Evaluation of Pharmaceutical Stability and Antimicrobial Activity
Currently, microorganisms resistant to multiple antimicrobials represent a major challenge in the treatment of infections. An important strategy for reducing microbial resistance is the discovery of new substances with antibacterial and antifungal properties, mainly from natural sources. Ocimum gratissimum, popularly known as alfavaca and manjeric瓊o, is used in Brazil as a local antiseptic against fungi and bacteria. Due to this activity, it is one of the species considered for inclusion in the phytotherapy programme of the Unified Health System (SUS). As O. gratissimum causes toxicity when administered orally, the alternative to its use is in topical preparations. This research has shown that it is possible to incorporate the plant's oil into formulations and that they have satisfactory physicochemical characteristics and stability, representing technological feasibility for the pharmaceutical area.
Intellectual Property Rights
"Intellectual Property Rights" offers a comprehensive exploration of the fundamental concepts and intricacies of intellectual property (IP) law. This book delves into the various forms of IP, including patents, trademarks, copyrights, and trade secrets, providing a thorough understanding of their legal frameworks and practical applications. Through detailed case studies, the book examines notable IP disputes and their implications on innovation, business, and society. It also addresses contemporary issues such as digital piracy, global IP enforcement, and the balance between protecting creators' rights and promoting public access to knowledge. With insights from legal experts and industry professionals, "Intellectual Property Rights" serves as an essential guide for students, practitioners, and anyone interested in the dynamic field of intellectual property.
Pharmacy Informatics
Pharmacy Informatics is a specialized field within healthcare that focuses on leveraging data and technology to optimize medication-related processes and improve patient care outcomes. It involves the application of information technology, data analytics, and automation systems to manage medication-related information effectively. Overall, Pharmacy Informatics plays a vital role in modern healthcare by harnessing data-driven approaches to optimize medication management processes, enhance patient safety, and facilitate evidence-based decision-making across the continuum of care.
Access to medicines
Pharmaceutical services are part of Pharmaceutical Assistance, are part of health services and aim to guarantee qualified access to medicines for the population in a comprehensive and continuous manner. In Primary Health Care, the minimum structuring of these services, as well as user guidance activities, is recommended in the Guidelines and Manuals of Brazilian health organisations. However, studies have shown various organisational and structural problems in these services, which compromise guaranteed access to medicines. Considering the difficulties faced by users in obtaining their medicines with the proper guidance, this study aimed to find out the perceptions of users of pharmaceutical services in the Basic Health Units of Divin籀polis, Minas Gerais, in relation to access to medicines. The research was based on the Servir Project, a qualitative study carried out in 2014. Data related to the sociodemographic, economic and health profile of users, perceptions about the physical structure of the services, obtaining medicines and dispensing practices were extracted from the Servir Project database.
Microparticulate Drug Delivery Systems
Microparticulate drug delivery systems offer a viable way to transform the delivery of drugs. The encapsulation of pharmaceuticals by these small particles enhances their targeting, stability, and bioavailability. Microparticles can improve patient compliance and therapeutic efficacy by lowering side effects and dosage frequency by regulating the medication's release rate. This technology is an essential field of study in modern medicine as it has enormous potential for a number of drugs.
Present and Future Perspectives of Vascular Interventional Radiology
The field of vascular interventional radiology has witnessed remarkable advancements, transforming the landscape of patient care for both vascular and non-vascular pathologies. Through minimally invasive techniques, we can now offer therapeutic alternatives with reduced complications to patients who are not eligible for conventional treatments. With the emergence of personalized therapies tailored to specific pathologies, disease stages, and patient characteristics, we find ourselves at the forefront of a new era in medicine where treatments are uniquely tailored to each individual. This Special Issue of the Journal of Personalized Medicine features a comprehensive collection of 16 articles, primarily focusing on embolization, a major theme in vascular interventional radiology. Embolization techniques have revolutionized the field, providing effective treatment options for various conditions. Within this issue, we delve into various aspects of embolization, including the embolization of the prostatic artery, splenic trauma, polycystic liver disease, soft tissue hematomas, pulmonary arteriovenous malformation, gastrointestinal bleeding, and even emerging themes such as musculoskeletal embolization. These articles showcase the breadth and depth of research in the field, offering insights into the latest advancements and personalized approaches in embolization therapies.
The Use of Motion Analysis for Diagnostics
This Reprint is dedicated to the recent technological advances that are transforming the field of motion analysis. This collection of articles provides an overview of the various clinical applications of motion analysis, highlighting how this technique is influencing the diagnosis of medical conditions in multiple disciplines, from orthopedics to neurology. The methodologies employed across the studies vary widely, encompassing innovative approaches ranging from dataset creation and algorithm development to systematic literature reviews and validation studies. Overall, the collection provides a comprehensive overview of the current state of motion analysis research, offering insights into emerging trends, technological advancements, and future directions. Each contribution serves as a catalyst for further exploration and innovation in the dynamic field of motion analysis, hoping researchers will continue pushing the boundaries of knowledge and application in pursuit of enhanced healthcare outcomes and patient well-being.
