Chemistry of Materials for Energy and Environmental Sustainability
This reprint introduces the recent research progress made in the chemistry of materials for energy and environmental sustainability. The topics included cover rational designed composite electrode materials for energy storage, effective additives for promoting solar cells, powerful adsorbents for hazardous dyes in water, and versatile membranes for oil-water separation, among others.
Natural Health Sciences
Natural Health Sciences: A Comprehensive Guide serves as a valuable resource for both healthcare practitioners and business professionals, supporting ongoing professional development by bridging the gap between proponents of traditional or natural health systems and those who follow scientific or medical perspectives. The book synthesizes existing literature and fosters a more nuanced understanding of the benefits and limitations of natural health practices.By presenting academic and scientific evidence in an accessible format, it offers evidence-based insights into a broad spectrum of natural health approaches. These include herbal remedies, nutritional strategies, lifestyle interventions, and alternative therapies, covering key areas such as Ayurveda, bioenergetic therapy, music therapy, traditional Chinese medicine (TCM), and aromatherapy. It also addresses criticisms, ethical and regulatory concerns, and the future of natural health sciences.With the increasing awareness of the limitations and side effects of conventional medicine, people are seeking natural, preventive, and personalized approaches to maintain and improve their health. Natural Health Sciences: A Comprehensive Guide provides a comprehensive overview of natural health sciences and its various sub-disciplines, allowing readers to gain a deeper understanding of these practices and make informed decisions about their health.
Advances in the Diagnosis of Oral and Maxillofacial Disease
This Special edition titled "Advances in the Diagnosis of Oral and Maxillofacial Disease", offers a comprehensive exploration of innovative diagnostic approaches tailored to the complexities of oral and maxillofacial conditions. This edition features cutting-edge advancements in radiological techniques, such as cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI), which provide critical insights for precise disease localization and treatment planning. Non-invasive optical imaging and diagnostic tools are also highlighted, emphasizing their potential for early disease detection and monitoring treatment responses. Contributions on pathology and biopsy techniques underscore the pivotal role of histopathological analysis in confirming diagnoses, with a focus on improving tissue sampling accuracy and reliability. The integration of molecular diagnostics showcases the transformative impact of genetic and molecular markers in early-stage disease detection and personalized treatment strategies. A key emphasis is placed on prognostic assessments, particularly the identification of biomarkers linked to disease progression and treatment efficacy. By synthesizing these advancements, this Special Issue bridges the gap between cutting-edge research and clinical application, serving as a valuable resource for healthcare professionals and researchers in the field.
Coronaviruses
This reprint compiles thirty-two peer-reviewed articles that capture the broad landscape of COVID-19 research three years after the pandemic. Organized into six thematic sections-Epidemiology and Public Health Perspectives (7 papers: 1-7), Pathophysiology and Mechanistic Insights (9 papers: 8-16), Diagnostics and Detection Methods (7 papers: 17-23), Therapeutics and Clinical Management (5 papers: 24-28), Vaccines and Immunization Studies (2 papers: 29-30), and Long COVID and Future Directions (2 papers: 31-32)-these works address key scientific and clinical developments in viral evolution, host-pathogen interactions, and public health policies. Articles within these sections examine innovative diagnostics, therapeutic strategies, vaccine approaches, and the broader epidemiological impact of SARS-CoV-2. They also probe the long-term complications of infection and shed light on emerging directions for future research. By uniting diverse scientific perspectives, this reprint aims to support healthcare professionals, scientists, and policymakers seeking evidence-based solutions to mitigate the global burden of COVID-19.
An Account of the Extraordinary Medicinal Fluid, called Aether.
An Account of the Extraordinary Medicinal Fluid, called Aether." is a classic book, that has held significant value throughout history, and to ensure its timeless wisdom is never lost, Alpha Editions has carefully preserved it by republishing it in a modern, accessible format for both present and future generations. Thoughtfully reformatted, retyped, and newly designed, this edition offers a clear and readable text-free from scanned copies of the original work. Alpha Editions is dedicated to breathing new life into antique and classic books, making these literary treasures available once again for readers who cherish history, culture, and timeless knowledge.
