Practical Pharmaceutical Analysis
With the blessing of my Parents, teachers and well-wisher herewith I present the book entitled "Practical Pharmaceutical Analysis" to active academics and students, especially for B.Pharma. This book is written as per the new B.Pharma course as per PCI regulation.The main purpose of the subject is to understand about Practical aspects and how it can be applied to industry and thus to improve the quality of the products. The subject covers the complete information about methodologies for Chemical and Instrumental analysis and application. The information provided in this book has been collected from a different journal, websites, official compendia like IP, BP and USP.The contents are well merged from different resources in simplified language. It will be helpful for the student to understand the basics of in a single platform and also for their early professional carrier from an industry point of view.
Clinical Trials based on Artificial Intelligence
"Clinical Trials with Artificial Intelligence" explores the transformative impact of AI on the landscape of medical research and drug development. This comprehensive guide delves into the integration of advanced machine learning algorithms and AI technologies in the design, execution, and analysis of clinical trials. The book highlights how AI enhances precision, efficiency, and predictive power, ultimately leading to more effective treatments and improved patient outcomes.Key topics include: - AI-Powered Trial Design: Leveraging AI to optimize study protocols and patient selection.- Data Management and Analysis: Utilizing AI for real-time data monitoring, anomaly detection, and robust statistical analyses.- Ethical and Regulatory Considerations: Addressing the challenges and opportunities of incorporating AI within regulatory frameworks.- Case Studies and Applications: Real-world examples demonstrating successful AI integration in clinical trials across various therapeutic areas.
Feature Papers in Diabetology 2023
As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue "Diabetology: Feature Papers 2023" has now been published in book format. Diabetology (ISSN 2673-4540) is an international, peer-reviewed, scientific, open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In the following Special Issue, "Diabetology: Feature Papers 2023", we aim to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community.
Migraines and Beyond
Migraine and headache are highly prevalent common diseases; however, the pathogenesis of these primary headaches has not been completely revealed. Recent advances and clinical applications of CGRP blocking therapies have provided great advances for both basic and clinical research into headaches. This Special Issue has collected cutting edge original research articles, reviews and case reports of migraines and headaches. I hope this Special Issue may contribute the current understanding of migraines and headaches at large.
Research Methodology & Biostatistics
"Research Methodology & Biostatistics" involves the systematic processes and techniques used to plan, conduct, and analyze scientific research. Research methodology focuses on the principles and procedures for designing studies, collecting data, and ensuring valid and reliable results. It encompasses various research designs, such as experimental, observational, and qualitative methods, each suited to different types of inquiries. Biostatistics, on the other hand, applies statistical methods to biological and health-related fields, helping to interpret complex data and draw meaningful conclusions. It includes techniques for data analysis, such as descriptive statistics, inferential statistics, regression analysis, and hypothesis testing. Biostatistics is crucial for determining the significance of research findings, assessing relationships between variables, and making predictions based on data. Together, these disciplines are essential for producing credible and actionable research findings, guiding evidence-based practice, and informing policy decisions in healthcare and other scientific fields.
McQs for the European Exam in General Cardiology
Everything you need to know to pass the European Exam in Core Cardiology (EECC) is in this book. Based on the bestselling MCQs for Cardiology Knowledge Based Assessment this new resource has been fully updated and refreshed to reflect the ESC core curriculum for cardiology. It contains over 700 multiple choice questions with detailed explanations and links to related ESC guidelines for further reading. Providing a thorough assessment of the reader's knowledge, each chapter has been carefully mapped to the curriculum allowing for focused revision. Written by a team of cardiology registrars and experienced consultants, this resource has been cleverly designed to give you hands-on experience of the level and type of questions you can expect in the exam, as well as high-quality, concise answers possible under time constraints. Complete and comprehensive, MCQs for the European Exam in Core Cardiology is the ideal companion for cardiology trainees preparing to sit this high-stakes exam, as well as a valuable reference for practising cardiologists.
