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Stomatognathic Diseases
This reprint focuses on the stomatognathic system, an heterogenous anatomic apparatus consisting of different organs which may be affected by pathologies linked to general health conditions. From reciprocal influences between periodontitis and diabetes to multiorgan pathologies such as lichen planus and oral mucosae/salivary gland cancer, novel therapeutic approaches and the best clinical practices have been studied by authors from around the world, with a special focus on relations with systemic conditions. As one of the events mainly impacting healthcare worldwide in recent years, the effects of COVID-19 on oral potentially malignant disorders (OPMD) will also be discussed.
Cardiopulmonary Resuscitation
This reprint, entitled "Cardiopulmonary Resuscitation: Clinical Updates and Perspectives", encompasses significant advancements in CPR, reflecting its critical role in emergency care. This Special Issue consolidates thirteen meticulously selected papers, including eleven research articles and two reviews, highlighting the latest in CPR research and practices. The key areas explored here include high-fidelity simulation models in enhancing training effectiveness, innovative pre-hospital interventions like drone-delivered AEDs, and telemedicine advancements. The contributions in this Special Issue emphasize the importance of pre-hospital care, with studies showcasing improved survival rates through early interventions. This reprint also delves into post-resuscitation care, discussing neuroprognostication and novel therapeutic approaches. Additionally, it addresses pediatric resuscitation challenges, emphasizing age-appropriate techniques. Emerging concepts like Controlled Automated Reperfusion of the Whole Body (CARL) represent a paradigm shift, aiming to optimize organ recovery post cardiac arrest. This Special Issue underscores the dynamic evolution of CPR practices, driven by continuous clinical updates and collaborative innovation, ultimately enhancing patient outcomes across diverse age groups and clinical scenarios.
RBTIOM Concepts and Principles
RBTIOM is the acronym for the Reams Biological Theory of Ionization, in combination with the application of Original Medicine.This book provides the basics of Original Medicine and RBTI topics to empower the reader with a practical understanding of how this combination can be used to achieve optimum health and vitality.Perfect Health = 1.5 + 6.4/6.4 + 6.5C + .04M + 3/3WHY YOU WANT TO READ THIS BOOK- Provides a foundational understanding of the irrefutable, time-honored 8 laws of health- Describes a powerful analytical tool for measuring compliance to the original medicine 8 laws of health- Learn how to add 15 to 30 productive years to your life- Understand the basics of a science-based, laboratory-level test that can be performed at home or in an office environment
The Survival of Colon and Rectal Cancer
Colorectal cancer is the third most common cancer in men and the second most common cancer in women. In 2020, there were more than 1.9 million new cases of colorectal cancer. With increasing life expectancy, we are seeing more elderly patients. However, the number of young patients under 50 is also increasing. Survival rates have improved by optimising surgical procedures such as total mesorectal excision (TME) and complete mesocolic excision (CME) and multidisciplinary approaches, especially for advanced carcinomas. In recent decades, standardisation of treatment has been an important tool for improving survival rates. Today, with increasing therapeutic options and the results of prognostic factor research, the possibilities to individualise therapy are increasing. Both under- and overtreatment should be avoided. Quality management is essential to improve outcomes. However, not only is the length of survival time important, but also the patient's quality of life.
Pediatric Gastrointestinal Diseases
This Special Issue highlights the necessary multidisciplinary and transdisciplinary approaches in pediatric gastrointestinal disorders in order to provide the adequate management of these patients. The articles were written by experts in their fields, with high expertise in the clinical management of disorders which involve crossing borders between specialties.
Advances in Trauma and Orthopedic Surgery
This reprint is dedicated to showcasing innovations in the treatment of traumatized patients. These include modern developments in implants and osteosynthesis materials, new approaches, and the application of the latest intraoperative technology. Many of these innovations are based on the findings of translational research, for example, in the field of biomechanics. Therefore, this reprint targets multifactorial improvements in trauma and orthopedic surgery with the goal of improving daily clinical practice through scientific recommendations for the benefit of our patients. In addition to the latest clinical care approaches, translational topics will also be considered.