Biologics and Biosimilars
Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases.This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines.Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.
The Consultation in Phytotherapy
A seminal text exploring the means by which the herbal practitioner can seek to appreciate the individual patient's predicament.
Why the Dose Matters
Each day we are exposed to a myriad of natural and human-made chemicals in our food, drinking water, air, soil, at home or at the workplace--pesticide residues, food additives, drugs, household products--but how can we gauge the human health risk posed by these chemicals? Should we believe the somber headlines that depict a serious threat for humans and the environment, or should we follow the reassuring voices of others who claim that the angst is totally unfounded?Why the Dose Matters: Assessing the Health Risk of Exposure to Toxicants uses a rational, science-based approach to explain in plain language that a quantitative view is key for understanding and predicting potentially toxic effects of chemicals. Key Features: Explains the basics of toxicology in easily understandable terms. Includes numerous examples. Clears up common misconceptions and dispels myths. Provides take-home messages for each chapter. This book is aimed at interested laypeople. It uses numerous examples to illustrate the basic concepts and ensure that the reader will get a better understanding of why not only the hazard but also the overall exposure will determine whether some chemicals pose a serious risk while others are of little or negligible concern.
The Art and Science of Physiologically-Based Pharmacokinetics Modeling
This state-of-the-art text describes the science behind the system and drug-dependent components of PBPK models, its applications in translational and regulatory science, e.g., guiding drug discovery and development, and supporting precision medicine initiatives. To incorporate state-of-the-art knowledge, each chapter is written by leaders in the field and illustrated by clear case studies. Connecting basic and applied science, this book explores the potential of PBPK modeling for improving therapeutics and is designed for a wide audience encompassing graduate students as well as biopharmaceutics scientists and clinical pharmacologists.Features: 1. Provides a basic understanding of the physiologically-based pharmacokinetic modeling and its applications2. Assists the reader in understanding product performance to allow for rapid product development and establish bioequivalence3. Well-constructed content and added value of real examples4. Illustrates how using available resources via modeling and simulation leads to a reduction in the costs related to drug development, which directly affects the costs to patients
Pharmaceutical Analysis Laboratory Manual
Pharmaceutical analysis is a critical aspect of drug development, manufacture, and quality control. It involves the application of analytical techniques to evaluate the purity, identity, and stability of active pharmaceutical ingredients (APIs), excipients, drug products, and food samples. This laboratory manual is designed to provide practical guidance in the fundamental principles and techniques of pharmaceutical analysis.This lab manual contains thirteen chapters, which cover a range of topics from the basic concepts of pharmaceutical analysis to the more advanced techniques used in the analysis. This manual covers the basics of pharmaceutical analysis and focuses on the basic calculations used in pharmaceutical analysis, such as percent purity, and concentration determination.In addition, it provides principles, procedures, and applications of various titration techniques, including acid-base titration, redox titration, precipitation titration, back titration, potentiometric titration, and pH titration with numerous practical applications in pharmaceutical manufacturers.Furthermore, it discusses various important topics related to pharmaceutical analysis.
Probiotics
Nutrients are important for the growth and healthy operation of the human body. Nutrient bioavailability is more of a concern than whether there is an adequate quantity of nutrients in the diet. A dairy product that contains probiotics also offers a variety of important minerals, such as calcium and protein. The creation of bone and teeth, as well as the control of enzymes and many other processes, are just a few of the functions that calcium, one of the essential minerals, plays in the human body. Around 99% of calcium is contained in teeth and bones, making it the most important vitamin. Many studies have revealed that in some populations, consuming a proper quantity of calcium lowers the risk of fracture, osteoporosis, hypoglycemia, and diabetes. The present study provides information regarding the relationship between probiotics and calcium, providing enhanced bioavailability of calcium and promising improved bone health. Several studies have revealed that probiotics have a key role in improving calcium uptake and absorption. Probiotics play a substantial impact in calcium absorption and, consequently, bioavailability, according to the review study in this area.
Textbook of Cosmetic Formulation
The "Textbook of Cosmetic Formulation" is an essential guide for students and industry professionals, offering a balanced approach to cosmetic science. Purpose: This textbook simplifies cosmetic formulation, offering a structured approach to understanding complex processes. It empowers readers with the knowledge to excel in the dynamic field of cosmetics.Scope: The textbook covers cosmetic science basics and emerging trends like sustainability, nanotechnology, and personalized skincare, offering insights into industry advancements.Key Themes: Scientific Foundations: Learn the core principles of cosmetic science, covering chemistry, biology, and physics, to understand formulation better.Formulation Techniques: Master formulation skills with detailed discussions on emulsions, suspensions, and delivery systems, unlocking the secrets to creating stable cosmetic products.Ingredient Selection: Understand cosmetic ingredients, from botanical extracts to synthetics, and their roles in formulating products for different skin and hair types.Emerging Technologies: Explore cutting-edge technologies like nanotechnology, 3D printing, and AI, and their applications in cosmetic formulation.Consumer Trends: Adapt to changing consumer preferences, including clean beauty, personalized skincare, and sustainability, to meet market demands.Regulatory Considerations: Navigate cosmetic regulations to ensure compliance with guidelines governing formulation and marketing.
Atividade antibiofilme do oleo de palmarosa (Cymbopogon martini)
Due to the increase in hospital infections and the resistance of pathogenic microorganisms and the lack of drugs to combat and inhibit their growth, new alternatives have been sought to combat them. These include urinary tract infections, which are among the four most common types of hospital infection, caused by Candida albicans, representing a growing threat to human health, causing nosocomial infections and candidemia, which can lead to death. Candida albicans' ability to form biofilms on inert surfaces, such as urinary catheters, is responsible for increasing its pathogenicity and triggering resistance to antifungal drugs. This study therefore demonstrates new alternatives for combating these resistant microorganisms, using Palmarosa Oil (Cymbopogon martini), which has shown significant results, such as its antibiofilm and antifungal activity against Candida albicans in urinary catheters.
Impact of the Covid-19 health crisis on the Algerian population
Covid-19 has become a public health issue since its discovery in China in 2019. This pandemic has had significant consequences on the physical, mental and social health of affected individuals. The aim of this research was to determine the impact of coronavirus infection on the Algerian population through a retrospective descriptive survey, and to identify the organic and psychosocial sequelae caused by the infection, known as Covid long. The results showed that half of the respondents (52%) had symptoms of Covid long, including a variety of symptoms, the most frequent of which were joint pain (72%), fatigue (70%), diabetes (67%), dyspnoea (52%), arterial hypertension (44%) and arrhythmia (37%). Anxiety was the most marked psychological symptom, followed by depression. Although recourse to hospitalization is rare, these prolonged forms will have a major social impact, necessitating the implementation of appropriate preventive and public measures.
Dosage Form Formulation Technologies for Improving Bioavailability
This Special Issue welcomed original research papers, but was not limited to cooperative works between academia and pharmaceutical companies where reformulations or original dosage form designs were performed. Papers or reviews including the principles of Quality by Design to improve the bioavailability of drugs belonging to BCS Classes of II or IV were warmly encouraged for submission. We were looking for manuscripts that optimized innovative technology through the design of experiments as well. Non-pharma institutes or departments and their innovative research projects were also invited to contribute to this Special Issue if their novel and original results could be adapted to dosage form formulation or production.
deep-sensory
Gudrun Leyendecker has been an author since 1995. She was born in Bonn in 1948. See Wikipedia. She has published around 98 books, including non-fiction, crime novels, romance novels and satire. Leyendecker also writes as a ghostwriter for well-known directors. She is a member of writers' associations and an Italian cultural association. She also gained experience for her work during her decades as a life counselor.
How You Are Being Poisoned
"How You Are Being Poisoned " by the author of the "P53 Diet & Lifestyle" David W. Brown is designed to equip aspiring plant-based nutrition specialists and health enthusiasts with comprehensive knowledge about various harmful toxins present in food, consumer products, and the environment. You will learn about the types of toxins, their sources, their adverse effects on health, and strategies to mitigate exposure. This in-depth book aims to empower anyone to make informed decisions regarding nutrition and lifestyle choices to promote overall well-being.Book Objectives: Understand the concept of toxins and carcinogens also known as bad chemistry.Identify common harmful toxins found in food additives, artificial sweeteners, food dyes, toxic metals, food toxins (naturally formed), plastics, pesticides, and volatile organic compounds (VOCs).Evaluate the potential health risks associated with exposure to various toxins such as cancers and other ailments.Develop strategies to minimize exposure to harmful toxins through dietary and lifestyle modifications.Analyze case studies and real-life scenarios to apply knowledge of harmful toxins in practical situations.Understand how cancers and other ailments can develop from toxins.Stay informed about emerging research and developments in the field of toxicology and its implications for plant-based nutrition.The "How You Are Being Poisoned " book provides everyone with essential knowledge and skills to identify, assess, and mitigate the risks associated with exposure to harmful toxins. By understanding the sources and effects of toxins on human health, people can make informed decisions to support their own well-being and advocate for safer, more sustainable practices in food production, consumer products, and environmental management.
Single Point Acupuncture Clinical Treatment
The Single point therapy is a significant therapy in Traditional Chinese Medicine. Using the Single point therapy has the characteristics of good curative effects. This book guides you by the principles governing the prescription and combination of points of Acupuncture, and it lets to find easily acupuncture points of diseases. This book tells you and shows you easily understandable explanation for finding the acupuncture points of diseases. This book is for Acupuncture students and practitioners.
Human Motor Development
Human Motor Development: A Lifespan Approach, Eleventh Edition provides an overview of the academic field of study known as human motor development, the examination of lifelong changes in human movement. The book uses a holistic approach and emphasizes the importance of intellectual, social, and physical development and their impact on human motor development at all ages. The unique approach of this book includes the relationships between motor development and critical interactions with cognitive, social, and physical changes across the lifespan.Organized into five parts, the book examines key topics in motor development, including the relationship between cognitive and social development and motor development, factors affecting development, changes across the lifespan, and assessment in motor development, with special attention being applied to adulthood and older adulthood, given the increasing numbers of people in those age groups worldwide. Each chapter includes chapter objectives, a summary, a list of key concepts, questions for reflection, a list of related online resources, and an extensive reference list.Highly illustrated and written for student accessibility by providing access to a fully updated companion website, which includes laboratory exercises, an instructors' manual, a test bank, and lecture slides, Human Motor Development: A Lifespan Approach is essential reading for students of motor control and development, kinesiology, and human performance and for students interested in physical therapy, physical education, and exercise science.
Nanotechnology in Drug Discovery
This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine. Key Features -Explains the fundamentals of nanotechnology in drug discovery -Includes up-to-date information on modern nanopharmaceutical manufacturing, nanomaterials, and nanoparticle-based drug therapy -Practice questions for learners and a list of references for advanced readers for each chapter
Pharmaceutical compression
This comprehensive handbook on pharmaceutical compression explores challenges and solutions for optimizing the compression process, with an emphasis on integrating new equipment. Topics ranging from tablet cohesion mechanisms to techniques for optimizing rotary press performance are covered. The importance of quality control, equipment qualification and maintenance is highlighted to ensure tablet conformity and quality. Highlighting the concept of QbD and the impact of artificial intelligence, this manual offers resolutions and tactics for improvement, while encouraging ongoing research and the adoption of new technologies to maintain industrial competitiveness.
Inappropriateness in Prescription Among the Geriatrics Patients
With nearly, 7.7% of the Indian population being geriatrics polypharmacy and inappropriate prescribing poses a challenge to tackle the erratic use of medication for the elderly, in the treatment of their one or many underlying conditions. The prescription of multiple medications could lead to the rise of ADRs during the treatment period. To prevent the rise of such potential conditions, prescription screening tools such as START (Screening Tool to Alert Right Treatment) and STOPP (Screening Tool of Older Persons Prescription) are used to alert PIM`s and optimize therapy.The aim of the study was to understand the prevalence of polypharmacy and potentially inappropriate prescription and medication use in the geriatric population. Using the START/STOPP screening tools.Present prospective observational study was conducted using the case sheets of 166 patients older than 65 years (51.8% male) (48.1% female). The 916 medications within all the cases were screened for Potentially inappropriate medications using the START/STOPP screening tool.
Tactical Medicine
This is a matter of life and death. Tactical Medicine is emergency first aid. "Tactical Medicine" is an umbrella term for medicine outside the typical comfort zone. "Tactical Combat Casualty Care" (TCCC) is about caring for the wounded under very special circumstances, while deployed and under fire. The principles and procedures of Tactical Medicine also apply in situations where regular rescue services won't work or aren't available. With this book, Carsten Dombrowski, himself an experienced medic, clarifies standard operating procedures and helps the reader to understand TCCC principles more easily. By understanding and applying these basics, the reader can and should be able to deal with many possible applications of Tactical Medicine in the field. Topics include: - TCCC Theory and Statistics - Schemes for Examination, First Aid, Reporting, Rescue, and Evacuation - How to Set Up a Helicopter Landing Zone - Handling of Knockoff and Counterfeit Products - Individual First Aid Kit (IFAK)
Essentials of Pharmacodynamics and Drug Action
The book provides a comprehensive exploration of the dynamic field of pharmacology and its fundamental principles. It delves into the intricate interactions between drugs and the human body, focusing on pharmacokinetics, which explains the dynamics of drug actions in the body, and pharmacodynamics, which uncovers the mechanisms through which drugs exert their effects. The book also emphasizes the crucial aspects of therapeutics and gene-based therapy, shedding light on modern approaches to disease treatment. Readers will gain insights into drugs that target the autonomic nervous system, influencing functions beyond voluntary control, and drugs that act on the central nervous system, impacting neurological processes. Additionally, the book examines medications affecting renal and cardiovascular functions, playing a significant role in maintaining homeostasis. Moreover, it explores the realm of drugs influencing gastrointestinal function, essential for digestive health.Furthermore, the book covers pharmacotherapy for microbial diseases, addressing the challenge of infectious agents and their treatment. It also investigates hormones and hormone antagonists, pivotal in regulating various physiological processes. Lastly, it provides a comprehensive understanding of drugs used for immunomodulation, which plays a crucial role in enhancing or suppressing the immune system.The book serves as a resource for students, researchers, and healthcare professionals seeking a deep understanding of drug interactions, therapeutic applications, and cutting-edge approaches in pharmacology.
A Practical Handbook of Biochemistry
The manual is written according to the PCI Syllabus of practical biochemistry for the Ist year pharmacy students. This book mainly guides students to get knowledge about basis of biochemistry. Students will find it a clear and concise overview of Biochemistry laboratory work. Most of the informations in this book has represented in a very simple manner. The aim of this book is to make the subject easy and understandable to the students. It aims at giving a good exposure of various aspects of biochemistry including the role of biochemistry in Pharmacy.These practical books mainly aim in guiding the under graduate and graduate students and overcoming the obstacles faced by them in practical aspects of Biochemistry. The major objective of this practical book is to present the information in alucid condensed manner to fulfill the requirements of students. This practical book tries to cover the syllabus of Biochemistry from most of the university from India.
Herbal Treatment of Anxiety
Herbal Treatment of Anxiety: Clinical Studies in Western, Chinese and Ayurvedic Traditions explains the nature and types of anxiety, its neurobiology, the pathophysiology that exacerbates and perpetuates it, and the psychopharmacology of the chemical agents that relieve its manifestations. Throughout the text are discussions of Western, Chinese and Ayurvedic herbal treatments that have been clinically shown to be effective in relieving anxiety. The book also features a scientific discussion of the use of herbs and essential oils in aromatherapy and the mechanisms by which they may work. The book concludes by providing bases upon which herbs can be chosen to treat the anxiety of patients according to their individual needs.Additional features include: Examines the increasingly popular subject of the use of herbs as a natural alternative treatment and provides a much-needed scientific basis for treatments often considered as merely "folk medicine." Discusses the psychoactive phytochemicals contained in herbs. Includes a chapter discussing the nature and mechanisms of action of adaptogens. Adds to the armamentarium of anxiolytics for providers who have become reluctant to prescribe benzodiazepines as treatment of anxiety, particularly in the context of the opiate crisis. Gives an introduction to herbal treatments of traditional Chinese and Ayurvedic medicine. Offers practical advice on initiating and managing herbal treatments. Herbal Treatment of Anxiety is a valuable reference for psychiatrists, psychiatric nurse practitioners, primary care providers, naturopathic doctors and therapists interested in the most current scientific information on the effects of herbal treatments of anxiety disorders.
Reconstructive Microsurgery
The subspecialty of reconstructive microsurgery utilizes microsurgical techniques to allow surgeons to operate on the smallest of structures, including vessels, lymphatics, and nerves. Traditionally, these procedures have been used by microsurgeons to reconstruct complex tissue defects through the use of free tissue transfer, which involves the transfer of tissue (free flaps) between distant anatomic sites on the body. As the field has advanced, microsurgical techniques have been applied to even smaller structures, opening the door for new procedures, such as lymphatic reconstruction in the management of lymphedema and new types of free flaps. In addition, refinement in the technique has allowed microsurgeons to now perform many of these procedures with minimal donor site morbidity. Lastly, trends in plastic and reconstructive surgery have also resulted in the more widespread use of other applications for microsurgery, such as gender-affirming surgery and vascularized tissue allotransplantation. In this Special Issue, the latest research in reconstructive microsurgery is presented, including in the areas of microsurgical technique, robotic microsurgery, and program development.
Advances in Paediatric Spine Surgery
The always-evolving field of pediatric spine surgery has seen tremendous advancements in recent years. Improvements in surgical planning, techniques, implants, and peri-operative pathways have greatly benefited our patients and their families. Nevertheless, there are still many questions to be answered and there is room for improvement. Modern technologies, including vertebral body tethering (VBT), patient-specific strategy, self-growing rods, minimally invasive robotic assistance, and surgical navigation, are active areas of investigation. Similarly, enhanced recovery after surgery (ERAS) protocols as well as newer strategies for peri-operative management are promising tools to hasten recovery after surgery. This Special Issue focuses on idiopathic and neuromuscular scoliosis surgery with a special interest in new technologies, new surgical techniques, and peri-operative management protocols.
Vascular, Oxidative and Inflammatory Dysregulation in Neurodegenerative Diseases
Up to one billion individuals globally may be impacted by neurological illnesses, according to recent World Health Organization (WHO) research. Medical definitions of neurological illnesses include conditions that impact not only the brain but also the spinal cord and nerves in the human body. A variety of symptoms may be brought on by structural, biochemical, or electrical anomalies in the brain, spinal cord, or other nerves. Among the most prevalent are neurodegenerative diseases like Alzheimer's and other dementias, strokes, migraines, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, polyneuropathies, neurological infections, brain tumours, and conditions resulting from nervous system trauma like head injuries.
From Back Pain to Productivity
The goal of this book is to give the necessary helpful information to you, leaders, who want to understand what back pain is and how this can influence the company's productivity and cost-effectiveness. It is providing essential instructions on managing employees suffering from back pain about the different origins of the back pain making you understand how spine functions and the factors that amplify the symptoms. It emphasises the critical role of ergonomics in creating a safe work environment. Understanding the principles of ergonomics enables leaders to design workspaces that support proper posture and minimise strain on the back, thus reducing the likelihood of exacerbating existing pain or causing new injuries.Moreover, describes in depth the importance of acknowledging the range of motion of the body. Leaders are encouraged to promote flexibility and movement within the workplace, implementing strategies such as regular stretching breaks or adjustable desks. By accommodating varying physical needs, businesses can empower employees to maintain optimal comfort and mobility throughout the workday.In addition the necessity of assistance for the employees with back pain has to be stressed and it is another key aspect covered with the content of this work. Provision of necessary support, whether through ergonomic furniture, specialised equipment, or access to healthcare professionals is mentioned within it. By investing in the well-being of workforce, companies foster a culture of care and promote employee satisfaction and loyalty. Serenity and reduction of stress among individuals is been amongst the important elements helping back pain management. Stress-relief initiatives such as mindfulness programs, relaxation spaces, or employee assistance programs are part of the material studied within the present book. By prioritising mental and emotional well-being, businesses can enhance overall job satisfaction and mitigate the negative impact of stress on physical health.Furthermore, the book highlights the direct correlation between employee health and productivity. Leaders are reminded that a pain-free workforce is a more productive workforce. By addressing back pain and creating a supportive environment, businesses can optimise performance, reduce absenteeism, and boost employee morale, ultimately driving greater success and profitability. It underscores the importance of achieving equilibrium between social and working life. Encouragement to foster a balanced environment where employees feel supported both professionally and personally is paramount. By promoting work-life balance and offering resources for self-care, businesses can cultivate a united and resilient team, leading to sustained success and fulfilment for all involved.This book is mainly for educational purposes and stresses the need for further exploration on the touched within these pages material, placing the foundations for further research. On the other hand it could be taken as an initial guide for business leaders seeking to understand and effectively manage employees with back pain. By integrating principles of ergonomics, providing necessary assistance, promoting serenity, and fostering work-life balance, companies can create a supportive environment conducive to both employee well-being and organisational success.
Phytochemicals Beneficial to Human Health
To date, numerous research groups have focused on the study and characterization of herbal extracts to identify numerous plant metabolites that have remarkable effects on biological systems.
Aromatherapy
Recent clinical studies have demonstrated an impact of aromatherapy on the control of symptoms associated with human diseases not fully controlled by conventional therapy. Aromatherapy: Basic Mechanisms and Evidence Based Clinical Use provides an up-to-date compilation of background scientific information that advocates the application of currently developed clinical studies on the effects of aromatherapy to the treatment of human diseases such as mild, stress-induced mood disorders, infectious diseases, and age-related disturbances.The book encompasses all aspects of successful clinical use of aromatherapy, including phytochemistry, technology, and clinical trials. It outlines a rational basis for clinical translation of aromatherapy for treating human diseases in need of safer therapies. It also describes evidence-based use of aromatherapy in controlling clinical manifestations of severe diseases for which conventional therapies often fail, such as managing agitation and aggression associated with Alzheimer� �s disease and other neurodegenerative diseases.Containing a wealth of references and a thorough presentation of knowledge on essential oils and aromatherapy, this book is a valuable resource for students, researchers, clinicians, and policy makers in health care systems. It details the current clinical uses of aromatherapy while promoting further clinical development in areas where therapy is lacking.
Fundamentals of Pharmaceutics and Dispensing Pharmacy
Fundamentals of Pharmaceutics and Dispensing Pharmacy is a must-have guide for all pharmacy students and professionals. This book serves as an extensive guide that provides practical application of dispensing pharmacy along with theoretical knowledge, helping the reader understand the intricacies and complexities of the profession. Designed to be used along with textbooks and reference books, this comprehensive guide covers the essential elements of an ideal pharmacy professional, including dosage forms and the challenges encountered within extemporaneous dispensing. It also features worked examples that have been thoroughly tested in laboratories, providing readers with an opportunity to practice extemporaneous formulation exercises. Perfect for undergraduates of B. Pharm. students, the book is in accordance with PCI and Indian Pharmacopoeia standards, making it a valuable resource for those preparing for GPAT exams and practicing pharmacists who need a quick reference text.Fundamentals of Pharmaceutics and Dispensing Pharmacy is an essential resource for enhancing your knowledge and understanding of the field.
Frontiers in Anti-Infective Drug Discovery
Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The tenth volume of this series features 4 reviews on the following topics: -Pharmacotherapy of Posterior Segment Ocular Infections -Discovery and Development of Antimalarial Drug-Resistance Reversal Agents -Omics Technologies and Anti-Infective Drug Discovery -Possible Cutaneous Adverse Effects of Anti-Infective Vaccinations
Regeneration by Design
The superpower of eternal life comes with a caution: living longer does not guarantee living better - unless you regenerate by design. Dive into a science-fuelled journey of transformation and experience ageing not as inevitable pain, but as superhuman strength and rejuvenation. Read Regeneration By Design to: Unleash your regenerative superpowers: Master the Six Superhuman Steps to minimise external disturbances and optimise your body's regenerative capacity for lifelong mobility Revolutionise your life with science: Adopt a systematic approach to your health, blending physics, chemistry and biology to protect and enhance musculoskeletal function Eat and live like a superhuman: Leverage advanced dietary insights and practical lifestyle modifications to fuel your body's innate healing and regeneration processes Craft your health blueprint: Harness the power of AI and digital technology to create a personal health plan for informed decisions on regenerative treatments Become the master of your medical destiny: Navigate the complexities of modern medical advice with confidence and make educated choices about treatments and interventions for regenerative living
How to update my knowledge of topical Bionanocomposites
Book summaryYou may find this book interesting, dear readers, if you want to be informed about the latest scientific research into the subject of antiseptic bionanocomposites. You'll get the most important general ideas on a subject that captivates the attention of today's passionate medical students. Thank you very much for giving your attention to this book, which is highly recommended in view of recent scientific advances.
Final dissertation
Molecular monitoring of BCR-ABL transcript levels by quantitative PCR is increasingly used to assess patient response to treatment. This has become particularly interesting in the imatinib era when residual disease falls below the detection threshold of conventional cytogenetics. The main objective of our work is to study the evolution of CML by quantifying the BCR/ABL molecular transcript during the therapeutic phase. This is a retrospective, descriptive study of 30 patients followed in the hematology department of Tizi Ouzou University Hospital, in the consultation unit. Molecular follow-up showed that 70% of patients achieved MMR with imatinib 400 mg, and 20% of patients who failed imatinib 400 and 600 mg were substituted with a second-generation TKI with 100% MMR. Quantification of the BCR/Abl ratio showed that 96% of patients on imatinib 400mg were cured. In conclusion, optimizing treatment and using the various TKIs available requires biomolecular monitoring of BCR/Abl transcripts right from diagnosis.
Micoses
This book aims to provide knowledge in the area of Clinical Mycology, both superficial and systemic pathologies in a clear and objective way. To help with your studies in the field or in your clinical laboratory. We hope to provide you with the knowledge you need for your diagnosis and treatment to be as efficient as possible and thus improve your health more and more through the constant search for knowledge. Happy reading!
Emergency Medicine
I am proud to present this Special Issue, "Emergency Medicine: Clinical Advances and Challenges in Diagnosis and Treatment," dedicated to new advances and challenges in emergency medicine. In an ever-evolving world, emergency medicine remains a benchmark for knowledge and prompt action in critical situations. This reprint is a tribute to the medical achievements, dedication, and profound compassion of those who dedicate their lives to saving others. This Special Issue describes the clinical advances and complex challenges in diagnosis and treatment. Each article is designed to give readers a deeper understanding of the latest findings and solutions in this dynamic field. In closing, I hope you can join this journey of knowledge and contribute, each uniquely, to the evolution and improvement of this fascinating field, emergency medicine. I express my gratitude to all of the authors for their valuable contributions and efforts in making this reprint a reality and to our readers for joining this expedition.
Dietary Supplements in Cardiovascular and Metabolic Diseases
This Special Issue begins with two preclinical studies on bergamot fruit extract (Citrus bergamia) showing reductions in oxidative stress and dyslipidemia both in vitro and in vivo. Additionally, a review explores the potential therapeutic use of combining SGLT2 inhibitors with plant extracts. In another in vivo study, humanized mice supplemented with L-carnitine and essential oil emulsions exhibited prebiotic effects on gut microbiota, reducing plasma trimethylamine N-oxide (TMAO) levels and increasing fecal short-chain fatty acids (SCFAs). Preclinical studies also examined the impact of copper nanoparticles on oxidative stress and vascular relaxation, and assessed the quality of herbal teas and dietary supplements, revealing deficiencies in their nutraceutical content. Two reviews highlight the health benefits of astaxanthin and taurine. Clinical studies include a retrospective analysis linking glucosamine usage to increased cardiovascular risk in osteoarthritis patients, and a trial demonstrating the efficacy of L-Arginine plus vitamin C supplementation in long-COVID patients. The issue concludes with three placebo-controlled trials: one showing Coenzyme Q10 plus NADH benefits on fatigue and quality of life in chronic fatigue syndrome patients, another revealing the antioxidant effects of water-soluble tomato concentrate in healthy adults, and a third highlighting the positive impact of bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome, and zinc on lipid profiles, inflammation, NAFLD, and endothelial reactivity in hypercholesterolemic individuals.
