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Cell Therapy, Bispecific Antibodies and other Immunotherapies Against Cancer
This Special Issue in Cancers is focused on cell therapy, bispecific antibodies, and other immunotherapies against cancer. It includes reports on cell therapies such as CAR-NK cell therapies, and bispecific antibodies against multiple myeloma and B cell lymphoma. Immunotherapies against solid tumors include TGF-beta-PDL-1 fusion protein and EpCAM-CD3 bispecific antibody generated with mRNA-lipid nanoparticles (LNP) against colorectal tumors. The clinical studies ongoing with bi- and tri-specific T cell engager antibodies against solid tumors and advantages versus cell therapies are discussed. This Special Issue highlights novel approaches to cell therapies, bispecific antibodies, vaccines, and immunotherapies that will be interesting for cancer cell researchers, biologists, and oncologists.
Gastrointestinal Malignancies
Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life.Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
Challenges and Opportunities in Application of Cochlear Implantation
Restoring the hearing and enabling the integration of individuals with severe to profound deafness into mainstream society are remarkable achievements, and this Special Issue contributes to the discussion on the latest challenges and advancements in cochlear implantation. This reprint celebrates the remarkable progress in the field as it is dedicated to showcasing a collection of articles that capture the essence of these developments. These articles collectively provide an insightful overview of the advancements in the field of cochlear implants and cover a wide range of topics, from surgical techniques and electrophysiology to auditory rehabilitation and prognosis factors. Readers and researchers can explore these publications to gain a deeper understanding of the latest developments in this transformative technology with the ultimate goal of improving the lives of cochlear implant recipients.
Antimicrobial Prescribing and Stewardship, 2nd Volume
The second volume of the Special Issue entitled "Antimicrobial Prescribing and Stewardship" consists of manuscripts, including original research articles, review articles, and opinion papers regarding antimicrobial stewardship-related topics, including disease-based/organism-based antimicrobial stewardship; the influence of antimicrobial utilization changes on antimicrobial resistance; the impact of antimicrobial stewardship on quality performance measures and patient outcomes; novel antimicrobial stewardship education and training approaches or interventions aimed toward the public and/or healthcare workers; behavioral change approaches to antimicrobial stewardship; collaborative practice agreements in antimicrobial stewardship; antimicrobial stewardship in special populations (e.g., pediatrics, geriatrics, emergency medicine, hematology/oncology); tackling AMR through antimicrobial stewardship in low- and middle-income countries; antimicrobial stewardship for animal health; antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, resource-limited settings, small and rural hospitals); antimicrobial use and stewardship in the context of the COVID-19 pandemic; and global collaborations to tackle AMR through antimicrobial stewardship.
The Spinal Cord During the Middle Second Trimester Through the 4th Postnatal Month 130- To 440-MM Crown-Rump Lengths
This last of 15 short atlases reimagines the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition focuses on the spinal cord during the third trimester and early postnatal period are illustrated and annotated in great detail, together with 3D reconstructions.
Recent Advances in Long-Acting Drug Delivery and Formulations
The Special Issue titled "Recent Advances in Long-Acting Drug Delivery and Formulations" encompasses versatile and innovative research domains of oral, ocular, brain, and topical delivery systems and chemical approaches (e.g., prodrugs), highlighting the progress made in identifying excipients (e.g., basic amino acids to ameliorate gastric side effects of non-steroidal anti-inflammatory drugs (NSAIDs)), polymers, and molecular targets to achieve more effective sustained release systems and safer medicine. In this Special Issue, 78 authors have contributed, with eleven original research articles spanning five continents (Asia, Europe, Africa, North America, and Australasia) providing important insights into the pharmaceutical sciences.