Molecular Detection, Characterization, Antimicrobial Resistance and Genomic Epidemiology of Pathogenic Bacteria
Recently, growing attention has been directed worldwide toward antimicrobial-resistant (AMR) bacterial pathogens. The infections caused by multidrug-resistant bacteria were declared a 'silent pandemic' due to increased patient morbidity and mortality. To combat such infections, specialists in various fields need to work together, which will ensure a better understanding of the mechanisms driving resistance dissemination.The resistance spreading in bacteria is driven by several lineages called 'global clones', the surveillance of which is an important task. Monitoring of AMR gene presence within samples of various origins is essential for tracking resistance acquisition and developing control measures within the scope of the One Health paradigm. Currently, molecular and whole-genome sequencing (WGS)-based methods are the gold standard for global clone detection and investigation of the pathogenicity factors in bacteria. This collection describes various applications of molecular biology, WGS, and genomic epidemiology methods for investigating bacterial pathogens, with a focus on population structure and AMR gene detection, and highlights the importance of genomic epidemiology methods for studying the clonal structure and AMR gene content of bacteria from various sources. The data provided will be useful for researchers in various fields involving bacterial pathogen surveillance, detection, and treatment, especially in the emerging field of genomic epidemiology.
Bioactive Compounds from Natural Sources
The Special Issue "Bioactive Compounds from Natural Sources: Discovery, Evaluation, and Applications" explored the discovery, evaluation, and innovative application of bioactive compounds from natural sources such as plants, marine organisms, and microorganisms. Targeted at researchers, academics, students, and professionals in the pharmaceutical and biotechnology industries, as well as policymakers and healthcare providers, this Special Issue serves as a valuable resource for those interested in the health benefits of natural products.
Clostridioides difficile Infection, 2nd Edition
This reprint collects multidisciplinary research articles focused on Clostridioides difficile infection. The contributions collected here shed some light on grey areas of our knowledge of Clostridioides difficile, including the identification of Clostridioides difficile carriers at high risk of developing infection or infection recurrence, the intra-hospital and community spread of Clostridioides difficile, the rate of Clostridioides difficile infection during the SARS-CoV-2 pandemic, the current treatment approach, and the use of bezlotoxumab to prevent infection recurrence.
New Challenges in Ocular Drug Delivery
The clinical treatment of diseases affecting the eye globe is often hindered by the physiological protection structures and mechanisms of the organ, as well as by the unsuitable physico-chemical features of the active molecules, specifically with regard to the retina and posterior eye segment. Intravitreal injections of drugs and monoclonal antibodies are at present the most common therapeutic procedure to reach the retinal area. However, such vaccinations are associated with a high risk of side effects, apart from those requiring the intervention of a physician. One of the 'dream goals' in this field remains the ability to reach the retinal area using a simple topically applied eye-drop formulation. Research in recent years has progressively made available new strategies and technologies to overcome the problems that hinder an efficacious ocular drug bioavailability, leading to even more safe, easy-to-use and highly compliant therapeutic means. This Topic is aimed at collecting the most recent experiences from worldwide laboratories to update of existing state-of-the-art methods and introduce new perspectives toward innovative and effective ocular therapies. We are extremely delighted to present the latest research and review works which demonstrate the new challenges to achieving an effective ocular drug delivery in order to increase bioavailability and therapeutic efficacy, reducing at the same time the risk of side effects.
Reiki As a Complementary Therapy For Patient Care
This Reiki training manual is to be used in conjunction with IMREIKINOW's Continuing Education Provider course approved by the California Board of Registered Nursing, "Reiki as a Complementary Therapy for Patient Care." The information within this manual educates clinicians on how to assess the need for Reiki based on the patient's symptoms, understand how to incorporate Reiki into the patient care plan, perform Reiki therapy for patients, and evaluate the outcome of Reiki as a complementary therapy for patient care.Clinicians will develop the knowledge, skill, and confidence to integrate Reiki healing into their clinical practice while learning to mitigate personal biases and promote a culture of accountability through lectures, by practicing Reiki sessions using the hands-on and hands-off method, and discussing reflective exercises. Clinicians will also gain insights into the potential benefits of Reiki for patients and peers alike, fostering a more holistic and compassionate approach to healthcare delivery.At the conclusion of the manual and training course, clinicians will officially become Level Two KA Reiki Practitioners and be prepared to incorporate Reiki as a complementary therapy within not only a clinical setting, but within their personal lives. This contributes to improved patient outcomes, enhanced patient satisfaction, and greater personal fulfillment in their clinical and personal roles.
