Container-content interactions
In the pharmaceutical sector, container-content interactions refer to the transfer of substances between manufacturing equipment, packaging or medical devices, and the drug. These phenomena include the adsorption of active ingredients or excipients onto container walls, their penetration into the interior of materials or their diffusion into the external environment. In addition, these phenomena include the migration of substances from the container to the drug, or from the external environment to the drug.Such interactions can compromise the quality, efficacy and safety of pharmaceutical products, leading to potentially serious adverse effects for patients, such as changes in therapeutic efficacy or toxic reactions.In this work, we have reported on examples of container-content interactions, specifying the circumstances in which they occur, the methodologies used to study them and their impact on both the drug and the patient.
Cobert Mnl Drug Safety (4th Ed)
Cobert's Manual of Drug Safety and Pharmacovigilance, Fourth Edition, is an updated how-to manual of guiding principles and concepts for those working in the fields of drug safety, clinical research, pharmacology, regulatory affairs, risk management, quality/compliance, and in government and legal professions.This comprehensive and practical guide discusses the theory and the practicalities of drug safety and pharmacovigilance, and provides essential information on drug safety and regulations in the United States, European Union, and more, including: recognizing, monitoring, reporting, and cataloging serious adverse drug reactions.Cobert's Manual of Drug Safety and Pharmacovigilance, Fourth Edition, teaches the daily practice of drug safety in industry, hospitals, the FDA and other health agencies - both in the United States and around the world - and provides critical information about what to do when confronted with a drug safety problem.
Cobert Mnl Drug Safety (4th Ed)
Cobert's Manual of Drug Safety and Pharmacovigilance, Fourth Edition, is an updated how-to manual of guiding principles and concepts for those working in the fields of drug safety, clinical research, pharmacology, regulatory affairs, risk management, quality/compliance, and in government and legal professions.This comprehensive and practical guide discusses the theory and the practicalities of drug safety and pharmacovigilance, and provides essential information on drug safety and regulations in the United States, European Union, and more, including: recognizing, monitoring, reporting, and cataloging serious adverse drug reactions.Cobert's Manual of Drug Safety and Pharmacovigilance, Fourth Edition, teaches the daily practice of drug safety in industry, hospitals, the FDA and other health agencies - both in the United States and around the world - and provides critical information about what to do when confronted with a drug safety problem.
Exam Essentials: Sbas for Pre-Hospital Emergency Medicine
'Exam Essentials: SBAs for Pre-Hospital Emergency Medicine' is a single best answer (SBA) exam preparation book for those sitting exams for pre-hospital emergency medicine and all associated areas. It is structured around the curriculum for the Fellowship in Immediate Medical Care (FIMC) providing a crucial resource for those sitting this tenacious exam. It would also be an exceptional resource for those attempting the Diploma in Immediate Medical Care (DIMC). With questions covering a variety of topics, including working in emergency medical systems, providing pre-hospital emergency care, equipment, rescue and extrication, transfer, major incidents, and team resource management, professionals sitting the Diploma in Retrieval and Transfer Medicine (DRTM) and the Diploma in Major Incident Management (Dip MIM), will also find the book useful. Other examples of relevant exams include the Membership of the Royal College of Emergency Medicine (MRCEM), Fellowship of the Royal College of Emergency Medicine (FRCEM), European Board Examination in Emergency Medicine (EBEEM) (European Society for Emergency Medicine), US Board of Certification in Emergency Medicine (BCEM), Diploma of Pre-hospital and Retrieval Medicine (Australasian College for Emergency Medicine, Australia), but this list is not exhaustive. Candidates sitting for postgraduate examinations in emergency medicine, pre-hospital emergency medicine, and retrieval and transfer medicine across the globe will find this an immeasurably helpful resource for exam technique and an invaluable guide to boost their knowledge and understanding.This book is designed to give the reader as much practice at single best answer (SBA) questions as possible. These questions can be notoriously tricky to navigate, and it is through practice that builds competence in exam technique. Each question is provided with the correct answer, corresponding rationale and further resources.
