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Recent Advances in Polymeric Delivery Vehicles for Controlled and Sustained Drug Release
The latest advances in drug delivery systems are aimed at delivering drugs in a controlled fashion both temporally and spatially. Polymers have recently been employed in these approaches for drug delivery, tissue engineering, cell encapsulation, the fabrication of medical devices, and a diversity of other biomedical applications. These recent successful applications have demonstrated the superior potential of such polymeric drug-delivery systems in biomedicine.This Special Issue aims to provide an updated account of recent advances in the synthesis, characterization, engineering, and use of polymers, being synthetic or natural, for drug delivery and sustained drug release. We thank all authors for reporting developed novel polymer-based carriers in therapeutics and diagnoses that overcome the limitations associated with drug administration and enhance patients' quality of life.
Progress in Biomaterials and Technologies in Dentistry
Dear Colleagues, dentistry is an interdisciplinary field that combines the principles of medical and material sciences toward the development of therapeutic strategies. Continuous progress in the biomaterials field allows for the development of new studies and methods to treat and rehabilitate patients. The growth of pharmaceutics and biomaterials as a research field has provided a novel set of therapeutic strategies for dental applications. Topics in this Special Issue include, but are not limited to, the following: new restorative materials, new regenerative materials, and translational research in all fields of dentistry.
Digital Pathology
Digital pathology workflow implementation remains challenging. In laboratories worldwide, there are growing examples of successful implementation and pathologists acknowledging the advantages of this new model of practicing pathology.This Special Issue of Diagnostics is a collection of records of successful digital pathology implementation for primary diagnosis or secondary applications, that serve as an inspiration to those readers who are still skeptical about it. These records highlight the advantages of the use of whole slide images such as sharing and the image analysis, as well as the virtues of the digital workflow per se. The holistic approach of the digital workflow comprehends practical interventions in the laboratory workstations that are demonstrated in this Special Issue, as well as their respective monitorization, quality control and impact on clinical practice.
Dentistry
Dear Colleagues, this Special Issue presents a comprehensive collection of studies showcasing the latest innovations in dentistry, emphasizing the integration of multidisciplinary approaches and technological advancements. With a focus on improving patient outcomes and advancing oral health care, the contributions explore a range of topics, including the development of new biomaterials, minimally invasive techniques, and novel treatment protocols. These innovations have broad applications in restorative dentistry, prosthodontics, oral surgery, implantology, pediatric dentistry, orthodontics, and the management of temporomandibular disorders. The research presented in this reprint reflects the significant progress made in dental science and its application to clinical practice, offering valuable insights for both researchers and clinicians.
New Perspectives in Oral Health for Patients with Special Needs and Compromised Older Adults
This Special Issue was designed to provide a multifaceted look at the latest clinical and research findings in the field of geriatric dentistry, which has rapidly gained importance since the beginning of the 21st century. It covers oral frailty, rapid oral health deterioration (ROHD), and oral hypofunction syndrome as comprehensive disease concepts related to the oral health of older people, explains their causes, and introduces the latest technology for diagnosing the deterioration of the oral environment and of oral function. It also discusses the strategy and methodology of oral healthcare in order to prevent declines in oral health and analyzes the impact of the COVID-19 pandemic. Furthermore, the impact of declining oral health on the overall health of older people is discussed from the perspectives of nutritional status, sarcopenia, and frailty.
Traumatology for the Emergency Doctor
This handy and practical book assists emergency doctors in their daily practice offering a quick reference tool to properly diagnose and manage traumatic musculoskeletal lesions. In the opening part it provides readers with basic traumatology knowledge, enabling them to have a constructive discussion with the specialist. The other sections are devoted to upper limbs, lower limbs, pediatric trauma and skull and spine trauma. Following this anatomical subdivision, the authors offer practical tips to recognize hidden injuries, minimize diagnostic errors and avoid common pitfalls. Readers will learn how to combine careful questioning with a thorough clinical examination, backed up by appropriate, high-quality complementary tests. With its handy and easy-to-read format this book is an invaluable tool for emergency doctors and orthopedic residents alike.