Cardiovascular and Metabolic Disease
Cardiovascular diseases (CVDs) continue to be the leading cause of mortality worldwide, with an estimated 17.9 million deaths in 2019, representing 32% of all global deaths. Heart attacks and strokes accounted for approximately 85% of these fatalities The prevalence of CVDs is worsened by metabolic diseases, particularly diabetes, which affects about 422 million people globally, primarily in low- and middle-income countries, and causes 1.5 million deaths annually. Early detection and intervention of CVDs and metabolic diseases are crucial, as many cases can be prevented by addressing modifiable behavioral risk factors such as tobacco use, unhealthy diet, obesity, physical inactivity, and harmful alcohol consumption. Significant advancements in treatment, from pharmacological developments to both invasive and non-invasive techniques, are continuously being made. Given the complexity and clinical significance of this topic, Biomedicines is proud to present a Special Issue titled "Cardiovascular and Metabolic Disease: New Treatments and Future Directions 2.0". This issue aims to compile contemporary scientific information on emerging treatments for CVDs and metabolic diseases. They provide valuable insights to the field and enhance our understanding of these interconnected health challenges.
Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases
Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases delves into the intricate mechanisms underlying neurodegenerative disorders and highlights cutting-edge diagnostic methods and innovative immunotherapeutic strategies. This comprehensive book addresses several key themes crucial to understanding and combating these debilitating conditions with an updated understanding of neurodegenerative disorders and a review of the latest advancements in diagnostic and treatment strategies. Key Themes Neuroinflammation: examines the complex molecular pathways involved in neuroinflammatory responses and their impact on disease dynamics.Gut-Brain Axis: A thorough discussion on the relationship between the gut microbiome and neurodegenerative processes is presented.Advanced Diagnostics: A state-of-the-art review of diagnostic techniques provides updates on advanced neuroimaging modalities, cerebrospinal fluid biomarker analysis, and genetic testing.Epigenetic Regulation of Microglia: Covers the emerging field of epigenetic modifications and their role in modulating microglial activation and function.Immunotherapeutics: Learn about the potential of monoclonal antibodies, immune modulators, and repurposed drug therapies in slowing disease progression and improving patient outcomes. This book serves as a valuable resource for researchers, clinicians, and students in the fields of molecular biology, neuroimmunology, and clinical neurology.
A Treatise on Fever
A Treatise on Fever, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on the Plague and Yellow Fever With an Appendix, containing histories of the plague at Athens in the time of the Peloponnesian War; at Constantinople in the time of Justinian; at London in
A Treatise on the Plague and Yellow Fever With an Appendix, containing histories of the plague at Athens in the time of the Peloponnesian War; at Constantinople in the time of Justinian; at London in 1665; at Marseilles in 1720, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Fire Your Doctor; How to be Independently Healthy
If you want something done right, you have to do it yourself. This especially includes your health care. Natural healing is not about avoiding doctors, it is about not needing to go to doctors. The idea is to be well. Each of us is ultimately responsible for our own wellness, and we should consider all options in our search for better health. That is the focus of this book, how we can get better using practical, effective, and safe natural therapies.
Treatment of hemorrhoids, and other non-malignant rectal diseases
Treatment of hemorrhoids, and other non-malignant rectal diseases, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on Acupuncturation
A Treatise on Acupuncturation, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Stammering, Its Cause and Cure
Stammering, Its Cause and Cure, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Statistical Inquiry Into the Nature and Treatment of Epilepsy
A Statistical Inquiry Into the Nature and Treatment of Epilepsy, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on Regional Iodine Therapy for the Veterinary Clinician
A Treatise on Regional Iodine Therapy for the Veterinary Clinician, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Treatise on the Diseases Produced By Onanism, Masturbation, Self-Pollution, and Other Excesses
A Treatise on the Diseases Produced By Onanism, Masturbation, Self-Pollution, and Other Excesses, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
A Statement of Facts Tending to Establish an Estimate of the True Value and Present State of Vaccination
A Statement of Facts Tending to Establish an Estimate of the True Value and Present State of Vaccination, a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Treatment of Cholera in the Royal Hospital, Haslar During the months of July and August, 1849, with remarks on the name and origin of the disease.