Self-Medication and Drug Storage Practices
The high prevalence of chronic diseases and ease of availability of over-the-counter medications have favored both prescribed and self-medication consumption among the needy. It's equally important to ensure that not only patients but everyone should be aware of appropriate storage requirements to prevent negative health and economic consequences. A cross-sectional study to evaluate self-medication and drug storage practices among pharmacy students at Banasthali Vidyapith, Rajasthan, was considered. A semi-structured, validated questionnaire with 21 open and closed-ended questions addressing several domains-knowledge, attitude, and practices were used to collect the data after informed consent was obtained. A total of 300 subjects satisfying both the inclusion and exclusion criteria participated in the study. STROBE guidelines for the cross-sectional study were considered. The study adjudged that the students of pharmacy have good knowledge of self-medication and storage requirements/practices to be considered for medications.
Literature Survey of Momordica Medicinal Plants
The "Handbook on Literature Review on Momordica Medicinal Plants" offers a comprehensive exploration of the Momordica genus, renowned for its significant medicinal properties. The handbook bridges traditional uses with modern scientific applications, showcasing the genus's relevance in drug development and healthcare. Additionally, it identifies research trends and gaps, encouraging further studies to unlock the full potential of Momordica plants. A valuable resource for researchers, academicians, and professionals, this handbook serves as an indispensable guide to understanding the therapeutic significance of Momordica medicinal plants.
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus
We present a reprint of the Special Issue titled "Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus". The Special Issue welcomed original works and review articles focusing on the cellular and molecular mechanisms underlying SLE in its different phases, with the goal of contributing novel knowledge of the pathogenesis of SLE and improved diagnostics, surveillance, prevention of long-term damage, and overall patient management. We also welcomed original works or review articles that evaluated immune components that could serve as diagnostic biomarkers, biomarkers of disease activity, or biomarkers of long-term outcomes.
Practical manual on Controlled and Targeted Drug Delivery Systems
This book demonstrates the experiments related to controlled and novel drug delivery systems. This book will cover the basic principles of formualating various novel drug delivery systems like floating drug delivery, transdermal patches, microspheres, matrix systems. This book also covers various targeted drug delivery systems like liposomes, gastroretentive drug delivery systems. It illustrates step by step details of formulating novel drug delivery.
The Prophetic Medicine
"The Prophetic Medicine" by Ibn Qayyim al-Jawziyya is a timeless masterpiece that offers profound insights into the Prophet Muhammad's guidance on health, healing, and holistic well-being. Drawing from authentic Hadiths, this book explores natural remedies, spiritual practices, and dietary guidelines that promote both physical and spiritual health.The book begins with the Prophet's approach to disease prevention and hygiene, emphasizing the importance of cleanliness and moderation in dietary habits. It details the therapeutic properties of natural substances like honey, citron, and camel milk, revered for their healing virtues in traditional Islamic medicine. The Prophet's teachings on spiritual practices for fostering emotional resilience and inner peace underscore the interconnectedness of physical health with spiritual well-being, a core principle of Islam.Beyond remedies, "The Prophetic Medicine" emphasizes preventive medicine, offering practical advice on maintaining well-being and avoiding diseases through mindful living aligned with Islamic ethics. The book also touches on the ethical considerations in medical practice, advocating for competent healthcare and cautioning against misuse of medicinal treatments.This book is more than just a guide to remedies; it is a comprehensive resource on wholesome living, health, and ethical conduct, harmonizing faith with well-being. For anyone seeking to rediscover the wisdom of Islamic medicine, it offers invaluable teachings on leading a healthier, more spiritually fulfilling life."The Prophetic Medicine" stands as an indispensable resource for those seeking to embrace timeless wisdom and cultivate a balanced life enriched by faith, health, and well-being.
Pro-vax
With Pro-vax, Samantha Vanderslott opens a whole new avenue of research. This thought-provoking book will be a landmark for years to come as the research community moves towards a richer understanding of contemporary debates surrounding vaccination. (Dr Jeremy Ward, Charg矇 de Recherche, INSERM) Vanderslott's book, Pro-vax, sheds light on the important dimension of positive activism around vaccination, which is against the tide of a challenging environment that she also considers in her thoughtful, well-written book. (Professor Heidi Larson, Department of Infectious Disease Epidemiology, LSHTM) This book tackles a distinction we have taken for granted for too long: that between anti-vaccine and pro-vaccine attitudes. Building on her longstanding expertise in the history and politics of vaccination, Samantha Vanderslott provides a compelling account of pro-vaccine movements. By shifting our attention to those who express public support for vaccination, and away from those who do not, this book represents a unique intervention in both scholarly and political discourse. With its use of historical sources, images, and accessible language, the book will be invaluable for scholars of vaccination and vaccine advocates alike. (Assistant Professor Katharina T. Paul, Department of Political Science, University of Vienna) Vaccination is both a social activity on a grand scale and an experience that is very personal and individual. Add to the mix the understanding of vaccination in culture, the media, and others around us in society, and attitudes to vaccination become complex. For a long time, the concentration has been on attitudes to vaccination by those who are in opposition (the anti-vax), neglecting the majority who are supportive. This book aims to reconsider vaccination as a phenomenon from the perspective of those who are pro-vax, who actively support and vocally promote vaccines. Using contemporary and historical examples, the book explores public support of vaccination, focusing on civil society in action through activism, petitions, and trials.