Clinical Research on Type 2 Diabetes and Its Complications
The huge prevalence of type 2 diabetes is a leading human and economic concern worldwide. The diagnosis code of type 2 diabetes includes multiple clinical phenotypes showing different degrees of obesity, fat distribution patterns, types of dyslipidemia, and characteristics of insulin resistance syndrome. In addition, subjects with type 2 diabetes could develop different clinical trajectories, with age being a critical factor in progression. The chronic complications of type 2 diabetes are a major cause of mortality and disability, and are ranked in the top places in western countries' scores. The pathophysiological heterogeneity of type 2 diabetes is not captured by the current classifications and guidelines. The potential for diabetes progression and complications developing is different depending on the type 2 diabetes cluster, which is mostly regardless of the degree of glycemic control. However, the impact on quality and life expectancy with the current therapeutic approach is not always the same for every individual. Clinical research is the key to reducing the burden of diabetes. New basic, digital, and clinical approaches are obtaining useful knowledge and designing more individualized interventions to prevent, track, and treat diabetic complications. This Special Issue is a clear reflection of this methodological evolution.
Bariatric Surgery
This reprint is a compilation of cutting-edge knowledge in the field of bariatric surgery. It addresses the growing obesity epidemic and provides in-depth insights into the latest innovations in bariatric surgery and its future prospects. The content of the work includes a comprehensive review of modern surgical techniques. Additionally, it explores key aspects of preoperative assessment, postoperative follow-up, and the management of potential complications. The reprint highlights the benefits of bariatric surgery in improving the health and quality of life of morbidly obese patients. The reprint also addresses emerging trends in research and technology, such as robotic surgery and gene therapy, which hold the promise of further revolutionizing the field.
Evidence-Based Diagnosis and Management of Facial Nerve Disorders
With increasing speed, new diagnostic and therapeutic approaches for facial nerve disorders are being published. Many of them have improved decision-making, treatment, and the rehabilitation of patients. Unfortunately, there is often a lack of high-quality studies that prove long-term effects or identify subgroups that are of particular benefit. Even a reliable characterization of patients with facial nerve disabilities is often complicated. Therefore, evidence-based management remains challenging.With this Special Issue on the topic of "Evidence-Based Diagnosis and Management of Facial Nerve Disorders", we have brought together experts from various fields, including speech pathology, plastic surgery, otolaryngology, neurology, and physical therapy, to present the latest developments in relation to facial nerve disorders and to present a great variety of topics to our readership. We can see that the topic of facial nerve palsy offers a vast and dynamic spectrum of developments, and hope that the research presented in this Special Issue shows the importance of a multidisciplinary approach. We hope it will not only enhance our knowledge of this condition, but also ultimately improve patient outcomes and their quality of life to some extent.
Breast Cancer-Therapeutic Challenges, Research Strategies and Novel Diagnostics
Thanks to the breast cancer research of recent decades, effective methods and strategies have been established, allowing the mortality rates of breast cancer patients to decrease more and more. However, we still face many challenges. The role of certain biomarkers or mutations is still not clear for treatment and surveillance. Novel drugs are often associated with a different spectrum of adverse events than that seen for conventional therapies, accordingly having an impact on patients' compliance behaviors. In breast cancer surgery, in some cases, the question remains whether to escalate or deescalate. Additionally, with regard to diagnostics, in a digitalized world, home-based tools and therapy monitoring options are of high importance, especially under the tough conditions and supply problems seen during the COVID-19 pandemic.This Special Issue gathers original research articles and reviews demonstrating therapeutic challenges, current research strategies, and novel diagnostics in breast cancer.
Going for Gaps in Glaucoma
Glaucoma is a major cause of blindness that can be prevented if detected and treated in the early stages of the disease. This reprint includes original research studies and reviews that focus on strategies to help identify and treat patients with glaucoma more effectively, improve their treatment adherence, review the potential impact of psychopharmacological therapy on intraocular pressure, and increase knowledge of potential treatment targets for neuroprotection.