Zone therapy; or, Relieving pain at home
Zone therapy; or, Relieving pain at home" is a classic book, that has held significant value throughout history, and to ensure its timeless wisdom is never lost, Alpha Editions has carefully preserved it by republishing it in a modern, accessible format for both present and future generations. Thoughtfully reformatted, retyped, and newly designed, this edition offers a clear and readable text-free from scanned copies of the original work. Alpha Editions is dedicated to breathing new life into antique and classic books, making these literary treasures available once again for readers who cherish history, culture, and timeless knowledge.
The Sweating Sickness in England
The Sweating Sickness in England" is a classic book, that has held significant value throughout history, and to ensure its timeless wisdom is never lost, Alpha Editions has carefully preserved it by republishing it in a modern, accessible format for both present and future generations. Thoughtfully reformatted, retyped, and newly designed, this edition offers a clear and readable text-free from scanned copies of the original work. Alpha Editions is dedicated to breathing new life into antique and classic books, making these literary treasures available once again for readers who cherish history, culture, and timeless knowledge.
Swat the Fly!
Swat the Fly!: A One-Act Fantasy" is a classic book, that has held significant value throughout history, and to ensure its timeless wisdom is never lost, Alpha Editions has carefully preserved it by republishing it in a modern, accessible format for both present and future generations. Thoughtfully reformatted, retyped, and newly designed, this edition offers a clear and readable text-free from scanned copies of the original work. Alpha Editions is dedicated to breathing new life into antique and classic books, making these literary treasures available once again for readers who cherish history, culture, and timeless knowledge.
Antimicrobial Resistance and Environmental Health
This reprint comprises 11 articles addressing diverse aspects of the environmental dimension of AMR. It provides a comprehensive update on antimicrobial resistance and environmental health. One article reviewed the impact of tetracycline pollution on AMR in the environment and its ripple effect on ecological and human health. The authors further evaluated possible remediation strategies for tetracycline-polluted environments. If not addressed, environmental antimicrobial pollution could lead to the development of new AMR traits and the evolution of already existing ones in different environmental matrices, as reviewed by another chapter in this volume. Two articles address the presence and transmission of AMR fomites in households and vegetables in farms. Still focusing on unconventional environmental settings, one article provides a perspective on elucidating the role of bioaerosols on AMR transmission. Two other articles discuss AMR in wastewater, one in clinical and community settings, and the other reviewed wastewater AMR in Africa while pointing out the knowledge gaps and suggesting a future perspective for the successful application of the wastewater-based epidemiology of AMR. Two articles used genomic approaches to provide insight into environmental AMR, including in the marine environment. Finally, one article proposed a community-focused framework measuring One Health drivers of AMR as an approach to promote building "antibiotic-smart communities".
Symptoms in the Pharmacy
Community pharmacies are often the first source for information and advice when health problems arise. Increasingly patients are being referred to pharmacists by other health care professionals through Pharmacy First and similar schemes. This book presents a decision-making framework along with 'red flags', 'when to refer' and evidence-based treatment recommendations. A unique feature is that case studies appear throughout, in which pharmacists, doctors, nurses and patients describe assessment and treatment of a wide range of common problems. Highlights of this substantially updated Tenth edition are: The addition of seven major sections covering the initial Pharmacy First scheme in England: acute otitis media (AOM); impetigo; infected insect bites; shingles; acute sinusitis; sore throat; and uncomplicated urinary tract infection in women. A changed book title to reflect the increasing remit of community pharmacy in disease prevention, with extended content on topics such as blood pressure measurement and shingles vaccination. 'The consultation' expanded in a new chapter, including decisions about supplying antibiotics with a suggested framework to reflect antimicrobial stewardship. Pharmacy continuation of contraceptive pills and the Pharmacy Contraception service. Revisited and updated information on COVID-19 and long-COVID in the light of the transition of COVID-19 to an endemic state. Practicing and Foundation trainee pharmacists, as well as undergraduate pharmacy students and many other healthcare professionals, will find Symptoms in the Pharmacy: A Guide to the Management of Common Illnesses and Disease Prevention invaluable.