Natural Poisons and Venoms
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs. Numerous images of plants and chemical structural formulas complete the book, as well as extensive references for further reading. The multivolume reference is an essential resource for physicians, veterinarians, pharmacists, chemists, biochemists, food chemists and biologists, for students in the relevant fields, and maybe for interested laymen. All aspects of natural toxins based on the latest scientific knowledge are included: All aspects of the toxicology of all living organisms and natural foods, chemistry, action mechanisms, symptoms of intoxications. The only book arranged on a strictly scientific base according to the biogenetic origin and chemical structure. Natural Poisons and Venoms in 5 Volumes: Volume 1: Plant Toxins: Terpenes and Steroids 2023, ISBN 978-3-11-072472-1 Volume 2: Plant Toxins: Polyketides, Phenylpropanoids and Further Compounds 2024, ISBN 978-3-11-072851-4 Volume 4: Animal Toxins 2023, ISBN 978-3-11-072854-5 Volume 5: Fungal and Microbial Toxins 2025, ISBN 978-3-11-072856-9
Enhancing Irbesartan Bioavailability via Solid Dispersion
Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 μg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like β-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. β-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that β-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using β-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension.
Alnus glutinosa
Alnus glutinosa (Betulaceae) is a medium-sized tree native to the northern hemisphere. The leaves of this species are used in several Eastern countries as an anti-diarrheal, anti-inflammatory and antipyretic. The aim of this study was to investigate the antioxidant and anti-inflammatory effects and to measure the total polyphenol and flavonoid content of two extracts obtained from A . glutinosa leaves in acetone and methanol. Polyphenol content was determined by the Folin-Ciocalteu reagent method, using gallic acid as the standard. Flavonoids were assessed using the AlCl3 method. Antioxidant activity was measured using the 1,1-diphenyl-2 picrylhydrazyl (DPPH) radical scavenging assay. Anti-inflammatory activity was assessed by measuring the inhibition of denaturation of fresh egg albumin.
Pharamacology - II
This book provides a comprehensive guide to the PHARMACOLOGY-II Practical syllabus, focusing on various in-vitro and in-vivo experiments. Each chapter delves into the methodology, principles, and analysis of pharmacological tests using animal models. The book covers key experiments that demonstrate the effects of drugs on physiological systems, including: In-vitro pharmacology and physiological salt solutions.Drug effects on isolated frog heart and blood pressure in dogs.Bioassays of histamine, serotonin, oxytocin, and acetylcholine using animal tissues.Dose-response curves (DRC) and modifications with agonists and antagonists.Diuretic activity of drugs in rats and mice.The anti-inflammatory and analgesic activity of drugs using standardized models.Each chapter includes detailed explanations of experimental procedures, results analysis, and the significance of the findings in pharmacology. The book is designed as a practical manual for students, providing step-by-step guidance on conducting these important pharmacological experiments.
Frontiers in Drug Design and Discovery
Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. Volume 12 of this series brings together reviews covering homology modeling and anti-infective drug discovery. Topics included in this volume are: -Homology Modelling: A Computational Tool in Drug Design and Discovery. -Anti-trypanosomatid Drugs/Candidates in Clinical Trials: What's New and What's Missing? -Nitroheterocyclics As Anti-Tuberculosis Agents: An Overview. -SARS-CoV-2 Protease Inhibitors of Natural Origin: Current Scenario and Future Prospects as Anti-COVID-19 Agents.
Invasive Aspergillosis - Diagnosis and Recommended Therapy
There is great concern on the part of health professionals about invasive infections, since the mortality rate is high and there is still a delay in truly effective forms of diagnosis. We realise how important it is to know about invasive aspergillosis and the factors surrounding this disease, such as the mode of contamination, risk factors, diagnosis and treatment, in order to improve the diagnosis and treatment of this illness.
A Comparision of Meteriovigilance in India and USA
In recent years, the use of medical devices has increased. Despite this, there are not enough safeguards in place to safeguard people from unfavorable outcomes related to the use of medical devices. Materiovigilance programmes are designed to examine, track, and stop the recurrence of negative effects brought on by the use of medical devices.In India, Silicone Sound Abatement Foam Delamination and the possibility of false results are the primary reasons why medical devices are recalled. Only a small number of products were recalled in 2020. Compared to 2020, a lot of products were recalled in 2021. Less products were recalled in 2022.