Advances in the Development of New Drugs and Treatment Targets for Brain Cancers
The Special Issue features original research articles and review articles that discuss new therapy tactics and target medications, emphasizing the significance of brain tumors at the cellular and molecular levels. In recent decades, potent chemotherapeutic agents, oligonucleotides, and antibodies for targeted therapy, multifunctional nanomedicines, immunotherapies, and cell-based therapies have been developed and proposed to overcome most of the issues that arise due to the locations of brain tumors and their biological barriers. Ongoing research is focused on comprehending the biology of brain tumors, discovering new treatment targets, and creating breakthrough medicines like immunotherapy and tailored drug delivery systems. These endeavors show potential for enhancing results and increasing survival rates in the future.
Imaging in Ophthalmology
Ophthalmic imaging tools currently play a fundamental role in the clinical assessment, diagnosis, management, and monitoring of a wide variety of conditions, involving both the anterior and posterior segment. The introduction and developments of imaging technologies, including anterior and posterior segment optical coherence tomography (OCT), OCT angiography, retinal photography, specular and confocal microscopy, corneal topography, and ocular ultrasound, has dramatically improved the morphological and functional evaluations of ocular structures. Moreover, multimodal imaging has led to the successful identification of biomarkers and predictors for high-incidence ocular and neurological disorders. Recently, the application of artificial intelligence (AI) and deep learning in ophthalmology has received growing amounts of interest among researches, due to the promising results in terms of the accuracy and sensitivity of the detection of common eye diseases, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, highlighting the potential of these methods to serve as crucial tools in the screening, diagnosis, long-term follow-up, and prediction of disease progression. This Special Issue includes original studies and reviews regarding the principles, clinical and intraoperative applications, updates, and potential future advances of the ophthalmic imaging tools/methods, applications, and potential developments of artificial intelligence and deep learning, in both anterior and posterior segments.
Dermatology
This reprint presents a meticulous compilation of 11 cutting-edge articles from leading authors in the field of dermatology, originally featured in our previous manuscript. This collection illustrates the significant advancements and innovations that have shaped dermatological science and practice in recent years.Each article within this compendium delves into various aspects of dermatological advancements, ranging from the development of novel therapeutic approaches and understanding the genetic underpinnings of skin diseases to the exploration of new diagnostic tools and the integration of technology in dermatological care. The authors provide insightful analyses and discussions on the latest research findings, clinical trials, and emerging trends in dermatology.This reprint reflects the dynamic and evolving nature of dermatology, showcasing the collaborative efforts of the global dermatological community to push the boundaries of knowledge and improve patient care. This collection of manuscripts stands as a cornerstone for those dedicated to the pursuit of excellence in dermatology, offering a perspective on the future of skin health and disease management.
New Advances in Pharmacologic and Non-pharmacologic Therapy in Heart Failure and Heart Transplant
In light of the continuous development of new pharmacological agents and device-based therapies, we made the decision to bring together the most innovative clinical studies and the most practical reviews as a part of this Special Issue to offer readers new evidence useful for the management of both patients with heart failure and heart transplant patients.
Chronic Pain Management
This reprint provides a rich and varied collection of articles reflecting the landscape of contemporary research and scholarship on chronic pain and its management. The collection includes reviews and primary research that challenge established beliefs and open new avenues for exploration. The collection has been edited by Mark I. Johnson, PhD, Professor of Pain and Analgesia, and Director of the Centre for Pain Research at Leeds Beckett University. Mark has investigated the science of pain and its management for over 35 years, focusing on factors influencing pain experience and response to treatment. More recently, he has explored art and pain, community-support pain services, and the concept of painogenicity.
Polycystic Ovary Syndrome (PCOS)
This Special Issue of the Journal of Clinical Medicine is dedicated to polycystic ovary syndrome (PCOS). It includes 12 interesting papers from all around the world that contribute important new information regarding the pathogenesis, clinical evaluation, and treatment of this very common disorder that affects about 10% of all women during their adult life. The first paper presents an evolutionary model of PCOS that has profound consequences on the methods of preventing and treating this syndrome. Other papers describe problems related to differential diagnosis from hypothalamic amenorrhea and the use of questionnaires for detecting alterations in the quality of life of these women. Two papers are dedicated to sexual problems that may arise in these patients. Many papers analyze the actual treatment of PCOS, from the promotion of physical activity to the use of oral versus intravaginal contraceptives. Articles also investigate how to optimize the clomiphene induction of ovulation or to improve pregnancy outcomes. One paper analyzes the importance of hypoglycemia in determining the long-term effects of different diets. Finally, two important papers report on the results of new treatments for high body weight in women with PCOS.
