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Recent Advances in Psychopathology in Neurodevelopmental Disorders
Psychopathology, including functional psychiatric disorders, such as schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders, and also dementia and challenging behaviour, is common in people with neurodevelopmental disorders (NDDs), such as intellectual and developmental disabilities (IDD), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and is the cause for a major public health concern. Much research has been conducted in the last three decades to understand this issue and develop effective interventions. Still, a lot remains unknown, for which high-quality translational research is urgently needed. In this Special Issue, we drew together research on recent advances addressing these issues. The areas covered included life expectancy among people with and without intellectual disabilities, the social and emotional development of people with intellectual disabilities and ASD, the influence of external environmental factors in determining aggressive behaviour in people with intellectual disabilities, parent and child training for children with autism and intellectual disabilities, how the presence of deafness influences quality of life, the views of prescribers on the deprescribing of antipsychotics among adults with intellectual disabilities, the views of people with intellectual disabilities who took part in the deprescribing, the views of direct-care workers on the causes of challenging behaviours in people with intellectual disabilities, and the validation of tools to detect cognitive decline in adults with intellectual disabilities.
Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives
Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially bringing about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of the mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases. Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use. Starting from these premises, the demand for new, effective, and safe anti-inflammatory drugs has led research in new therapeutic directions. The recent and emerging scientific community slant is oriented towards natural products/compounds that could represent a boon for the discovery of new active molecules and for the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases. We hope that it will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interest such as acute and chronic inflammation, inflammatory pain, inflammation-related diseases (e.g., autoimmune diseases), amongst others.
Diabetology
As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue "Diabetology: Feature Papers 2022" has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, "Feature Papers", we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community.This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.
Model-Informed Precision Dosing
Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
Stroke Recovery What Now?
In "Stroke Recovery; What Now? When Physical Therapy Ends but Your Recovery Continues" Tracy brings as much knowledge and experience as she can, with hope to help survivors continue with their personal stroke recovery.She teaches about the biomechanics of the body's movements based on science. Tracy has helped several survivors achieve continued success in their stroke recovery. In "Stroke Recovery; What Now?" Tracy's desire is to bring understanding to why specific muscles must be strengthened before other movements in the body can improve. Included in this book, are several important exercises for survivors and anyone who wants to become more stable when they stand and walk. There are also descriptions of why each exercise works.Tracy shares knowledge, tips, and exercises to help: Improve a Drop foot.Spasticity.Muscle strength.Balance and Posture.Being and Feeling Safer in MovementsStanding and StabilizationSpatial Awareness and ProprioceptionCognitive SkillsBrain care and more.Tracy asked more than one hundred survivors about the struggles and challenges they faced when they were left on their own to continue their recovery. She was surprised by many of the tough challenges some faced, and she was determined to include all concerns in this book Stroke Recovery; What Now? There is no period in stroke recovery. Learning ways to help your brain build new pathways and helping your body move correctly will assist you toward further recovery. You will also learn what a stroke is and descriptions of different types of strokes. AWARD WINNING BOOK!Gold Medal - Reader Views - Readers' Choice Award 2022-2023 Nominated for an Eric Hoffer Bood Award - 2023 PenCraft Book Award 2023 1st Place in Non-Fiction - Health & Medical
Novel Anticancer Strategies
Novel Anticancer Strategies reviews important findings and updates within the cancer therapy field, of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key features: Nanoparticle-based drug delivery in cancer therapy; Extracellular vesicles for anticancer drug delivery; Peptide-based drug conjugates; Cancer stem cells as a valuable target to eradicate tumor relapse; Spheroids in preclinical model for cancer research; and cancer immunotherapy.