Metabolites of Medicinal Plants
Metabolites of Medicinal Plants: Insightful Approaches provides a comprehensive exploration of the bioactive compounds found in medicinal plants and their pharmacological significance. The book covers key topics such as the economics of medicinal and anticancer plants, phytochemistry, therapeutic potential, and advanced applications like nanotechnology-based drug delivery systems and CRISPR-Cas techniques. It also examines the role of these plants in combating diseases like diabetes and metabolic syndrome and their role in traditional medicine systems. This resource is essential for students, researchers, and professionals in phytochemistry, pharmacology, drug discovery, and healthcare practices. Key Features: 1. Wide range of topics from medicinal plant economics to pharmacological applications.2. Latest discoveries in plant bioactive compounds and their therapeutic uses.3. Novel drug delivery methods to enhance efficacy.4. Linking genes to metabolites through advanced omics approaches.
Acute Respiratory Distress Syndrome (ARDS)
Acute respiratory distress syndrome (ARDS), which is marked by severe inflammation and poor gas exchange, poses a significant challenge. ARDS research has advanced in the past ten years as we have enhanced our understanding of the range of presentations, the significance of focusing on particular pathophysiological processes, and how these can affect each patient's response to treatment in the context of personalized medicine. Despite advancements in supportive care, mortality rates remain high, underscoring the urgent need for customized treatment regimens. With an emphasis on the need to tailor treatments to each patient's particular profile, this Special Issue aimed to explore innovative approaches to the treatment of ARDS. The contributions to this Specail Issue cover a wide range of topics, such as the utilization of advanced imaging techniques to monitor lung function, the use of biomarkers to predict treatment response, and the application of machine learning algorithms in therapeutic decision-making. Additionally, novel medications and adjunctive or rescue treatments such as extracorporeal membrane oxygenation (ECMO) and immunomodulatory therapies are discussed. By promoting interdisciplinary collaboration and the dissemination of innovative research, this Special Issue investigated the path to more effective, customized therapy for ARDS patients. This Special Issue presents articles that address the pathophysiology and classification of ARDS, pharmacological and supportive therapies, chest imaging, and the identification of biological sub-phenotypes as a target for possible novel treatment strategies.
Pharmacological Potential of Marine Natural Products
Marine natural products (MNPs) have proven to be an important resource for original drug discovery. It is of great research value and application potential to search for lead molecules with significant pharmacological activity from marine drug-derived organisms. In the past few decades, MNPs used as new lead compounds with high value have gained considerable attention. In particular, some MNPs were discovered to have significant antitumor, antiviral, and antibacterial activities, which have great potential for development. MNPs exhibiting profound biological activities have been and continue to be an important source for the discovery and development of new medicine and agricultural agents.This Special Issue aims to highlight the discovery and bioactivity of marine natural products, including the biological activity of new secondary metabolites from marine organisms, molecular structure identification, and potential pharmacological activities of MNPs.
Polymers in Modern Medicine - Part 2
Polymers in Modern Medicine - Part 2 examines the innovative use of polymers in advanced healthcare applications, focusing on personalized medicine, regenerative therapies, and diagnostics. The book highlights groundbreaking topics such as polymer-based nanomedicine for cancer therapy, polymeric hydrogels, biopolymers, and the role of polymers in diagnostics and vaccines. Building on foundational principles, it explores polymeric approaches to sustainable and patient-specific treatments.Readers will gain a deep understanding of emerging polymer technologies and biocompatible materials and their impact on cutting-edge medical solutions. This resource bridges the gap between scientific research and practical implementation in the pharmaceutical, biomaterial, and medical device industries. Key Features: - Covers polymers in regenerative medicine, nanomedicine, and diagnostics.- Insights into polymeric hydrogels, biopolymers, and smart polymers.- Sustainability and patient-specific applications in healthcare.