Brain Tumor Microenvironment
This Special Issue explores the brain tumor microenvironment, a complex interplay crucial for tumor behavior. We aim to achieve the following: characterize tumor microenvironment features; investigate cell-environment interactions; identify novel therapeutic targets; understand the role of extracellular vesicles; develop and validate preclinical models; and integrate advanced imaging. Gliomas, like glioblastoma, pose significant challenges due to their aggressive nature and resistance to therapies. By understanding the microenvironment, we can develop more effective treatments, improve patient outcomes, and advance our understanding of tumor biology. This Special Issue is for neuroscientists, oncologists, radiologists, immunologists, pharmacologists, and researchers. This work builds upon research emphasizing the heterogeneity of the brain tumor microenvironment, the importance of patient-derived models, the role of extracellular vesicles in tumor progression, and the potential of artificial intelligence. By exploring these intricate interactions, we can unlock new avenues for therapeutic intervention and ultimately improve patient outcomes.
Nanocarriers-Based Antimicrobial Drug Delivery
This reprint, titled Nanocarriers-Based Antimicrobial Drug Delivery, presents original research on the topic of enhancing antimicrobial activity through drug conjugation to inorganic nanoparticles and nanosization for applications across various fields, including dental and dermatological care. This reprint also examines a range of polymeric and inorganic nanocarrier formulations aimed at enhancing the therapeutic efficacy of established antimicrobial agents such as gentamicin and amphotericin.
Diagnostic and Interventional Imaging in Various Diseases
Diagnostic and interventional imaging is the main tool in the management of complex cases in various medical and surgical domains such as neonatology, neurology, neurosurgery, otorhinolaryngology, dentistry, gynecology, and urology.
Interventions to Promote Physical Activity and Healthy Ageing
The Healthy Ageing Challenge aims for people to enjoy at least five extra healthy independent years of life by 2035 while narrowing the gap between the experiences of the richest and poorest. Regular physical activity is important for healthy ageing, not only for maintaining health in midlife but also for maintaining health, independence, and quality of life as people become older. Global physical activity guidelines highlight the benefits and importance of helping adults to adopt and maintain regular physical activity participation throughout the course of life and not only in later life, and interventions and activities that support this aspiration are so important. As experienced researchers, Professor Andy Pringle and Dr Nicky Kime's text, Interventions to Promote Physical Activity and Healthy Ageing, features contributions reporting the impact and implementation of physical activity interventions for adults and older adults, as well as the experiences of performing research and evaluation in this context in a diverse range of projects.
Therapeutic Radionuclides in Nuclear Medicine
Dear Colleagues, Recently, the theranostic principle has been used with tumor receptor-specific radiopharmaceuticals containing therapeutic nuclides, such as 161Tb, 177Lu, 188Re, 212Pb, and 225Ac. The production mode, availability, and costs of radionuclides have a significant impact on their clinical use and are often bottlenecks for broader applications. Therefore, cyclotron-produced neutrons could open a new era for producing relevant radionuclides. The identification of tumor-specific binding sites, the development of tumor-addressing conjugates, opportunities for enhanced target enrichment, and the protection of critical organs define the potential of therapeutic radiopharmaceuticals. The combination of radiotherapeutics with other pharmaceuticals to modulate the target or repair systems exploits synergistic effects. Combining radiotherapeutics with the body's immune system or immunotherapeutics raises hopes for immunization against cancer and could explain the success of targeted alpha therapy vs. targeted beta therapy. This reprint is dedicated to nuclear oncologists, health physicists, radiopharmacists, radiochemists, radiobiologists, and all other oncologists. We thank all our colleagues and would like to express our respect for their contributions to this reprint.
