![The Chemist and Druggist [electronic Resource]; Vol. 121 = no. 2859 (24 Nov. 1934)](https://cdn.kingstone.com.tw/english/images/product/1001/9781014461001m.webp "The Chemist and Druggist [electronic Resource]; Vol. 121 = no. 2859 (24 Nov. 1934)")
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Bibliometric Studies and Worldwide Research Trends on Global Health
Global health, conceived as a discipline, aims to train, research and respond to problems of a transboundary nature, in order to improve health and health equity at the global level. The current worldwide situation is ruled by globalization, and therefore the concept of global health involves not only health-related issues, but also those related to the environment and climate change. Therefore, in this Special Issue, the problems related to global health have been addressed from a bibliometric approach in four main areas: environmental issues, diseases, health, education and society.
Caffeine
Caffeine provides information on composition, processing, consumption, health effects, and epidemiological correlations for the methylxanthine beverages and foods and serves as a useful tool for anyone interested in the methylxanthine-containing products.
Human Risk Assessment
This book explores the factors which are critical in the selection of an appropriate animal species for toxicology studies and the subsequent extrapolation of the data to humans. It provides some future directions for risk assessment activities at the Environmental Protection Agency.
Antithrombotic Drugs in Thrombosis Models
This book presents a critical review of the use of thrombosis models and an original, highly sensitive methodology for testing antithrombotics based on a more adequate understanding of thrombotic processes. It is useful for those who are actively working on drug research.
Formulation and Evaluation of Fast Dissolving Tablet of Clopidogrel
The present investigation involves formulation and evaluation of fast dissolving tablet of clopidogrel, which is used to prevent coronary disorder. Platelet aggregation is part of the sequence events leading to the formulation of a thrombus (clot). Antiplatelet therapy with one or more drugs decreases the ability of blood clot to form by interfering with the platelet activation process in primary homeostasis. Tablets were formulated by three different methods Viz., Direct compression method, Solid dispersion method and Sublimation method. Different excipients such as, crospovidone as super disintegrants, croscarmellose as superdisintegrant, magnesium stearate as lubricant, talc as glidant etc. were used. Based on in-vitro release studies tablets prepared by sublimation method clopidogrel was selected as optimizes formulation. In-vitro release studies indicated more than 95% release of drug in 30 mins. The accurate stability studies indicated no change in in-vitro release and other property of the tablet. Thus sublimation method can be a promising strategy in enhancing the solubility and dissolution studies of clopidogrel bisulphate.
Zur Geschichte der Lokalan瓣sthetika im 19. und fr羹hen 20. Jahrhundert
Projektarbeit aus dem Jahr 2020 im Fachbereich Pharmazie, Note: 2,3, Ruprecht-Karls-Universit瓣t Heidelberg, Sprache: Deutsch, Abstract: In der vorliegenden Arbeit wird die geschichtliche Entwicklung der Lokalan瓣sthetika im 19. und fr羹hen 20. Jahrhundert untersucht. Im Mittelpunkt steht dabei die damalige Nutzung des Kokains als Lokalan瓣sthetikum, wobei seinerzeit die Schreibweise 'Cocain' verwendet wurde. Zun瓣chst wird die Entwicklung bis hin zur Entdeckung des Cocains als Lokalan瓣sthetikum aufgezeigt. Im weiteren Verlauf wird dargelegt, in welchen medizinischen Bereichen Cocain zur lokalen An瓣sthesierung eingesetzt wurde. Ausgehend vom Erkennen der Gefahren des Cocains wird er繹rtert, wie sich die Suche nach Ersatzpr瓣paraten gestaltete. Ber羹cksichtigung finden hierbei u.a. Orthoform, Eucain B, Stovain und Novocain.
Formulation and Evaluation of Simvastatin Tablet
To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.The liquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material.Simvasatin Liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.
Formulation Development and Characterization of Nanosuspension
This study was to identify and optimize formulation and process variables affecting characteristic and scale-up of nanosuspension manufacturing process on bead mill i.e media milling buttom down technique considering industrial perspective. Formulation factors evaluated were ratio of different polymer to drug and to beads. Whereas process parameters were milling bead concentration and stabilizer concentration. Responses measured in this study include zeta potential and mean particle size. The test revealed that ratio of polymer to drug have significant effect on zeta potential whereas variable milling bead concentration at constant milling speed and milling time have significant effect on the particle size distribution of nanosuspension. The X-ray powder diffraction pattern of drug milled at high and low speed reveals no form conversion when compared with unmilled drug. The formulated nanosuspension has shown a faster % cumulative release.
Drug Design and Development
Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy. The book highlights why it is important that all practicing pharmacists, including those working in hospitals or high street stores, have a solid understanding of the process of the design and development of the drugs they interact with. It adopts an integrated approach, formulated to complement courses which are designed in line with the General Pharmaceutical Council's new curriculum requirements. Furthermore, this is the only integrated textbook to consider both drug design and development within one volume. Throughout the book, the journey of the drug, from discovery to market, is presented in an integrated fashion, emphasising the interconnection of all the processes involved.
Urine
Urine is not a human waste but a medical treasure.- Human Urine proteome: a powerful source for clinical research.- Comparison of urinary proteomes among three animal models.- Urimen, a membrane that store urinary components for largescale biomarker study.- Post-translation modifications of human urine.- Application of Peptide Level and Post translational Modifications to Integrative Analyses in Proteomics.- Urinary Protein Biomarker Database 2.0: a literature-curated database for protein biomarkers in urine.- Urine glucose levels are disordered before blood glucose level increase was observed in Zucker diabetic fatty rats.- Cancer Biomarker Discovery in Urine of Walker 256 Tumor-bearing Models.- Candidate Urinary Biomarker Discovery in Gliomas.- Changes in the Urinary Proteome in a Patient-Derived Xenograft (PDX) Nude Mouse Model of Colorectal Tumor.- Urine is an ideal biomarker resource in early detecting neurodegenerative diseases.- Urinary proteome biomarkers for early detection of respiratory diseases.- Application of urine proteome in cardiac diseases biomarker discovery.- Changes of Urinary Proteins in infectious disease models.- The application of urinary proteomics in early detection of digestive diseases.- Serial changes of urinary proteome in animal models of renal diseases.- Effects of extrinsic factors on the urinary proteome.- Exhaled Breath: Another Biomarker Source that Complementary to Urine.- Tears: potential window for monitoring systemic conditions.
Taste Masked Oral Distinguishing Tablets of Tolterodine Tartrate
The work presented in the book is useful for both academia and industry. Tolterodine Tartrate Oral Disintegrating Tablets were prepared by direct compression method using superdisintegrants, evaluated their preformulation and tabletting properties.Taste evaluation studies revealed that the metallic taste of Tolterodine Tartrate was completely masked by using eudragit EPO. This work is supported by Management, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India.
Bioadhesive Buccal Tablets of Losartan Potassium
The work presented in this book is useful for both Academia and Industry. The work reflects the potential use of natural gums in the formulation of Buccal tablets. The gums used in the formulation are Xanthum gum and Locust bean gum, which were proved as bioadhesive gums. By successful usage of these gums buccal tablets of Losartan Potassium were prepared and evaluated for bioadhesive properties, ex vivo permeation, in vitro dissolution and mechanical properties.
Physico-Chemical Evaluation of Four Brands of Paracetamol Tablets
The quality evaluation of the pharmaceutical products in every step of the production process is very important to ensure product quality, safety, efficacy, and bioavailability. The purpose of this research work was to assess the physico-chemical quality of four brands of paracetamol tablets by using official test parameters. About four brands paracetamol 500mg tablets were collected from local drug market in Greater Noida and the tablets were analyzed by different official quality control evaluation parameters such as weight uniformity test, thickness, hardness, friability, disintegration, drug release test, and drug content assay by using modern analytic techniques UV spectrophotometer as per IP specification limit. Based on the result of this study, all the selected brands were passed hardness, thickness, diameter, weight uniformity test and comply with the IP specification limit.
Experimental and Clinical Treatment of Subarachnoid Hemorrhage after Rupture of Saccular Intracranial Aneurysms
The Special Issue "Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms" provides an excellent insight into the many facets of aneurysmal subarachnoid hemorrhage. It includes three original papers, three reviews, two case reports and one technical note. This book represents a compilation of important clinical and preclinical papers by innovative researchers that enhance our understanding of subarachnoid hemorrhage and intracranial aneurysms.
Bile Acids and Their Receptors
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
Last Help
When the first antibiotic was discovered, it revolutionized medicine, and in many ways, the world. Illnesses that had previously decimated countless suddenly had a treatment, and those antibiotics were used judiciously - and have been ever since. Our Modern Medicine is so inundated with antibiotics that the bacteria and micro-organisms they were first created to destroy have found their own defense, a resistance to these duper drugs that have made them super bugs... and we need a way to fight back. While many look to the future creation of new, stronger antibiotics, the answer may very well lie in our own medical past. In 1915, two enterprising scientists discovered that bacteriophages were present in the stools and bodies of sick patients right before they began to recover. When they found that bacteriophages were also present wherever bacteria grew, it prompted a new line of thought - and the formation of Phage Therapy. This insightful and scientifically accurate book takes us on a journey 100 + years in the making, from the very beginnings of Phage Therapy, through its many varieties and applications and then on to the future of this medical practice - and how the medical breakthrough we have all been waiting for may have already happened.
Just Test!
We were inspired to write this manual by the multitude of topics we have seen that can come up during a consultation and the need to make a basic test more direct, clear and structured as well as making the information more accessible. It is a compact to the point manual, offering a large amount of information. This translation of the Spanish second edition is aimed at all those who use Kinesiology or other forms of testing such as the pendulum and the tensor in their therapeutic work as a consultation tool. The intention of this book is to provide a work manual to help facilitate testing sessions, notwithstanding that each professional already has their working procedures. We hope you will find this book useful and enjoyable.
Pharmacognosy and Phytochemistry I
Pharmacognosy and Phytochemistry I - A Practical handbookThis practical hand book will be useful for B.Pharm IV Semester students for identification of unorganized drugs through macroscopical, microscopical and chemical evaluation. This book also details about the identification of medicinal plants belonging to important families such as Solanaceae, Leguminoseae, Rubiaceae, Rutaceae, Labiatae, Liliaceae, Apocyanaceae Umbelliferae. This book serves as an user friendly guide for analyst employed in pharmaceutical concerns dealing with manufacturing herbal products. I hope that students and teachers of Pharmacy as well as analysts in the industry find this book very useful.
Advances in Pharma Business Management and Research
Chapter 1. Introduction: Trends and developments in the pharmaceutical and life sciences industry.- Chapter 2. Relevance of instruments for measurements of Quality of Life in the AMNOG Context.- Chapter 3. The quality management system for R&D project and portfolio management in a pharmaceutical company.- Chapter 4. Brexit and Its Impact on Pharmaceutical Law - Implications for global pharma companies.- Chapter 5. Implementation of Measurable and Sustainable Actions to Improve Employee's Engagement and Business Performance - Global Medical Clinical & Regulatory Affairs (GMCRA) - A Role Model at Fresenius Kabi.- Chapter 6. Leadership Models and Work Behavior: An Empirical Analysis of Consequences of Authentic and Transformational Leadership.- Chapter 7. Alliance Management at Merck - Establishing an operational 100-day plan for alliance launches and management.
A Textbook of Pharmaceutical Microencapsulation
Various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. Solid microspheres have numerous applications depending on what material they are constructed of and what size they are.
Orodispersible Tablets Of Rizatriptan Benzoate
In the present investigate is an attempt towards developing a formulation of Anti-migraine drug. Innovations in the area of Oral Dispersible Tablets are aimed at both increasing the performance of the dosage form by decreasing the disintegration time and increasing the patient compliance by masking the objectionable taste of the ingredient by direct compression technique. It containing Rizatriptan Benzoate as model drug used for the treatment of migraine disease. Formulation were prepared by using different Super disintegrate and suggested nine formulation F01-F09 & prepared Oral Dispersible Tablets F01-F09 by direct compression techniques containing Croscarmellose sodium and Crospovidone as Super disintegrant in different concentration (10.5,13.0 and 15.5mg). Optimized F08 formulation containing concentration of Crospovidone 10.5mg, Pregelatinized Starch 20mg, Aspartame 5mg as sweetener and Peppermint 1mg as flavor, Mannitol 94.77mg, Microcrystalline cellulose Avicel pH 101 37.20mg &Avicel pH 102 5mg, and Mag Stearate 12mg were used and further evaluated.
Effect of Diazepam on steroidogenesis and spermatogenesis in male rats
Infertility is one of the most serious problems around the world and the male counterpart contributes half of the infertility cases. Infertility can be caused by androgen deficiency or low testosterone level. The evaluation of infertility can aid in determining the underlying cause of infertility as well as giving treatment to allow conception to occur. Diazepam is used to treat anxiety, convulsions and for sedation . The severity of adverse effects induced by diazepam forces physicians to pay attention and exercise caution to side effects when they prescribe this drug. Recent studies found that diazepam acts as Ca+2 channels antagonist as it can produce a complete inhibition of voltage-dependent Ca+2 uptake and that the Na+/Ca+2 exchange carrier in mitochondria may be a common receptor for diazepam and calcium channel blockers. Calcium ion contributes in many cellular functions in both somatic and germ cells in the testis, especially, mediating the responses to endocrine hormones and local regulators in genital tracts and thus any change in the transport of Ca+2 across the cell membrane could result in an extreme impact on steroidogenesis and spermatogenesis.
Practical Text Book of Pharmaceutics & Physical Pharmacy
The word pharmaceutics is used in pharmacy and pharmaceutical sciences to encompass many areas related to formulation of the medicines. Medicines are rarely with single ingredient, they need additives to convert them into dosage forms and this in turn introduces the concept of formulation. The Physical Pharmaceutics-Experiment is a very important subject at Second year of the course of B. Pharm. programme. In this book wherever needed full forms and abbreviations, pictorial diagrams, tabular data, examples of formulation including marketed products and manufacturers are given and their kinetics of the Formulation.
Carriers For Drug Delivery System
Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. At present, no available drug delivery system behaves ideally achieving all the lofty goals, but sincere attempts have been made to achieve them through novel approaches in drug delivery. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be predicted to prolong the existence of the drug in systemic circulation, and reduce the toxicity, if selective uptake can be achieved. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. Advances have since been made in the area of vesicular drug delivery, leading to the development of systems that allow drug targeting, and the sustained or controlled release of conventional medicines.
Solid Lipid Nanoparticle
This book entitled "Solid Lipid Nanoparticles" is a collection of different topics that are fundamental on nanotechnology, second chapter gives a special emphasize on various method of preparation of solid lipid nanoparticles such as with its advantages and disadvantages, and also gives broad techniques used for the characterisation of solid lipid nanoparticles and finally this book gives an idea about various impotent applications of solid lipid nanoparticles in biomedical research. This book is focuses to provide a broad understanding of designing and application of solid lipid nanoparticles used in Cancer treatment, Parkinson's Treatment, Inflammation, Ocular drug delivery, Infectious disease and Cosmetics. This book useful for Nano medicine researchers, under and post graduate of Pharmacy. This book will also be intended as a text book for advanced course in the field of solid lipid nanoparticles for biomedical application.
Polyherbal Shampoo
The study was aimed at formulating and evaluating a complete herbal shampoo containing only traditionally used plant materials. The shampoo contained aqueous extracts of Nettle Leaf extract Amla (Fruit), Onion (Bulb), Fenugreek (seeds), Ritha, Neem (Leaves), Curry (Leaves), Hibiscus(Flower), Aloe vera(Pulp), Gelatin, Lemon juice, Argon oil .The physicochemical parameters such as color, clarity, pH, and skin irritation, the percentage of solid contents, dirt dispersion, foaming ability and foam stability, wetting time and stability studies were studied using recommended procedures. The organoleptic evaluations of the polyherbal shampoo showed good results. The pH of the polyherbal shampoo range to be 7.00, which was near to the skin pH. The percentage of solid content of prepared shampoo was found to be 22.2%. The surface tension of developed shampoo was found to be 31.12 dynes/cm respectively
Pinaverium sustained release matrix tablets for colonic drug delivery
This book deals with the Development and Characterization of sustained matrix tablets of a novel drug Pinaverium using different polymers.To facilitate the pH-independent drug release of Pinaverium, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared then the tablets were coated with Ph dependent polymers. Eudragit RLPO and S100 were used as enteric coating polymers. The pre-compression mixture of all formulations was subjected to various flow property tests and each one the formulations were passed the tests. The tablets were coated by polymers and so the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F6 formulation was found to be optimized as a result of it had the drug release of up to 12 hours and showed most of 98.45% drug release.
Transdermal Patch of Lamivudine and Stavudine-Loaded Ethosomes
TDDS are the ideal delivery system for drug that undergo hepatic first pass metabolism. Lamivudine and Stavudune drug was successfully designed and developed by trial and error method. Formulations were prepared by employing combination of HPMCK15M, PVPK30, and EC in various ratios. From the evaluation results it was conclude that TF5 show highest release at 12 hrs. with suitable polymer ratio and penetration enhancer and it was observed that Higuchi kinetics model most suitable kinetic model for drug release from all patches.
A Study of Fast Dissolving Tablets of Febuxostat
The idea of formulating Fast Dissolving Tablets of Febuxostat is to provide an acceptable and practical approach for the objectives of faster disintegrating and dissolution characteristics. In the current work Fast Dissolving Tablets of Febuxostat were prepared by sublimation technique after preparing solid dispersion of Febuxostat in which co- precipitation gives high solubility in ratio of 1:0.5:1.2 (Drug: PEG 6000: Mannitol), using sodium starch glycolate, croscarmellose sodium, kyron T -134 and kyron T-314. All the Fast Dissolving Tablets of Febuxostat were subjected to thickness, diameter, hardness, friability, weight variation, disintegration time, wetting time, water absorption ratio and drug content uniformity.
Preparation and Characterization of Co-crystal
A co-crystal might be the expected outcome of a co crystallization experiment in which the final crystal contains at least two distinct species connected by intermolecular forces. Pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical sciences. A pharmaceutical co-crystal is a single crystalline solid that incorporates two neutral molecules, one being an API and other a co-crystal former The basic physiochemical properties of co-crystal can usually be characterized by: A. Fourier transport Infrared spectroscopy [FTIR]; B. Differential scanning calorimetry [DSC]; C. X-ray diffraction [XRD].
Formulation and evaluation of hydrogel
The data obtained from the study of, "Formulation and Evaluation of hydrogel containing antimicrobial drug (Azithromycin) and silver nanoparticles" reveals that Silver nanoparticles were reported to have good antimicrobial activity in lower concentration and can combine with other antimicrobial agent to get synergistic effect.The Silver nanoparticles were prepared by green synthesis approach with the help of reduction ofsilver nitrate by Azadirachta indica leaves extract. Azithromycin was chosen as antimicrobial drug, however it shows adverse effect when administered in high dose, hence to reduce dose of azithromycin it was decided to make formulation containing silver nanoparticles and azithromycin.The drug loading and drug delivery techniques were searched for topical as well as bone grafting purpose.
Psychopharmacology
Psychopharmacology: A Concise Overview, 3rd Edition is an evidence-based overview of the major classes of psychiatric medications and their use in clinical practice. Clinical considerations as to when, why, and how to use each individual medication are discussed in depth, as are relevant clinical controversies and treatment caveats. Each chapter also features an updated table of individual medications and their generic and brand names, dosing information, pertinent clinical comments, black box warnings, and Food and Drug Administration indications. This overview will equip readers with an essential framework of the concepts of psychopharmacology in an accessible length and style ideal for use as either a primer or refresher text. Medical students, residents, practicing physicians, nurse practitioners and other prescribers, as well as non-prescribing mental health clinicians who need to have a functional familiarity with available pharmacotherapies, will benefit from reading this concise book.
Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin
The objective of present research work was to develop a self-emulsifying drug delivery system of Rosuvastatin Calcium (RC) for increasing its solubility, and oral bioavailability. Solubility of RC was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB (Hydrophilic lipophilic balance) value. To identify the microemulsion existing zone Pseudo-ternary phase diagrams were constructed. Solubility analysis was also done for optimization of formulation. The optimised microemulsion formulation was evaluated for Powder X-Ray Diffraction (XRD), SEM (Scanning electron microscopy) analysis, globule size, zeta potential and phase separation study. Average globule size and zeta potential of the optimized microemulsion formulation were found to be 30 nm, and -11.5 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type.The solubility of RC was successfully enhanced up to 82.32%. Percent drug release at the end of 60 min was found to be 76.74 %. The solubility of Rosuvastatin Calcium was significantly enhanced after formulating into self-emulsify microemulsion.
Just Test!
Nos ha impulsado a escribir este manual la multitud de temas que hemos visto que puede abarcar una consulta y la necesidad de ordenar y estructurar algunos de estos temas para realizar un testaje b獺sico m獺s directo, m獺s claro y m獺s ordenado y tener m獺s f獺cilmente a mano toda la informaci籀n. Es un manual compacto, con mucha informaci籀n y que va al grano. Esta segunda edici籀n revisada, est獺 dirigida a todas aquellas personas que usen la Kinesiolog穩a u otras formas de testaje como el p矇ndulo y el tensor en sus disciplinas m矇dicas o naturales como herramienta de consulta. La intenci籀n de este libro es proporcionar a dichas personas un manual de trabajo que facilite la organizaci籀n de una sesi籀n de testaje. Damos por hecho que cada m矇dico o terapeuta ya tiene su propia manera de trabajar. Esperamos que encuentren de utilidad este libro y que lo disfruten.
Calcitonin Gene-Related Peptide (Cgrp) Mechanisms
This book provides a thorough review of the key recent research into the role of CGRP in health and disease. In particular, it enables and enriches understanding of CGRP in migraine pathophysiology. Provides a full update of the latest therapeutic perspectives and clinical advancements with potential therapeutic agents that block the actions of CGRP.
Good Research Practice in Non-Clinical Pharmacology and Biomedicine
1. Quality in Non-GxP Research Environment.- 2. Guidelines & Initiatives for Good Research Practice.- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices.- 4. General Principles of Preclinical Study Design.- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research.- 6. Blinding and Randomization.- 7. Out of control? Managing baseline variability in experimental studies with control groups.- 8. Quality of Research Tools.- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies.- 10. Building robustness intro translational research.- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research.- 12. Minimum Information in In Vivo Research.- 13. A reckless guide to P-values: Local evidence, global errors.- 14. Electronic Lab Notebooks and Experimental Design Assistants.- 15. Data storage.- 16. Design of meta-analysis studies.- 17. Publishers' responsibilities in promoting data quality and reproducibility.- 18. Quality governance in biomedical research.- 19. Good Research Practice - Lessons from Animal Care & Use.- 20. Research collaborations and quality in research: foes or friends?.- 21. Costs of implementing quality in research practice.
Cafer’s Antidepressants
Written for prescribers, this book makes complex concepts easy to understand and provides tools for remembering more than you thought possible.To help you match trade names with generic names of 50 medications, this book features mascots akin to the Xyzal "Wise Owl" and Myrbetriq Bladder characters. Each medication's mascot is incorporated into a visual-mnemonic framework designed for recollection of pharmacokinetic interactions. For instance, CYP2C19 substrates are represented as flowers with CYP2C19 inhibitors as watering cans to make the flowers grow. CYP1A2 substrates are trees to be chopped down by axes (CYP1A2 inducers). In addition to 36 antidepressant mascots, this book includes 14 mascots for related medications (atomoxetine, solfriamfetol), other serotonerigcs (LSD, dextromethorphan, buspirone, tramadol, meperidine, etc), and antiserotonergics (ondansetron, cyproheptadine).
Alternative Medicine of Sport Stars
Alternative Medicine Of Sport Stars: Scientifically proven Physical Vascular Therapy International Champions Use It - Improve Your Health Too Therapy: with many different kinds, it's hard to know where to start. One therapy that is being used more and more is sports therapy. Used by those who occasionally play sports, to professional athletes who play regularly and are injured often. Another type of therapy is physical therapy, used by many different people who have medical conditions, illnessesor injuries that limit their regular ability to move and function. Do you want to know how therapy works? How will you know what is right for you? Start by reading 'Alternative Medicine Of Sport Stars: Scientifically proven Physical Vascular Therapy' to learn all you need to know so you can make that decision with confidence, and learn why it is so beneficial. With information on different kinds of therapies, how they work, additional information on alternative therapies, and bonus information: 10 ways therapy can benefit you - you will be equipped with all you need to know. Read NOW and take control of your health!
Pruebas de Laboratorio Interpretaci籀n Cl穩nica
Los ex獺menes de laboratorio ayudan al m矇dico en el diagn籀stico de las enfermedades. El resultado de una prueba que confirme o excluya un diagn籀stico est獺 determinado por su sensibilidad y especificidad. Los m矇dicos cl穩nicos deben recordar que el diagn籀stico de una enfermedad se basa en lahistoria cl穩nica y el examen f穩sico del paciente, y que las pruebas de laboratoriose emplean 繳nicamente para confirmar una impresi籀n diagn籀stica.El llamado "perfil de laboratorio" para una enfermedad en particular es unmito porque desafortunadamente no existen pruebas de laboratorio infaliblespara una patolog穩a en particular. Por lo tanto, los ex獺menes a solicitardependen de la orientaci籀n cl穩nica inicial y son de mucha utilidad, dadoque permiten confirmar r獺pidamente la impresi籀n diagn籀stica y aplicar untratamiento apropiado. De igual manera la confiabilidad de las pruebas dependeen gran medida de la excelencia del Bioanalista.
Hallelujah Moments
The discovery of novel drugs that fill unmet medical needs is important for the health and well-being of people everywhere. However, the general public knows too little about the pathways through which basic research discoveries are translated into products that protect or restore human health. In the second edition of Hallelujah Moments, Eugene H. Cordes reveals the processes and pitfalls on the route from the laboratory bench to the bedside. These are adventure stories in which wit and grit created several of the most important drugs in human medicine. This new edition adds four new tales of drug discovery: for therapy of cancer, hepatitis C, HIV/AIDS, and for weight control. The stories emphasize the integration of basic research in academe and applied research in the pharmaceutical industry and introduce the key scientists. In each case, success resulted from imagination, risk-taking, problem solving, and perseverance. Cordes shares his firsthand knowledge of the drug-discovery world, having spent a long and distinguished career in both academic and industrial settings. The eleven drug discovery tales take the reader from concept to clinic for some of the most important drugs in human health including the statins, ACE inhibitors, antibiotics, avermectins, Januvia, and Taxol. These stories offer exciting insights into the fascinating world of drug discovery.
Covid-19
COVID-19: Life-Saving Strategies The News Media Will Never Tell You By Paul Thomas, M.D. Want to Survive COVID-19? This Is The Book That Shows You How Written By A Respected M.D. Are you worried that you or a loved one might die from COVID-19? It is your healthy immune system that protects you and keeps you alive. In COVID-19: Life-Saving Strategies the News Media Will Never Tell You, Paul Thomas, M.D. provides possible solutions backed by sound science and his experience in his own clinical practice. In this book, you will discover: - The best type of immune-boosting diet. - Why a ventilator should only be used as a last resort. - 6 essential dietary supplements that support immunity and lung health (Hint: It's not just about vitamin C). - 1 possible way to get a conventional doctor to administer vitamin C while you're in the hospital. - Many other easy-to-implement key action steps to strengthen your immune system. This book provides a way to take your destiny into your own hands and dramatically increase your chances of staying healthy. The many scientific references included in the book also make it an ideal resource for health care providers.
Medicine of the Gods
Ayurveda is an Asian medical system which has its beginnings in India during approximately the sixth century bce and thrives even to the present-day. Medical ideas underpin a great deal of Eastern thought especially Tantrism, alchemy, yoga and the science of love. The book is not intended as a series of health tips or as a textbook for the clinical practice of medicine, which in the Ayurveda tradition requires at least seven years intensive training. The book is aimed at students and lovers of South Asian culture, perhaps also anthropologists and others with a need for a straightforward introduction to the core principles of another scientific tradition. The author was for several years an advanced student in the department of Oriental studies of Oxford University where his teacher was the late Professor B K Matilal, one of the foremost experts on Asian rational thought and logic. Praise for first edition: 'The author's main purpose, introducing ancient Indian medical theory in a . . . trustworthy manner . . . while at the same time being intellectually challenging, is quite well served by this book.' Rahul Peter Das in Traditional South Asian Medicine Vol 6 2001Ayurveda is an Asian medical system which has its beginnings in India during approximately the sixth-century BCE and thrives even to the present-day. Medical ideas underpin a great deal of Eastern thought especially Tantrism, alchemy, yoga and the science of love. The book is not intended as a series of health tips or as a textbook for the clinical practice of medicine, which in the Ayurveda tradition requires at least seven years intensive training. The book is aimed at students and lovers of South Asian culture, perhaps also anthropologists and others with a need for a straightforward introduction to the core principles of another scientific tradition. The author was for several years an advanced student in the department of Oriental studies of Oxford University where his teacher was the late Professor B K Matilal, one of the foremost experts on Asian rational thought and logic. Praise for first edition: 'The author's main purpose, introducing ancient Indian medical theory in a . . . trustworthy manner . . . while at the same time being intellectually challenging, is quite well served by this book.' Rahul Peter Das in Traditional South Asian Medicine Vol 6 2001
CBD for Dummies
An informative, easy-to-understand resource that unveils the mysteries of CBD CBD has emerged as a popular health product, but what's all the fuss about? CBD For Dummies reveals the reasons for the surge in interest about cannabidiol (CBD) and explains how to buy and use this remarkable product safely and responsibly. In an accessible, no-nonsense manner, author Blair Lauren Brown lays out the facts about CBD and outlines the many health conditions that may be helped by using CBD oil. This book covers topics that people new to CBD have questions about. Highlights include: What CBD oil is and how it works in the body How to buy CBD from a reputable source and understanding a product's potency Knowing what conditions can be eased with CBD, including muscle pain, inflammation, autoimmune conditions, eating disorders, mental health disorders, and neurological conditions Preparing your own CBD edibles Perfect for anyone interested in understanding the therapeutic potential of CBD, CBD For Dummies introduces you to everything you need to know about this cool compound.
Caring for the Family Caregiver
Caring for the Family Caregiver examines the high cost and poorly addressed exigencies of the family caregiver in chronic illness, including health literacy, palliative care, and health outcomes, through the prism of communication. This book uses an interdisciplinary approach to identify the impact of communication and its burdens on the caregiver and presents four caregiver profiles: the Manager, Carrier, Partner, and Lone caregiver, each emerging from a family system with different patterns of conversational sharing and expectations of conformity. By synthesizing current data assessing the experiences of caregivers, as well as integrating the narrative experiences of a range of caregivers living through a variety of illnesses and their specific demands, the authors deliver an unflinching gaze at the journey of the caregiver. With an author team comprised of three health communication researchers and a nurse and health literacy expert, this volume integrates literature addressing caregiver needs and burdens, communication theory and practice, palliative care and health literacy research, and the real stories of caregivers. Caring for the Family Caregiver presents the groundbreaking concept of the Caregiver Types and an innovative set of support resources to facilitate improved pathways to better care for the caregiver, making it an essential resource for providers, students, clinicians, policy makers and family caregivers alike.
Evidence-Based Clinical Chinese Medicine
Chronic Cough is the 20th volume of the Evidence-based Clinical Chinese Medicine series. It provides a multi-faceted "whole evidence" analysis of the management of chronic cough, including cough variant asthma, upper airways cough syndrome, and gastroesophageal reflux disease in Chinese medicine. Evidence from the classical Chinese medicine literature, contemporary clinical literature, the outcomes of clinical trials and experimental studies are reviewed, analysed and synthesised. The data from all these sources are condensed to provide evidence-based summaries and identity implications for the clinical practice of Chinese medicine and for future research.This book can inform clinicians and students in the fields of integrative medicine and Chinese medicine regarding contemporary practice and the current evidence base for a range of Chinese medicine therapies used in the management of chronic cough, including herbal formulas and acupuncture treatments, in order to assist clinicians in making evidence-based decisions in patient care.Currently, Chinese medicine practitioners who develop a special interest in a particular health condition, such as chronic cough need to consult a diversity of resources to expand their knowledge. Such sources typically included specialty books and journal articles sourced from biomedical databases published in Chinese and English. However, not all practitioners have access to such sources to obtain information on the evidence-based management of chronic cough. By providing all this information in one handy, easy to use reference, this book allows practitioners to focus on providing high quality health care, with the knowledge it is based on the best available evidence.
Antioxidants in Human Health and Disease
Living organisms require oxygen for survival, but it is also a highly reactive molecule that can damage organisms by producing reactive oxygen species. Oxidation is the chemical reaction that produces free radicals and thereby leads to chain reactions with the potential to damage the cells of organisms. Antioxidants inhibit oxidation. Ascorbic acid or thiols are antioxidants that can terminate these chain reactions. Organisms have a complex system of antioxidant metabolites and enzymes that work in tandem to prevent oxidative damage to DNA, proteins and lipids. However, reactive oxygen species have useful cellular functions as well, such as redox signaling. Antioxidant systems therefore do not remove oxidants completely but keep them at an optimum level. The role of oxidative stress in degenerative diseases, such as diabetes, kidney disease, neurological disorders, obesity, cancer and aging is understood. This makes antioxidant dietary supplements a potential strategy to overcome these conditions. This book provides comprehensive insights into antioxidants and their role in human health and disease. It will also provide interesting topics for research, which interested readers can take up. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.
Medicinal Chemistry
Medicinal chemistry deals with the design, chemical synthesis and development of pharmaceutical agents for the market. It makes use of principles from numerous sciences such as synthetic organic chemistry, pharmacology and other biological fields. The organic compounds which are used as medicines are classified into small organic molecules and biologics. This field also studies the inorganic and organometallic compounds which are used as drugs. Medicinal chemistry plays an important role in studying the chemical aspects of identification and synthetic alteration of new chemical entities to make them suitable for therapeutic agents. This book presents the complex subject of medicinal chemistry in the most comprehensible and easy to understand language. While understanding the long-term perspectives of the topics, it makes an effort in highlighting their impact as a modern tool for the growth of the discipline. Those in search of information to further their knowledge will be greatly assisted by this book.
Pharmaceuticals: Clinical Studies
A pharmaceutical drug is a drug that is used to diagnose, treat or prevent disease. Pharmaceuticals are classified based on the level of control, mode of action, therapeutic effects, biological system affected or route of administration. Some classes of drugs are analgesics, antipyretics, antibiotics, antiseptics, oral contraceptives, tranquilizers, hormone replacements, etc. Drugs can be administered in various dosages in the form of pills, capsules or tablets, and their administration can be parenteral, enteral, topical, intranasal, rectal, etc. Drug discovery, drug development and drug delivery are important areas of research in pharmaceutical science. Biotechnology is a major driver in the discovery of biopharmaceuticals. There has been constant research around the development of novel antibiotics and antibacterials as well as on the use of biological agents for antibacterial therapy. This facilitates better drug design and development. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the field of pharmacology. From theories to research to practical applications, case studies related to all contemporary topics of relevance to pharmaceuticals have been included in this book. It will help the readers in keeping pace with the rapid changes in this field.