PET/CT Imaging in Oncology
This reprint focuses on the most recent advances in PET/CT imaging within the field of oncology. These innovations include studies on novel or experimental tracers, such as [18F]FES for the imaging of advanced breast cancer and [68Ga]Ga-Nitroimidazole for visualizing hypoxic tumour components; research on new radiopharmaceuticals represents, in fact, one the most important study fields of PET research. Advanced image analysis, such as radiomics, is also featured in this reprint; this method has been applied to both traditional nuclear medicine clinical issues, such as thyroid nodules, as well as in the setting of new therapeutic approaches, such as CAR-T cell therapy. Finally, the theranostic implications of PET radiotracers and the diagnostic processes of rare tumours are explored in this reprint.
A Short View of the Frauds and Abuses Committed by Apothecaries As well in Relation to Patients, as Physicians
A Short View of the Frauds and Abuses Committed by Apothecaries As well in Relation to Patients, as Physicians: And Of the only Remedy thereof by Physicians making their own Medicines., is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Pharmacy and materia medica
A text-book on hygiene and pediatrics from a chiropractic standpoint
A text-book on hygiene and pediatrics from a chiropractic standpoint, is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Therapeutics, Pharmacology
Ten Days in a Mad-House; or, Nellie Bly’s Experience on Blackwell’s Island. Feigning Insanity in Order to Reveal Asylum Horrors. The Trying Ordeal of the New York World’s Girl Correspondent.
Ten Days in a Mad-House; or, Nellie Bly's Experience on Blackwell's Island. Feigning Insanity in Order to Reveal Asylum Horrors. The Trying Ordeal of the New York World's Girl Correspondent., is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Internal medicine
The Royal Road to Health; or, the Secret of Health Without Drugs
The Royal Road to Health; or, the Secret of Health Without Drugs, is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Therapeutics, Pharmacology
The Third Great Plague A Discussion of Syphilis for Everyday People
The Third Great Plague A Discussion of Syphilis for Everyday People, is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Internal medicine
Sexual Neuroses
Sexual Neuroses, is a classical and a rare book, that has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and redesigned. These books are not made of scanned copies of their original work, and hence their text is clear and readable. This remarkable volume falls within the genres of Medicine Internal medicine
Advances in Parvovirus Research 2022
Viruses in the Parvoviridae family constitutes a most diverse and intriguing field of research. Parvoviruses have a long evolutionary history and, beneath an apparent simplicity and uniformity, can differ widely in structure, genome organization and expression, virus-cell interaction, and impact on the host. In addition to interest in the study of basic virology, the translational implications of research on parvoviruses are relevant since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and the inherent complexity in the biology of these apparently simple viruses is an ongoing commitment for the scientific community to address. This Special Issue entitled 'Advances in Parvovirus Research 2022' continued the series dedicated to research on viruses belonging to the Parvoviridae family and collected the latest contributions in the field of parvovirus research.
Frontiers in Vascular Stiffness
The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases.
Formulation, Development and Textural Characterization of Nano-Engineering Strategy Assisted Topical Antifungal Nanolipogel
Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, grade: 9.5, language: English, abstract: The aim of the present research work was to formulate, develop and characterize topical antifungal nanolipogel using hundred-times-washed cow ghee base known as shatadhautaghrita. It is used as a permeation enhancer to increase the permeation rate of fluconazole. Nine formulations of nanolipogel were prepared using different concentrations of carbopol and shatadhautaghrita. The optimized batch of nanolipogel (formulation F7) was evaluated for pH, percentage yield, drug content, extrudability, rheology. The consistency, spreadability and formation of nanosize particles were assessed through texture profile analysis and zetasizer. Fluconazole (FLZ) is an antifungal agent used mainly in topical formulations to treat various skin disorders such as oropharyngeal candidiasis, cryptoccocal meningitis and cutaneous dermatophyte infections. FLZ is a synthetic triazole derivative that acts as an antifungal. FLZ preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation. Shatadhautaghrita(SDG) is used as a natural permeation enhancer in topical products. It is prepared by washing cow ghee 100 times with water.shatadhautaghrita is (shata = one hundred, dhauta = washed) clarified butter fat that has been washed 100 times. The use of shatadhautaghrita in managing conditions such as burns, chicken pox, scars, wounds, herpes, leprosy and other skin diseases and as a vehicle for drugs for external application are mentioned in traditional texts. The characteristic odour and granular, oily consistency of cow ghee are not present in shatadhautaghrita, and so it is a homogeneous, smooth, non-oily product that is easier to apply. The neutral pH of shatadhautaghrita compared with the acidic pH value of ghee makes shatadhautaghrita beneficial by preventing skin irritation. The reduced particle size of shatadhautaghrita makes th
Impact of COVID-19 on the Dental Community
The COVID-19 pandemic is considered to be a global public health emergency. Due to its route of transmission via contact with droplets and aerosols, dentists are at high risk of acquiring an infection while treating patients. The impact of the coronavirus on the dental community is eminent, and the greatest challenge is how we can offer dental treatment despite the outbreak. Dental education programs in both under- and postgraduate forms will also suffer from the ramifications of the pandemic. This topical collection offers many perspectives on the management of the COVID-19 crisis within the dental community.
