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Traditional Chinese Medicine in the Treatment of Post-COVID-19 Syndrome
The COVID-19 pandemic dominated the globe for at least three years, and infected a large proportion of the worldwide population. After the acute infection, many stay in poor health for months. The nature of this aftermath is not yet fully understood, therefore the management of this syndrome through biomedical therapy is not ideal. Health services are struggling to help those who are still suffering. The condition has now been recognised as post-COVID-19 syndrome (PCS) -- providing a common platform for academic exchange.Traditional Chinese Medicine (TCM) has been applied to similar conditions for over 2,000 years, including in the aftermath of previous pandemics, and this understanding of such conditions has been validated in clinical practice. In TCM, patterns are established to group the weakness, the residue of pathogens or interaction between pathogens and the defence system. Those patterns form the framework for understanding the illness after acute infections. The authors use this ancient understanding in their own contemporary practice, which is particularly rewarding when the illness within PCS is treated with acupuncture, Chinese herbs, and other therapies in tandem. This is the holistic TCM approach strongly recommended by the authors as they demonstrate great outcomes. The whole-system TCM approach for PCS is now presented in this book to health professions for PCS.This book has been awarded 2023 International Contribution Award of Chinese Medicine - Works Award issued by the World Federation of Chinese Medicine Societies.
Textbook of Ion Channels Volume III
The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium-calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes.All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.
Respiratory Disease in the COVID-19 Era
Coronavirus disease 2019 (COVID-19) is a new respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused a global pandemic. COVID-19 patients often develop acute respiratory distress syndrome (ARDS), which involves acute and lethal respiratory failure. In a meta-analysis, the median incidence of ARDS in COVID-19 patients was found to be 35 (2-79)%, while the mortality rate in COVID-19-associated ARDS patients was found to be 39 (12.5-73.1)% (Hasan, et al. Expert Rev Repoir Med. 2020; 14: 1149). As of 12 December 2021, 270,373,764 cases had been confirmed as COVID-19 and 5,321,321 cases had resulted in death, according to the World Health Organization webpage. Various symptoms such as persistent fatigue, myalgia, and insomnia can persist after recovery from COVID-19; these symptoms are called "long COVID-19". Patients with COVID-19 who survive but develop pulmonary fibrosis may experience persistent dyspnea upon exertion, a decrease in pulmonary function, and/or a radiological abnormal shadow. Antifibrotic drugs including nintedanib and pirfenidone are candidate drugs for the treatment of pulmonary fibrosis due to COVID-19; randomized controlled trials are ongoing.However, there are limited studies about respiratory disease caused by COVID-19. Given the clinical significance of this topic and its impact on clinical practice and public health, Medicina have published a Special Issue entitled "Respiratory Disease in the COVID-19 Era" with the aim of gathering accurate and up-to-date scientific information of this topic.
HPLC Basics
This book describes the powerful analytical technique, i.e., HPLC, used to separate, identify, and quantify components in a mixture. This book is helpful for various fields, including pharmaceuticals, biochemistry, environmental analysis, food and beverage testing, and forensics. This book discusses the types of HPLC apparatus, their use, components, standard operating procedures, and their limitations.
Nanoparticles in Ocular Drug Delivery Systems
Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations.
Office-Based Laryngeal Surgery
This book provides a detailed description of laryngeal procedures performed under topical anesthesia in an office setting. The last two decades have witnessed a major evolution in laryngology practice toward office-based surgery, thus reducing the risk of general anesthesia and containing healthcare costs while also hastening recovery rates from the time of diagnosis. Beginning with a comprehensive review of the anatomy and physiology of phonation, the book then provides systematic assessment of patients with voice dysfunction secondary to structural and functional laryngeal disorders. It offers detailed instructions on patient selection, safety, tolerance, and proper administration of topical anesthesia. The book supplies detailed descriptions of the various surgical techniques commonly used in office-based laryngeal surgery using color illustrations, photographs and videos. Different surgical approaches are presented including transcervical, transnasal and per-oral techniques. Thebook also supplies a thorough review of the literature on the current status of the most commonly performed office-based laryngeal surgeries including patient care, surgical outcome, and complications. Office-Based Laryngeal Surgery will help laryngologists operating on awake patients in an office setting to be both well-equipped and well-informed.