Treatment of Cholera in the Royal Hospital, Haslar During the months of July and August, 1849, with remarks on the name and origin of the disease., a classical book, has been considered important throughout the human history, and so that this work is never forgotten we at Alpha Editions have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies of their original work and hence the text is clear and readable.
Potentially Inappropriate Medicines for the Elderly
The aging process is marked by a greater number of chronic-degenerative diseases, which predisposes the geriatric population to be treated with a greater number of drugs, thus increasing the risks related to therapy, such as adverse reactions and drug interactions. This work is an important piece of research for the completion of the Pharmacy course. The data obtained in this study was relevant in the context of public health, as it revealed important variables relating to knowledge of the pharmacoepidemiology of potentially inappropriate medicines for the elderly. Highlighting the risks of using PIMs in the elderly, as was done in this study, demonstrates that pharmaceutical interventions should be carried out in the context of multidisciplinary care to ensure access to safe medicines that are appropriate to the specificities of the elderly's pharmacotherapy.
Study of the use of anesthetics
The effort to suppress pain caused by surgical procedures through the use of drugs dates back to antiquity, including the oral administration of ethanol and opiates. The study was carried out in a public hospital in Campina Grande-PB, using a qualitative-quantitative approach. Sixty-five patients were analyzed, aged between 41 and 60 years, hysterectomy was the most common procedure and the majority of patients were not hypertensive. Among the anesthetics studied, heavy bupivacaine had the highest incidence in the study, followed by morphine and midazolam. It was also observed that vomiting and dizziness were the most common ADRs. Cephalothin and dipyrone were the most commonly used concomitant drugs. In the post-surgical period, the most commonly used drugs were metoclopramide, followed by dipyrone and cephalothin. The results of this study serve as a basis for future studies on the choice of appropriate anaesthetic techniques for surgical procedures, with the aim of minimizing the occurrence of adverse effects that could prolong hospitalization.
Analysis of mRNA Vaccines
Messenger RNA became the focus of research in molecular medicine, as it is a non-toxic molecule that allows transient caprotein expression in virtually all cell types, including dendritic cells. The principles behind nucleic acid vaccines are rooted in Watson and Crick's central dogma - that DNA is transcribed into mRNA, which in turn is translated into protein. The mRNA is synthetically produced and formulated into vaccines. In mRNA vaccine synthesis mRNA transcripts are purified by high performance liquid chromatography (HPLC) to remove contaminants and reactants. mRNAs are translated into corresponding antigens after being inoculated into host cells, imitating virus-infection-like humoral immunity and cellular immunity. By the help of mRNA Vaccine Increasing the antigen reactiveness can be done. the optimized mRNA vaccines should meet the requirement that the innate immunity is fully activated to initiate the adaptive immunity. The first vaccine candidate launched into clinical trials is an mRNA vaccine delivered via lipid nanoparticles. This advantage determines the rapid immune responses after mRNA administration. MRNA vaccine widely for infectious diseases.
A Practical Handbook of Pharmacognosy & Phytopharmaceuticals
This pharmacognosy practical manual covers macroscopical, microscopical study of some important drugs, which will be useful for D Pharmacy, Pharm D & B Pharm students. This practical manual is designed for Pharmacy students since it covers the practical according to pharmacy syllabus. It covers the morphological/macroscopical study of crude drugs, transverse section and powder analysis of crude drugs, analysis of lipids such as acid value, saponification value and iodine value and chemical test for carbohydrates such as acacia, agar, tragacanth, gelatin and starch. This book aims to provide you information regarding Pharmacognosy, herbs and medicinal plants, structured from basic issues such as the macro morphological characteristics of the vegetative organs or photosynthesis, to the deeper and more complex Pharmacognosy issues as the analysis of active ingredients and other substances or compounds such as essential oils, their uses and medicinal properties. At the same time it offers an increasing amount of information about medicinal plants, listed by common name, scientific name, and active ingredients and components, as well as pharmacological and therapeutic indication.
Parenteral controlled drug delivery by novel direct injectable polymer
The development of drug delivery systems took place just a few decades ago, and its evolution has brought about considerable therapeutic and economic impact. The progress from preformed implants to in situ forming implants has opened new avenues of possibilities to the patients and the healthcare providers. Procedures there were once not convenient and exposed patients with possible complications can be done nowadays by the patients through a syringe in the safety of their home. The products on the market have aided the patients to combat difficult health conditions so far and will still play an important role in the future. Nevertheless, the continuation of science and technology allow us to look for further improved products. In this regard, an implant that can cause minimal damage to the patients and put them at least risk is not available yet. However, with the progress being made, this will not take a long time until it becomes a reality. The work with nanoparticles made of PGA has been covered before in our research group and others. Further study in our group has dealt with new possibilities to work with poly(glycerol adipate) as a drug conjugate.
Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms
This book details the novel nanocarriers named 'invasomes" and how they are used for dermal and transdermal drug delivery. The text describes their composition, usage of skin as a drug delivery route and liposomes as skin delivery systems. Included are reviewed studies revealing the importance of invasomes in this field.
Role of NO in Disease
This Special Issue of Biomedicines, "Role of NO in Disease: Good, Bad or Ugly", focuses on the roles of nitric oxide (NO) in disease from various aspects. NO plays an important role in several physiological processes with numerous biological targets, such as cardiovascular homeostasis, angiogenesis, neural signaling, inflammatory processes, and immune regulation. Hence, it is obvious that essentially all cells and biological activities are modulated by NO. This reactive and toxic two-atom gaseous molecule has an unpaired electron and is therefore considered a free radical. It is one of the most important signaling molecules. NO was most likely generated by volcanic emissions in the early atmosphere, from CO2 and N2, approximately 4.5 billion years ago, long before the appearance of the living organisms that now contribute significantly to the cycling of nitrogen species. Endogenous NO is catalyzed from L-arginine by mammalian nitric oxide synthases (NOS). However, NOS-like enzymes have also been found in procaryotes, bacteria, and eukaryotes, suggesting a basic role of NO in the evolutionary process. Thus, it is not surprising that NO signaling is spread throughout the entire phylogenetic scale.
Epidermal Growth Factor and Health Benefits of Collagen
Collagen is the most abundant protein in mammalian systems, and it can be discovered in organs such as kidney, bones, heart, the liver, skin, and teeth. Collagen is defined as a coiled-coil trimer molecule, each of which is included the repeated sequence of amino acids Gly-X-Y, where X and Y are usually found to proline and hydroxyproline amino acids. The utilization of collagen from different sources also related to its thermal stability that may have direct connection with the body temperature and living environment of several species, and the thermal stability of collagen protein is directly connected to the amino acid composition. Fibrillar collagens are collagens I, II, III, V, XI, XIV, and XXVII. Non-fibrillar collagens are collagens IV which is the basement membrane collagen, collagen VII which is anchoring collagen, collagens VI, XXVIII, XXIX which are microfiber building collagens, and collagens VIII and X which are active in forming network systems collagen.
Drug Discovery and QSAR Techniques
The book was written about Drug discovery and Quantitative Structural Activity. Quantitative structure-activity relationships (QSAR) have been applied for decades in developing relationships between physicochemical properties of chemical substances and their biological activities to obtain a robust statistical model for predicting the activities of new chemical entities or molecules.QSAR attempts to correlate structural, chemical, statistical, and physical properties with biological potency using various mathematical methods.Drug discovery is the process of identifying and characterizing molecules with the potential to safely modulate disease, aiming to bring medicines that can improve patients' lives. Target Identification And Validation.Hit Discovery Process.Assay Development And Screening.High Throughput Screening.Hit to Lead.Lead Optimization.Active Pharmaceutical IngredientThe discovery of a new drug molecule is required for treating a disease or illness for which no other treatment exists or it provides additional advantages over the prevailing treatments such as lesser adverse effects, higher therapeutic efficacy, improved amenability, and fewer drug-drug interactions, etc.
Organelle and Molecular Targeting
Drugs must be delivered to the target tissue or, better yet, the target organelles. A more specific target minimizes toxicity and side effects and maximizes therapeutic effect. This book is a comprehensive review of Organelle Targeting.
Medicinal Plants and Natural Compounds in Health and Disease
This Special Issue offers a collection of original contributions and scientific reviews on the following topics: cellular and molecular aspects of phytochemicals and other natural compounds and their therapeutic effects (with an emphasis on the innovative plant-based therapeutic approaches based on ancient medical heritage), the pharmacokinetics of herbal medicines, and the use of technology for expanding traditional medical knowledge.