EMT Study Guide 2023-2024
Introducing our EMT Study Guide 2023-2024: 2 Full Practice Exams and NREMT Prep Book! Ascencia Test Prep's EMT Study Guide 2023-2024 includes everything you need to pass the NREMT exam the first time.Quick review of the concepts covered on the NREMT exam2 full practice tests with detailed answer explanationsTips and tricks from experienced EMTsAccess to an additional online practice test and moreAscencia Test Prep's EMT Study Guide 2023-2024 is aligned with the official NREMT framework. Topics covered include: Human Anatomy and PhysiologyPatient Assessment and TransferRespiratory EmergenciesCardiovascular EmergenciesMedical EmergenciesEnvironmental EmergenciesPsychiatric EmergenciesTraumaObstetrical EmergenciesPharmacology and ToxicologySpecial PopulationsEMS OperationsThe Psychomotor Exam The National Registry of Emergency Medical Technicians (NREMT) was not involved in the creation or production of this product, is not in any way affiliated with Ascencia Test Prep, and does not sponsor or endorse this product. About Ascencia Test PrepAt Ascencia Test Prep, we understand that healthcare professionals need high-quality educational resources. That's why our test prep materials are developed by credentialed experts with years of experience who are excited to share their knowledge with you. Whether you're just starting your career or ready to climb higher, we're here to help you feel ready on test day.
Mental Health Challenges during the COVID-19 Pandemic
The aim of the reprint was to provide readers with updated research findings on the psychological and psychiatric consequences of the pandemic. The wide scope of the reprint reflects the complexity of the impact of the COVID-19 pandemic on mental health. The focus of the studies ranges from the psychological consequences of social distancing and the closure of schools to the neurological consequences of the viral infection, and from the stressful impact of an increased workload on frontline health workers to the unmet needs of special populations such as pregnant women, veterans and patients with neurodevelopmental disorders. Thanks to its richness in content and worldwide perspectives (contributors were from Canada, Croatia, Greece, India, Israel, Italy, Pakistan, the Philippines, Poland, Spain, and the USA), the reprint is a valuable source of information to researchers and clinicians interested in the mental health implications of the COVID-19 pandemic.
Optic Neuropathies
Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood-optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma.
Voices
To the ReaderThe structure of this work is quite straightforward.In a sparsely furnished family physician's office, patients arrive alone to tell their story.What is important to this doctor? Only that which is important to his patients - nothing more and nothing less.Some come once, never to return. Others frequent his office repeatedly as they struggle to make sense of what has befallen them.None come for judgment; a few for advice; but all simply to be heard.On the left facing page are notations of several types: VOICE OVER - introduces the speaker&- commentary on how the poem is to be read&&- personal reflections of the writer on the meaning of the poemReaders may very well wonder if each poem represents a single patient. In a few instances, this is the case. But most of them are composites based upon repeated contact with people who have contended, in their unique ways, with common crises.I have been privileged to have had no less than 150,000 patient encounters (100 patients per week - 50 weeks per year - 30 years).Despite our differences, at the end of the day, we confront the same basic issues of life and living.
Challenges and Opportunities for Effective Cancer Immunotherapies
Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments.
Focus on Antibiotics
The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases.
Nurses’ Papers on Tuberculosis
Nurses' Papers on Tuberculosis: read before the Nurses' Study Circle of the Dispensary Department, Chicago Municipal Tuberculosis Sanitarium, has been considered important throughout human history. In an effort to ensure that this work is never lost, we have taken steps to secure its preservation by republishing this book in a modern format for both current and future generations. This complete book has been retyped, redesigned, and reformatted. Since these books are not scans of the authors' original publications, the text is readable and clear.
Mental diseases
Mental diseases: a public health problem, has been considered important throughout human history. In an effort to ensure that this work is never lost, we have taken steps to secure its preservation by republishing this book in a modern format for both current and future generations. This complete book has been retyped, redesigned, and reformatted. Since these books are not scans of the authors' original publications, the text is readable and clear.