Polymers in Modern Medicine (Part 1)
Polymers in Modern Medicine - Part 1 offers an in-depth exploration of the transformative role of polymers in healthcare and medical innovation. This comprehensive book examines the diverse applications of polymeric materials in areas such as controlled drug delivery, tissue engineering, diagnostics, regenerative medicine, and personalized therapies. With chapters spanning polymeric scaffolds, nanotechnology, smart polymers, biopolymers, and polymer-based implants, it provides detailed insights into the science and technology shaping modern medicine. The book also highlights cutting-edge advancements in polymeric coatings for medical devices, cancer nanomedicine, and vaccine development, emphasizing sustainability and biocompatibility. Key Features: - Latest advancements in polymer nanotechnology, scaffolds, hydrogels, and smart polymers.- Applications in drug delivery, prosthetics, diagnostics, and regenerative medicine.- Discusses biocompatible, sustainable, and personalized polymeric materials.- Bridges the gap between academia, industry, and clinical research.
Pharmacological Activities of Flavonoids and Its Analogues
Dear Colleagues, The development of new drugs continues to be an important point for global society. In recent years, there has been increased interest in the study of polyphenols due to the multiple pharmacological activities that they have demonstrated. Flavonoids are a class of polyphenols that have been widely studied; they are characterized as having a 15-carbon skeleton with a 2-phenylbenzopyranone core structure. They are classified as flavones, isoflavones, flavonols, anthocyanidins, flavanones, flavanols, chalcones, and aurones. Within the various classes, further differentiation is possible based on the number and nature of substituent groups attached to the rings; moreover, flavonoids can exist as free aglycones or conjugated glycosidic bonds. Flavonoids are present in almost all types of nourishment, and recent studies have focused on their biological, nutritional, pharmacological, and medicinal relevance. These kind of molecules, as well as their analogues, are of utmost relevance due to their multiple applications. Considering the above, we invite researchers to publish their findings on the pharmacological applications of flavonoids, as well as their analogs, while highlighting the importance of using these molecules as a basis for the development of new drugs.
Applications of artificial intelligence in healthcare
In this work, we carried out a literature review on the application of artificial intelligence in healthcare and its impact on medical and pharmaceutical practices, while specifying the challenges and issues associated with its use.In medicine, we presented the advances of artificial intelligence in medical imaging, including pelvic and thoracic ultrasound, as well as in the diagnosis of autism, depression and diabetic retinopathy. In addition, we examined the progress of algorithms in predicting serious diseases such as pancreatic cancer and COVID-19 mortality.In pharmaceuticals, we analyzed how artificial intelligence has revolutionized the discovery of new drugs, particularly antibiotics and innovative therapies in the fight against the COVID-19 pandemic. We presented tools for predicting the virus' protein structure, analyzing scientific publications and searching for potential treatments.
A Fighting Chance
This book is a motivating and empowering peek into real-life events that offer hope, assurance, and a fighting spirit during trauma. I invite you to take a glimpse into the journey of determination, endurance, mindfulness, faith, and resilience of a woman to regain her quality of life.A Fighting Chance: How to Rise Against Severe Trauma is a memoir describing Shannon's journey of survival. This is the survival story of a middle-aged woman shot in the back of the head and suffering a stroke, which led to unforeseen physical, mental, and legal issues while also dealing with a traumatic brain injury (TBI).You are invited to take a glimpse into Shannon's real-life trials and victories as she continues to fight, determined to never give up. This is a journey of strength, inspiration, and faith from a middle-aged professional woman who learned how to use several coping strategies to rise again and fight for a new life after severe brain trauma.Regrouping and fighting after any type of severe trauma in life is a journey with many twists and turns. You may have a few roadblocks in life, but if you stumble or get knocked down, don't quit and never lose hope. Therefore, never give up, because you still have a fighting chance.This book was written to encourage and inspire anyone who has experienced any type of trauma, which can include, but is not limited to a mental, physical, or emotional ordeal, or anything that has profoundly affected your life-changed your way of thinking and negatively impacted your life. As you journey with me through my story, take a moment to reflect on the questions provided at the end of each chapter. Within this book, I hope you find a spark of inspiration that will light up your life and set you on fire with flames of encouragement to keep fighting and never give up.