Marine Natural Products as Anticancer Agents 2.0
Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, "Marine Natural Products as Anticancer Agents 2.0", gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
Therapeutic Potential for Cannabis and Cannabinoids
Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims. This Special Edition of Biomedicines, "Therapeutic Potential for Cannabis and Cannabinoids", was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models examining the efficacy of cannabis and cannabinoid derivatives on pain, anxiety, cancer, and other diseases; and cell and molecular models of cannabinoid pharmacokinetics, drug-drug interactions, and disease treatment. These studies are of great importance not only for progressing the cannabis field, but also for validating the use of cannabis and cannabinoids as therapeutics.
Pathogenesis and Novel Therapeutics in Asthma
Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment is eosinophilic asthma; however, even in some of these patients, anti-IL5 treatment is ineffective. Furthermore, about a quarter of patients, especially those with a severe phenotype, develop progressive and irreversible airway obstruction, leading to persistent symptoms despite optimized treatment. Therefore, new therapeutic approaches are still needed, particularly in severe asthma. The Special Issue presents asthma research focusing on modern personalized therapeutic approaches. Particular interest is directed to novel asthma biomarkers, including molecular and epigenetic ones, shining new light on pathogenesis, phenotyping, and customized therapy in various airway inflammatory patterns of the disease. In addition, research articles on airway epithelial cell dysfunction, airway remodeling, and the overlap between asthma and chronic obstructive pulmonary disease are welcomed.Stanislawa Bazan-Socha (Guest Editors)
Data Monitoring Committees (Dmcs)
This book provides an overview of Data Monitoring Committees(DMC) - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended 800 DMC meetings from 200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotechnology and pharmaceutical company and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to expertly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the impact of DMC activity on safeguarding the trial is so important.This book provides the following: Provides thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation;Includes practical and hands-on information on DMC implementation;Discusses a wide range of clinical trial - by phase and therapeutic area.
Pomegranate
Pomegranate (Punica granatum L.) is one of the oldest edible fruits in the Mediterranean and has been used extensively in folk medicine. This book summarizes the antioxidant properties and bioactive polyphenolic ingredients in Greek pomegranate varieties and the vasculoprotective and neuroprotective effect of various parts of pomegranate and its main compounds, especially hydrolysable tannins, ellagitannins, ellagic acid, and their metabolites. Research has shown that pomegranate extracts possess unusual and potent broad-spectrum activities against Gram-positive and Gram-negative bacteria, fungi, viruses, and parasites. As such, the book also explores the role of pomegranate in the treatment of cancer and SARS-CoV-2 infection. Finally, the book investigates the post-harvest management of pomegranate in industrial processing to improve pomegranate utilization for human health.
Cardiovascular and Metabolic Disease
The present Special Issue will lead you to discover the association between cardiovascular and metabolic diseases, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of cardiovascular event prevention. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures.
Abuse of Minors in Clinical Studies
With the emergence of effective drugs and observed drug toxicities in babies, two mantras emerged: that children are therapeutic orphans, and that children are not small adults. US and EU laws demand pediatric studies as a condition for the approval of new drugs in adults. This is called "Pediatric Drug Development" (PDD). Although apparently reasonable, there are catches. Children are vulnerable at birth, but they grow and become bodily mature with puberty, well before coming of age. Minors are not another species. The 18th birthday, an administrative/ legal limit, does not correspond to a physiological change. Drugs treat the body, not the legal status. PDD results in pointless studies in bodily mature adolescents, and in exaggerated studies in younger minors. An originally well-intentioned concept results in thousands of questionable studies worldwide.This book draws attention to conflicts of interest and ethical dilemmas of PDD and questions its applicability for adolescents and minors that are no longer babies.
Functional Foods as a New Therapeutic Strategy
The articles discussed in this book show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases.