2-Pyrazoline-1-Carboxamide Derivatives
2-Pyrazoline derivatives are synthesized by diverse reaction schemes and display a broad spectrum of potential pharmacological activities. The derivatives are present in numerous pharmacologically active molecules such as azolid/ tandearil (anti-inflammatory), phenazone/ amidopyrene/ methampyrone (analgesic and antipyretic), anturane (uricosuric) and indoxacarb (insecticide). New therapeutic agents having improved potency and lesser toxicity are developed by changing in their structure, and it has offered a high degree of diversity that has proven useful for the new drug development. The aim of the present research was thus focused on 2-pyrazoline-1-carboxamide derivatives. The 2-pyrazoline-1-carboxamide derivatives were synthesized by convenient, economical methods in less reaction time and with better yield of products with high level of purity. The compounds numbered 4d-4e, 4j-4k, and 4m-4t were most protective against MES even at 30 mg/kg dose levels. The synthesized compounds were showing minimal neurotoxicity. Thus, it is concluded that all the tested compounds are protective against MES at 100-300 mg/kg dose levels and show promising anticonvulsant activity.
The Back Pain Manual -- A Guide to Treatment
Back pain is the single leading cause of disability worldwide; the World Health Organization regards back pain as a condition for which the greatest number of people may benefit from rehabilitation. It is estimated that low back pain alone affects 619 million people globally and this is estimated to rise to 843 million people by 2050. Up to 60% of the adult population will have low back pain at some point in their lifetime; 5-7% of adults over 45 years of age are estimated to have chronic low back pain. Healthcare professionals see people with back pain routinely in their clinical practice and so education and awareness of back pain and the various treatment options are vital for an effective outcome in these situations. Research has shown that healthcare professionals have a considerable and enduring influence upon the attitudes and beliefs of people with back pain. This book will help clinicians to positively influence the outcome of people suffering from back pain. This book discusses back pain in great detail and is written in an easy-to-understand style, while keeping an evidence-based approach. Doctors, nurses, physiotherapists, occupational therapists, medical students, and other healthcare professionals will find this book informative. People who suffer with back pain will also find the information useful to expand their knowledge in order to successfully manage the condition. This book is of immense use to candidates preparing for examinations conducted by the Faculty of Pain Medicine of the Royal College of Anaesthetists, UK (FFPMRCA), American Board of Anesthesiology (ABA), Royal College of General Practitioners, UK (MRCGP), College of Anaesthesiologists of Ireland (FFPMCAI), American Board of Pain Medicine (ABPM), European Pain Federation (EFIC) (European Diploma in Pain Medicine [EDPM]), Faculty of Pain Medicine of the Australian and New Zealand College of Anaesthetists (FPM), and the World Institute of Pain (FIPP/CIPS). The authors are both senior consultants in pain medicine practising in the United Kingdom and are consulted by thousands of patients every year. They have lectured at many international, national and regional meetings and are invited lecturers to public and patient groups on various health topics. They have organised workshops, meetings and seminars for the national anaesthetic and pain societies. They have published many articles, research and textbooks on pain medicine. Their aim is to create an awareness of chronic pain conditions among other healthcare professionals and the public.
Good Clinical Practices in Pharmaceuticals
Good clinical practice (GCP) is a set of internationally recognized ethical and scientific quality requirements that must be followed when designing, conducting, recording, and reporting trials that involve the participation of human subjects. Compliance with GCP assures patients and the public that the rights, safety, and wellbeing of people taking part in studies are protected and that research data is reliable. Presents details on GCP, the international ethical, scientific, and practical standard to which all clinical research is conducted. Provides the most up-to-date and best practices, techniques, and methodologies in good clinical practice. Discusses applicable laws and regulations supporting GCP compliance, quality and operations. Describes who is responsible for implementing and maintaining quality assurance and quality control systems to ensure that studies are conducted and data are generated, documented, and reported in compliance with the protocol.
Handbook of Pharmaceutical Manufacturing Formulations, Third Edition
The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume Six, Sterile Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this sixth volume of a six-volume set, compiles data from FDA and EMA new drug applications, patents and patent applications, and other sources of generic and proprietary formulations including author's own experience, to cover the broad spectrum of cGMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent.Features: 聶 Largest source of authoritative and practical formulations, cGMP compliance guidance and self-audit suggestions聶 Differs from other publications on formulation science in that it focuses on readily scalable commercial formulations that can be adopted for cGMP manufacturing聶 Tackles common difficulties in formulating drugs and presents details on stability testing, bioequivalence testing, and full compliance with drug product safety elements聶 Written by a well-recognized authority on drug and dosage form development including biological drugs and alternative medicines
Handbook of Pharmaceutical Manufacturing Formulations, Third Edition
The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume Three, Liquid Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this third volume of a six-volume set, compiles data from FDA and EMA new drug applications, patents and patent applications, and other sources of generic and proprietary formulations including author's own experience, to cover the broad spectrum of cGMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent.Features: 聶 Largest source of authoritative and practical formulations, cGMP compliance guidance and self-audit suggestions聶 Differs from other publications on formulation science in that it focuses on readily scalable commercial formulations that can be adopted for cGMP manufacturing聶 Tackles common difficulties in formulating drugs and presents details on stability testing, bioequivalence testing, and full compliance with drug product safety elements聶 Written by a well-recognized authority on drug and dosage form development including biological drugs and alternative medicines
Handbook of Pharmaceutical Manufacturing Formulations, Third Edition
The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume One, Compressed Solid Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this first volume of a six-volume set, compiles data from FDA new drug applications, patent applications, and other sources of generic and proprietary formulations to cover the broad spectrum of GMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent.