Clinical Advances in the Diagnosis and Treatment of Biliary Tract Diseases
In recent years, there have been remarkable advances in the diagnosis and treatment of biliary tract diseases. Among them, the advanced endoscopic treatments and anti-tumor therapies for biliary tract cancer are outstanding. This reprint contains the latest research articles and review articles focusing on the diagnosis and treatment of biliary tract diseases using endoscopic retrograde cholangiopancreatography (ERCP) or endoscopic ultrasounds (EUSs) for biliary stricture, cholecystitis, cholangitis, ampullary tumors, and chemotherapy for biliary tract cancer.
Advances in Postoperative Pain Management and Chronic Postoperative Pain
This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
Physical Activity, Exercise Testing and Clinical Assessment in Sports Medicine
Physical activity and exercise testing are two key points in sports medicine. Sports medicine is a field of medicine concerned with the prevention and treatment of injuries and disorders that are related to participation in sports. Clinical assessment in sports medicine can solve many questions about diagnosis, treatment, and prognosis related to health in sports. Physical activity could be defined as any bodily movement produced by skeletal muscles that requires energy expenditure. Physical activity refers to all movement including during leisure time, for transport to get to and from places, or as part of a person's work. Both moderate- and vigorous-intensity physical activity improve health. Regular physical activity is proven to help prevent and manage noncommunicable diseases such as heart disease, stroke, diabetes, and several cancers. It also helps prevent hypertension, maintain a healthy body weight, and can improve mental health, quality of life, and well-being. Exercise could be defined as a subset of physical activity that is planned, structured, and repetitive and has as a final or an intermediate objective, such as the improvement or maintenance of physical fitness. Gait and posture analysis, clinical assessment, biomechanical analysis, reliability and repeatability research, force platform and electromyography analysis are key in order to improve our knowledge in this area.
Clinical Research Advances in Congenital Heart Disease
Though the number of infants born with heart disease each year is relatively small (approximately 1% of the population), it is still a substantial issue worthy of investigation, which is why this Special Issue focuses on congenital heart disease in both children and adults. Advances in the treatment of such malformations have led to increased life spans for this population. Consequently, today, most patients treated for congenital heart disease are adults. The purpose of this Special Issue is to deal with the latest developments in the care of the fetus, infants and children, and how these patients should be treated, as well as to describe the results of follow-ups and the potential special needs of adults with congenital heart disease.
Anesthetic Management in Perioperative Period
There are a variety of anesthetic management options during surgery, and these are constantly evolving. Both innovative and confirmatory research are important if the scientific community aims to develop and improve people's quality of care. This reprint introduces new avenues and covers questions regarding innovative anesthetic techniques and unmet needs after surgery, paving the way for future improvements. It can be useful for both clinicians and clinical researchers, especially in light of the expansion of concepts like personalized care.