Physical Activity and Pandemics
The pandemic of COVID-19 has caused public health-related, and economic consequences regarding lifestyles. Due to social distancing strategies, physical inactivity has increased in various societies, which might lead to an increase in the burden of non-communicable diseases in long term. The health benefits of physical activity consist of a wide range, including physical, mental, and social dimensions. Therefore, this book discusses whether engaging in regular physical activity is effective in preventing COVID-19 infection, reducing the severity of symptoms, reducing mortality, or eliminating COVID-19 complications.The book will serve as a practical guideline for public health experts and physicians. It covers COVID-19 and physical inactivity prevalence in different regions, physical activity and risk of COVID-19 infection, physical activity and course of COVID-19 infection including disease severity, hospitalization rate, ICU admission, and mortality, physical activity as a vaccine booster in different populations, post- COVID-19 physical rehabilitation, and strategies for enhancing physical activity in the COVID-19 pandemic.
Drug and Therapy Development for Triple Negative Breast Cancer
Drug and Therapy Development for Triple Negative Breast Cancer The first comprehensive and up-to-date compilation of modern diagnostic and treatment methods for triple negative breast cancer In Drug and Therapy Development for Triple Negative Breast Cancer, a team of distinguished practitioners delivers an in-depth and authoritative discussion of contemporary methods for treating triple negative breast cancer (TNBC). The editors have included material that covers its molecular causes, initial detection, diagnostic tools, treatment procedures, pharmacology, and new and experimental therapies--including nanotherapeutics and photothermal therapies. As the first comprehensive compilation of modern treatment methods for TNBC, this reference is an unmatched source of information about current and future treatment approaches, including machine learning methods for earlier detection and more accurate diagnosis. Readers will also find: A thorough introduction to HER receptors in breast cancers Comprehensive explorations of the etiology and therapy of hormone receptor-positive breast cancer and the early-stage diagnosis of breast cancer Application of artificial intelligence to breast cancer diagnosis New insights on the role of DNA replication stress and genome instability in breast cancer Perfect for medicinal and pharmaceutical chemists, Drug and Therapy Development for Triple Negative Breast Cancer will also benefit oncologists and professionals working in the pharmaceutical industry or in hospital settings.
Alternative Medicine
A thorough yet simple and easy-to-read guide that discusses the many different components of alternative medicine and how they might help you. This guide covers many different alternative therapies, such as: - Hypnosis - Color therapy - Yoga - Meditation - Herbal remedies - Vitamin therapy - And many more! Here is just some of what you will learn by reading this amazing book: - The differences between conventional and alternative treatment methods - plus, how to know if an alternative treatment is right for you!- The history of alternative medicine - you may be very surprised by what you read here!- The type of alternative medicine that 25% of the world's population practices - along with its five most popular treatment methods and what each can do for you!- A type of alternative medicine that relies almost solely on herbal remedies - this treatment method has been around for over 2,500 years and could be just what you need to begin feeling better in no time!- The alternative medicine techniques of Native American Indians - these techniques have been used effectively for over 40,000 years, according to many experts ... and they work just as well today as they ever have!- Why practitioners of Ayurvedic Medicine believe the body must be balanced - and how that can be accomplished quickly and easily!- The most popular form of alternative medicine - and five reasons why you should try it to begin feeling better immediately!- Herbal remedies for common ailments - find out how to naturally cure acne, anxiety, burns, warts and much more here!- How to cure numerous ailments including arthritis, constipation, depression and the flu with herbal tea - you'll be amazed at how easy it is to do when you follow these simple tips!- How five products produced by bees could have you feeling better fast - you'll be simply amazed when you read this!- And much, much more.
Minimally Invasive Urological Procedures and Related Technological Developments
We are in the modern era of innovations, technological developments and minimisation in the field of urology. While laparoscopy and robotic surgery have revolutionised pelvic and upper tract oncology, there is continuous evolution and increasing use of these in the field of benign conditions and paediatric urology. As lasers have changed endourology, new minimally invasive surgical techniques (MISTs) have given a new meaning to benign prostate hyperplasia (BPH) surgery. Oncological developments for prostate cancer now include treatments such as robotic prostatectomy, brachytherapy, radiotherapy, cryotherapy and HIFU. Robotic partial nephrectomy and cryotherapy have changed the face of renal cancer. While robotic cystectomy is also gaining popularity for muscle-invasive bladder cancer, new concepts of En-bloc resection of bladder cancer are emerging and being increasingly adopted. MISTs for BPH include laser (Holmium, thulium and green light), water-based treatments (Rezum, Aquablation) and other minimally invasive procedures such as prostate artery embolisation (PAE), TIND and Urolift. There is increasing emphasis on the role of suction in endourological procedures, while the quest for better intrarenal pressure and temperature monitoring continues. The use of Thulium fibre laser (TFL), Moses technology and small disposable ureteroscopes all help in pushing the boundaries of ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) procedures. These new technological developments have led to improvements in patients' quality of life (QoL), shorter hospital stays and reductions in complication rates.
