiological or biological - with essential skills and knowledge to safely and effectively manage casualties. It includes basic information about hazmat agents and provides easy to remember algorithmic approaches for the on-scene management of a hazmat event. Essential information on setting up medical operations, triaging and approach to hazmat casualties, personal protective equipment, decontamination, wound management, life support as well as paediatric-specific issues are presented in this book.In this second edition, the content have been revised and updated but still keeping to the same basic approach targeted at medical personnel who are first responders or receivers to hazmat events. New resources especially regarding chemical weapons, antidotes as well as biological agents have been added to keep up to date with current practices. The systematic and practical approach as well as the focus on basic and key issues for specific hazmat agents would be useful foundational training for all levels of medical responders.
Bioactive Encapsulation
Dive into the cutting-edge world of pharmaceutical technology with this comprehensive exploration of luteolin encapsulation and drug delivery systems. This authoritative work presents a detailed examination of luteolin's structure, physiochemical properties, and its remarkable chemo-preventive functions, including anti-inflammatory, antioxidant, and anti-cancer activities. The book meticulously covers various encapsulation techniques, from spray drying to bed fluidized coating, offering readers practical insights into improving bioavailability and drug efficacy. Scientists, researchers, and pharmaceutical professionals will find invaluable information on measuring encapsulation efficiency, optimizing delivery systems, and understanding the critical factors that influence successful bioactive compound preservation. With its thorough analysis of current methodologies and future perspectives, this resource serves as an essential guide for anyone working in drug delivery system development and bioactive compound research.
Modern Community Pharmacy and management
Community pharmacy plays a vital role in delivering primary healthcare services directly to the public. It serves as the first point of contact for patients seeking medical advice, medications, and health education. Over the years, the role of community pharmacists has evolved from traditional dispensing to more patient-centered services such as medication therapy management, chronic disease monitoring, immunization, and lifestyle counseling. This work explores community pharmacy's development, current practices, and future potential, highlighting its importance in improving health outcomes, ensuring medication safety, and enhancing public health. With a focus on accessibility, trust, and cost-effectiveness, community pharmacies act as a bridge between healthcare systems and the population, especially in underserved areas. The summary also addresses challenges faced by community pharmacists, such as regulatory changes, increasing responsibilities, and the need for continuous professional development. By examining global trends and local scenarios, this project underscores the transformative role of community pharmacy in strengthening healthcare delivery.
Lipid Nanocarriers for Cancer
Lipid nanocarriers are a novel drug delivery system that utilizes tiny, fat-based particles to target and treat cancer cells. These nanocarriers have shown great promise in: Targeted delivery: Directly delivering anticancer drugs to tumor sites, reducing side effects, and improving efficacy. Improved bioavailability: Enhancing the absorption and distribution of drugs, leading to better therapeutic outcomes.Enhanced therapeutic index: Maximizing the therapeutic effect while minimizing toxicity.Combination therapy: Allowing for the co-delivery of multiple drugs, targeting various aspects of cancer biology. The benefits of lipid nanocarriers include: Biocompatibility: Composed of natural lipids, reducing toxicity and immunogenicity. Flexibility: Can be engineered to deliver a wide range of anticancer agents.Scalability: Can be produced on a large scale, making them a viable option for clinical translation. Overall, lipid nanocarriers offer a promising approach for cancer treatment, providing a targeted, efficient, and safe way to deliver anticancer therapies.
Textbook of Receptor Pharmacology
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors.The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition's focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text.A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.
WBC Immune Enhancer Tonic
"WBC Immune Enhancer Tonic" explores a scientifically grounded and traditionally inspired herbal formulation designed to naturally boost the body's immune defense system, especially by enhancing the function and activity of white blood cells (WBCs). Rooted in ancient herbal knowledge and supported by modern pharmacological research, this book provides an in-depth analysis of each ingredient's role in immunity enhancement, its mechanism of action, and therapeutic significance.From the basics of immune physiology to advanced evaluation techniques, readers will journey through the formulation process, pharmacognosy, phytochemistry, clinical evaluation, and validated applications of the tonic. Whether you're a researcher, healthcare professional, herbal enthusiast, or student, this comprehensive guide bridges traditional herbal wisdom with contemporary scientific validation-offering a promising approach for natural immune modulation in today's health-conscious world.
Gene Therapy
Gene therapy involves introducing genetic material into a patient's cells to treat or prevent a disease. It can work by replacing a faulty gene with a healthy one, adding a new gene, or modifying existing genes. This is often achieved using vectors, like modified viruses, which act as carriers to deliver the therapeutic gene to the target cells. Gene therapy has shown promise in treating various conditions, including genetic disorders, cancer, and infectious diseases. Present study focus on introduction and types of gene therapy.
The Novel Drug Delivery System
Novel Drug Delivery Systems (NDDS) are advanced methods designed to improve the delivery, effectiveness, and safety of pharmaceutical compounds. Traditional drug delivery often faces limitations such as poor bioavailability, systemic side effects, and lack of targeting. NDDS aims to overcome these challenges through innovative technologies like nanoparticles, liposomes, transdermal patches, implants, and targeted delivery systems. These systems enable controlled and sustained release of drugs, improve drug stability, enhance absorption, and ensure site-specific delivery, reducing side effects and improving therapeutic outcomes. NDDS is particularly significant in the treatment of chronic diseases, cancer, and neurological disorders, where precision and sustained action are critical.The development of NDDS combines principles from pharmaceutics, nanotechnology, biotechnology, and biomedical engineering. As the pharmaceutical industry evolves, NDDS continues to play a crucial role in advancing personalized medicine and improving patient compliance.
Synthesis and Antimicrobial Evaluation of 1,2,4-Triazole Derivatives
Heterocyclic chemistry has long stood at the forefront of pharmaceutical and medicinal research, owing to its immense therapeutic potential and structural diversity. Among the wide array of heterocyclic compounds, triazoles and oxadiazoles have emerged as particularly significant due to their diverse biological activities and favorable pharmacokinetic profiles. This book is the result of a focused effort to contribute to this important domain by synthesizing and evaluating novel compounds that incorporate both 1,2,4-triazole and 1,3,4-oxadiazole moieties.The present work aims to synthesize Schiff bases containing a 1,2,4-triazole nucleus, further hybridized with an oxadiazole scaffold, and to evaluate their in-vitro antimicrobial properties. The synthesis strategies employed include the use of key intermediates such as thiocarbohydrazide, nicotinahydrazide, and appropriately substituted benzaldehydes. Careful selection of reagents and conditions allowed for efficient synthesis and subsequent characterization of the target compounds.
Food and Nutraceutical
In recent years, the convergence of food science and nutraceuticals has captured the attention of both researchers and consumers. This book delves into the multifaceted world of food and nutraceuticals, exploring their scientific foundations, practical applications, and potential implications for human health.Each chapter offers a thorough overview of the latest research on food supplements. We examine how these substances are identified, isolated, and studied for their potential health benefits, while also addressing the challenges and controversies surrounding their use.We extend our gratitude to all the contributors whose expertise and dedication have made this book possible. Their insights and research are invaluable in shaping the narrative of this burgeoning field.Our collective understanding of food and nutraceuticals continues to grow, driven by curiosity, innovation, and a commitment to improving human health. We invite you to embark on this journey with us and explore the fascinating world where food meets medicine.
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A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris
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A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris
