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Precision Medicine

This colligated Special Issue of Pharmaceutics on Precision Medicine: Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy offers to the reader a series of articles that describe the concept of Precision Medicine, discuss its implementation process and limitations, demonstrate its value by illustrating some clinical cases, and open the door to new and more sophisticated techniques and applications.

9折 特價4062元

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Crosstalk between Depression, Anxiety, and Dementia

This Special Issue highlights the most recent research on depression, anxiety and dementia, with attention to comorbidity in a range of diseases. The symptoms of depression, anxiety and dementia are the most common comorbid manifestations present in patients suffering from neurodegenerative and psychiatric diseases. Together, these illnesses constitute an extremely complex and challenging research field due to their inherent multifactorial causative factors, heterogeneous pathogenesis, and mental and behavioral manifestations. This Special Issue covers laboratory, clinical and statistical studies on the crosstalk between depression, anxiety, dementia, Alzheimer's disease, multiple sclerosis, schizophrenia, diabetes mellitus, Down's syndrome, and/or compulsive disorders. It contains contributions from 71 authors, has been reviewed by 25 referees, and edited by three academic editors and one managing editor.

9折 特價5137元

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I-em-hotep and Ancient Egyptian medicine

This book "" I-em-hotep and Ancient Egyptian medicine: II. Prevention of valvular disease; The Harveian Oration delivered before the Royal college of physicians on June 21, 1904 "", has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.

9折 特價1053元

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Jaundice

This book "" Jaundice: Its Pathology and Treatment; With the Application of Physiological Chemistry to the Detection and Treatment of Diseases of the Liver and Pancreas "", has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.

9折 特價1145元

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Heal Using Intuition And Energy

Are you ready to dissolve your suffering? It's time to experience bottomless joy, to love fearlessly, and to have peace of mind as attainable as oxygen. Healing is accessible to everyone. From curing an illness, moving from pain to freedom, anger to acceptance, or sadness to joy, your healing journey will be as original as your fingerprints.You are going to receive answers, healing, and integrate with your higher self throughout the practices in the book. YOU will be the healer of your life. Discern the different energy systems of the body, and utilize your extra sensory perceptions to heal your aura. Enhance your psychic tools and your ability to breakdown spiritual symbolism from your intuition. Featured at the end of the book is a channeled mental/emotional root cause to a comprehensive list of physical health conditions and major life challenges.If you ever ponder, "What is my purpose? Where is my joy?", the answer is not behind or in front of you, but within you. And it's only accessible in the now.

9折 特價1285元

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Vienna - A Doctor's Guide

"The streets of Vienna are paved with history of medicine" the famous Viennese writer and journalist Karl Kraus could have said. In fact, the attentive visitor can't move through the city without being reminded by all the street names, historical buildings, monuments or memorial stones that Vienna has been a capital of medicine, attracting students and doctors. This city guide is written for all visitors to this fascinating city who are interested in the history of medicine. 15 walks through the city show the reader the traces of the old medical Vienna: the Fools' Tower, Freud's private practice and apartment, the workplaces of many famous physicians, through the old General Hospital, the old university, and the most important pathological museums. Many little-known details and anecdotes are included as well as a short history of Vienna and some gourmet tips, plus the famous Viennese coffee shops for relaxing.

9折 特價3392元

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Plants and Phytomolecules for Immunomodulation

This book describes the process of immunomodulation and the plants which possess immunomodulation properties to boost the immune system. The immunomodulation process is highly relevant to address emerging as well as existing diseases in humans. A better immune system triggers the cellular responses for neutralizing and combating the onset of disease conditions. Chapters in the book discuss plants that have profound effects on the health and well-being of humans. They discuss the natural phytochemicals that have immense diversity and uniqueness of molecules. Molecules belonging to phenylpropanoids, terpenoids, steroids, alkaloids, and tannins etc possess a variety of pharmacological activities. The chapters describe how bioactive exert effects even when taken as part of the diet, supplement, and or as traditional herbal medicine. This book provides up-to-date scientific knowledge about the activities and mechanisms and leads in the area of medicinal plants and phytochemicals with immunomodulation properties. This book is meant for students, academics, researchers, and industry professionals interested in pharmacology, immunology, and plant secondary metabolites.

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Pharmacology of Drug Stereoisomers

The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.