Biomarkers in Neurodegenerative Diseases 2.0
This book follows up on the previous volume focusing on the different biomarkers for neurodegenerative diseases. It includes original research works and review articles focusing on an improved understanding of disease mechanisms. It also aims to identify aspects of early therapeutic intervention for enhanced disease management. Some critical approaches include studies involving human tissue samples, mouse disease models, and different imaging techniques. These studies present the essential information necessary to address such pathological conditions in the future.
PTCB Exam Study Guide 2023-2024
Introducing our PTCB Exam Study Guide 2023-2024: 4 Full-Length Practice Tests and Prep for the Pharmacy Technician Certification (PTCE)! Ascencia Test Prep's PTCB Exam Study Guide includes everything you need to pass the Pharmacy Technician Certification Exam the first time.Quick review of the concepts covered on the PTCE4 FULL practice tests with detailed answer explanationsTips and tricks from experienced pharmacy techniciansAccess to online flash cards, review questions, cheat sheets, and moreAscencia Test Prep's PTCB Exam Study Guide is aligned with the official PTCE framework. Topics covered include: MedicationsPharmacologyDrug Effects and IndicationsFederal RequirementsLegal GuidelinesRegulation of Controlled SubstancesPatient Safety and Quality AssurancePrescription ErrorsSafety in the WorkplaceOrder Entry and ProcessingOrder ProcessingPharmacy Math The PTCB was not involved in the creation or production of this product, is not in any way affiliated with Ascencia Test Prep, and does not sponsor or endorse this product.
Plant-Derived Phenolic Compounds
Plant-derived phenolic compounds whose most important classes are flavonoids (i.e., catechin, epicatechin) quinones, stilbenes (i.e., resveratrol) and essential oils (i.e., thymol, carvacrol), widely found in fruits, seeds, flowers, and leaves, are considered as beneficial molecules for prevention and treatment of several diseases, since it has been shown that they have antioxidant, anticarcinogenic, cardioprotective, neuroprotective, and anti-inflammatory properties. The Special Issue contains contributions concerning different aspects of the use of phenolic plant-derived molecules for prevention and therapy of several diseases, in order to understand the mechanisms involved in their protective role, their bioavailability and their metabolism in human tissue. Moreover, the use of different strategies for extraction, synthesis, and delivery of these compounds, has been covered.
Nanomedicine Based Drug Delivery Systems
This reprint entitled "Nanomedicine Based Drug Delivery Systems: Recent Developments and Future Prospects" contains 14 articles in total. This includes one editorial, ten research articles, and three review articles. All articles are associated with nanomedicine-based drug delivery systems for the solubility, bioavailability, and therapeutic enhancement of active drug molecules. In recent years, there has been a tremendous amount of research on nanomedicine-based drug delivery systems. This reprint has brought together prominent scientists who have explored a diverse range of applications of nanomedicine-based drug delivery systems. I believe that further clinical and toxicological studies on both animal and human models are still required to explore the complete potential and commercial exploitation of nanomedicine-based drug delivery systems. The diverse and critical perspectives within this reprint provide sufficient information on the development, characterization, and evaluation of nanomedicine-based drug delivery systems.
Medicinal Agroecology
Medicinal agroecology brings together the realms of medicinal plants and phytomedicine with the world of agroecology. This book aims to communicate the benefits of using natural solutions to manage the challenges of unsustainable practices in human healthcare, veterinary medicine, agriculture, and forestry.
Novel Approaches for Overcoming Biological Barriers
The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery.
Emerging Chemical Risks in the Work Environment
The book will provide the tools for occupational risk assessment for chemical agents and measures to protect human health and reduce chemical hazards at the workplace. Increased awareness about new emerging risks related to chemical agents will result in the reduction of several illnesses such as cancer, abnormal child development, and diabetes.