Medicinal Chemistry, Practical Manual, Pharm.D-III Year
A Medicinal Chemistry Practical Manual typically provides hands-on laboratory techniques and experimental protocols used in the study and development of medicinal compounds. The practical manual is designed for students and researchers in the field of medicinal chemistry to familiarize them with the key principles and processes involved in drug discovery and development. A Medicinal Chemistry Practical Manual is a resource designed for students or professionals to apply theoretical knowledge in laboratory settings. It typically includes experimental procedures, synthesis techniques, and characterization methods for studying medicinal compounds.
Pharmaceutical Jurisprudence
Pharmaceutical jurisprudence is the cornerstone of ethical and lawful practice in pharmacy. This book, titled The Legal Compass for Pharmacists: Understanding Pharmaceutical Jurisprudence, serves as an essential guide for pharmacists, students, and professionals in the pharmaceutical field to understand the legal framework and ethical guidelines governing their profession. The book offers a comprehensive exploration of pharmaceutical laws, regulatory policies, and ethical principles that pharmacists must adhere to in their practice.
Beyond Results
Your Guide to Understanding Pregnancy Blood Chemistry for Better Maternity OutcomesAs a practitioner, you understand the importance of ensuring the best outcomes for your clients. However, traditional maternity care often overlooks in-depth education on lab analysis, leaving practitioners ill-equipped. Beyond Results: The Practitioner's Guide to Functional Lab Analysis in Pregnancy decodes critical nutritional and functional lab patterns often missed in traditional maternity care. This practical guide draws from current and emerging research to give practitioners the skills to feel confident in their understanding of maternal physiology and its effects on blood chemistry. Inside these pages, you'll learn how to...Identify underlying nutritional deficiencies and functional etiologies of common lab patterns.Implement evidence-based treatment protocols based on diet and lifestyle modifications.Utilize comprehensive insights from blood work to make informed clinical decisions and improve patient care.Differentiate your practice by offering advanced functional medicine approaches that address the root causes of maternity health issues.Improve your clinical outcomes throughout all stages of your patients' childbearing years.From understanding the effects of maternal physiology on reference ranges to developing treatment plans centered on diet and lifestyle, this book will help you transform your practice and bridge the gap between conventional and functional medicine in patient care.
Novel Drug Delivery Systems (Part 2)
Novel Drug Delivery Systems (Part 2) covers the advanced techniques and innovations transforming pharmaceutical sciences, with a focus on enhancing drug efficacy and patient outcomes. This comprehensive guide explores a wide array of delivery methods, including nasopulmonary, transdermal, ocular, nanotechnology-based, implantable, and controlled-release injectables. Each chapter provides an in-depth analysis of these unique delivery routes, presenting both foundational knowledge and the latest technological advancements in the field. Designed for students, researchers, and professionals in pharmaceuticals and medicine, this book bridges basic concepts with cutting-edge practices, emphasizing the science and impact of controlled drug delivery. Key Features: - Detailed exploration of nasopulmonary, transdermal, ocular, and implantable delivery systems- Insight into nanotechnology's role in drug delivery- Comprehensive coverage of controlled-release injectables
Novel Drug Delivery Systems (Part 1)
Novel Drug Delivery Systems - Part 1 provides a comprehensive exploration of controlled drug delivery systems (NDDS) and their impact on patient outcomes and therapeutic effectiveness. Covering key topics like the principles of controlled-release dosage forms, the role of polymers, and innovative techniques like microencapsulation and mucoadhesive systems, this book bridges foundational concepts with cutting-edge advancements. It also addresses specialized systems like gastroretentive, transdermal, and ocular drug delivery methods. Ideal for pharmaceutical professionals, students, and researchers, this book serves as a critical resource for understanding and developing advanced drug delivery technologies.Key Features: - Comprehensive introduction to controlled drug delivery concepts - In-depth analysis of pharmacokinetics and polymers in NDDS - Exploration of microencapsulation and mucoadhesive systems - Insights into gastroretentive and transdermal drug delivery - Overview of nanotechnology and implantable devices in drug delivery - Coverage of the latest developments in injectables and ocular systems
Handbook of Pharmaceutical Chemistry
Pharmaceutical chemistry is a branch of chemistry that deals with the design, synthesis, and development of pharmaceutical agents, including drugs and their formulations. Books on pharmaceutical chemistry often cover topics related to medicinal chemistry, drug discovery, chemical analysis of pharmaceuticals, and the principles behind the development of safe and effective drugs. These books serve as vital resources for students, researchers, and professionals in the pharmaceutical industry.