Patient Safety in Developing Countries
Understanding the various aspects of patient safety education, practice, and research in developing countries is vital in preparing a plan to overcome the challenges of improving patient safety. This unique volume discusses patient safety in developing countries, and the achievements and challenges faced in those places when trying to improve patient safety education and practice.This book includes a compilation of over 100 case studies surrounding patient safety in all aspects of health care. Both real and simulated scenarios are provided to help medical students and professionals apply their knowledge to solve the cases and prepare for real practice.Features Describes the achievements and challenges of patient safety in developing countries Includes real and simulated case studies and key answers on patient safety issues Prepares medical students and practitioners for real-life situations Diverse audience including those in medication to safety testing, patient education, dispensing changes, and the design of health systems Aids medical students and practitioners to improve their skills to solve cases
Prevalence and Risk Factors of Obesity and Hypertension
This Special Issue focuses on the prevalence of obesity and hypertension, shedding light on several critical aspects of these conditions. It underscores the profound effects of obesity and sedentary lifestyles on metabolic and cardiovascular health, highlighting the alarming disparities in obesity rates among adolescents. Furthermore, it examines the cardiovascular risk factors that have emerged in the wake of the COVID-19 pandemic, emphasizing the need for a comprehensive approach to public health strategies.
Perioperative Medicine
In recent years anesthesiologists have developed a more active role in the entire peri-operative period-from the decision for surgery, through recovery, discharge and beyond. In addition, the core training curriculum of anesthesiology has changed significantly to now include many non-operating room anesthesia rotations.General anesthesiology texts include varying degrees of perioperative management information, and a few titles are devoted specifically to the area. However, none combines a problem-based approach with review questions and answers with explanations. Following the format of the Anesthesiology Problem-Based Learning Approach series, each chapter in Perioperative Medicine describes a specific condition or situation and a virtual case presented through a series of questions and answers. With 48 chapters covering a broad array of conundrums encountered in clinical perioperative medicine, the text focuses on preoperative optimization of patients with different comorbidities, such as coronary artery disease, heart failure, chronic obstructive pulmonary disease, obstructive sleep apnea, diabetes mellitus, cirrhosis, substance use disorder, and anemia. Sections on how to choose preoperative tests, medication management, and handling ethical issues, like informed consent, DNR, and uncomfortable conversations with patients, are discussed in detail. Perioperative Medicine: A Problem-Based Learning Approach provides an up-to-date compendium of topics commonly presenting in daily practice and serves as a unique learning opportunity for the busy perioperative clinician approaching a new case and for clinicians in training who need to learn the basics.
Attention Deficit Hyperactivity Disorder (ADHD)
This reprint explores diverse dimensions of Attention-Deficit/Hyperactivity Disorder (ADHD), integrating cutting-edge research across clinical, neuropsychological, and psychosocial domains. It highlights innovative approaches to the diagnosis, treatment, and understanding of ADHD, offering a comprehensive perspective on this complex condition. The collection includes studies on psychotic-like experiences in ADHD, elucidating mechanisms such as rumination, trauma, and negative affect. The Creative Awareness Theory presents a novel perspective on inherent self-regulation among individuals with ADHD. Diagnostic advancements are represented by the Distractor-Embedded Auditory Continuous Performance Test, an objective tool that addresses challenges in ADHD assessment. Neurodevelopmental impairments are further explored in psychosomatic patients, while the "push-pull" mechanism of attention and emotion in children provides insights into behavioural dynamics. The prevalence and correlates of ADHD in adults with multiple sclerosis, as well as the link between ADHD and dyslipidaemia, highlight co-occurring conditions and their implications. Additional studies address the systematic stimulation of executive functions in ADHD populations, risks of premature discontinuation in opioid withdrawal treatment, and the development of female-specific ADHD treatment programmes. Predictive tools, such as a nomogram for identifying ADHD and ASD in child and adolescent mental health services, round out this multidisciplinary examination. This Special Issue serves as a valuable resource for clinicians, researchers, and practitioners aiming to advance the understanding and management of ADHD.