Trends in Counterfeit Drugs
This book addresses trends in counterfeit drugs over the past 5-10 years, and discusses approaches to reducing counterfeit medicines in the market. The text shows perspectives from both crime lab and toxicology lab personnel, as well as academic researchers.
PTCB Exam Prep 2023-2024
Become a certified pharmacy technician and land the job of your dreams with this comprehensive study guide that will fully prepare you for the PTCB Exam!Worried about failing the upcoming pharmacy technician exam? Looking for the best study guide possible to help you pass it on your first try?Each year, thousands of candidates give their all in an effort to pass the PTCB exams.With a passing rate of only 59% over the past 7 years, the exam has earned a reputation for being extremely difficult.But there's no reason to stress out. With the proper preparations and focused, consistent study, you can be one of the special few who only need to take it once.While self-study and making your own materials are good options, you'll save time and effort with a ready-made comprehensive study guide covering all the topics that will be included in the test. You'll have a significant head start on the exam without having to sift through mountains of materials.In this manual, you won't just find all the information you need to study - you'll also have detailed practice tests, similar to what you'll encounter in the exam, so you know what to expect on the big day.Inside, you'll discover: A rundown of the PTCB exam, its objectives, and who is eligible to take itStudy strategies to help you avoid burnout and do well on the testA breakdown of the PTCB exam's four subject areas and corresponding study guides for eachA closer look at pharmacology: drug classifications, interaction and contradictions, therapeutic equivalence, compounding, and moreStrategies for the safe handling and disposal of substances and waste, as well as the laws and regulations governing the work of a pharmacy technicianPatient safety and quality assurance initiatives to safeguard the health of drug users and reduce the likelihood of medical mistakes, sketchy prescriptions, and moreOrder entry and processing - study up on compounding non-sterile products, reading prescriptions, working with drug administration supplies, and dealing with expired medicationsA compilation of commonly prescribed drugs and medications, along with their brand and generic names, to help you study4 complete sets of practice tests with extensive explanations to help you prepare for exam dayAnd much more!While there is always a second chance if you don't pass the first time, it's best to succeed the first time around.There will be many obstacles and diversions on your path, but if you follow this reviewer you will have a good chance of achieving your goals.Every second counts, so don't procrastinate any longer and dive headfirst into your PTCB study material!If you want to level up your PTCB exam preparation, then you need this book today!
Thrombolysis and Thrombectomy in Acute Ischemic Stroke
In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke.
Recent Advances in Dual Disorders (Addiction and Other Mental Disorders)
Dual disorders, meaning the coexistence in the same individual of a substance use disorder and another mental disorder, have become an area of great interest in the fields of psychiatry and addiction and in health overall due to their high prevalence, clinical relevance and multicultural presence. This book includes a compilation of papers published between the end of 2021 and the beginning of 2023 focused on recent advances in dual disorders.The contributions present a broad look at various relevant aspects. Among them are the characterization of patients treated in different services, with special interest in the risk of overdoses, suicidal attempts and HIV, as well as the so-forgotten gender perspective and the impact of the COVID-19 pandemic on the attention of addiction centers. One of the first studies to consider the comorbidity of gambling disorders with substance use is also presented. The possible usefulness of explanatory models of machine learning for diagnosis and for performing chronobiological measurements that allow a more individualized treatment stand out among the novel contributions to the field of dual disorders. The aim of each of the contributions of this book is to be transferred for the benefit of clinical practice.