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Predicting Psychopathological Onset

The aim of this Special Issue is to collect valuable contributions from scientists worldwide working on the role that biological, behavioral, and cognitive markers can have in predicting the onset of neuropsychiatric disorders. We were able to collect 13 original articles and two reviews on this topic. The results published in this Special Issue could provide significant support in pre-clinical phases for the identification of vulnerability factors, to better understand the course of the illness, and to predict its outcome, as well as aiding clinicians in the therapeutic decision-making process.

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Personalized Medicine

The first English-language introduction to the developing science of endobiogeny. Dr Lapraz developed a diagnostic method that, while being rooted in modern science, allows an insight into the true causes of imbalance and disease in a patient. This innovative medical concept, based on a refined view of the neuro-endocrine system, integrates classical medicine with herbs and supplements, essential oils, and dietary and lifestyle modifications to create a truly holistic treatment approach to illness. The book sets out endobiogenic principles and methods, including the modelling system known as the Biology of Functions, and is full of remarkable case histories that attest to the efficacy of this approach. It is aimed both at the general public and at members of the health professions.

9折 特價1982元

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Water-Insoluble Drug Formulation

Water-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.

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Natural Substances for Cancer Prevention

Natural Substances for Cancer Prevention explores in detail how numerous investigations in chemical biology and molecular biology have established strong scientific evidence demonstrating how the properties of naturally occurring bioactive chemicals hamper all stages of cancers (from initiation to metastasis).

9折 特價3548元

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Bio-Targets and Drug Delivery Approaches

The advances in drug delivery systems over recent years have resulted in a large number of novel delivery systems with the potential to revolutionize the treatment and prevention of diseases. Bio-Targets and Drug Delivery Approaches is an easy-to-read book for students, researchers and pharmaceutical scientists providing a comprehe

9折 特價3548元

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Applying Pharmacogenomics in Therapeutics

This book covers the principles, practice, and potential of pharmacogenomics and personalized medicine, employing patient case profiles to illustrate key concepts and clinical applications. Featuring contributions from well-established pharmacologists/scientists, this authoritative text depicts the use of genetic biomarkers in drug discovery and

9折 特價3548元

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Textbook of Drug Design and Discovery

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

9折 特價3809元

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Good Design Practices for GMP Pharmaceutical Facilities

This revised publication serves as a handy and current reference for professionals engaged in planning, designing, building, validating and maintaining modern cGMP pharmaceutical manufacturing facilities in the U.S. and internationally. The new edition expands on facility planning, with a focus on the ever-growing need to modify existing legacy

9折 特價3548元

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The Great Pestilence (A.D. 1348-9), Now Commonly Known as the Black Death

This book "" The Great Pestilence (A.D. 1348-9), Now Commonly Known as the Black Death "", has been considered important throughout the human history, and so that this work is never forgotten we have made efforts in its preservation by republishing this book in a modern format for present and future generations. This whole book has been reformatted, retyped and designed. These books are not made of scanned copies and hence the text is clear and readable.

9折 特價1332元

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Cytochrome P450

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. Authoritative and practical, Cytochrome P450: In Vitro Methods and Protocols serves as a key guide for researchers in the area of discovery and development of new medicines.

9折 特價6785元

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Perspectives on Contemporary Pakistan

This book analyses problems of governance, development and environment affecting contemporary Pakistan; issues that lie at the centre of federal and provincial policy deliberations, formulation and implementation.

9折 特價2922元

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Hydroxytriazenes and Triazenes

Organic chemistry research has moved rapidly toward synthesis and medicinal application of nitrogen-containing compounds such as triazenes, triazines, and hydroxytriazenes due to their excellent biological activities. Many of them are presently in clinical trials. Triazene compounds have excellent medicinal properties and limited toxicity. Hydroxytriazenes are excellent chelating agents for transition metals. Newer studies show very promising biological and medicinal applications of these classes of compounds. Hydroxytriazenes and Triazenes: The Versatile Framework, Synthesis, and Medicinal Applications highlights synthetic methods, recent advances, and potential applications of triazines, triazenes, and hydroxytriazenes. This book includes holistic information on synthetic methods for novel compounds based on this moiety, up-to-date information on the how and why of their diverse or even multitargeted medicinal application, and future state of the art of both aspects. Other features include: Highlights recent advances and diverse possible applications of biological functions Covers the chemistry of triazine, triazene, and hydroxytriazene systems On the basis of in silico predictions, the book highlights synthetic methods and their applications A valuable source of information for those actively engaged in medicinal chemistry, drug discovery, and synthetic organic chemistry

9折 特價3600元

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Key Heterocyclic Cores for Smart Anticancer Drug-Design Part I

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship (sar) studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an updates (2017-2020)