Alcohol, Drugs, and Impaired Driving
Alcohol, Drugs, and Impaired Driving addresses many theoretical and practical issues related to the role played by alcohol and other psychoactive drugs on driving performance, road-traffic safety, and public health. Several key forensic issues are involved in the enforcement of laws regulating driving under the influence of alcohol and/or other drugs, including analytical toxicology, pharmacology of drug action, as well as the relationships between dose taken, concentration levels in the body, and impairment of performance and behavior. Our knowledge of drunken driving is much more comprehensive than drugged driving, so a large part of this book is devoted to alcohol impairment, as well as impairment caused by use of drugs other than alcohol.For convenience, the book is divided into four main sections. The first section gives some historical background about measuring alcohol in blood and breath as evidence for the prosecution of traffic offenders. The important role of the Breathalyzer instrument in traffic-law enforcement, especially in Australia, Canada, and the USA is presented along with a biographical sketch of its inventor (Professor Robert F. Borkenstein of Indiana University) with focus on the man, his work and his impact. The second section discusses several issues related to forensic blood and breath-alcohol alcohol analysis as evidence for prosecution of traffic offenders. This includes how the results should be interpreted in relation to impairment and an evaluation of common defense challenges. Because most countries have adopted concentration per se laws, the main thrust of the prosecution case is the suspect's measured blood- or breath-alcohol concentration. This legal framework necessitates that the analytical methods used are "fit for purpose" and are subjected to rigorous quality assurance procedures. The third section gives a broad overview of the current state of knowledge about driving under the influence of non-alcohol drugs in various countries. This includes adoption of zero-tolerance laws, concentration per se statutes, and clinical evidence of driver impairment based on field sobriety tests and drug recognition expert evidence. The fourth section deals with epidemiology, enforcement, and countermeasures aimed at reducing the threat of drunken and drugged driving.All articles have appeared previously in the international journal Forensic Science Review, but all are completely updated with current data, references, and the latest research on developments since the articles were published. This book contains a convenient collection of the best articles covering recommendations for blood and breath testing methods, public policy relating to such methods, and forensic and legal implications of the enforcement of measures to counter driving under the influence.
Handbook of Pharmaceutical Manufacturing Formulations, Third Edition
The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume Four, Semisolid Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this fourth volume of a six-volume set, compiles data from FDA and EMA new drug applications, patents and patent applications, and other sources of generic and proprietary formulations including author's own experience, to cover the broad spectrum of cGMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent.Features: 聶 Largest source of authoritative and practical formulations, cGMP compliance guidance and self-audit suggestions聶 Differs from other publications on formulation science in that it focuses on readily scalable commercial formulations that can be adopted for cGMP manufacturing聶 Tackles common difficulties in formulating drugs and presents details on stability testing, bioequivalence testing, and full compliance with drug product safety elements聶 Written by a well-recognized authority on drug and dosage form development including biological drugs and alternative medicines
Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products
Freeze-drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulations that impact lyophilization practices. This volume addresses these changes with revised chapters on emerging developments in lyophilization technology, research, and industry procedures. Providing both a scientific and industrial perspective, this comprehensive text is a valuable resource for all those who use freeze-drying technology.
Pharmaceutical Stress Testing
The second edition of Pharmaceutical Stress Testing: Predicting Drug Degradation provides a practical and scientific guide to designing, executing and interpreting stress testing studies for drug substance and drug product. This is the only guide available to tackle this subject in-depth. The Second Edition expands coverage from chemical stability into the physical aspects of stress testing, and incorporates the concept of Quality by Design into the stress testing construct / framework. It has been revised and expanded to include chapters on large molecules, such as proteins and antibodies, and it outlines the changes in stress testing that have emerged in recent years.Key features include: A renowned Editorial team and contributions from all major drug companies, reflecting a wealth of experience. 10 new chapters, including Stress Testing and its relationship to the assessment of potential genotoxic degradants, combination drug therapies, proteins, oligonucleotides, physical changes and alternative dosage forms such as liposomal formulations Updated methodologies for predicting drug stability and degradation pathways Best practice models to follow An expanded Frequently Asked Questions section This is an essential reference book for Pharmaceutical Scientists and those working in Quality Assurance and Drug Development (analytical sciences, formulations, chemical process, project management).