Alternative Medical procedures
An in-depth look at the many various aspects of alternative medicine and how they might benefit you. Concise, easy to read, and comprehensive. This guide covers many different alternative therapies, such as: - Hypnosis - Color therapy - Yoga - Meditation - Herbal remedies - Vitamin therapy - And many more! Here is just some of what you will learn by reading this amazing book: - The differences between conventional and alternative treatment methods - plus, how to know if an alternative treatment is right for you!- The history of alternative medicine - you may be very surprised by what you read here!- The type of alternative medicine that 25% of the world's population practices - along with its five most popular treatment methods and what each can do for you!- A type of alternative medicine that relies almost solely on herbal remedies - this treatment method has been around for over 2,500 years and could be just what you need to begin feeling better in no time!- The alternative medicine techniques of Native American Indians - these techniques have been used effectively for over 40,000 years, according to many experts ... and they work just as well today as they ever have!- Why practitioners of Ayurvedic Medicine believe the body must be balanced - and how that can be accomplished quickly and easily!- The most popular form of alternative medicine - and five reasons why you should try it to begin feeling better immediately!- Herbal remedies for common ailments - find out how to naturally cure acne, anxiety, burns, warts and much more here!- How to cure numerous ailments including arthritis, constipation, depression and the flu with herbal tea - you'll be amazed at how easy it is to do when you follow these simple tips!- How five products produced by bees could have you feeling better fast - you'll be simply amazed when you read this!- And much, much more.
Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0
Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features of the disease, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used in the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of heart attack and other cardiovascular problems. It is therefore crucial that we continue to research the pathogenesis of arthritis and seek to discover novel modes of therapy. This book summarizes the themes of the 29 articles published in our Special Issue "Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0". This book details important novel research discoveries that contribute to our current understanding of arthritis.
Orthopedics and Trauma in Children
Discover the complexities of pediatric orthopedics in this comprehensive reprint book. Pediatric orthopedics present unique challenges in diagnosis and treatment, necessitating the expertise of skilled specialists. Congenital, developmental, and acquired orthopedic issues, including infectious, neuromuscular, nutritional, neoplastic, psychogenic, and traumatic conditions, are explored. With a focus on evidence-based recommendations, this book addresses the management of orthopedic deformities in children by considering different clinical scenarios. From upper and lower limb injuries to severe trauma, readers will gain insights into decision-making processes for reconstruction or amputation. As a valuable resource for orthopedic surgeons, pediatricians, and healthcare professionals, this reprint fills knowledge gaps to optimize patient care.
Bio-Active Products from Mangrove Ecosystems
Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas, between 5簞N and 5簞S latitudes, spanning over 118 countries. The special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for the metabolic pathway via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have taken the limelight as an attractive biodiversity hotspot, attracting significant attention from organic chemists and pharmacologists. Additionally, many unique and novel chemical structures with a wide range of structural classes have suggested various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles describing recent studies and pertinent reviews focusing on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of putting together a group of top researchers whose work we would like to feature in this collection, and we would like you to participate.
Sample Sizes for Clinical Trials
This book assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them.
Strategies to Enhance Drug Permeability across Biological Barriers
Overcoming biological barriers is a significant challenge in drug development, and recent advancements in drug delivery systems and technologies offer promising solutions. This Special Issue highlights the innovative approaches and techniques being used to improve drug permeability and absorption, as well as their potential impact on a wide range of therapeutic goals. These advancements being made in drug delivery and permeability offer exciting possibilities to improve patient outcomes.
Molecular Recognition in Pharmacology
This unique volume gives the basics of thermodynamics and kinetics of complex formation between ligands and receptors. The book is intended for pharmacologists, chemists, physics engaged in the creation of new medicinal substances.
Climbing Medicine
This book comprehensively discusses the medical aspects of sports climbing, a still young but emerging sport, which will be one of the disciplines at the Tokyo Olympics. Its rapid development from niche to popular sport has been accompanied by an increase in the number of climbing-sports-specific injuries and has attracted growing interest within the sports medicine community. Gathering expertise from around the globe, the book covers all aspects related to this discipline - from physiology, biomechanics and anatomy through upper and lower extremity injuries to cardiology, gynecology, pediatric and adolescent conditions. Following a coherent structure, each chapter equips readers with evidence-based diagnostic and therapeutic guidelines. Enriched by a wealth of pictures, this manual offers a timely and up-to-date resource for sports physicians, orthopedic surgeons and traumatologists, as well as trainers, physiotherapists and other health professionals involved in climbing.