9折 特價4018元

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HowExpert Guide to Phlebotomy

If you want to learn about blood draws, lab work, panels, plasma, tests, and the profession of a phlebotomist, then check out HowExpert Guide to Phlebotomy.HowExpert Guide to Phlebotomy is a glimpse into the life of being a phlebotomist in a private clinic, hospital, or plasma plant. It includes an in-depth description of the types of patients we see, the equipment we use, and how to perform blood draws. The most important part of our profession is drawing blood by inflicting the least amount of pain possible for the patient. This means that you need to be educated on the procedures for specific tests such as a Heparin Quant Assay, a PTINR, and Lipid Panels. If you don't know these tests, odds are they will need to be redrawn, and the patient will have to undergo an unnecessary procedure. This is a safety problem since every time we puncture the skin of a patient, we risk introducing infection into their bloodstream. This book will also teach you about the order of draw, descriptions of veins, descriptions of patients, and a multitude of different scenarios. If you are beginning a career or are interested in beginning a career in phlebotomy, this book will give you a good foundation of knowledge to build upon with tangible experience.Check out HowExpert Guide to Phlebotomy to learn about blood draws, lab work, panels, plasma, tests, and the profession of a phlebotomist.About the AuthorMackenna Balsewicz is a 20-year-old mother of one who has spent the last three years working as a phlebotomist at different professional facilities. She started her training at Biomat Plasma Center, where she gained the confidence and skill to draw blood and care for donors. After working at Biomat for 12 months, she transferred to Bryan Hospital to work in the laboratory department. She has fallen in love with performing phlebotomy in the hospital setting and now works at Nebraska Medicine, where she draws upwards of 60 people daily. Along with being a phlebotomist, she will be graduating from the University of Nebraska Lincoln in May of 2023 with her bachelor's degree in Psychology.HowExpert publishes how to guides by everyday experts.

9折 特價1376元

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HowExpert Guide to Phlebotomy

If you want to learn about blood draws, lab work, panels, plasma, tests, and the profession of a phlebotomist, then check out HowExpert Guide to Phlebotomy.HowExpert Guide to Phlebotomy is a glimpse into the life of being a phlebotomist in a private clinic, hospital, or plasma plant. It includes an in-depth description of the types of patients we see, the equipment we use, and how to perform blood draws. The most important part of our profession is drawing blood by inflicting the least amount of pain possible for the patient. This means that you need to be educated on the procedures for specific tests such as a Heparin Quant Assay, a PTINR, and Lipid Panels. If you don't know these tests, odds are they will need to be redrawn, and the patient will have to undergo an unnecessary procedure. This is a safety problem since every time we puncture the skin of a patient, we risk introducing infection into their bloodstream. This book will also teach you about the order of draw, descriptions of veins, descriptions of patients, and a multitude of different scenarios. If you are beginning a career or are interested in beginning a career in phlebotomy, this book will give you a good foundation of knowledge to build upon with tangible experience.Check out HowExpert Guide to Phlebotomy to learn about blood draws, lab work, panels, plasma, tests, and the profession of a phlebotomist.About the AuthorMackenna Balsewicz is a 20-year-old mother of one who has spent the last three years working as a phlebotomist at different professional facilities. She started her training at Biomat Plasma Center, where she gained the confidence and skill to draw blood and care for donors. After working at Biomat for 12 months, she transferred to Bryan Hospital to work in the laboratory department. She has fallen in love with performing phlebotomy in the hospital setting and now works at Nebraska Medicine, where she draws upwards of 60 people daily. Along with being a phlebotomist, she will be graduating from the University of Nebraska Lincoln in May of 2023 with her bachelor's degree in Psychology.HowExpert publishes how to guides by everyday experts.

9折 特價917元

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Herbal Treatment of Anxiety

This book explains the nature of anxiety and the pharmacological methods that can relieve its symptoms, such as herbal treatments. Discussed in the text is the clinical effectiveness of various Western, Chinese and Ayurvedic herbs, as well as the use of herbs in Aromatherapy, and the mechanisms by which they work.

9折 特價7047元

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Herbs, Shrubs, and Trees of Potential Medicinal Benefits

This book discuses traditional knowledge, chemical derivatives, and potential health benefits of various medicinal plants.