Decoding The Body's Messages
From the Multi-Award-Winning Transformational Coach and Wellness Therapist & Internationally Bestselling Author, Rachel Claire Farnsworth. Your body speaks the truth, and its language is pain and symptoms. Where the symptoms are tells a deeper story. This book helps you uncover the suppressed emotions behind your symptoms. It teaches you the link between trauma and your symptoms and gives you powerful and straightforward steps you can take to help yourself achieve true health. After Rachel helped her daughter overcome her autoimmune disease, her method soon evolved into her 'Decode Root Cause Method', which uses the infinite intelligence of your subconscious mind to find your unique personal root cause and understand and release it. Rachel Claire Farnsworth is an internationally best-selling author with three co-author books; this is her first solo endeavour. She is a multi-award-winning therapist and has been called a 'Spiritual Midwife' by her clients. When we understand the messages the body is conveying to us and release the old negative stories of feeling unlovable, rejected, and unworthy, we find our diamond, the soul essence of who we truly are. We are not just a body but a spiritual being having a human experience. From this perspective, we get to create the life of our dreams when we learn how. This book will guide you through exploring the subconscious mind, your core beliefs, and the three that really wound you. We explore the correlation between trauma and symptoms. We go deeper into the A-Z of ailments and diseases and discover the emotional roots behind them. In the 'Unlocking' section, we explore straightforward, powerful, and life-changing techniques that you can put into practice to improve your health and wellness.
Cosmetics and Healthy Life
Dermocosmetic products are considered as care products that contain active ingredients obtained from natural sources and are applied to the skin, and are between medicine and cosmetic products. The cosmetic industry in the world is growing rapidly with its benefits seen for health, aesthetics and beauty purposes. With the advancement of technology and medicine, the structure of the skin and human physiology is better explained and cosmetic products are updated accordingly. This book aims to evaluate the content and effects of a wide variety of dyes, creams, perfumes, lotions and serums; retinol derivatives, proteins and peptides, moisturizers, plant-based, animal-based and biological products that people use for many different purposes such as looking beautiful, looking younger, smelling nice, changing the appearance of their hair, protecting their skin from sun, wind and cold; and to discuss different solution suggestions and provide current approaches. I hope this book will be useful to those who read it.
The drug clonazepam in the context of the Family Health Strategy
The work deals with the use of the drug clonazepam in a basic pharmacy in the Family Health Strategy (ESF) by various users who sought to solve their problems by using the drug alone or in combination with others. The intention of recovering health would often go beyond the ideal purpose, since the trajectory in which the facts occurred would generally not be based solely on the vision of professionals specialising in the psychiatric area. Thus, health must occur in its entirety, always comprising the partnership and well-being between patient and health professionals, together with the rational use of medicines.
Dietary Components and Immune Function
Each stage of the body's immune response relies on the presence of nutrients. The energy and nutrient needs of the immune system can be met from exogenous diets. Dietary components can influence the development and maintenance of the immune system or play a very specific role in reducing chronic inflammation. The healthy diet regulates the fine balance of pro-inflammatory and anti-inflammatory mediators and immune cells to help the immune system fight infection. They can also protect our bodies from harmful autoimmune diseases, chronic inflammatory diseases or cancer, and fetal infection following cancer or before harmful autoimmune diseases. In contrast, malnutrition or excessive intake of micronutrients can impair immune function. For example, iron supplementation will increase morbidity and mortality in those in malaria-endemic regions. Researchers have always had many questions about nutrition and the immune system: How can different dietary components effectively treat immune deficiencies associated with inadequate intake? Can specific nutritional interventions further enhance immune function in subclinical settings to prevent inflammatory disease infection or chronic disease? The authors of papers included in this Special Issue shared some valuable knowledge, including but not limited to research on different dietary components related to the immune system. Ultimately, we hope that this reprint will be useful for clinical practitioners and inspire further innovative research.