Unlearn Pain
This book shows concrete techniques and exercises of psychological pain management, with which it is possible to reduce pain permanently. It is aimed at all pain patients who want to actively manage pain and at all therapists and doctors who want to support their patients in this. The more than 30 successful techniques and exercises, such as mindfulness exercises, relaxation techniques or hypnosis procedures, can be used alone at home without a doctor or therapist. Each exercise is explained step-by-step and simply, is scientifically recognized, has no side effects, and is effective regardless of the cause or location of the pain. The book also provides a wealth of background information on the development of pain and numerous practical tips. The 4th edition is completely updated.
Pathological Mechanisms in Diabetes
Diabetes is a worldwide public health problem that can be explained by the classic model of the determinants of health. Thus, success in preventing diabetes mellitus and its associated complications not only depends on the individual but also on social and community networks as well as general socioeconomic, cultural, and environmental conditions. For that reason, we need to create conditions that ensure good health and social care for an entire population through the development and implementation of preventive strategies, promotion of healthy lifestyles, protection from diseases, and the design of targeted screening strategies. This aligns with the United Nations Sustainable Development goal number 3, good health and well-being, which includes the achievement of universal health coverage and access to quality essential healthcare services. In addition, this also has a direct link to goal number 10, which focuses on reducing inequalities within and among countries. Pathological Mechanisms in Diabetes is a compilation of high-quality scientific evidence aimed at unraveling the molecular mechanisms involved in the association between diabetes and comorbidities and at describing their clinical and therapeutic implications. The variety of updated topics included from different approaches shows the need for more efficient preventive activities to reduce the incidence of this disease and its related complications.
Update on Robotic Gastrointestinal Surgery
Since the introduction of robotic surgery in the early 2000s, several studies have demonstrated its safety and feasibility in various complicated procedures, including esophageal, gastric, and colorectal surgery (for both benign and malignant pathologies), hepatobiliopancreatic surgery, and gynecological and urological procedures.Robot-assisted surgery provides the advantages of a magnified tridimensional view and movement stability without a tremor, which facilitate a precise dissection. The EndoWrist instrument also facilitates dissection at difficult angles, thus enabling surgery in complex conditions.Even if some of the advantages of robotic surgery have been defined, we are still far from clearly recognizing precise indications for a robotic approach in gastrointestinal surgery.With this Special Issue, we aim to investigate the conditions that support the robotic approach in gastrointestinal surgery toward the definition of gold-standard robotic procedures, as established in urological surgery for prostatectomy.
Artificial Intelligence in Pharmaceutical Sciences
This cutting-edge reference book discusses the intervention of artificial intelligence in the fields of drug development, modified drug delivery systems, pharmaceutical technology, and medical devices development. It discusses the role of machine learning in the automated detection and sorting of pharmaceutical formulations.
Leaders in Cardiovascular Research
The arterial pole is one of the most complex parts of the heart both in development and disease. It involves the collaboration and orchestration of contributions from the first and second heart fields as well as the neural crest. The precursor cells differentiate into endocardial cushions and putative cardiac valves, the myocardium, and epicardium of the heart, but also into the different layers of the main arterial vessels. These include not only the aorta and the pulmonary trunk but also the pulmonary and coronary arteries, and during development, the arterial duct. Many transcriptional and signaling networks act in timely concert to acquire the proper asymmetric development and function and pressure and flow dynamics. This is not only a human or even mammalian 'enterprise, ' but is also taking place in so-called ancestral forms from fish to reptiles, including birds. In humans, it is small wonder that many clinical syndromes may arise when something in this complexity is amiss.This Special Issue of JCDD contains contributions focussed on the heart fields, congenital cardiac malformations and associated syndromes, with special emphasis on the cardiac outflow tract.The Issue is devoted to Prof. Dr. Adriana Gittenberger-de Groot, who dedicated her extensive career to research on cardiovascular development.
Basic Chemistry for Life Science Students and Professionals
Organic chemistry plays a vital role in the pharmaceutical industry. Knowledge of organic compounds is used to inform research and further the discovery and development of new medicines. Likewise, organic chemistry is fundamental to understanding biological reactions, mechanisms and all life sciences in general. Basic Chemistry for Life Science Students and Professionals is an ideal introduction to organic chemistry in the context of the life sciences and pharmacy related disciplines; utilising drug molecules to illustrate the chemical basis of their efficacy and interaction with biological targets. This book builds upon the basic concepts of organic chemistry to develop the reader's understanding of the importance of organic chemistry to the life sciences from natural product sources, their synthesis, and approaches to drug discovery. Ideal for undergraduate students in the natural sciences, this book is also an excellent primer for postgraduates in a variety of disciplines including forensic science and allied-health programmes as well as professionals working in related fields seeking a comprehensive introduction to organic chemistry in the context of pharmaceuticals.