9折 特價3548元

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Brenner and Stevens’ Pharmacology

More detailed than an outlined review but less overwhelming than an encyclopedic reference, Brenner and Stevens' Pharmacology, 6th Edition, focuses on the essential principles you need to know in a concise, easy-to-understand manner. Authored by Craig W. Stevens, PhD, this highly illustrated introductory text helps you learn and retain key information in pharmacology-taking you from course exams and the USMLE Step 1 right through to clinical practice. New and extensively revised content keeps you up to date with the latest pharmacologic mechanisms and applications.Teaches the fundamental aspects of pharmacology using full-color illustrations, detailed explanations, and a consistent format to present classification of drugs for each system/diseaseHelps you understand both the basic science foundations and clinical applications of pharmacology, with useful tables, drug classifications boxes, case studies, and self-assessments in each chapter to help you review and prepare for course exams and Step 1Includes the latest drugs and therapeutic indications (more than 100 are new to this edition), along with an entirely new chapter on recent developments of immunopharmacology drugs, including antivirals and vaccinationsAddresses key topics such as antiviral and monoclonal drugs to treat COVID-19, the opioid epidemic, and gene therapyFeatures more than 700 new and updated images, with many revised figures focused on clearing presenting the mechanism of action of drugsIncludes access to bonus eBook content such as animations, an additional glossary, chapter-by-chapter summaries and case studies, a full list of featured drugs, 150 USMLE-style self-assessment questions, and moreEnhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

9折 特價4445元

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Managed Entry Agreements and Funding for Expensive Therapies

Managed Entry Agreements and Funding for Expensive Therapies examines the concept of MEA, detailing how depreciation of some specific therapies through intangible amortization is unavoidable.

9折 特價4018元

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Ginseng

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Current Techniques and Materials in Dentistry

With advances in dental materials and their clinical applications, as well as innovations in computer technology, dental treatment is constantly evolving. In particular, adhesion technology to the tooth surface, implant treatments, and the application of CAD/CAM technology are very interesting topics for clinical dentists. As a bonding technique, the influence of the pre-etched area of the tooth surface on the adhesive strength can be reduced by the new application of a functional monomer. Additionally, the effect of an advanced adhesive system as a universal adhesive-derived primer, when compared with the two-step adhesive, is helpful for updating the applications of new materials. Dental implants are one of the most interesting dental treatments. PEEK (polyetheretherketone) has recently been reported as a further innovation in polymer implant materials, although it has not yet met the requirements to be a biomechanical requirement. In the placement of mini-screws used in orthodontic treatments, micro-cracks caused by overtorquing in thick and hard bone, and the consequent heat production, can reduce the success rate. Computer-aided design/computer-aided manufacturing (CAD/CAM) techniques are becoming increasingly popular. Since complete dentures can be produced using an additive (3D printing) or subtractive (milling) process, CAD/CAM techniques for denture fabrication have many clinical and laboratory advantages. Innovative and convenient dental material technology will be more and more expected in the future. This book has limited findings, but we hope that your clinical capability will be integrated and upgraded.

9折 特價3770元

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Sport and Exercise Medicine

The complete guide for all candidates studying and working in the field of sport and exercise medicine, including higher specialist training and post graduate examinations. This revision guide covers all key elements of the UK National Curriculum in Sport and Exercise Medicine. Key features to facilitate learning include: A pictorial summary at the start of each chapter 'Clinical consideration' sections that show how knowledge can be applied to working clinical practice MCQ questions for each chapter, including answers MFSEM examination candidates, MSc students in sport and exercise medicine, sport and exercise medicine specialist trainee doctors, physiotherapists and general practitioners with an extended role in musculoskeletal or sport and exercise medicine will all benefit from this new text.

9折 特價4175元

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Recent Advances in Antibody Therapeutics

Since first receiving approval in 1986, antibody-based therapeutics have been the most successful modality for the treatment of various diseases. This Special Issue of IJMS, "Recent Advances in Antibody Therapeutics", presents leading-edge articles and reviews for discovery, development, and clinical applications of therapeutic antibodies, covering antibody drug conjugates (ADCs), GPCR-targeting antibodies, a functional antibody screening, bioassay of bispecific antibodies, antibody applications for cardiovascular diseases, antibody delivery to CNS, etc. The excellent studies in this Special Issue would valuable insight for scientists and clinicians in the field of therapeutic antibodies

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Research Topics in Medicines and How Our Board Members Are Engaged in Them

With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of "Medicines". As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure-activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.

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Tendinopathy

A comprehensive, user-friendly guide to up-to-date diagnostic and management information for tendinopathies of the upper and lower extremitiesDiscusses clinical presentation, physical exam, imaging, and both surgical and non-surgical treatment techniques, including when to refer for surgeryAn excellent resource for sports medicine specialists, orthopedic surgeons, physical therapy and rehabilitation specialists

9折 特價5741元

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Inducing Targeted Protein Degradation

Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications Drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates A discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.