Therapeutic Nutrition in Ayurveda
This book emerges as a pilot project to discuss the clinical experiences directly and the concept of Nutra-vigilance, by the experienced authors of respective specialties. It broadly discusses diet & nutrition based on 12 different groups of diet in Ayurveda.
The Challenges of COVID-19 with Obesity-Related Cancers
This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
Thrive State, 2nd Edition
How did some people seem to emerge from the COVID-19 pandemic relatively unscathed? How did some organizations and businesses maintain profitability while retaining a highly resilient and motivated workforce? What one trait allows humans to thrive through pressure and change while others barely survive? Kien Vuu, MD, popularly known as Doctor V, answers these questions using his Bioenergetic Model, which is at the heart of Thrive State-the energetic state of being that activates the biology of human performance and longevity-the state of Optimized Human Potential.Doctor V blends the Science of Longevity and the Art of Living along with his personal experiences as a medical doctor and his study of the world's longest-lived populations and highest-performing individuals to make the case that every individual has the power to activate the Thrive State. Plus, he shows how optimized human potential creates healthy, engaged, resilient, and thriving ecosystems of families, teams, communities, businesses, and organizations.Imagine a world where humanity embraces a standard of health and performance that enables us to be happier, live longer and more fully, and contribute our gifts to the planet with joy and intention. Thrive State is the blueprint for you to move towards that vision. By the time you finish this book, you will not only be armed with a wealth of new practical knowledge about your health and performance, but also hold a roadmap to lead others to realize their highest potential.
Integrative Clinical Research
This book embraces a comprehensive range of research across several disciplines, providing insights and fresh perspectives on clinical topics, emphasizing the integrative medical approach. The book also addresses an increasing role of artificial intelligence in the development of clinical methodologies, research, and patient-oriented care. The authors share expertise and experience in rehabilitation medicine whose healing-effects particularly depend on the interaction between the therapist and patient. Chapters present novel approaches in manual rehabilitative therapy of common painful and disabling neuromuscular ailments, exemplified but not limited to low back pain and migraine. The myofascial trigger point release therapy includes specific manipulations to muscles and connective tissue which reduce pain. Other chapters address the issues of providing long-range medical care to older adults burdened with chronic diseases, notably hypoxia-related pathologies and theirsequalae, pointing to the advantages of care provided by a single primary care physician. Changing paradigm of care is essential in chronic atherosclerosis-based diseases like cardiovascular disorders or diabetes. Chapters provide results of international cohort studies on predictive factors for the long-range progress of such ailments based on anthropometric and lifestyle indicators. The book aims to meet the increasing interest and importance to patients of integrative health therapies. Medical rehabilitation and lifestyle changes increasingly gain scientific support in difficult-to-treat chronic conditions and should be integrated in a controlled manner into conventional medicine. The book is addressed to physiotherapists, medical scientists and clinicians, and allied healthcare professionals.
Concise Pharmacology
PHARMACOLOGY IS A VAST SUBJECT IN WHICH MEDICAL STUDENT AND THE PRESCRIBING PHYSICIAN ARE PRIMARILY CONCERNED WITH THE APPLIED ASPECTS, CORRECT AND SKILLFUL APPLICATION OF DRUGS IS IMPOSSIBLE WITHOUT A PROPER UNDERSTANDING OF THEIR BASIC PHARMACOLOGY. I MADE THIS BOOK SO THAT I CAN HELP AS MANY STUDENTS AS POSSIBLE SO THAT THEY CAN LEARN PHARMACOLOGY EASILY.