Mistletoe and the Emerging Future of Integrative Oncology
Human disease is an elaborate dance between behavior, our environment, and chance. Medicine tries to tame human disease with science, but when our knowledge falls short, disease wins. This is too often the case with cancer. We spend billions of dollars each year trying to better understand it and develop tools to ease its effects. Today, many allopathic medical practitioners are beginning to seek out a greater connection with holistic and integrative approaches. The authors of this book introduce one specific therapy and make a case for integrative health in general, including anthroposophically extended medicine, naturopathy, and other holistic approaches. Mistletoe therapy has long been considered a viable treatment for cancer by the European medical community and is beginning to gain recognition in North America, as well. The mistletoe plant possesses many remarkable properties. As a therapy, it represents a rediscovery of ancient wisdom and shows us how the science of modern medicine might expand its reach and reconnect with a more human-centered medicine.The book was structured following the syllabus for a three-day practitioner training hosted by the Physicians' Association for Anthroposophic Medicine (PAAM). The chapters highlight several of our key lectures in a condensed form. The book serves as an introductory summary of--not a replacement for--those intensive professional trainings.This book is constructed as a journey and is meant to be read in its entirety, whether by a patient, a practitioner, a supporter of integrative oncology, or anyone who takes a deep interest in one's own health concerns. The text is accessible, and the reader does not need a science background to understand the majority of the content.While this book should not be considered a treatment or diagnostic manual, it is intended to both prepare practitioners to begin mistletoe therapy training and to make this information available in an accessible form to anyone interested in learning about this approach to treating cancer.Illustrated in color and b/w
Chinese Medicine for Upper Body Pain
This book explores other pain management options, introducing treatments such as acupuncture, herbal medicine, and Tui Na (Chinese bodywork). It provides concise explanations in terms of anatomy, pathology, and etiology for both Western and Chinese medicine, and also provides selfcare instructions that are effective and easy to follow.
From Pharmd to Industry
For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one's pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application processAn understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professionalThis book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.
Doubt Is Their Product
"Doubt is our product," a cigarette executive once observed, "since it is the best means of competing with the 'body of fact' that exists in the minds of the general public. It is also the means of establishing a controversy." In this eye-opening expose, David Michaels reveals how the tobacco industry's duplicitous tactics spawned a multimillion dollar industry that is dismantling public health safeguards. Product defense consultants, he argues, have increasingly skewed the scientific literature, manufactured and magnified scientific uncertainty, and influenced policy decisions to the advantage of polluters and the manufacturers of dangerous products. To keep the public confused about the hazards posed by global warming, second-hand smoke, asbestos, lead, plastics, and many other toxic materials, industry executives have hired unscrupulous scientists and lobbyists to dispute scientific evidence about health risks. In doing so, they have not only delayed action on specific hazards, but they have constructed barriers to make it harder for lawmakers, government agencies, and courts to respond to future threats. The Orwellian strategy of dismissing research conducted by the scientific community as "junk science" and elevating science conducted by product defense specialists to "sound science" status also creates confusion about the very nature of scientific inquiry and undermines the public's confidence in science's ability to address public health and environmental concerns Such reckless practices have long existed, but Michaels argues that the Bush administration deepened the dysfunction by virtually handing over regulatory agencies to the very corporate powers whose products and behavior they are charged with overseeing. In Doubt Is Their Product Michaels proves, beyond a doubt, that our regulatory system has been broken. He offers concrete, workable suggestions for how it can be restored by taking the politics out of science and that concern for public safety, rather than private profits, guides our regulatory policy.
Macrobiotic Quisine and Metastases
To hand a helping hand You might for example make drze out of Shio Miso (like generics etc..) In my life and not only as a doctor I was always told that you should search for medicine in nature, herbs, minerals and healing substances and not create toxic vaccines and treatments that derange the metabolism.