Pharmacokinetics of Moxifloxacin in Goats
Pharmacokinetics of moxifloxacin @ 5mg.kg-1.b.wt was studied in healthy and bifenthrin intoxicated goats (n=4), following its IV administration. The MIC of moxifloxacin in plasma was maintained up to 8h in healthy goats whereas it was maintained only up to 6h in bifenthrin-intoxicated goats. The AUC was significantly decreased from 7.86簣0.06g.ml-1h to 6.90簣0.076g.ml-1h in bifenthrin-intoxicated goats. The distribution half-life (t1/2) and volume of distribution at steady state Vd(ss) 竅observed were 0.08簣0.0008 h and 2.43簣0.01L.kg-1 respectively in healthy goats and 0.081簣0.0006h and 2.32簣0.03L.kg-1 in bifenthrin intoxicated goats. Total body clearance was increased from 636.06簣4.68 ml.kg-1h-1 in healthy to 725.4簣7.92 ml.kg-1h-1 in intoxicated goats. However, decrease in elimination half life (t1/2) from 2.81簣0.04h to 2.61簣0.01h was observed in intoxicated goats. The dosage regimen of moxifloxacin calculated in healthy animals is 4.99 mg.kg-1 followed by 4.73 mg.kg-1 at 12h interval effective against bacterial isolates with MIC
A Journey through Crystallization and Lyophilization
"A Journey through Crystallization and Lyophilization" is a comprehensive guide that delves into the intricate processes of crystallization and lyophilization within the pharmaceutical industry. This book provides an in-depth exploration of the principles, techniques, and applications of these critical processes, offering valuable insights for professionals and researchers in the field.The journey begins with an overview of crystallization, highlighting its significance in the isolation and purification of active pharmaceutical ingredients (APIs). Readers will gain a deep understanding of crystal formation, nucleation, and growth, along with the factors that influence these processes, such as supersaturation, temperature, and solvent selection. The book also addresses the challenges of polymorphism and provides strategies for achieving the desired crystal form and properties.Moving into the realm of lyophilization, the book explains the principles of freeze-drying and its importance in stabilizing sensitive biopharmaceutical products.
Advances in Cancer Multimodal Approach
Cancer is the leading cause of death worldwide, accounting for more than 10 million deaths each year and an even larger number of patients who are diagnosed with this disease and have to undergo various procedures. All of this has happened following the increased number of risk factors that have impacted our lives over the past few decades, such as tobacco use, obesity and different unhealthy diets, alcohol consumption, viral infections, and exposure to certain chemicals or radiation. Our goal as medical practitioners or scientists is to obtain the best outcome for our patients, from prophylactic procedures to a correct diagnosis, specific multimodal treatment, and rigorous follow-up. All of these factors have significantly improved in the last few years because of a better understanding of the genetic and molecular mechanisms of cancer development, the emergence of new technologies in cancer detection or surgical techniques, and breakthroughs in oncological therapies. However, there remains a huge field to explore, considering the current unknowns and the alert dynamics under which cancer evolves. Oncology is the medical field that requires the mobilization of most medical specialties in order to outline the particular profile of each individual patient and optimize the necessary treatment.
Ashwagandha for Quality of Life
This book offers a comprehensive overview of the scientific evidence supporting the diverse health benefits of Ashwagandha. Each chapter delves into specific aspects, exploring its effects on stress management, cognitive function, physical performance, immune system support, sleep quality, and hormonal balance. Through an evidence-based approach, the text aims to bridge the gap between traditional wisdom and modern scientific understanding, presenting Ashwagandha as a promising herb for enhancing quality of life. Ashwagandha for Quality of Life: Scientific Evidence begins by highlighting the origin and botanical characteristics of Ashwagandha and explores the wide range of its traditional and modern applications. By identifying the main active compounds and their functions, readers gain insight into the herb's potential physiological effects. Further, the book investigates Ashwagandha's potential for preventing and treating COVID-19. The book is intended for general readership, herbalists, naturopaths, alternative medicine practitioners, and life science/medical students and researchers to gain a comprehensive understanding of Ashwagandha's potential in improving health and well-being, while also emphasizing the importance of quality and chemotyping for optimal benefits.
Phytopharmacological studies of Solanum indicum berries.
Solanum indicum, also recognized as Vanbhanta or Brihati, holds a significant place in traditional medicinal practices, notably Ayurveda. This review concentrates on a thorough examination of Solanum indicum fruits, encompassing their Pharmacognostical evaluation and potential pharmacological applications. The assessment encompasses various facets such as the plant's morphological traits, microscopic attributes, chemical constituents, and physical constants, offering valuable insights into the plant's quality and purity. Solanum indicum fruits exhibit distinct Pharmacognostical characteristics facilitating their identification and quality assessment. Noteworthy features include the presence of small, spherical berries in shades of yellow to orange, typically measuring 1-2 cm in diameter.The fruit's exterior is smooth, housing numerous small seeds within the inner pulp. Microscopic scrutiny reveals abundant parenchyma cells, vascular bundles, and distinct glandular trichomes. The pharmacological potential spans diverse therapeutic areas, including anticancer, antioxidant, and antipyretic properties, showcasing their versatility as a natural remedy.
Cardiopulmonary Resuscitation
This reprint, entitled "Cardiopulmonary Resuscitation: Clinical Updates and Perspectives", encompasses significant advancements in CPR, reflecting its critical role in emergency care. This Special Issue consolidates thirteen meticulously selected papers, including eleven research articles and two reviews, highlighting the latest in CPR research and practices. The key areas explored here include high-fidelity simulation models in enhancing training effectiveness, innovative pre-hospital interventions like drone-delivered AEDs, and telemedicine advancements. The contributions in this Special Issue emphasize the importance of pre-hospital care, with studies showcasing improved survival rates through early interventions. This reprint also delves into post-resuscitation care, discussing neuroprognostication and novel therapeutic approaches. Additionally, it addresses pediatric resuscitation challenges, emphasizing age-appropriate techniques. Emerging concepts like Controlled Automated Reperfusion of the Whole Body (CARL) represent a paradigm shift, aiming to optimize organ recovery post cardiac arrest. This Special Issue underscores the dynamic evolution of CPR practices, driven by continuous clinical updates and collaborative innovation, ultimately enhancing patient outcomes across diverse age groups and clinical scenarios.
Post-COVID Symptoms in Long-Haulers
In 2020, the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) led to the worst worldwide healthcare crisis of this century. Several publications regarding the pathogenesis and etiology of SARS-CoV-2 virus have enahnced our understanding of coronavirus disease, 2019 (COVID-19), the condition provoked by SARS-CoV-2. Once the COVID-19 pandemic ended, clinicians and researchers were faced with the long-lasting consequences of this condition, namely the presence of symptoms persisting years after the main infection; this has been named long-COVID, or post-COVID-19 condition. In fact, it is estimated that millions of COVID-19 survivors will be long haulers. This Special Issue in the Journal of Clinical Medicine, entitled "Post-COVID Symptoms in Long-Haulers: Definition, Identification, Mechanisms, and Management-Part II", focuses on the identification, underlying mechanisms, and mangement of long-COVID. The thirteen papers published in this Special Issue address heterogeneous topics such as risk factors, long-term prevalence data, the healthcare burden, medical co-morbidities, clinical trials concerning rehabilitation treatments, and data concerning children with long-COVID.
Stomatognathic Diseases
This reprint focuses on the stomatognathic system, an heterogenous anatomic apparatus consisting of different organs which may be affected by pathologies linked to general health conditions. From reciprocal influences between periodontitis and diabetes to multiorgan pathologies such as lichen planus and oral mucosae/salivary gland cancer, novel therapeutic approaches and the best clinical practices have been studied by authors from around the world, with a special focus on relations with systemic conditions. As one of the events mainly impacting healthcare worldwide in recent years, the effects of COVID-19 on oral potentially malignant disorders (OPMD) will also be discussed.
RBTIOM Concepts and Principles
RBTIOM is the acronym for the Reams Biological Theory of Ionization, in combination with the application of Original Medicine.This book provides the basics of Original Medicine and RBTI topics to empower the reader with a practical understanding of how this combination can be used to achieve optimum health and vitality.Perfect Health = 1.5 + 6.4/6.4 + 6.5C + .04M + 3/3WHY YOU WANT TO READ THIS BOOK- Provides a foundational understanding of the irrefutable, time-honored 8 laws of health- Describes a powerful analytical tool for measuring compliance to the original medicine 8 laws of health- Learn how to add 15 to 30 productive years to your life- Understand the basics of a science-based, laboratory-level test that can be performed at home or in an office environment
The Survival of Colon and Rectal Cancer
Colorectal cancer is the third most common cancer in men and the second most common cancer in women. In 2020, there were more than 1.9 million new cases of colorectal cancer. With increasing life expectancy, we are seeing more elderly patients. However, the number of young patients under 50 is also increasing. Survival rates have improved by optimising surgical procedures such as total mesorectal excision (TME) and complete mesocolic excision (CME) and multidisciplinary approaches, especially for advanced carcinomas. In recent decades, standardisation of treatment has been an important tool for improving survival rates. Today, with increasing therapeutic options and the results of prognostic factor research, the possibilities to individualise therapy are increasing. Both under- and overtreatment should be avoided. Quality management is essential to improve outcomes. However, not only is the length of survival time important, but also the patient's quality of life.
Advances in Trauma and Orthopedic Surgery
This reprint is dedicated to showcasing innovations in the treatment of traumatized patients. These include modern developments in implants and osteosynthesis materials, new approaches, and the application of the latest intraoperative technology. Many of these innovations are based on the findings of translational research, for example, in the field of biomechanics. Therefore, this reprint targets multifactorial improvements in trauma and orthopedic surgery with the goal of improving daily clinical practice through scientific recommendations for the benefit of our patients. In addition to the latest clinical care approaches, translational topics will also be considered.
Pediatric Gastrointestinal Diseases
This Special Issue highlights the necessary multidisciplinary and transdisciplinary approaches in pediatric gastrointestinal disorders in order to provide the adequate management of these patients. The articles were written by experts in their fields, with high expertise in the clinical management of disorders which involve crossing borders between specialties.
Bioactive Compounds from Natural Sources
The Special Issue "Bioactive Compounds from Natural Sources: Discovery, Evaluation, and Applications" explored the discovery, evaluation, and innovative application of bioactive compounds from natural sources such as plants, marine organisms, and microorganisms. Targeted at researchers, academics, students, and professionals in the pharmaceutical and biotechnology industries, as well as policymakers and healthcare providers, this Special Issue serves as a valuable resource for those interested in the health benefits of natural products.
Molecular Detection, Characterization, Antimicrobial Resistance and Genomic Epidemiology of Pathogenic Bacteria
Recently, growing attention has been directed worldwide toward antimicrobial-resistant (AMR) bacterial pathogens. The infections caused by multidrug-resistant bacteria were declared a 'silent pandemic' due to increased patient morbidity and mortality. To combat such infections, specialists in various fields need to work together, which will ensure a better understanding of the mechanisms driving resistance dissemination.The resistance spreading in bacteria is driven by several lineages called 'global clones', the surveillance of which is an important task. Monitoring of AMR gene presence within samples of various origins is essential for tracking resistance acquisition and developing control measures within the scope of the One Health paradigm. Currently, molecular and whole-genome sequencing (WGS)-based methods are the gold standard for global clone detection and investigation of the pathogenicity factors in bacteria. This collection describes various applications of molecular biology, WGS, and genomic epidemiology methods for investigating bacterial pathogens, with a focus on population structure and AMR gene detection, and highlights the importance of genomic epidemiology methods for studying the clonal structure and AMR gene content of bacteria from various sources. The data provided will be useful for researchers in various fields involving bacterial pathogen surveillance, detection, and treatment, especially in the emerging field of genomic epidemiology.
New Challenges in Ocular Drug Delivery
The clinical treatment of diseases affecting the eye globe is often hindered by the physiological protection structures and mechanisms of the organ, as well as by the unsuitable physico-chemical features of the active molecules, specifically with regard to the retina and posterior eye segment. Intravitreal injections of drugs and monoclonal antibodies are at present the most common therapeutic procedure to reach the retinal area. However, such vaccinations are associated with a high risk of side effects, apart from those requiring the intervention of a physician. One of the 'dream goals' in this field remains the ability to reach the retinal area using a simple topically applied eye-drop formulation. Research in recent years has progressively made available new strategies and technologies to overcome the problems that hinder an efficacious ocular drug bioavailability, leading to even more safe, easy-to-use and highly compliant therapeutic means. This Topic is aimed at collecting the most recent experiences from worldwide laboratories to update of existing state-of-the-art methods and introduce new perspectives toward innovative and effective ocular therapies. We are extremely delighted to present the latest research and review works which demonstrate the new challenges to achieving an effective ocular drug delivery in order to increase bioavailability and therapeutic efficacy, reducing at the same time the risk of side effects.
Reiki As a Complementary Therapy For Patient Care
This Reiki training manual is to be used in conjunction with IMREIKINOW's Continuing Education Provider course approved by the California Board of Registered Nursing, "Reiki as a Complementary Therapy for Patient Care." The information within this manual educates clinicians on how to assess the need for Reiki based on the patient's symptoms, understand how to incorporate Reiki into the patient care plan, perform Reiki therapy for patients, and evaluate the outcome of Reiki as a complementary therapy for patient care.Clinicians will develop the knowledge, skill, and confidence to integrate Reiki healing into their clinical practice while learning to mitigate personal biases and promote a culture of accountability through lectures, by practicing Reiki sessions using the hands-on and hands-off method, and discussing reflective exercises. Clinicians will also gain insights into the potential benefits of Reiki for patients and peers alike, fostering a more holistic and compassionate approach to healthcare delivery.At the conclusion of the manual and training course, clinicians will officially become Level Two KA Reiki Practitioners and be prepared to incorporate Reiki as a complementary therapy within not only a clinical setting, but within their personal lives. This contributes to improved patient outcomes, enhanced patient satisfaction, and greater personal fulfillment in their clinical and personal roles.
Clostridioides difficile Infection, 2nd Edition
This reprint collects multidisciplinary research articles focused on Clostridioides difficile infection. The contributions collected here shed some light on grey areas of our knowledge of Clostridioides difficile, including the identification of Clostridioides difficile carriers at high risk of developing infection or infection recurrence, the intra-hospital and community spread of Clostridioides difficile, the rate of Clostridioides difficile infection during the SARS-CoV-2 pandemic, the current treatment approach, and the use of bezlotoxumab to prevent infection recurrence.
Cardiovascular and Metabolic Disease
Cardiovascular diseases (CVDs) continue to be the leading cause of mortality worldwide, with an estimated 17.9 million deaths in 2019, representing 32% of all global deaths. Heart attacks and strokes accounted for approximately 85% of these fatalities The prevalence of CVDs is worsened by metabolic diseases, particularly diabetes, which affects about 422 million people globally, primarily in low- and middle-income countries, and causes 1.5 million deaths annually. Early detection and intervention of CVDs and metabolic diseases are crucial, as many cases can be prevented by addressing modifiable behavioral risk factors such as tobacco use, unhealthy diet, obesity, physical inactivity, and harmful alcohol consumption. Significant advancements in treatment, from pharmacological developments to both invasive and non-invasive techniques, are continuously being made. Given the complexity and clinical significance of this topic, Biomedicines is proud to present a Special Issue titled "Cardiovascular and Metabolic Disease: New Treatments and Future Directions 2.0". This issue aims to compile contemporary scientific information on emerging treatments for CVDs and metabolic diseases. They provide valuable insights to the field and enhance our understanding of these interconnected health challenges.
Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases
Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases delves into the intricate mechanisms underlying neurodegenerative disorders and highlights cutting-edge diagnostic methods and innovative immunotherapeutic strategies. This comprehensive book addresses several key themes crucial to understanding and combating these debilitating conditions with an updated understanding of neurodegenerative disorders and a review of the latest advancements in diagnostic and treatment strategies. Key Themes Neuroinflammation: examines the complex molecular pathways involved in neuroinflammatory responses and their impact on disease dynamics.Gut-Brain Axis: A thorough discussion on the relationship between the gut microbiome and neurodegenerative processes is presented.Advanced Diagnostics: A state-of-the-art review of diagnostic techniques provides updates on advanced neuroimaging modalities, cerebrospinal fluid biomarker analysis, and genetic testing.Epigenetic Regulation of Microglia: Covers the emerging field of epigenetic modifications and their role in modulating microglial activation and function.Immunotherapeutics: Learn about the potential of monoclonal antibodies, immune modulators, and repurposed drug therapies in slowing disease progression and improving patient outcomes. This book serves as a valuable resource for researchers, clinicians, and students in the fields of molecular biology, neuroimmunology, and clinical neurology.
A Statement of Facts Tending to Establish an Estimate of the True Value and Present State of Vaccination
A Statement of Facts Tending to Establish an Estimate of the True Value and Present State of Vaccination, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Stammering, Its Cause and Cure
Stammering, Its Cause and Cure, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Statistical Inquiry Into the Nature and Treatment of Epilepsy
A Statistical Inquiry Into the Nature and Treatment of Epilepsy, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Treatment of Cholera in the Royal Hospital, Haslar During the months of July and August, 1849, with remarks on the name and origin of the disease.
Treatment of Cholera in the Royal Hospital, Haslar During the months of July and August, 1849, with remarks on the name and origin of the disease., a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on the Plague and Yellow Fever With an Appendix, containing histories of the plague at Athens in the time of the Peloponnesian War; at Constantinople in the time of Justinian; at London in
A Treatise on the Plague and Yellow Fever With an Appendix, containing histories of the plague at Athens in the time of the Peloponnesian War; at Constantinople in the time of Justinian; at London in 1665; at Marseilles in 1720, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on Acupuncturation
A Treatise on Acupuncturation, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on the Diseases Produced By Onanism, Masturbation, Self-Pollution, and Other Excesses
A Treatise on the Diseases Produced By Onanism, Masturbation, Self-Pollution, and Other Excesses, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on Regional Iodine Therapy for the Veterinary Clinician
A Treatise on Regional Iodine Therapy for the Veterinary Clinician, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Fire Your Doctor; How to be Independently Healthy
If you want something done right, you have to do it yourself. This especially includes your health care. Natural healing is not about avoiding doctors, it is about not needing to go to doctors. The idea is to be well. Each of us is ultimately responsible for our own wellness, and we should consider all options in our search for better health. That is the focus of this book, how we can get better using practical, effective, and safe natural therapies.
Treatment of hemorrhoids, and other non-malignant rectal diseases
Treatment of hemorrhoids, and other non-malignant rectal diseases, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on Fever
A Treatise on Fever, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Study of the use of anesthetics
The effort to suppress pain caused by surgical procedures through the use of drugs dates back to antiquity, including the oral administration of ethanol and opiates. The study was carried out in a public hospital in Campina Grande-PB, using a qualitative-quantitative approach. Sixty-five patients were analyzed, aged between 41 and 60 years, hysterectomy was the most common procedure and the majority of patients were not hypertensive. Among the anesthetics studied, heavy bupivacaine had the highest incidence in the study, followed by morphine and midazolam. It was also observed that vomiting and dizziness were the most common ADRs. Cephalothin and dipyrone were the most commonly used concomitant drugs. In the post-surgical period, the most commonly used drugs were metoclopramide, followed by dipyrone and cephalothin. The results of this study serve as a basis for future studies on the choice of appropriate anaesthetic techniques for surgical procedures, with the aim of minimizing the occurrence of adverse effects that could prolong hospitalization.
