A Guide to Particulate Science in Pharmaceutical Product Development
Simulations and Applications of Augmented and Virtual Reality
Lamotrigine Tablets
Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. While traditional anticonvulsant drugs are primarily antimanic agents, lamotrigine is recognized as one of the most effective drugs for the treatment and prophylaxis of bipolar depression. Two novel drug delivery systems were developed for lamotrigine: orally disintegrating tablets (ODTs) and sustained release tablets (SRTs). ODTs are particularly useful for pediatric and geriatric patients, as well as for those who have difficulty swallowing, providing rapid onset of action to control emergencies. In contrast, sustained release tablets offer the advantage of reduced dosing frequency by prolonging drug action. In this project, both ODTs and SRTs of lamotrigine were prepared using simple methods to address different therapeutic needs in epilepsy management.
Synthesis and Antimicrobial Evaluation of 1,2,4-Triazole Derivatives
Heterocyclic chemistry has long stood at the forefront of pharmaceutical and medicinal research, owing to its immense therapeutic potential and structural diversity. Among the wide array of heterocyclic compounds, triazoles and oxadiazoles have emerged as particularly significant due to their diverse biological activities and favorable pharmacokinetic profiles. This book is the result of a focused effort to contribute to this important domain by synthesizing and evaluating novel compounds that incorporate both 1,2,4-triazole and 1,3,4-oxadiazole moieties.The present work aims to synthesize Schiff bases containing a 1,2,4-triazole nucleus, further hybridized with an oxadiazole scaffold, and to evaluate their in-vitro antimicrobial properties. The synthesis strategies employed include the use of key intermediates such as thiocarbohydrazide, nicotinahydrazide, and appropriately substituted benzaldehydes. Careful selection of reagents and conditions allowed for efficient synthesis and subsequent characterization of the target compounds.
Gene Therapy
Gene therapy involves introducing genetic material into a patient's cells to treat or prevent a disease. It can work by replacing a faulty gene with a healthy one, adding a new gene, or modifying existing genes. This is often achieved using vectors, like modified viruses, which act as carriers to deliver the therapeutic gene to the target cells. Gene therapy has shown promise in treating various conditions, including genetic disorders, cancer, and infectious diseases. Present study focus on introduction and types of gene therapy.
The Novel Drug Delivery System
Novel Drug Delivery Systems (NDDS) are advanced methods designed to improve the delivery, effectiveness, and safety of pharmaceutical compounds. Traditional drug delivery often faces limitations such as poor bioavailability, systemic side effects, and lack of targeting. NDDS aims to overcome these challenges through innovative technologies like nanoparticles, liposomes, transdermal patches, implants, and targeted delivery systems. These systems enable controlled and sustained release of drugs, improve drug stability, enhance absorption, and ensure site-specific delivery, reducing side effects and improving therapeutic outcomes. NDDS is particularly significant in the treatment of chronic diseases, cancer, and neurological disorders, where precision and sustained action are critical.The development of NDDS combines principles from pharmaceutics, nanotechnology, biotechnology, and biomedical engineering. As the pharmaceutical industry evolves, NDDS continues to play a crucial role in advancing personalized medicine and improving patient compliance.
Modern Community Pharmacy and management
Community pharmacy plays a vital role in delivering primary healthcare services directly to the public. It serves as the first point of contact for patients seeking medical advice, medications, and health education. Over the years, the role of community pharmacists has evolved from traditional dispensing to more patient-centered services such as medication therapy management, chronic disease monitoring, immunization, and lifestyle counseling. This work explores community pharmacy's development, current practices, and future potential, highlighting its importance in improving health outcomes, ensuring medication safety, and enhancing public health. With a focus on accessibility, trust, and cost-effectiveness, community pharmacies act as a bridge between healthcare systems and the population, especially in underserved areas. The summary also addresses challenges faced by community pharmacists, such as regulatory changes, increasing responsibilities, and the need for continuous professional development. By examining global trends and local scenarios, this project underscores the transformative role of community pharmacy in strengthening healthcare delivery.