New Insights into Contraception
Today, a great variety of contraceptive techniques are available to women; this, coupled with improving the educational levels of female children and adults, is hastening a decline in fertility and consequently, population growth. With the advent of sustained fertility rates lower than replacement levels in many countries, including China and India, we are already witnessing major economic, social, environmental, and geopolitical consequences.Given this situation, today, the promotion of the use of contraception means improving health, not demography, placing emphasis on individuals and not just on methods alone; on the quality of services, and not simply on availability. Indeed, there is an increasing awareness that contraception can help women reduce health risks that are associated with reproductive events and specifically, with unwanted pregnancies. This means that, no matter how ideal a method may be from a purely scientific viewpoint, it must be submitted to the free, decision-making of well-informed women.To contribute to this new user-centric perspective, this reprint presents a series of articles in which technology is considered withing the broader concept of women's health. Five articles deal with issues related to the users' and providers' perspectives; three discuss a modality that is receiving increasing attention, the so-called Long-Acting Reversible Contraception (LARC); and the last three contributions highlight the new advances in oral hormonal contraception.
The Nature of Suffering and the Goals of Nursing
The Nature of Suffering and the Goals of Nursing is a pragmatic text assisting nurses at every career level through the challenges and rewards of their everyday duty to care. It advances the seminal work of Drs. Betty Ferrell and Nessa Coyle to give voice to the suffering of patients, their families, and their communities, as well as the suffering of nurses and other clinicians. This second edition has been updated in light of health and social care changes from the COVID-19 pandemic with a focus on the social determinants of health and increased visibility of marginalized populations across physical, mental, spiritual, emotional, ethical, cultural, and end-of-life domains to support whole-person and whole-people care. Contributing authors emphasize the qualitative experience of those who suffer alongside the best available evidence for person-centered nursing to promote meaning, growth, and introspection within the field of nursing. New and expanded chapters offer broader perspectives of patient populations across diseases and across the lifespan. Concrete steps for nurses to grow toward personal and professional healing and wholeness are provided. Compassionate and holistic, The Nature of Suffering and the Goals of Nursing reflects the lived experience of patients, families, and communities at the intersection of high-quality evidence, offering a rare window into what it means to practice nursing today in response to the suffering of those they serve.
Pharmacological Studies on Combretum Albidum in Thiruvadisoolam Forest
In "Pharmacological Studies on Combretum Albidum in Thiruvadisoolam Forest," author R Palani presents a comprehensive investigation into the phytochemical and pharmacological properties of Combretum Albidum, a plant species found in the Thiruvadisoolam Forest of Kanchipuram District, Tamil Nadu, India.Palani explores the traditional uses of Combretum Albidum in indigenous medicine and ethnobotanical practices, and investigates the plant's phytochemical profile, highlighting its potential medicinal properties. He also examines the plant's pharmacological effects, including its anti-inflammatory, antioxidant, and antimicrobial properties, and discusses its potential therapeutic applications.The book includes detailed descriptions of the chemical constituents of Combretum Albidum, as well as their isolation and characterization. It also presents a review of the current scientific literature on the plant's pharmacological effects, including its potential use in the treatment of various diseases."Pharmacological Studies on Combretum Albidum in Thiruvadisoolam Forest" is a valuable resource for researchers, students, and practitioners in the fields of pharmacology, traditional medicine, and ethnobotany. It offers insights into the potential medicinal properties of Combretum Albidum and underscores the importance of preserving the biodiversity of Thiruvadisoolam Forest for future research therapeutic discoveries.