Acupuncture and Osteopathy to Treat Musculoskeletal Pain of the Extremities
Treat musculoskeletal pain more quickly and effectively with acupuncture and osteopathic treatment! Handbook of Acupuncture and Osteopathic Techniques in the Treatment of Musculoskeletal Pain: The Mazzanti AcuOsteo Method(R) details the treatment of musculoskeletal pain using a new combined approach that integrates two branches of medical science: acupuncture and osteopathy. Written by Umberto Mazzanti, an expert in acupuncture, osteopathy, physiotherapy, rehabilitation, and sports medicine, along with co-authors who are experts in acupuncture, this text approaches diagnostics and therapy by integrating Western, Traditional Chinese, and Osteopathic Medicine, offering acupuncture and osteopathic practitioners and students, along with medical doctors, a triple perspective on pain management. Comprehensive coverage teaches how a correct diagnosis of the cause of the pain is made and how to choose the right treatment, whether it be acupuncture, osteopathy, or a combination of both. Western medicine concepts and red flags to manage emergency conditions are included. An enhanced ebook, included with print purchase, offers video demonstrations of the procedures described in the text.Clear instructions explain how to use the fundamental methods of acupuncture techniques and osteopathic maneuvers to treat musculoskeletal painStep-by-step videos in the enhanced ebook, included with print purchase, demonstrate how acupuncture and osteopathy can be combined for effective treatment of musculoskeletal pain of the extremitiesWritten by an expert in acupuncture, osteopathy, physiotherapy, rehabilitation, and sports medicine, along with co-authors who are experts in acupunctureCoverage of Western medicine concepts and red flags prepares you to manage emergency conditionsAn enhanced ebook, included with print purchase, provides access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud
50 Pharmacotherapy Studies Every Palliative Practitioner Should Know
50 Phamarcotherapy Studies Every Palliative Practitioner Should Know is a compilation of key pharmacotherapy studies that form the foundation of evidence-based practice. The studies cover topics including: agitation and delirium, fatigue, nausea and vomiting, pain, anorexia and cachexia, ALS, seizure, dyspnea, anxiety, pruritis, symptom clusters, COPD, cancer, and more. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. Brief information on other relevant studies is provided, and an illustrative clinical case offers readers the opportunity to conceptualize findings. As with all books in the "50 Studies" series, each study was selected using an objective selection criterion that included citations per year, high levels of evidence, clinical studies and trials, and a 3-stage Delphi review by international experts in the field. This book is a must-read for palliative practitioners, pharmacists, advance practice nurses, and physician assistants, and anyone who wants to learn more about the data behind clinical practice.
To Command Is to Serve
First-line Manager is the most important position in a Pharmaceutical Organization. They play an essential role. They form the backbone of pharmaceutical industry. Today the role of a first-line manager has changed in view of the changed environment. They must possess leadership qualities. They not only control, appraise and analyze, they also encourage, improve and inspire medical representatives. But how do you become a successful Pharma First-Line Leader? To Command Is To Serve provides the answer. It gives you a complete framework for becoming a successful Pharma First-Line Leader.Among the significant features of this book are: Leadership skills of a Pharma first-line leader Supervision and Managerial functions of a first-line leader Joint Field WorkAccording to John Adair, 'If communication is sister to leadership, then motivation is brother.' This book will help you: To understand what motivates medical representatives and To improve your communication skillsIf you are a first-line leader or want to lead a team of medical representatives, this book is for you.
Development and Assessment of an Emulgel with Melissa Officinalis Oil
Lemon balm (Melissa officinalis) is an aromatic herb from the mint family (Lamiaceae), known for its lemon-scented leaves. Essential oils derived from lemon balm contain plant compounds called terpenes, which contribute to the herb's relaxing and antimicrobial effects. Lemon balm also contains tannins, which may be responsible for many of its antimicrobial properties. Pre-formulation studies on lemon balm oil revealed that it is a pale-yellow volatile liquid with a lemon-like odor. Preliminary phytochemical screening has identified the presence of phenols, flavonoids, aldehydes, and volatile oils. An emulgel was prepared by incorporating an oil-in-water (O/W) emulsion into a gelling agent. The prepared emulgel was evaluated based on various parameters, including physical appearance, homogeneity, grittiness, and in-vitro antimicrobial activity. Based on the results, a Melissa officinalis oil emulgel was formulated. The prepared formulations exhibited prolonged release, which can reduce the frequency of administration. Additionally, the emulgel demonstrated antimicrobial activity.