Orthopedic Treatment of Diseases and Fractures in Elderly
Elderly frailty represents the poor resolution of homeostasis following stress and an increased risk of adverse outcomes, including falls, delirium and disability. This reprint is focused on the diagnosis and treatment of fractures and orthopedic diseases among elderly people. In particular, this concerns medical, orthopaedics and rehabilitative factors. This reprint includes original articles, narrative or systematic reviews and meta-analysis, aiming to provide readers with the correct approach to these pathologies.
New Insights into Pediatric Pulmonology
Children with pulmonology issues have always introduced challenges for pediatricians. This Special Issue provides a platform for researchers and clinicians to discuss the novel methods of functional assessment, new insights into exercise physiology, the effect of maturation and puberty on pulmonary parameters, the translational aspects of overweight and obesity, the evaluation of active rehabilitation in pediatric pulmonology, long-term and post-COVID-19 illnesses, the pediatric origin of adult diseases, etc.
Modern Aspects of Pharmaceutical Quality Assurance
The pharmaceutical quality system ensures that the process performance is suitably achieved, the product quality is regularly met, improved opportunities are identified and evaluated, and the knowledge is constantly expanded. Auditing also plays a crucial role within the pharmaceutical industry. It helps to assess and review quality to improve and build a better system for the benefit of companies. This book aims to develop a tool that will substantially decrease the number of Inspectional Observations and Warning letters, thus eliminating Import Alerts and Consent Decree. This book targets the Pharmaceutical Industry and students of Pharmaceutical Quality Assurance so they can get in hand-ready consolidated information on Pharmaceutical Quality guidelines, Quality metrics, and implementation of simplified SOP guidelines, plant layouts to implement Quality metrics for Pharmaceutical Manufacturing systems in tablets, capsules, liquid orals, and semi-solid dosage forms. The chapters cover the various aspects of Pharmaceutical Quality Assurance. The selection of topics is mainly based on the requirements of Pharmaceutical regulatory guidelines of India, the UK, the USA, Australia, and South Africa. Each chapter includes the abstract, detailed explanation, implementation guidelines, flowcharts, layouts, and Standard Operating Procedure of quality metrics for the Pharmaceutical Manufacturing System
Novel Diagnostic and Therapeutic Approaches in Temporomandibular Disorders (TMDs) and Myofascial Pain
This Special Issue aimed to cover a diverse scope of topics, from diagnostics to the management of temporomandibular disorders and myofascial pain, with a special focus on innovations in those areas. Intense research progress in the subject as well as technological development, access to knowledge, and novel digital tools allow developing more precise, reproducible, and dedicated diagnostic and therapeutic protocols.
Optical Coherence Tomography Imaging
The advent of optical coherence tomography (OCT) has arrived in an era in which the in vivo, cross-sectional imaging of both the retina and choroid is possible. Infra-red rays of light are used to image the chorioretinal layers with an image resolution reaching 10-15 microns. During the last three decades, OCT technology has undergone several improvements, such as spectral domain OCT (SD-OCT), swept source OCT (SS-OCT), enhanced depth imaging (EDI-OCT), wide field OCT, intraoperative OCT, OCT angiography (OCTA), and adaptive optics OCT. These enhancements help in both the qualitative and quantitative analysis of chorioretinal parameters in pathologies such as macular edema, neurosensory detachment, retinoschisis, macular holes, epiretinal membranes, and choroidal tumors. An added advantage is the role of OCT in the evaluation of optic disc disorders, including optic neuritis and glaucoma, via the quantitative analysis of the retinal nerve fiber layer. Moreover, OCT being non-invasive provides an opportunity for serial imaging during follow-up visits. Overall, OCT imaging provides tissue details, closely mimicking the histopathology, and is an invaluable asset in the armamentarium of retina physicians. This special issue includes applications of OCT in various chorioretinal disorders.
Multidisciplinary Approach to Oral Cancer
The growing improvement of medical sciences in the diagnosis and treatment of head and neck oncological diseases has produced a significant increase in the life expectancy of affected patients. it is therefore necessary to direct new energies towards understanding and protecting the quality of life of cancer patients. This reprint presents the fruit of the research protocols of numerous groups around the world on the topics of life expectancy and quality of life of patients suffering from head and neck cancer.