PTCB Exam Prep 2023-2024
Become a certified pharmacy technician and land the job of your dreams with this comprehensive study guide that will fully prepare you for the PTCB Exam!Worried about failing the upcoming pharmacy technician exam? Looking for the best study guide possible to help you pass it on your first try?Each year, thousands of candidates give their all in an effort to pass the PTCB exams.With a passing rate of only 59% over the past 7 years, the exam has earned a reputation for being extremely difficult.But there's no reason to stress out. With the proper preparations and focused, consistent study, you can be one of the special few who only need to take it once.While self-study and making your own materials are good options, you'll save time and effort with a ready-made comprehensive study guide covering all the topics that will be included in the test. You'll have a significant head start on the exam without having to sift through mountains of materials.In this manual, you won't just find all the information you need to study - you'll also have detailed practice tests, similar to what you'll encounter in the exam, so you know what to expect on the big day.Inside, you'll discover: A rundown of the PTCB exam, its objectives, and who is eligible to take itStudy strategies to help you avoid burnout and do well on the testA breakdown of the PTCB exam's four subject areas and corresponding study guides for eachA closer look at pharmacology: drug classifications, interaction and contradictions, therapeutic equivalence, compounding, and moreStrategies for the safe handling and disposal of substances and waste, as well as the laws and regulations governing the work of a pharmacy technicianPatient safety and quality assurance initiatives to safeguard the health of drug users and reduce the likelihood of medical mistakes, sketchy prescriptions, and moreOrder entry and processing - study up on compounding non-sterile products, reading prescriptions, working with drug administration supplies, and dealing with expired medicationsA compilation of commonly prescribed drugs and medications, along with their brand and generic names, to help you study4 complete sets of practice tests with extensive explanations to help you prepare for exam dayAnd much more!While there is always a second chance if you don't pass the first time, it's best to succeed the first time around.There will be many obstacles and diversions on your path, but if you follow this reviewer you will have a good chance of achieving your goals.Every second counts, so don't procrastinate any longer and dive headfirst into your PTCB study material!If you want to level up your PTCB exam preparation, then you need this book today!
Genetic and Epigenetic Regulations of Tumor Progression and Metastasis
Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease.
Aṣṭāṅgahṛdaya
In eight comprehensive chapters, this book present a lucid summary of the teachings of Vāgbhaṭa. It provides a helping hand to those interested in rediscovering the teachings of Vāgbhaṭa and is a great resource for researchers of medicine, traditional and alternative medicine, pharmacology, and drug discovery.
Pharmacology Review - A Comprehensive Reference Guide for Medical, Nursing, and Paramedic Students
Pharmacology WORKBOOK - Over 350 questions and exercises designed to test your knowledge and memory retention so that you can feel more confident. Avoid failing the exam by making sure you are thoroughly prepared. Gain that extra edge to increase your chances of passing. Order this workbook together with your main pharmacology textbook. Are you struggling with pharmacology? Do you feel like no matter how much time you spend studying, you just can't seem to grasp the material? Don't worry, you are not alone! Many students find pharmacology to be a challenging and complex subject. But, with the right tools and resources, you can overcome this obstacle and achieve success in your studies. Introducing our pharmacology workbook, filled with over 350 questions and exercises designed to supplement and reinforce your understanding of the material. By working through these exercises and testing your knowledge, you will not only improve your retention of the material, but you will also gain that extra edge and confidence you need to excel on your exams. This book contains different types of exercises. Some examples are: Fill in the blanksMultiple choice questionsLabel the pictureFill out the correct classification If you have already gone through your pharmacology textbook and are ready to test your knowledge with some pertinent questions and exercises, then this workbook is exactly what you need. Serving as a complement to any pharmacology textbook, it can be used in the following ways: After you have finished the textbook, you can use this workbook to test your knowledge retention.If you have already studied this topic in the past, and you're feeling really confident, you can actually start off with the workbook first and see where you stand. If you find knowledge gaps, then you can go through the textbook to improve your grasp of the subject. We hope you will find this textbook a good practice tool to improve your understanding of the topic. Click 'Add to Cart' and start testing your knowledge.
Oscillator-Amplifier Free Electron Lasers an Outlook to Their Feasibility and Performances
This reprint is aimed at presenting strategic and design elements for the development of low-cost, low-size Free Electron Lasers.Different points of view are considered here, attempting to consider technologies and design conceptions that are fairly mature and may be viable solutions in the near or midterm future.The design conceptions proposed here are based on the so-called hybrid (or broader-approach) technologies, which put together, e.g., combinations of oscillator and amplifier configurations.These solutions, although developed almost thirty years ago, appear nowadays within the present technological capabilities.Other possibilities offered, for example, by the recirculated wave undulator FELs, represent border line technologies, which are worth carefully studying as the architecture of the mid-term future. Finally, the reprint addresses both theoretical and design considerations regarding proposals for the enhancement of coherent emission on higher harmonics.