Potentially Inappropriate Medicines for the Elderly
The aging process is marked by a greater number of chronic-degenerative diseases, which predisposes the geriatric population to be treated with a greater number of drugs, thus increasing the risks related to therapy, such as adverse reactions and drug interactions. This work is an important piece of research for the completion of the Pharmacy course. The data obtained in this study was relevant in the context of public health, as it revealed important variables relating to knowledge of the pharmacoepidemiology of potentially inappropriate medicines for the elderly. Highlighting the risks of using PIMs in the elderly, as was done in this study, demonstrates that pharmaceutical interventions should be carried out in the context of multidisciplinary care to ensure access to safe medicines that are appropriate to the specificities of the elderly's pharmacotherapy.
Analysis of mRNA Vaccines
Messenger RNA became the focus of research in molecular medicine, as it is a non-toxic molecule that allows transient caprotein expression in virtually all cell types, including dendritic cells. The principles behind nucleic acid vaccines are rooted in Watson and Crick's central dogma - that DNA is transcribed into mRNA, which in turn is translated into protein. The mRNA is synthetically produced and formulated into vaccines. In mRNA vaccine synthesis mRNA transcripts are purified by high performance liquid chromatography (HPLC) to remove contaminants and reactants. mRNAs are translated into corresponding antigens after being inoculated into host cells, imitating virus-infection-like humoral immunity and cellular immunity. By the help of mRNA Vaccine Increasing the antigen reactiveness can be done. the optimized mRNA vaccines should meet the requirement that the innate immunity is fully activated to initiate the adaptive immunity. The first vaccine candidate launched into clinical trials is an mRNA vaccine delivered via lipid nanoparticles. This advantage determines the rapid immune responses after mRNA administration. MRNA vaccine widely for infectious diseases.
Parenteral controlled drug delivery by novel direct injectable polymer
The development of drug delivery systems took place just a few decades ago, and its evolution has brought about considerable therapeutic and economic impact. The progress from preformed implants to in situ forming implants has opened new avenues of possibilities to the patients and the healthcare providers. Procedures there were once not convenient and exposed patients with possible complications can be done nowadays by the patients through a syringe in the safety of their home. The products on the market have aided the patients to combat difficult health conditions so far and will still play an important role in the future. Nevertheless, the continuation of science and technology allow us to look for further improved products. In this regard, an implant that can cause minimal damage to the patients and put them at least risk is not available yet. However, with the progress being made, this will not take a long time until it becomes a reality. The work with nanoparticles made of PGA has been covered before in our research group and others. Further study in our group has dealt with new possibilities to work with poly(glycerol adipate) as a drug conjugate.
A Practical Handbook of Pharmacognosy & Phytopharmaceuticals
This pharmacognosy practical manual covers macroscopical, microscopical study of some important drugs, which will be useful for D Pharmacy, Pharm D & B Pharm students. This practical manual is designed for Pharmacy students since it covers the practical according to pharmacy syllabus. It covers the morphological/macroscopical study of crude drugs, transverse section and powder analysis of crude drugs, analysis of lipids such as acid value, saponification value and iodine value and chemical test for carbohydrates such as acacia, agar, tragacanth, gelatin and starch. This book aims to provide you information regarding Pharmacognosy, herbs and medicinal plants, structured from basic issues such as the macro morphological characteristics of the vegetative organs or photosynthesis, to the deeper and more complex Pharmacognosy issues as the analysis of active ingredients and other substances or compounds such as essential oils, their uses and medicinal properties. At the same time it offers an increasing amount of information about medicinal plants, listed by common name, scientific name, and active ingredients and components, as well as pharmacological and therapeutic indication.
Epidermal Growth Factor and Health Benefits of Collagen
Collagen is the most abundant protein in mammalian systems, and it can be discovered in organs such as kidney, bones, heart, the liver, skin, and teeth. Collagen is defined as a coiled-coil trimer molecule, each of which is included the repeated sequence of amino acids Gly-X-Y, where X and Y are usually found to proline and hydroxyproline amino acids. The utilization of collagen from different sources also related to its thermal stability that may have direct connection with the body temperature and living environment of several species, and the thermal stability of collagen protein is directly connected to the amino acid composition. Fibrillar collagens are collagens I, II, III, V, XI, XIV, and XXVII. Non-fibrillar collagens are collagens IV which is the basement membrane collagen, collagen VII which is anchoring collagen, collagens VI, XXVIII, XXIX which are microfiber building collagens, and collagens VIII and X which are active in forming network systems collagen.