Immunomodulating study of Securidaca longipedunculata (Polygalaceae)
Securidaca longipedunculata has a long history of use in resolving health problems associated with immunological disorders. The immunomodulatory activity associated with Securidaca longipeduncula's anti-inflammatory effect has yet to be elucidated by scientific research. Qualitative and quantitative assays of the plant's phytochemical compounds have been carried out using in vitro tests. The plant's anti-inflammatory activity was assessed using chicken egg albumin denaturation inhibition and membrane stabilization tests. CAT, DPPH and lipoperoxidation inhibition tests were carried out to assess the plant's antioxidant activity in vitro. Immunosuppression was induced in vivo by cyclophosphamide. The immunomodulatory activity of S. longipeduncula is studied by measuring leukocyte titer by Blood Count. C-Reactive Protein is measured to assess the plant's anti-inflammatory activity in vivo. Lactate dehydrogenase titration showed the effect of S. longipeduncula extract on energy balance.
Marine Anti-inflammatory and Antioxidant Agents 3.0
The marine environment offers a wealth of bioactive compounds with significant therapeutic potential, especially for treating inflammatory diseases. The increasing demand for innovative and effective health products fuels ongoing research into the biological effects of marine natural compounds. This dynamic field has led to the success of the Special Issue "Marine Anti-inflammatory and Antioxidant Agents 3.0," which includes 13 original scientific papers. These studies underscore the crucial role of marine resources in creating anti-inflammatory treatments and functional products, in line with sustainability and circular bioeconomy. The Special Issue "Marine Anti-Inflammatory and Antioxidants Agents 3.0" gathers cutting-edge in vitro and in vivo research on marine-derived bioactive compounds as modulators of inflammation and/or oxidative stress. It explores the roles and mechanisms of these compounds in healthcare, functional food production, and environmental conservation. The studies cover scientific articles on a range of marine organisms, including marine plants, green algae, brown algae, red algae, microalgae, and bacterial strains, alongside two comprehensive reviews.
3D/4D Printing of Bioadhesive Pharmaceutical Systems
This book features a brief history of additive manufacturing and 3D/4D printing techniques, as well as the advantages, applications, and overall challenges facing the technology. It then focuses on the applications of bioadhesive systems for drug delivery.3D/4D Printing of Bioadhesive Pharmaceutical Systems: Additive Manufacturing and Perspectives, explores recent discoveries of 3D printing in the development of pharmaceutical systems and drug delivery. Specifically, it discusses the main polymers/materials used in the development of bio-adhesive pharmaceutical systems and explains the importance of bio-adhesiveness of drug release through 3D printing. The authors also introduce the main strategies necessary to achieve a proper drug delivery system through 3D printing, and examine the adhesiveness of these systems on the skin as the mucosa decreases with the elimination of the drug by the body. Finally, the book brings all the necessary specifications to obtain a bioadhesive system with suitable bio-ink to obtain the best 3D/4D printing.This book is written with the objective of helping students start their studies in pharmaceutical engineering, bioengineering and additive manufacturing. Moreover, engineering professionals can use the book to improve the performance of 3D/4D printers for this type of system.
Karch's Drug Abuse Handbook
Karch's Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices.For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs.With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.
Healthcare Strategies for Patients with Chronic Diseases in an Ageing Society
The ageing of society has become a significant global issue, with over 30% of the population aged 65 and above in some developed countries. In this context, the required forms of healthcare and medical services are also evolving. Integrated care, which seamlessly connects medical institutions, nursing facilities, local communities, and the homes of patients, is becoming increasingly vital. Medical IoT, utilising advanced technologies such as wearable devices, is expected to progress further and play a critical role in the success of such care.Many older individuals suffer from multiple chronic conditions, making collaboration among healthcare professionals across various specialities essential. Efficient cooperation between various professions and institutions, along with the swift and appropriate sharing of essential information, is highly effective in many areas, including patient safety, the effective delivery of care, and, ultimately, improving patient and family experience.Older individuals are vulnerable both physically and socially, and it is vital for society as a whole to support them. This Special Issue brings together research and discussions from various perspectives on the crucial issue of healthcare in an ageing society, gathering insights to improve both the quality of medical care and the patient experience. This reprint consists of 11 chapters, including 9 research reports and 2 reviews. We hope this reprint serves as a guide for exploring sustainable healthcare solutions for the future and for considering new frameworks and foundations.
The Fundamental Concepts of Pharmacovigilance
Pharmacovigilance is the science of detecting, assessing, understanding, and preventing adverse effects or any other drug-related problems. Its ultimate goal is to enhance patient safety and ensure that the benefits of a medication outweigh its risks. This involves continuous monitoring and analysis of drug performance and safety data throughout a drug's lifecycle. This present book is a sincere attempt to provide precise content on the fundamental concepts of pharmacovigilance with an easy way of understanding.