Quality Control for Pharmaceutical and Cosmetic Preparations
Quality Control for Pharmaceutical and Cosmetic Preparations is an exam guide for Pharmacy students. It includes Quality control tests for both Pharmaceutical dosage forms and Cosmetic preparations. As it is an advanced course for the pharmacy program, the important key points, test procedures, and international regulatory requirements are covered in this book. This book is also very useful for Industrial pharmacists, Quality controllers, entrepreneurs, and Principle scientists.
The Human Brain during the First Trimester 57- to 60-mm Crown-Rump Lengths
This is the seventh of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development.
Thrive State, 2nd Edition
How did some people seem to emerge from the COVID-19 pandemic relatively unscathed? How did some organizations and businesses maintain profitability while retaining a highly resilient and motivated workforce? What one trait allows humans to thrive through pressure and change while others barely survive? Kien Vuu, MD, popularly known as Doctor V, answers these questions using his Bioenergetic Model, which is at the heart of Thrive State-the energetic state of being that activates the biology of human performance and longevity-the state of Optimized Human Potential.Doctor V blends the Science of Longevity and the Art of Living along with his personal experiences as a medical doctor and his study of the world's longest-lived populations and highest-performing individuals to make the case that every individual has the power to activate the Thrive State. Plus, he shows how optimized human potential creates healthy, engaged, resilient, and thriving ecosystems of families, teams, communities, businesses, and organizations.Imagine a world where humanity embraces a standard of health and performance that enables us to be happier, live longer and more fully, and contribute our gifts to the planet with joy and intention. Thrive State is the blueprint for you to move towards that vision. By the time you finish this book, you will not only be armed with a wealth of new practical knowledge about your health and performance, but also hold a roadmap to lead others to realize their highest potential.
Recent Advances in Child and Adolescent Psychiatry
Psychiatric disorders in children and adolescents are relevant both in terms of their prevalence (they are roughly estimated to affect about 20% of school-aged children and adolescents) and of their impact on the quality of life of the child/adolescent and their family, but also on the society as a whole. Disorders affecting children and adolescents are increasingly seen as having highly specific features, and, therefore, require an equally specific approach despite the coexisting need to integrate contributions from other professions (e.g., pediatricians, psychiatrists, psychologists, and therapists of different sorts). However, the available data are still insufficient, especially for treatment options and too often therapeutic choices are still made based on studies conducted in adults. Even more important, the existence itself of some disorders is questioned especially outside the scientific field (e.g., ADHD). This Special Issue provided cutting edge data on different aspects of child and adolescent psychiatry, including etiopatogenesis, clinical characteristics and diagnosis, medical and neurological comorbidities (and psychiatric comorbidities of medical and neurological disorders), impact on patients/families/society (including school and other social groups), prognosis, and treatment options of the different disorders.
3D Printed Materials Dentistry
The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry.
Plant and Marine-Derived Natural Product Research in Drug Discovery
For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery
Antimicrobial Therapy in Intensive Care Unit
This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics.
Oxford Handbook of Obstetrics and Gynaecology
Fully revised for this fourth edition, the Oxford Handbook of Obstetrics and Gynaecology fully reflects new developments in the field. Featuring new sections on the outcomes of the MBRRACE report, abnormally adherent and invasive placenta, pregnancies in mothers of advanced age, assisted reproduction, and ovarian cancer screening, it provides a contemporary overview of this complex and important specialty. Written and reviewed by a team of highly experienced clinicians, academics, and trainees, this Handbook is a perfect starting point for preparation for postgraduate exams. Practical advice is presented with key evidence-based guidelines, supported by visual algorithms and top clinical tips. The previous edition was Highly Commended in the Obstetrics and Gynaecology category of the BMA Book Awards. The indispensable, concise, and practical guide to all aspects of obstetric and gynaecological medical care, diagnosis, and management, this fourth edition continues to be the must-have resource for all specialist trainees, junior doctors, and students, as well as a valuable aide memoire for experienced clinicians.