Role of NO in Disease
This Special Issue of Biomedicines, "Role of NO in Disease: Good, Bad or Ugly", focuses on the roles of nitric oxide (NO) in disease from various aspects. NO plays an important role in several physiological processes with numerous biological targets, such as cardiovascular homeostasis, angiogenesis, neural signaling, inflammatory processes, and immune regulation. Hence, it is obvious that essentially all cells and biological activities are modulated by NO. This reactive and toxic two-atom gaseous molecule has an unpaired electron and is therefore considered a free radical. It is one of the most important signaling molecules. NO was most likely generated by volcanic emissions in the early atmosphere, from CO2 and N2, approximately 4.5 billion years ago, long before the appearance of the living organisms that now contribute significantly to the cycling of nitrogen species. Endogenous NO is catalyzed from L-arginine by mammalian nitric oxide synthases (NOS). However, NOS-like enzymes have also been found in procaryotes, bacteria, and eukaryotes, suggesting a basic role of NO in the evolutionary process. Thus, it is not surprising that NO signaling is spread throughout the entire phylogenetic scale.
Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms
This book details the novel nanocarriers named 'invasomes" and how they are used for dermal and transdermal drug delivery. The text describes their composition, usage of skin as a drug delivery route and liposomes as skin delivery systems. Included are reviewed studies revealing the importance of invasomes in this field.
Drug Discovery and QSAR Techniques
The book was written about Drug discovery and Quantitative Structural Activity. Quantitative structure-activity relationships (QSAR) have been applied for decades in developing relationships between physicochemical properties of chemical substances and their biological activities to obtain a robust statistical model for predicting the activities of new chemical entities or molecules.QSAR attempts to correlate structural, chemical, statistical, and physical properties with biological potency using various mathematical methods.Drug discovery is the process of identifying and characterizing molecules with the potential to safely modulate disease, aiming to bring medicines that can improve patients' lives. Target Identification And Validation.Hit Discovery Process.Assay Development And Screening.High Throughput Screening.Hit to Lead.Lead Optimization.Active Pharmaceutical IngredientThe discovery of a new drug molecule is required for treating a disease or illness for which no other treatment exists or it provides additional advantages over the prevailing treatments such as lesser adverse effects, higher therapeutic efficacy, improved amenability, and fewer drug-drug interactions, etc.
Fabrication of Thiazole-Guanidine metal chelates
Inorganic chemistry has played a crucial role in the development of new drugs and therapies. Transition metal complexes have unique properties that make them attractive candidates for biological applications. For example, researchers have been exploring the use of metal-based drugs for the treatment of cancer, Alzheimer's disease, and other conditions. These drugs can be designed to target specific proteins or enzymes involved in disease processes, and their properties can be fine-tuned by modifying the structure of the metal complex. One of the advantages of metal-based drugs is their ability to interact with biological molecules in multiple ways, such as coordination bonding, electrostatic interactions, and redox reactions. This versatility allows for the design of drugs that can target a wide range of biological processes. Additionally, metal-based drugs can inhibit enzymes involved in DNA replication or repair, or they can interfere with cellular signaling pathways that are dysregulated in cancer cells. Another area of research in medicinal inorganic chemistry is the development of diagnostic agents, such as contrast agents for imaging studies.
Medicinal Plants and Natural Compounds in Health and Disease
This Special Issue offers a collection of original contributions and scientific reviews on the following topics: cellular and molecular aspects of phytochemicals and other natural compounds and their therapeutic effects (with an emphasis on the innovative plant-based therapeutic approaches based on ancient medical heritage), the pharmacokinetics of herbal medicines, and the use of technology for expanding traditional medical knowledge.
Organelle and Molecular Targeting
We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.