Adme Processes in Pharmaceutical Science
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. Whereas primarily oriented to Pharmacy students and graduates, it can also be useful for scientist from different fields elated to pharmaceutics and pharmacology. (e.g., material scientists, material engineers, medicinal chemists, physicians) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and related biological background.Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies are included as teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, in silico and in vitro prediction of ADME properties, or chronopharmacokinetic. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and is written with experts on the correspondent topic, including industrial scientists and academics from USA and UK.Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations. ADME Processes and Pharmaceutical Sciences is written as a core textbook for courses on pharmaceutical sciences: pharmacology, pharmacokinetics, drug delivery, biopharmaceutics, drug design and medicinal chemistry courses.
Outwitting Our Nerves A Primer of Psychotherapy (Annotated)
"Outwitting Our Nerve: Dr. Josephine A. Jackson; Helen M. Salisbury authored a book called "a Primer of Psychotherapy" in the late 20 century. The work mirrors the medical and psychological knowledge of its era and aimed to provide the general public a simple access to the principles of psychiatry, especially those connected with nervous conditions.Defying Our Nerves: Dr. Josephine A. Jackson, as well as Helen M. Salisbury created A Primer of Psychotherapy.The guide explores the sources as well as therapy of nervous conditions. The authors maintain that a good deal of nervous disorders are due to suppressed feelings and unresolved internal conflicts.Nervous Disorders as well as their Causes: The experts look into the causes individuals might suffer from nervous conditions. They discuss suppressed thoughts, last trauma as well as unhealthy thinking practices.Treatment Strategies: Jackson also as Salisbury highlight the benefits of introspection & knowing yourself. They highlight the job of the head both in the etiology and resolution of many nervous disorders. They give a procedure where individuals confront as well as repair their suppressed conflicts and feelings.Practical Advice: The guide offers readers a selection of valuable ideas and exercises to control and relieve symptoms. Relaxation methods, affirmations that are positive and techniques to alter one's concentration from bad to optimistic thoughts are actually included in that.Caveats: While the guide provides a historic viewpoint seated in the expertise of its medicine, psychology, and era nowadays have significantly advanced after its publication. A couple of the principles at the same time as treatments discussed are possibly dated or perhaps actually have been replaced by far more current theories and techniques."Outwitting Our Nerve" is actually a significant historical exploration of early twentieth century tips on psychotherapy and also the healing of nervous illnesses. Although several of its advice may still be viewed as valuable these days, it is essential to deal with it with an appreciation of its historical context.HISTORICAL CONTEXTPsychotherapy at its inception: The foundations of psychotherapy had been beginning to be built, mainly in Europe, by the beginning of twentieth century. The psychoanalytic concept of Sigmund Freud, based on the unconscious mind, buried memories along with unsolved conflicts had gained popularity. The concept that emotional and mental disturbances may also be treated via talking and introspective processes was innovative and a radical departure from earlier, much more physical methods of treatment.Medical Understanding is transforming: Numerous conditions which we today classify as psychological or psychiatry were frequently misunderstoomed before this era. A woman may often be diagnosed with' hypertension 'which describes a wandering womb. The early 20th century witnessed a shift toward viewing these conditions as intricate interplays of body and mind, instead of exclusively as physical ailments.Mental Health as well as Female's Roles: Women's roles were going through substantial transformation during this period. The suffrage movement had started spreading around the world with women starting to assert their rights and also rethink their positions within society. The redefinition posed difficulties and strains which occasionally showed themselves as "nervous disorders." These social changes can be reflected in literature and works like "Outwitting Our Nerves" as a reaction as well as reflection to these changes.
Pharmacognosy and Phytochemistry II
Is a much-awaited text on the subject, meant for B.Pharm students. It aims at eliminating the inadequacies in teaching and learning of Pharmacognosy & Phytochemistry - II by providing required information on relevant topics.Salient features of book: Simple and uniform pattern of explanation for all topics.Explained metabolic pathways in simplified manner.The inclusion of actual images of crude drugs to identify and remember.Various chemical structures were added to explain the chemistry in brief.Isolation methods are explained stepwise and in a simplified manner.The inclusion of flow diagrams for analytical techniques for easy understanding.Phytochemical analysis explained with modern concepts of Pharmacognosy.