9折 特價7803元

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Schein's Common Sense Emergency Abdominal Surgery

1. General Philosophy.- Section A: Before the Operation.- 2. The Acute Abdomen.- 3. Rational Diagnostic Procedures.- 4. Who Should Look After the "Acute Abdomen" and Where?.- 5. Optimizing the Patient.- 6. Pre-operative Antibiotics.- 7. Family, Ethics, Informed Consent and Medicolegal Considerations.- Section B: The Operation.- 8. The Incision.- 9. Abdominal Exploration: Finding What Is Wrong.- 10. Peritonitis: Contamination and Infection: Principles of Treatment.- 11. The Intestinal Anastomosis.- 12. Upper Gastrointestinal Hemorrhage.- 13. Perforated Peptic Ulcer.- 14. Acute Pancreatitis.- 15. Acute Cholecystitis.- 16. Acute Cholangitis.- 17. Small Bowel Obstruction.- 18. "Acute" Abdominal Wall Hernias.- 19. Acute Mesenteric Ischemia.- 20. Inflammatory Bowel Disease, .- 21. Colonic Obstruction.- 22. Acute Appendicitis.- 23. Acute Diverticulitis.- 24. Massive Rectal Bleeding.- 25. Gynecological Emergencies.- 26. Penetrating Abdominal Trauma.- 27. Blunt Abdominal Trauma.- 28. The Abdominal Compartment Syndrome.- 29. Abdominal Closure.- 30. Ruptured Abdominal Aneurysm.- Section C: After the Operation.- 31. Nutrition.- 32. Postoperative Antibiotics.- 33. Postoperative Care.- 34. Postoperative Ileus Versus Intestinal Obstruction -.- 35. Intra-abdominal Abscesses.- 36. Abdominal Wall Dehiscence.- 37. Re-laparotomies and Laparostomy for Infection.- 38. LIRS, SIRS, Sepsis, MODS and Tertiary Peritonitis.- 39. Anastomotic Leaks and Fistulas.- 40. Wound Management.- 41. The Role of Laparoscopy.- 42. In the Aftermath and the M & M Meeting.

9折 特價2870元

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Sbas for the Frcem

The Royal College of Emergency Medicine (RCEM) has implemented a new 2021 curriculum, with a new Single Best Answer (SBA) paper for the fellowship examination. Featuring 200 Single Best Answer questions and answers, this text is the first on the market to help prepare for this new examination. Mapped to the curriculum, this book covers core areas such as cardiology, environmental emergencies, mental health, toxicology, trauma, resuscitation and quality improvement. All of the answers are fully referenced to up-to-date guidelines and research, to allow for further reading. This is an essential text for postgraduate doctors in Emergency Medicine studying for the Fellowship of the Royal College of Emergency Medicine (FRCEM) SBA examination.

9折 特價2079元

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Advances in Pulmonary Drug Delivery

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug developmen

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Nanotechnology

Today we find the applications of nanotechnology in all spheres of life. Nanotechnology: Therapeutic, Nutraceutical and Cosmetic Advances discusses recent advances in the field, particularly with therapeutics, nutraceuticals and cosmetic sciences.

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Epidemiologic Research on Real-World Medical Data in Japan

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Psychocardiology

Psychosomatic diagnostics and therapy are of increasing importance in the acute treatment, prevention and rehabilitation of cardiovascular diseases. The connection between heart disease and the psyche as well as the psychosocial concomitant symptoms is well documented. Contents: - Basics of cardiology and psychosomatic medicine; - Doctor-patient relationship; - Ethical issues, gender effects, psychocardiology along the lifespan; - Psychosomatic problem areas and comorbidities in coronary heart disease: Personality factors, risk behaviours, depression, anxiety disorders; - Specific problems in other cardiovascular diseases and treatment settings; - Diagnostics; - Interdisciplinary cooperation, treatment and rehabilitation; - Training courses in psychocardiology.The book offers cardiologists, internists, general practitioners, psychotherapists and psychologists all practice-relevant basics to be able to treat their patients in the best possible way. It is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book may read stylistically differently from a conventional translation.