Niosomes
This book offers a thorough exploration of noisome, an innovative drug delivery system, encompassing their ultrastructure, different preparation techniques, and characterization. It also surveying their wide-ranging applications in various sectors. Detailed sections delve into niosomes' efficacy in combating bacterial, parasitic, and fungal infections, providing valuable insights for advancing therapeutic strategies. The final chapter delves into prospective research avenues, establishing this resource as indispensable for researchers, healthcare professionals, and students engaged in drug delivery and antimicrobial treatment studies.
Conjunctivitis Analysis - Pre, During & Post-COVID-19 Periods
Conjunctivitis Analysis - Pre, During, and Post-COVID-19 Periods: A Comparative Study. This study aims to conduct a comprehensive analysis of conjunctivitis patients by examining patterns before, during, and after the COVID-19 pandemic. The objectives include evaluating the prevalence, causes, symptoms, and treatment options for conjunctivitis across different time periods. Additionally, the study seeks to identify characteristic clinical features for accurate diagnosis, implement evidence-based management strategies, and enhance patient communication and interdisciplinary care coordination. The study included patients of all ages diagnosed with conjunctivitis, encompassing both male and female participants. This retrospective case study analysed patient records from Shree Santram Eye Hospital, focusing on the years 2019 (pre-pandemic) and 2023 (post-pandemic). The study compared the incidence, demographic distribution (age and gender), and clinical features of conjunctivitis cases between these two periods. The analysis revealed a significant increase in conjunctivitis cases after the pandemic. Comparisons across age, gender, and years highlighted notable shifts in the prevalence.
The bottleneck in the reorganization of the drug sector
SUMMARYWith the worrying situation of antibacterial resistance, a study was carried out on pharmacies open to the public in the city of Bukavu, in order to identify the factors contributing to the emergence of antibacterial resistance.Our study aims to describe and analyze the management of medicines and medical consumables in pharmaceutical dispensaries open to the public in the Ibanda health zone, in order to determine the factors that would negatively influence the dispensation of care and service within the structures, and to propose recommendations.As part of the national policy to improve the efficiency and viability of health facilities, several efforts are being made, but the results remain mixed. The case of pharmaceutical dispensaries open to the public in the Ibanda health zone is marked by the poor delivery of health services in these facilities. Documentary analysis, observation and interviews with pharmaceutical service providers enabled us to determine the effectiveness and viability, and to describe the process of managing medicines and consumables.
An Experimental Handbook for Medicinal Chemistry Volume 2
This book constitutes the synthesis of various intermediates for the synthesis of drugs and drug like molecules with their physical and chemical properties and applications. Students will be able to develop skills to synthesize organic and medicinal intermediates and API. This book also includes assay of many drugs as per Indian Pharmacopoeia (IP) which are already available in market. At last, students will get expertise to explore various drug design software and their application in drug discovery.
Pharmacogenetics of Antiplatelet Agents
This book offers an in-depth exploration of pharmacogenetics as applied to antiplatelet therapies, highlighting how genetic variations influence response to these drugs. The first section introduces the fundamentals of pharmacogenetics. The second part focuses on aspirin and variations in clinical response. Subsequent sections analyze P2Y12 receptor inhibitors, exploring individual responses influenced by genetic polymorphisms. The book also covers other classes of antiplatelet agents, such as phosphodiesterase inhibitors, glycoprotein IIb IIIa inhibitors, and protease-activated receptor inhibitors.In conclusion, the book assesses the impact of adjusting antiplatelet therapies based on genetic test results, offering an informed perspective on the potential benefits of precision medicine in the management of cardiovascular disease.
Healthy Nutrition as the Key Reference in Special Diets, Quality of Life, and Sustainability
Eating is about how we relate to food in various contexts, and it is influenced by difficult choices that take into account biological, social, cultural, economic, psychological, and access-to-food-related aspects. As a result, eating decisions go beyond basic physiological and nutritional requirements. They may occasionally be conscious, but they can also be automatic, habitual, or subconscious. In these ways, eating is a complicated amalgam of ingrained habits, social norms, and acquired attitudes and feelings toward food. Despite being a long-standing international human right, not everyone has access to enough food. As a result, this reprint seeks original research studies and reviews on the following topics: special diets; dietary restrictions; dietary patterns; gluten-free diets; sugar restriction; salt restriction; vegan diets; vegetarian diets; quality of life; and sustainability.