Diagnosis, Treatment, and Management of COPD and Asthma
Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients.
Pharmacognosy and Phytochemistry - I
The Pharmacognosy and Phytochemistry-I book is comprehensive guidance in lucid writing for following theory as well as experimental topics: Theory topics - Introduction to Pharmacognosy - Sources of Crude Drug - Quality Control of Drugs of Natural Origin - Cultivation and Collection of Medicinal Plants - Conservation of Medicinal Plants - Plant Tissue Culture Establishment and Nutritional Requirement - Edible Vaccines - Allopathy and Traditional Systems of Medicine - Introduction to Primary Metabolites and Secondary Metabolites - Fibers - Cotton, Jute, Hemp - Hallucinogenic - Teratogenic - Natural Allergens - Marine DrugsExperiments - Chemical Testing of Crude Drugs - Determination of Leaf Constants - Microscopical Measurements by Micrometer - Physicochemical Evaluation of Crude DrugsContents: Part - I: Pharmacognosy and Phytochemistry-I (Theory)Part - II: Practical Manual
Clinical Features of COVID-19 in Elderly Patients
This reprint "Clinical Features of COVID-19 in Elderly Patients" is a crucial resource dedicated to the medical challenges posed by the pandemic, with a specific focus on its impact on elderly people. Given their vulnerability, understanding the clinical aspects of COVID-19 in this demographic is paramount. This reprint compiles a wide array of studies and current knowledge tailored to address the unique challenges faced by elderly people during the pandemic. It surpasses literature reviews, offering critical analysis and in-depth discussions. Its primary goal is to encourage critical analyses and discussions about the clinical characteristics of COVID-19 in elderly people. Targeted towards medical professionals, researchers, and healthcare practitioners, it aids in the development of tailored treatment approaches and care protocols. As the COVID-19 pandemic persists, this reprint remains essential for those dedicated to combating the virus, enhancing elderly patients' care, and promoting public health.
Pharmaceutical Chemistry
The present book is a culmination of very honest and sincere efforts, keeping in view the level and aspiration of pharmacy students at the undergraduate level. The book includes simple language, neat and clean diagram, descriptive figures, flow charts, questions, multiple choice questions easy to understand by students All efforts have been made to make the book student friendly. This book is designed to impart basic knowledge on the chemical structure, storage conditions and medicinal uses of organic and inorganic chemical substances used as drugs and pharmaceuticals. It will discuss the following aspects of the chemical substances used as drugs and pharmaceuticals for various disease conditions. The chemical classification, chemical name, chemical structure, pharmacological uses, doses, stability and storage conditions of different types of formulations/dosage form available and their brand names. We have tried to make things simpler and easily understandable to our students, for whom this book has been written. Surely, our esteemed friends, while patronizing this book for their class room instruction, will also enjoy it. We honestly feel everyone will find the book refreshingly different and acceptable. Many valuable suggestions from esteemed colleagues and friends from various colleges have been given due weightage in the test.
Herbal Drug Technology
The Herbal drug technology book is comprehensive guidance in lucid writing for following theory as well as experimental topics: Theory topics - Herbs as Raw Materials - Indian Systems of Medicines - Nutraceuticals - Herbal-Drug and Herb-Food Interactions - Herbal Cosmetics - Herbal or Natural Excipients - Traditional and Novel Herbal Formulations - ICH Guidelines for the Assessment of Herbal Drugs - WHO Guidelines for the Assessment of Herbal Drugs - Stability Testing of Herbal Drugs - Patenting and Regulatory Requirements of Natural Products - Plant Based Industries and Institutions in India - Schedule T - Good Manufacturing Practice of Indian Systems of MedicineExperiments - Preliminary phytochemical screening - Evaluation excipients of natural origin - Preparation and evaluation of herbal cosmetics and herbal formulations - Phytochemical estimations - Monograph analysis
Molecules from Side Reactions II
"Molecules from Side Reactions II" is the second edition of the Special Issue "Molecules from Side Reactions". Both the Special Issues belong to the section "Organic Synthesis" of the journal Molbank (ISSN 1422-8599). "Molecules from Side Reactions II" showcases brief papers whose main topic is the synthesis and characterization of molecules obtained from unexpected and/or unpredictable synthetic routes. This Special Issue was revealed to be an important discussion forum for the dissemination of multidisciplinary research results.