Designing Next-Generation Drug-Like Molecules for Medicinal Applications
The development of new drugs/drug candidates for medical treatment remains an exciting but challenging process as only a limited number of synthetic compounds fit well into the discovery and development process after multiple experimentation and screening efforts in search of their preclinical properties. Over the years, this continuous demand has been fueled by the use of organic/synthetic chemistry protocols that deliver new molecules or improve the existing toolbox diversifying libraries of pharmacophores of medicinal interest. The application of new methodologies particularly employing green and sustainable commercial feedstock chemicals for the discovery and development of biological therapeutics opens up new avenues of research. In parallel, the discovery and development of new organic molecules have always proved effective in designing drugs while overcoming critical challenges to the pharmaceutical industry and providing innovative solutions toward commercialized medicines. This reprint aims to provide a far-reaching overview of the most recent developments in synthetic methodologies as well as medicinal chemistry applications of small-molecule inhibitors.
A Commemorative Issue in Honor of Professor Merlin G. Butler's Retirement
This Special Issue of the International Journal of Molecular Sciences is dedicated to Professor Merlin G. Butler, in recognition of his retirement and to commemorate his substantial contributions to the field of genetics and genomics-driven medical care. Dr. Butler has been a pioneer in the expansion of our understanding of how genetics can help inform healthcare professionals regarding individuals with neurodevelopmental syndromes and conditions. This commemorative Special Issue focuses on original research and review articles evaluating innovative molecular and computational approaches for studying the mechanisms underlying the expression and development of both common and rare genetic conditions.
Neglected and Underutilized Crops
This book provides a comprehensive review of the potential of neglected and underutilized crops in the prevention and treatment of various cancers. It explores various aspects of these crops and their bioactive compounds, shedding light on their role in health and nutrition. The initial chapters discuss neglected and underutilized crops, emphasizing their relevance in human disease and cancer management. These chapters also examine the bioavailability and formulation strategies of bioactive compounds derived from these crops. The book further delves into the isolation, availability, and therapeutic uses of these bioactive compounds, emphasizing their significant role in modern medicine. It also reviews the potential of the Indian gooseberry, quinoa, and seabuckthorn in cancer treatment and management. Additionally, the book discusses neglected medicinal plants of the Northwestern Himalayas, showcasing their potential applications in both traditional and modern medicine. It also highlights the importance of sustainable cultivation and conservation efforts to ensure the long-term availability of these crops. This book is of particular interest to scientists, researchers, and academics in fields such as agriculture, biochemistry, nutrition, and medicine.
Essentials of Pharmacotherapeutics
Essentials of Pharmacotherapeutics is an indispensable guide that connects the dots between pathophysiology, pharmacology and clinical application of drugs. Perfectly suited for pharmacy students and academic professionals, this book provides a recent and updated overview of pharmacotherapy in easy-to-understand language. The book is a perfect blend of reference and examination-oriented material. But the highlight of the book lies in the incorporation of various case studies at the end of each chapter, allowing students to apply theoretical concepts to real-life scenarios. This comprehensive text of therapeutics contains lucid language, diagrams, flowcharts and tables wherever necessary, making it highly accessible to students of all levels. Although the book has been carefully researched, the effectiveness of any therapy may vary based on clinical examinations and individual sensitivities. The book is a great resource for anyone looking to understand the fundamentals of pharmacotherapy of diseases and is an enthusiastic effort to provide a complete understanding of the field.