Fabrication of Thiazole-Guanidine metal chelates
Inorganic chemistry has played a crucial role in the development of new drugs and therapies. Transition metal complexes have unique properties that make them attractive candidates for biological applications. For example, researchers have been exploring the use of metal-based drugs for the treatment of cancer, Alzheimer's disease, and other conditions. These drugs can be designed to target specific proteins or enzymes involved in disease processes, and their properties can be fine-tuned by modifying the structure of the metal complex. One of the advantages of metal-based drugs is their ability to interact with biological molecules in multiple ways, such as coordination bonding, electrostatic interactions, and redox reactions. This versatility allows for the design of drugs that can target a wide range of biological processes. Additionally, metal-based drugs can inhibit enzymes involved in DNA replication or repair, or they can interfere with cellular signaling pathways that are dysregulated in cancer cells. Another area of research in medicinal inorganic chemistry is the development of diagnostic agents, such as contrast agents for imaging studies.
Evaluation of Pharmaceutical Stability and Antimicrobial Activity
Currently, microorganisms resistant to multiple antimicrobials represent a major challenge in the treatment of infections. An important strategy for reducing microbial resistance is the discovery of new substances with antibacterial and antifungal properties, mainly from natural sources. Ocimum gratissimum, popularly known as alfavaca and manjeric瓊o, is used in Brazil as a local antiseptic against fungi and bacteria. Due to this activity, it is one of the species considered for inclusion in the phytotherapy programme of the Unified Health System (SUS). As O. gratissimum causes toxicity when administered orally, the alternative to its use is in topical preparations. This research has shown that it is possible to incorporate the plant's oil into formulations and that they have satisfactory physicochemical characteristics and stability, representing technological feasibility for the pharmaceutical area.
Intellectual Property Rights
"Intellectual Property Rights" offers a comprehensive exploration of the fundamental concepts and intricacies of intellectual property (IP) law. This book delves into the various forms of IP, including patents, trademarks, copyrights, and trade secrets, providing a thorough understanding of their legal frameworks and practical applications. Through detailed case studies, the book examines notable IP disputes and their implications on innovation, business, and society. It also addresses contemporary issues such as digital piracy, global IP enforcement, and the balance between protecting creators' rights and promoting public access to knowledge. With insights from legal experts and industry professionals, "Intellectual Property Rights" serves as an essential guide for students, practitioners, and anyone interested in the dynamic field of intellectual property.
Access to medicines
Pharmaceutical services are part of Pharmaceutical Assistance, are part of health services and aim to guarantee qualified access to medicines for the population in a comprehensive and continuous manner. In Primary Health Care, the minimum structuring of these services, as well as user guidance activities, is recommended in the Guidelines and Manuals of Brazilian health organisations. However, studies have shown various organisational and structural problems in these services, which compromise guaranteed access to medicines. Considering the difficulties faced by users in obtaining their medicines with the proper guidance, this study aimed to find out the perceptions of users of pharmaceutical services in the Basic Health Units of Divin籀polis, Minas Gerais, in relation to access to medicines. The research was based on the Servir Project, a qualitative study carried out in 2014. Data related to the sociodemographic, economic and health profile of users, perceptions about the physical structure of the services, obtaining medicines and dispensing practices were extracted from the Servir Project database.
Pharmacy Informatics
Pharmacy Informatics is a specialized field within healthcare that focuses on leveraging data and technology to optimize medication-related processes and improve patient care outcomes. It involves the application of information technology, data analytics, and automation systems to manage medication-related information effectively. Overall, Pharmacy Informatics plays a vital role in modern healthcare by harnessing data-driven approaches to optimize medication management processes, enhance patient safety, and facilitate evidence-based decision-making across the continuum of care.
Microparticulate Drug Delivery Systems
Microparticulate drug delivery systems offer a viable way to transform the delivery of drugs. The encapsulation of pharmaceuticals by these small particles enhances their targeting, stability, and bioavailability. Microparticles can improve patient compliance and therapeutic efficacy by lowering side effects and dosage frequency by regulating the medication's release rate. This technology is an essential field of study in modern medicine as it has enormous potential for a number of drugs.