Current Trends in Otorhinolaryngology and Head and Neck Pathology
Otorhinolaryngology and head and neck specialists worldwide face an increasing incidence and prevalence of various pathologies, some of the cases neglecting the evolution of their condition during the period of COVID-19 pandemics, thus aggravating their evolution. This Special Issue contains reviews and selected rare case series to update the protocols of ENT and allied specialists worldwide. The aim was to present an interdisciplinary point of view of the numerous branches of pathology that form the otorhinolaryngology specialty.
Head and Neck Surgery
As Guest Editors, we are very delighted to see the reprint of our Special Issue, "Head and Neck Surgery: Clinical Updates and Perspectives", which is published in the Otolaryngology section of the Journal of Clinical Medicine. These papers are the joint effort of many excellent colleagues who have devoted their lives and careers to the exciting field of Otorhinolaryngology. As both clinicians and surgeons, we are actively advancing the diagnosis and management of the myriad of conditions affecting the head and neck region. Unprecedented discoveries in the field of genetics and molecular biology are always integrated with sound knowledge of the intricate anatomy of our discipline, while technological advancements now permit us to provide tailored and minimally invasive treatments for our patients. We wish to thank all the authors who contributed to this publication and we hope you enjoy reading it.
Genomics of Rare Hematologic Cancers
The primary aim of this reprint is to describe the genomics of splenic lymphomas, hairy cell leukemia, Cutaneous lymphomas, plasma cell leukemia, MDS with deletion 5q, mastocytosis, hypodiploid acute lymphoblastic leukemia, CLL with complex karyotype and other rare hematologic cancers.
Sudden Cardiac Death
Sudden cardiac death (SCD) affects more than four million patients per year worldwide, and accounts for up to 50% of all cardiovascular deaths. Related to the improved treatment options for cardiovascular diseases during the past several decades (e.g., improved guideline adherence to pharmacotherapies, increasing supply with cardiac devices, and better revascularization strategies), the characteristics of patients presenting with SCD have significantly changed, making risk prediction for SCD even more complex. The present Special Issue reprint addresses the prognostic impact of patients' characteristics (such as body mass index), airway and ventilation management in patients needing cardiopulmonary resuscitation, and the prognostic value of a targeted ambulance treatment quality improvement programme. Furthermore, the prognostic value of blood-derived biomarkers and cardiac pharmacotherapies for the prevention of SCD was investigated.
Recent Advances in Diagnosis and Treatment of Vestibular Disorders
Vestibular medicine relates to the assessment, diagnosis, and treatment of patients with dizziness and vertigo. In all these fields, there has been an enormous increase in research during recent years. This edition includes a discussion on the epidemiology of dizziness, the role of genetics in the development of vestibulopathy, diagnostic approaches, and interventions for patients with dizziness and vertigo: medical treatment, surgery, and vestibular rehabilitation.
Report On the Effects of Artificial Respiration, Intravenous Injection of Ammonia, and Administration of Various Drugs, &C. in Indian and Australian Snake-Poisoning, and the Physiological, Chemical, a
Originally published in 1907, this report documents the findings of a commission investigating snake-poisoning in India and Australia. It provides a detailed study of the effects of various treatments, including artificial respiration and the administration of different drugs, and offers insights into the nature of snake poisons. This work is a valuable resource for anyone interested in the science of toxicology.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