Modern Pharmaceutical Analytical Techniques
"Modern Pharmaceutical Analysis Techniques" is the complete guidebook for M. Pharmacy students who want to master spectroscopic methods of structure determination. This book serves as a primary textbook covering advanced analytical techniques for drug discovery, development, and stability studies, among other significant aspects. With its emphasis on essential theoretical concepts and practical applications, it offers a thorough understanding of each spectroscopic technique and its related tests. This book comprises twelve chapters divided into six units that systematically present the theoretical aspects and instrumentation of each technique. Students will benefit from the author's teaching expertise, and the clear explanations and examples that make the book easily accessible. The author has also included a range of questions to support students in mastering spectroscopic problem-solving skills. "Modern Pharmaceutical Analytical Techniques" is a must-read for anyone seeking solid support for drug discovery, development, stability studies, bioavailability, and pharmacokinetic studies. This book covers the complete syllabus prescribed by the Pharmacy Council of India.
Quality Assurance
"Quality Assurance" is the quintessential guidebook for those seeking to understand the ins and outs of quality control and assurance in the pharmaceutical industry. From cGMP to regulatory affairs, this book covers everything you need to know to ensure that your products meet the highest possible standards. With a focus on key aspects such as documentation and quality certifications, this book is an essential resource for students, professionals, and anyone seeking to improve their understanding of QA and QC departments. By the end of this course, readers will be equipped with the knowledge and skills needed to build a successful career in the pharmaceutical industry, and to ensure that their products are of the highest possible quality.
Quality Control of Herbal Drugs
"Quality Control of herbal Drugs: Standardisation and Regulations" offers a comprehensive guide to navigating the complexities of this industry.This book answers a multitude of important questions, such as: What are the different categories of herbal products? How do traditional AYUSH products differ from modern herbal products? What are the guidelines and regulations concerning the quality, safety, toxicity, and efficacy of AYUSH products, herbal drugs, and derived products?Furthermore, the book explores the process of standardizing herbal products, outlining the requirements for establishing a successful herbal industry. It also delves into the necessity of conducting preclinical and clinical studies for herbal products, shedding light on the importance of evidence-based practices."Quality Control of herbal Drugs: Standardisation and Regulations" provide practical insights into herbal entrepreneurship, but it also explores how herbal products are regulated in various countries. With the inclusion of QR codes after each chapter, readers can easily access additional supportive knowledge to enrich their understanding of the subject.Whether you are a researcher, practitioner, entrepreneur, or simply interested in the world of herbal medicine, this book is an essential resource for understanding the intricacies of quality control, standardization, and regulations in the herbal industry.
The Oil-Dispersion Bath
The Oil-Dispersion Bath by Werner Junge provides information about oil-dispersion bath therapy. The therapeutic technique is described, and a list of dispersion oils and their specific uses is included.
Spontaneous Intracranial Haemorrhage Caused by a Non-Aneurysmal Brain Vascular Malformation
Macleod's Essentials of Examination
Despite many diagnostic advances, expert clinical examination is fundamental to the practice of medicine. Macleod's Essentials of Examination provides a concise guide to examining each body system, ideal for senior medical students, doctors in training and other health professionals. Each chapter provides a standardised framework for examining a body system, along with important considerations for the clinician as well as self-test questions. The book is spiral-bound, portable and concise, with space for the reader to annotate and add their own notes - making it ideal as both a guide on the wards and as an exam revision aid. The second edition of this popular title has been fully revised to take into account current terminology, guidelines and diagnostic pathways. Written specifically for this format, the book can be used as a standalone resource or alongside its hugely successful parent text, Macleod's Clinical Examination and the other MacLeod's titles.Practical, quick-reference guide for senior medical students and doctors in training - can be used for both examinations and clinical practiceConcise, point-by-point template for examining all the major body systemsClear set of guidelines on what to do at each stage of the clinical examinationSpecific instructions around technique and key clinical points to considerTypical OSCE scenarios, exam questions and answers - with tips on presenting findings and how to maximise exam successSelf-test questions to consolidate knowledge and skillsCan be used alongside the other Macleod's titles or as a standalone resourceIncludes complete eBook version for easy access anytime, anywhereFully updated throughoutNew chapters on skin and eyesUpdated exam tips and questions/answers to ensure they are relevant, current and accurate
New Insights into Prostate Cancer Diagnosis and Treatment
This book addresses the latest studies and research findings on the detection, diagnosis and treatment of prostate cancer. It is intended to provide an overview of topics such as risk factors including genetic and environmental predispositions, as well as diagnosis and the latest available therapies and their complications in the field of prostate cancer. The goal is to enable better and more comprehensive care and to improve the quality of life of patients with prostate cancer.