Herbal Medicine for Rare Diseases
Many rare diseases are genetic and lack effective cures. Herbal medicine, developed by ancient healers without the benefit of modern cell biology knowledge, focuses on alleviating symptoms associated with uncommon conditions. Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations adopts an herbal medicine approach to addressing signs and symptoms of rare diseases.Each herb possesses a multitude of compounds that allow it to treat various conditions, while a single condition can often be addressed by several different herbs, illustrating complex relationships that artificial intelligence (AI) excels at deciphering. The herbal prescriptions in this book are generated using AI models, trained on a decade's worth of medical insurance data from Taiwan, featuring the use of Good Manufacturing Practice (GMP)-certified traditional Chinese medicine (TCM) products. The connection between deep learning and big data ensures that the trained AI model represents the collective wisdom of 5,000 herbal medical doctors in Taiwan who contributed to the training data.Features Prescribes granulated herbal products sourced from GMP-certified manufacturers to ensure quality and safety Provides precise dosage information for the GMP herbal products in every prescription Includes a wealth of common and alternative herbal prescriptions tailored for specific conditions or combinations thereof Cites evidence from preclinical and clinical studies of the herb and formula to offer insights into their efficacy and mechanisms In each section Herbal Medicine for Rare Diseases: Alleviating Symptoms by GMP Herbal Formulations, AI-generated prescriptions are meticulously annotated with evidence from modern pharmacological and phytochemical studies of the herbs and multi-herb formulas included in the prescriptions. This book is beneficial for health professionals and practitioners, particularly those who specialise in complementary, alternative, and herbal medicine.
Study of Refractory COD Removal from Pharmaceutical Wastewater
This study investigates the treatment of pharmaceutical wastewater containing recalcitrant, non-biodegradable compounds that are inadequately addressed by conventional treatment methods. The objectives include improving wastewater biodegradability and comparing the efficacy of various advanced treatment approaches. Untreated wastewater samples were collected from a pharmaceutical intermediate manufacturing unit. Initial characterization, including pH measurement and acute toxicity assessment, was conducted. Primary treatment involved neutralization, coagulation, flocculation, and settling. Advanced oxidation processes (AOPs) such as H₂O₂, TiO₂/H₂O₂, Fe簡⁺/H₂O₂ (Fenton), HCO₃⁻, and Fe簡⁺/H₂O₂/O₃ (Fentozone) were applied.Post-treatment analyses revealed varied improvements in biodegradability (BOD/COD ratio). The Fentozone process emerged as the most effective, achieving a BOD/COD improvement of 0.43 after 60 minutes. Comparative results showed moderate improvements with TiO₂/H₂O₂ (0.32) and Fe簡⁺/H₂O₂ (0.30), while H₂O₂ alone achieved a marginal improvement of 0.26. No improvement was observed with HCO₃⁻treatment.In conclusion, the Fentozone process proves to be a promising technology.
Synthetic Organic Chemistry and the Nobel Prize, Volume 3
The Nobel Prize is the highest award in science, as is the case with nonscience fields too, and it is, therefore, arguably the most internationally recognized award in the world. This unique set of volumes focuses on summarizing the Nobel Prize within organic chemistry, as well as the specializations within this specialty. Any reader researching the history of the field of organic chemistry will be interested in this work. Furthermore, it serves as an outstanding resource for providing a better understanding of the circumstances that led to these amazing discoveries and what has happened as a result, in the years since.
Method Development and Validation for Voriconazole Estimation
A rapid, sensitive, and specific RP-HPLC method with UV detection was developed and validated for the determination of voriconazole. Chromatography was performed on an Enable C18 G column (250 ? 4.6 mm) in isocratic mode, using a mobile phase of methanol and acetonitrile (60:40, v/v). The flow rate was set at 1 mL/min, and the effluent was monitored at 223 nm. Chromatographic analysis revealed a main peak for voriconazole at a retention time of 2.841 minutes. Methanol was selected as the solvent for the analysis, with the λmax determined to be 223 nm. The method exhibited linearity over a concentration range of 5-30 繕g/mL. Validation parameters, including linearity, range, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ), were assessed and met the required standards.