9折 特價6263元

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Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery

9折 特價6785元

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Salmonella

This third edition expands upon the previous edition with current, detailed methods on different aspects, and landmarks advancing knowledge on Salmonella research. With new chapters on molecular assays for detection, identification and serotyping of Salmonella, quantitative proteomic identification of host factors involved in salmonella infection, determination of antimicrobial resistance in salmonella, site-directed mutagenesis, chromosomal gene analysis, various microscopy methods to analyze salmonella interaction with host cells, in vitro modeling of gallbladder-associated salmonella colonization, and analysis of salmonella phages and prophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Salmonella: Methods and Protocols, Third Edition aims to provide methods that will have an impacted Salmonella research

9折 特價6785元

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Advance in the Treatment of Pediatric Leukemia

The book gives an overview on the progress that has been made in the treatment of acute lymphoblastic leukemia (ALL), of acute and chronic myeloid leukemia (AML, CML) and of juvenile myelomonocytic leukemia (JMML). Leukemia is the most common malignant disease in children, and 80% of patients are diagnosed with ALL and 15-20% with AML, whereas CML and JMML are rather rare. Although ALL was considered an incurable disease until the early 1960s, with the availability of cytotoxic drugs and the start of clinical multicenter studies, ALL has become an almost curable disease with a survival rate exceeding 90 % in high-income countries. These impressive results have mainly been achieved by a deeper understanding of the genomic landscape of the disease and the introduction of risk stratifications based on genetic features and response to chemotherapy as determined by the presence or absence of minimal residual disease (MRD). Immunotherapies including bispecific T-cell Engagers (BiTEs), Chimeric Antigen Receptor (CAR) T cells, monoclonal antibodies and improvements in the outcome of allogeneic stem cell transplantation (HSCT) have shown impressive results in chemorefractory or relapsed patients, and it is anticipated that the cure rate can be further increased. For countries with less resources, therapies have to be adapted to increase survival as well. This book also updates on the progress made in the treatment of AML. As in ALL, risk classification based on genetic factors and response to chemotherapy is most important for therapy guidance. The book also provides updates and guidance for the treatment of CML and JMML.

9折 特價5265元

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Opioid Receptors

This second edition presents an up-to-date chapters describing the most relevant and novel techniques employed to study the opioid receptors. Chapters detail transcriptional and post-transcriptional analysis, cellular detection of opioid receptors, analysis of signaling events modulated by opioid receptors, model systems to studying opioid receptor-mediated functions, and behavioral effects mediated by opioid receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Opioid Receptors: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

9折 特價7777元

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Protein-Ligand Interactions and Drug Design

9折 特價7307元

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The CBD Handbook

An accessible handbook for patients and practitioners, bringing new clarity to our understanding of CBD and cannabis. In recent years, the popularity of CBD products has exploded - with 'wonder drug' claims being made for nearly every ailment ranging from cancer to anxiety. But what do we actually know about this panacea? There is more often than not a cloud of confusion which surrounds CBD in its many forms. What does it actually do? What's the best way to use it? What's the difference between the vast array of products? Are there herb-drug interactions? Complementary practitioners are not trained in the benefits or contraindications of cannabis when used medically. A quick search on the internet often produces more confusion, with a plethora internet help forums springing up and manufacturers trying to jump onto the bandwagon - often creating products of dubious quality made from vague ingredients. Karin Mallion's new book aims to fill the gaps in our understanding of CBD. The CBD Handbook is an accessible guide, written for patients and practitioners alike, which provides readers with a history and overview of CBD and cannabis. It lists in detail which conditions and ailments CBD can help with and provides a detailed look at cannabinoids, THC, endocannabinoids and the endocannabinoid system. It also explores the different types of cannabis, the phytochemistry of cannabis, appropriate herbal medicine to use alongside CBD and cannabis, legal issues, case histories and issues around clinical use.

9折 特價1408元

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Anti-inflammatory Activity of Plant Polyphenols 2.0

This book collects some recent scientific data on the role of polyphenols in various pathological contexts, ranging from viral infection to metabolic or chronic disorders such as diabetes and renal fibrosis. The included studies showed both in vitro and in vivo evidence concerning positive effects of polyphenols in inflammation, apoptosis, and oxidative stress. The investigated molecules include: verbascoside from Olea europea, curcumin from Curcuma longa, phenolic acids from Antirhea borbonica, and phlorotannins from marine algae. Finally, the main flavonoids present in the human diet and their anti-inflammatory and anti-cancer roles were also discussed. The scientific data confirm the importance of the plant kingdom, both marine and terrestrial, in the search for new compounds with potential benefits for humans.

9折 特價3270元

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Pharmaceuticals and Health Policy

9折 特價7308元

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