New Diagnostic and Therapeutic Aspects of Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy caused by congenital or acquired severe deficiency of the von Willebrand factor cleaving protease, ADAMTS13. Acute TTP is a medical emergency requiring a rapid differential diagnosis and immediate treatment, which is often challenging due to the overlap between clinical and laboratory features and other thrombotic microangiopathies. Diagnostic and therapeutic advancements over the past decade, including the increased availability of ADAMTS13 testing and the development of caplacizumab, the first targeted therapy for acquired TTP, have significantly improved the management of acute TTP and reduced the burden of short-term outcomes such as mortality and exacerbation of acute disease. Concurrently, new clinical challenges have emerged, to mention but one, addressing the burden of long-term complications of TTP and cardiovascular comorbidities in TTP patients in remission.This Special Issue will cover new diagnostic and therapeutic aspects of TTP care, with the scope of advancing our knowledge and clinical intervention to address the current challenges of TTP management. Original, review, and guidance/guideline papers are welcome.
Prostate Cancer
The objective of this reprint is to facilitate an in-depth engagement with the subject matter of prostate cancer. The prostate is the largest accessory gland of the male reproductive tract. Together with the seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostate is frequently affected by a number of pathological conditions in males over the age of 40, including benign prostatic hyperplasia and cancer. Prostate cancer is one of the most prevalent forms of cancer among the male population on a global scale. According to the World Health Organization (WHO), in the year 2020, approximately 1.41 million men worldwide were affected by prostate cancer. Despite significant advances in treatment, including the advent of targeted and immune-checkpoint-inhibitor-based therapies, cancer remains one of the primary causes of death worldwide. This reprint presents the latest developments in prostate cancer diagnosis and treatment, including in vitro and in vivo approaches.
Enzyme Inhibitors from Marine Resources
Marine living organisms and their main and secondary compounds and metabolites are among the richest in biological diversity. Many of their fundamental qualities and applications are still fully or partially unexplored. Given that enzymes are essential in the plethora of biological functions of these organisms, it is increasingly evident that enzyme inhibitors are also involved in the control of these functions, as well as in many diseases and attack-defense processes. Research on the natural inhibitors found in marine organisms is, therefore, of great interest at present in a myriad of research perspectives.The present Special Issue collected novel research on non-peptide or peptide/protein inhibitors, or derived forms, with a focus on isolation, structure-function characterization, methods of action, variety, evolution, screening, and genomics-proteomics. Particular emphasis is placed on enzyme inhibitors from marine invertebrates, microorganisms, and algae, still not well understood. Additionally, studies on the potential value of such molecules for biological, biotechnological, and pharmaceutical/biomedical uses, particularly as drugs or lead compounds, are taken into account.
Systemic Lupus Erythematosus
The present Special Issue aims to provide a broad updated spectrum of knowledge on pathogenetic, diagnostic, and therapeutic aspects of Systemic Lupus Erythematosus (SLE). Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE carry a risk of progressive organ damage accrual, reduced health-related quality of life, and still have significant mortality. The early diagnosis of SLE can be beneficial for long-term outcomes. New tools allow for the earlier classification of SLE, whereas tailored early intervention and treatment strategies targeted at clinical remission or lupus low disease activity state (LLDAS) could offer the opportunity to reduce damage, thus improving long-term outcomes including mortality. Understanding the mechanisms and optimal treatment of comorbidities in SLE, improving the management of hard-to-treat manifestations, and optimizing the use of currently available therapeutics are among the current major unmet needs, and new research on these topics is covered in this Special Issue.