Case Studies in Emergency Medicine
In this book, experienced emergency physicians describe, in a way that is both suspenseful and instructive, often dramatic and humanly touching emergency scene calls with which they have been confronted in the course of their professional lives. Each case is discussed and finishes with a conclusion to help in future practice. Emergency physicians and ambulance staff thus receive valuable tips for their own future work.
Compassion as Remedy in Tibetan Medicine
This translation and commentary on an ancient Tibetan Buddhist text helps readers grasp the essence of healing and teaches healthcare practitioners how to develop limitless compassion, a quality that is essential-as our current healthcare situation makes starkly clear. Compassion as Remedy is a quietly revolutionary book about healthcare, ethics, and spiritual practice delivered as a commentary on a 2,500-year-old Tibetan text--the rGyud-bZhi (The Four Tantras), which is the guiding treatise for Traditional Tibetan Medicine. This book, which is a translation of "The Physician Chapter" of rGyud-bZhi, helps readers grasp the essence of healing and teaches healthcare practitioners how to develop limitless compassion, a quality that is essential--as our current healthcare situation makes starkly clear.Moral development and the practice of compassion should be of great importance to all medical practitioners and "The Physician Chapter" provides detailed instructions, drawn from a millennia-old culture and tradition that is attracting increased attention. Although many books have been written about Ayurveda, Traditional Chinese Medicine, and more, there are very few approachable books regarding the unique features of Tibetan medicine and spiritual and meditation practice.By integrating healthcare with spiritual practice, Compassion as Remedy provides guidelines for ethics, along with suggestions for developing wisdom and compassion. Throughout the world today, both medical practitioners and their patients are increasingly curious about holistic healing traditions, seeking to find natural, organic, and noninvasive remedies with few side effects. This book shows that compassion itself is a source for the alleviation of suffering.Dr. Yonten includes examples from his clinical practice, drawn from cross-cultural perspectives and neuroscience, giving readers a rare view of compassion as remedy. In the words of His Holiness the Fourteenth Dalai Lama, one of Dr. Yonten's teachers, "The ideal physician is one who combines sound medical understanding with compassion and wisdom."
Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases
This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
The Synopsis of Medicine
The most up-to-date concise yet exhaustive and adequately complete book on Medicine designed for Paramedical especially Operation Theatre Technician & Nursing students and practitioners. Each chapter provides knowledge on Medicinal conditions, prognosis, diagnosis plan and Treatment for easy assimilable understanding The book discusses procedures, protocols and preventions related to disease or medical emergency condition . Must-have reading reference for medical(OT) technicians, nursing staff and doctors.
Achieving Equilibrium
A different and exciting form of self-care in the form of practical mind to body self-regulation. In the challenging times of the 21st century, looking after oneself and navigating the bumps in the road has become more difficult than ever. However, this fascinating book, written by two psychotherapists with many years of experience, provides a simple and reliable means of restoring the balance which is vital for the robust body mind system we need if we are to be able to bounce back from adverse experiences. It is this balance (homeostasis) that provides us with the highway to wellbeing and it is our body mind system's innate capacity to self regulate which is at the core of this book. Using six key Autogenic Training exercises, the authors provide readers with the skillset to self regulate at any time or any place. These exercises can activate the parasympathetic nervous system and involve body scans, breathing and other bodily awareness exercises.
Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment
Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma
Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the "one-size-fits-all" approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients.