Present and Future Perspectives of Vascular Interventional Radiology
The field of vascular interventional radiology has witnessed remarkable advancements, transforming the landscape of patient care for both vascular and non-vascular pathologies. Through minimally invasive techniques, we can now offer therapeutic alternatives with reduced complications to patients who are not eligible for conventional treatments. With the emergence of personalized therapies tailored to specific pathologies, disease stages, and patient characteristics, we find ourselves at the forefront of a new era in medicine where treatments are uniquely tailored to each individual. This Special Issue of the Journal of Personalized Medicine features a comprehensive collection of 16 articles, primarily focusing on embolization, a major theme in vascular interventional radiology. Embolization techniques have revolutionized the field, providing effective treatment options for various conditions. Within this issue, we delve into various aspects of embolization, including the embolization of the prostatic artery, splenic trauma, polycystic liver disease, soft tissue hematomas, pulmonary arteriovenous malformation, gastrointestinal bleeding, and even emerging themes such as musculoskeletal embolization. These articles showcase the breadth and depth of research in the field, offering insights into the latest advancements and personalized approaches in embolization therapies.
The Use of Motion Analysis for Diagnostics
This Reprint is dedicated to the recent technological advances that are transforming the field of motion analysis. This collection of articles provides an overview of the various clinical applications of motion analysis, highlighting how this technique is influencing the diagnosis of medical conditions in multiple disciplines, from orthopedics to neurology. The methodologies employed across the studies vary widely, encompassing innovative approaches ranging from dataset creation and algorithm development to systematic literature reviews and validation studies. Overall, the collection provides a comprehensive overview of the current state of motion analysis research, offering insights into emerging trends, technological advancements, and future directions. Each contribution serves as a catalyst for further exploration and innovation in the dynamic field of motion analysis, hoping researchers will continue pushing the boundaries of knowledge and application in pursuit of enhanced healthcare outcomes and patient well-being.
Why the Dose Matters
This book uses a rational, science-based approach to explain in plain language that a quantitative view is key for understanding and predicting potentially toxic effects of chemicals.
Biologics and Biosimilars
This is a good book designed mainly to give students and clinicians a quick overview of the science, principles, and applications of biologics and biosimilars. It is a useful tool in the clinic setting. - Victor Nwoko, BA, PharmD, Lifespring Pharmacy Inc.
The Consultation in Phytotherapy
A seminal text exploring the means by which the herbal practitioner can seek to appreciate the individual patient's predicament.
The Art and Science of Physiologically-Based Pharmacokinetics Modeling
This state-of-the-art text describes the science behind the system and drug-dependent components of PBPK models, its applications in translational and regulatory science, e.g., guiding drug discovery and development, and supporting precision medicine initiatives. To incorporate state-of-the-art knowledge, each chapter is written by leaders in the field and illustrated by clear case studies. Connecting basic and applied science, this book explores the potential of PBPK modeling for improving therapeutics and is designed for a wide audience encompassing graduate students as well as biopharmaceutics scientists and clinical pharmacologists.Features: 1. Provides a basic understanding of the physiologically-based pharmacokinetic modeling and its applications2. Assists the reader in understanding product performance to allow for rapid product development and establish bioequivalence3. Well-constructed content and added value of real examples4. Illustrates how using available resources via modeling and simulation leads to a reduction in the costs related to drug development, which directly affects the costs to patients
Pharmaceutical Analysis Laboratory Manual
Pharmaceutical analysis is a critical aspect of drug development, manufacture, and quality control. It involves the application of analytical techniques to evaluate the purity, identity, and stability of active pharmaceutical ingredients (APIs), excipients, drug products, and food samples. This laboratory manual is designed to provide practical guidance in the fundamental principles and techniques of pharmaceutical analysis.This lab manual contains thirteen chapters, which cover a range of topics from the basic concepts of pharmaceutical analysis to the more advanced techniques used in the analysis. This manual covers the basics of pharmaceutical analysis and focuses on the basic calculations used in pharmaceutical analysis, such as percent purity, and concentration determination.In addition, it provides principles, procedures, and applications of various titration techniques, including acid-base titration, redox titration, precipitation titration, back titration, potentiometric titration, and pH titration with numerous practical applications in pharmaceutical manufacturers.Furthermore, it discusses various important topics related to pharmaceutical analysis.