Lipid Nanocarriers for Cancer
Lipid nanocarriers are a novel drug delivery system that utilizes tiny, fat-based particles to target and treat cancer cells. These nanocarriers have shown great promise in: Targeted delivery: Directly delivering anticancer drugs to tumor sites, reducing side effects, and improving efficacy. Improved bioavailability: Enhancing the absorption and distribution of drugs, leading to better therapeutic outcomes.Enhanced therapeutic index: Maximizing the therapeutic effect while minimizing toxicity.Combination therapy: Allowing for the co-delivery of multiple drugs, targeting various aspects of cancer biology. The benefits of lipid nanocarriers include: Biocompatibility: Composed of natural lipids, reducing toxicity and immunogenicity. Flexibility: Can be engineered to deliver a wide range of anticancer agents.Scalability: Can be produced on a large scale, making them a viable option for clinical translation. Overall, lipid nanocarriers offer a promising approach for cancer treatment, providing a targeted, efficient, and safe way to deliver anticancer therapies.
Textbook of Receptor Pharmacology
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors.The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition's focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text.A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.
Bioactive Encapsulation
Dive into the cutting-edge world of pharmaceutical technology with this comprehensive exploration of luteolin encapsulation and drug delivery systems. This authoritative work presents a detailed examination of luteolin's structure, physiochemical properties, and its remarkable chemo-preventive functions, including anti-inflammatory, antioxidant, and anti-cancer activities. The book meticulously covers various encapsulation techniques, from spray drying to bed fluidized coating, offering readers practical insights into improving bioavailability and drug efficacy. Scientists, researchers, and pharmaceutical professionals will find invaluable information on measuring encapsulation efficiency, optimizing delivery systems, and understanding the critical factors that influence successful bioactive compound preservation. With its thorough analysis of current methodologies and future perspectives, this resource serves as an essential guide for anyone working in drug delivery system development and bioactive compound research.
Food and Nutraceutical
In recent years, the convergence of food science and nutraceuticals has captured the attention of both researchers and consumers. This book delves into the multifaceted world of food and nutraceuticals, exploring their scientific foundations, practical applications, and potential implications for human health.Each chapter offers a thorough overview of the latest research on food supplements. We examine how these substances are identified, isolated, and studied for their potential health benefits, while also addressing the challenges and controversies surrounding their use.We extend our gratitude to all the contributors whose expertise and dedication have made this book possible. Their insights and research are invaluable in shaping the narrative of this burgeoning field.Our collective understanding of food and nutraceuticals continues to grow, driven by curiosity, innovation, and a commitment to improving human health. We invite you to embark on this journey with us and explore the fascinating world where food meets medicine.
Multidisciplinary Pain Medicine Fellowship
This book offers a comprehensive review of essential medical knowledge topics that pain fellows need to acquire to successfully graduate a Pain Medicine Fellowship Program. It enhances local curriculum in pain fellowships across the nation and offers standardized education of trainees while also serving as a reference for practitioners and trainees worldwide. The book serves several purposes: Guides and standardizes teaching curriculum for the 120 ACGME accredited pain fellowships and about 200+ non-ACGME accredited fellowships Offers trainees key references essential for their education and future career development Serves as board preparation material Guides pain program directors on developing a program-specific and fellow-specific curriculum tailored towards own institution Chapters follow a natural progression from basic science to topics on interventions, surgeries and emerging techniques in pain medicine. The reader is guided and directed towards concepts needed for progressing into becoming competent pain physicians. Together with introduction of essential topics in pain medicine, each chapter is introducing key publications that are requisite in learning the art and science of pain medicine. In the time where pain medicine is such a dynamic and innovation incubator, Multidisciplinary Pain Medicine Fellowship, will ensure that next generations of pain practitioners speak the basic common language of our specialty and advance best practices in pain medicine.
![A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris](https://cdn.kingstone.com.tw/english/images/product/3237/9781023893237m.webp?Q=f942f "A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris")
A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris
Prevalence of Diabetes, Obesity and Hypertension in Bangladeshi People
![A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris](https://cdn.kingstone.com.tw/english/images/product/8096/9781023898096m.webp?Q=3a1fb "A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris")
A New Supplement to the Pharmacop?]ias of London, Edinburgh, Dublin and Paris