Spinal Cord Injuries
Spinal cord injury is a catastrophic injury affecting all body functions and imposing significant life-long impairment. Advances in spinal cord injury rehabilitation are required to ensure optimal physical and psychological adjustments to its impacts, and make sure that quality of life and life expectancy improve. This Special Issue consisting of a collection of research papers fulfils a vital strategy for achieving improvements after spinal cord injury. The papers are innovative, and each paper proposes features that will result, it is hoped, in real advances in rehabilitation. The range of topics is broad, ranging from psychological to physiological approaches. For example, exploring cognitive reserve and its association to cognitive impairment, the benefits of electrical stimulation to mobility function and autonomic dysreflexia, machine learning for the early prediction of pressure ulcers and robot-assisted gait training, investigating activity-based therapy for mobility, function and quality of life, and studying hypnosis-enhanced cognitive behaviour therapy for pain in a ventilator-dependent patient. These are all outstanding contributions. The Editors hope you enjoy reading these outstanding contributions to spinal cord injury rehabilitation research.
Cardiovascular Risk Factors and Intervention Strategies for the Prevention of Cardiovascular Disease
This reprint provides insights into the cardiovascular risk landscape, emphasizing the impact of major risk factors and their interaction with the cardiovascular system. In this Special Issue, the role of other less established risk factors such as uric acid, sleep disorders, or blood pressure variability has been taken into consideration. Evidence-based strategies to prevent the detrimental consequences of these risk factors have been focused on in this Special Issue, with particular emphasis on glycemic control, lipid management, hypertension diagnosis, blood pressure regulation, and implementation of lifestyle modifications. By implementing the most modern strategies and fostering collaboration across disciplines, we can reduce the cardiovascular risk, thereby avoiding adverse outcomes.
Planning, Writing and Reviewing Medical Device Clinical and Performance Evaluation Reports (CERs/PERs)
A Practical Guide to Planning, Writing, and Reviewing Medical Device Clinical Evaluation Reports guides readers through clinical data evaluation of medical devices that is in compliance with the EU MDR requirements and other similar regulatory requirements throughout the world. This book brings together knowledge learned as the author constructed hundreds of CERs and taught thousands of learners on how to conduct clinical data evaluations. This book will support training for clinical engineers, clinical evaluation scientists, and experts reviewing medical device CERs, and will help individual writers, teams and companies to develop stronger, more robust CERs.
Vaccination a Delusion
Vaccination a Delusion: Its Penal Enforcement a Crime; Proved by the Official Evidence in the Reports of the Royal Commission, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Valere Aude
Valere Aude: Dare to Be Healthy, Or, The Light of Physical Regeneration, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
This book aims to fill research gaps in the search for chemotherapeutic and chemopreventive natural compounds. It includes a collection of detailed reviews focusing on bioactive compounds from plant sources that can be beneficial for cancer therapy. Topics covered include the role of antioxidants in cancer therapy, medicinal plants for cancer chemotherapeutics, bioactive compounds from marine plants, and a review of inhibiting nitric oxide reactions for preventing cancer. Chapters are contributed by researchers who have provided detailed lists and descriptions of the relevant plant sources, the compounds and the biochemical reactions. The book includes references for advanced reading. This book is intended as a reference for scholars and healthcare professionals studying natural medicines for cancer prevention and treatment.
Human Anatomy and Physiology-1
This subject is designed to impart fundamental knowledge on the structure and functions of the various systems of the human body. It also helps in understanding both homeostatic mechanisms. The subject provides the basic knowledge required to understand the various disciplines of pharmacy.Anatomy: The study of the body's structures, their forms, positions, and relationships. Physiology: The study of body part and system functions, including how the body's systems work together to maintain homeostasis.
Regulatory Strategies for the Approval of Combination Products
The primary objective of this book is to comprehensively evaluate the design, development, Regulatory considerations, and clinical implications of combination products in the healthcare industry. Through an in-depth analysis of existing literature, case studies, and regulatory frameworks, this research aims to identify key challenges and opportunities associated with the integration of different therapeutic modalities or medical technologies into a single product. Furthermore, this book seeks to propose practical guidelines and recommendations for optimizing the development and regulatory process of combination products, with a focus on ensuring efficacy, safety, and successful market introduction. By achieving these objectives, this research contributes valuable insights to the evolving landscape of combination products, facilitating informed decision-making among industry stakeholders and regulatory bodies.