Gender Difference in Diabetes
Sex and gender can affect the incidence, prevalence, symptoms, course and response to drug therapy in many illnesses, with sex (the biological side) and gender (the social‒cultural one) being variously interconnected. During the two days of the meeting "Gender Differences in Diabetic Disease" held in Olbia, Italy, on 4 and 5 December 2020, we discussed the various medical, social, ethnic, psychological and anthropological aspects of gender differences to build as broad a picture as possible of how these differences are present and evident in diabetic disease. Type 2 diabetes is the perfect example to justify gender medicine. During the meeting, we also tried to identify the still-unclear points that deserve further studies.This book describes several aspects of gender medicine that are related to diabetes. Physiopathology, drug treatment, sexual and psychological aspects, diabetes complication, migration, burden of working with a chronic disease and aspects related to COVID-19 infection are explored in a gender differentiation way. The authors are from different fields: medical doctors, biologist, psychologist, nurse, pharmacist, anthropologist and so on.
A Comprehensive Overview of Skin, Hair and Nail Problems
Human skin is the largest organ of the body. Any disease or condition that affects the skin is called a skin disease. However, keep in mind that skin conditions and treatments can vary widely in terms of symptoms and severity depending on their causes. Some skin conditions have situational causes, while others may be hereditary. Skin diseases are among the most common diseases in the world. Skin rashes, itchy skin, prominent bumps, peeling, blisters or sores, discoloration, etc. are some of the most common symptoms of skin disease. Moles and skin rumors that change color, size, shape must be checked by a dermatologist. Hundreds of skin diseases can occur in the human body. The most common skin diseases usually cause similar symptoms. It is better to know that skin diseases and problems include 1.79% of all diseases in the world and almost one out of four people in the world has some kind of skin disease. Therefore, knowing the common skin diseases and the warning signs of skin diseases can greatly help your health. But what are the most common skin diseases? What are itchy skin diseases? What is the picture of skin diseases?
The Effect of Diet on Cardiovascular Disease, Heart Disease and Blood Vessels
Cardiovascular disease (CVD), including coronary artery disease, heart disease, arrhythmias, and other types of vascular diseases, is one of the leading causes of death around the world. It is estimated that approximately half of the variabilities of CVD appear to be attributed to genetics. Therefore, the other half of them have been attributed to acquired factors, including diet. It is of note that even a genetic predisposition to CVD can be canceled out by a healthy lifestyle. In this regard, it is important to acknowledge that acquired factors, including diet, are causally associated with CVD. Based on these facts, important papers are presented in this Special Issue entitled "The Effect of Diet on Cardiovascular Disease, Heart Disease, and Blood Vessels".
Human Papillomavirus and Head and Neck Cancer
In the study of head and neck squamous cell carcinoma (HNSCC), we know that virally induced malignancies behave differently than those generated through other carcinogenic mechanisms. This paradigm extends into differences in tumor growth, treatment response and resistance, as well as invasion and metastasis. The inability to correctly diagnose and appropriately treat HNSCC at early stages has contributed to reduced survival for HNSCC patients, particularly those with HPV-negative disease. The examination of the molecular differences between HPV-positive and HPV-negative HNSCC will provide support for early diagnostic markers and guide appropriate treatment selection to improve patient care and survival.This Special Issue highlights current research efforts to understand the evolving contribution of human papillomavirus in HNSCC.
State-of-the-Art in Orthodontics and Gnathology
The objective of this reprint is to present the main evidence-based data on new developments and knowledge in diagnostic and treatment technologies in the orofacial field used in both children and adults. The published content has been met with great success in interdisciplinary fields, stimulating international authors to submit their original articles, reviews, or case reports based on various aspects of orthodontics as well as on the diagnosis and management of temporomandibular disorders and orofacial pain. Among the current highly debated topics, this reprint focuses on multiple disciplines as follows: gingival recessions and periodontal status after orthodontic treatment; a rare case of impacted central incisors; predictors of analgesic consumption in orthodontic patients; a systematic review about different dentoskeletal class III treatment approaches; evaluation of upper airway volumes; and cephalometric values in JIA patients.