Salbutamol Drug Delivery by Core in Cup Device
Core and cup tablet of Salbutamol sulphate for chronotherapeutic delivery was prepared to increase the effectiveness of drug by using optimization technique.The formulation contains three components a core tablet, impermeable layer and soluble hydrophilic polymer layer. The core tablet contains salbutamol sulphate drug and other excipients, impermeable layer is made up of Ethyl cellulose (EC), and the polymer layer is made of HPMC 15cps and HPMC 50cps. In this work the key ingredients like HPMC 15cps and HPMC 50cps were optimized by using 32 Factorial designing in this various proportions of HPMC 15cps and HPMC 50cps (polymers) were used in different levels in the preparation of core in cup tablet.
Development of Clotrimazole Emulgel
Clotrimazole is an imidazole derivative with a broad spectrum of anti-mycotic activity. The Present investigation is the design and characterization of Novel Emulgel of Clotrimazole. Nine different formulations of Emulgel were prepared by the proposed method of preparation by Mohammad et.al (2004), varying with different 2 different polymers of gelling agent such as Carbopol 934 and HPMC K15 M and their combinations in different ratios. All the Formulations were characterized for physical evaluation, drug content, Viscosity, spreadability, extrudability, and In-vitro Drug release studies. Stability studies were revealed with marginal differenceswith a good stability. Also this study refers to the kinetic data of the drug release studies.
Anti-Retroviral Therapy (ART) in HIV/AIDS patients
It was found that patients receiving ZLN show significant increase in levels of Triglycerides, Indirect Bilirubin serum creatinine and shows slight increase in levels of Total Bilirubin, and SGPT and show significant decrease in HB levels. Patients receiving TLE drug combination shows significant increase in levels of SGPT, Indirect Bilirubin, serum creatinine and shows slight increase in levels of Total cholesterol, CD4 count and slight decrease in levels of RBC, VLDL. So, the systems that were mostly affected due to ART therapy were found to be hepatic and renal systems along with significant alterations in the lipid profile. In order to slow down the deterioration process, drug use must be optimized along with the periodic monitoring of the systems.
Clinical Pharmacy Practice
This book equips students with foundational knowledge and practical skills necessary for pharmacy practice, focusing on delivering pharmaceutical care in clinical settings. Upon completion, students are expected to understand and provide comprehensive patient care, interpret laboratory results to support clinical diagnoses, and offer well-analyzed medicine and poison information to healthcare professionals for effective patient management.
Fundamentals of Gastroretentive Drug Delivery Systems
This book provides basic concepts related to gastroretentive drug delivery systems This book covers the aspects of anatomy & physiology of the GIT, approaches for gastric retention. This book also emphasizes on formulation aspects with detailed information and the evaluation aspects including the in vitro and in vivo parameters, applications and the research work done on gastroretentive systems This book will serve for under graduate students.
Biological Activities and Potential Applications of Phytotoxins
This reprint focuses on the isolation and characterization of some phytotoxins and the evaluation of their biological activities for potential application in different fields. Plants and microbes are able to produce several specialized (secondary) metabolites belonging to different classes of natural compounds. Among them, phytotoxins are substances that are poisonous or toxic to plants. They seem to play an important role in plant-pathogen interactions when produced by phytopathogenic fungi or bacteria, while plant-produced phytotoxins-including allelochemicals-seem to be involved in plant-plant interactions. Thus, the determination of their chemical structure and their identification are fundamental for chemical ecology and for understanding their function. However, most of these compounds have already shown other interesting biological activities and potential applications in fields such as agriculture or medicine. In fact, some phytotoxins have already been proposed for the development of biopesticides, cosmetics, and drugs.
Gastroretentive Floating Drug Delivery System of Zaleplon Tablets
Floating Drug Delivery Systems are retained in the stomach for a longer time and assist in improving the oral controlled delivery of drugs that have an absorption window in the particular region of the GI tract as well as for controlling the release of the drug having site-specific absorption limitationZaleplon is a highly effective sedative-hypnotic that was used as a model drug to develop a controlled-release formulation. Zaleplon exhibits pH-dependent solubility. It is more soluble in acidic pH and slightly soluble in neutral or alkaline conditions (intestinal environment). Hence an attempt was made to develop a gastroretentive delivery system Zaleplon which increased the bioavailability of Zaleplon and also reduced the frequency of administration, thereby improving patient compliance and therapeutic efficacy.
Scorpion Venom
This book provides a comprehensive overview of scorpion biology and the medical implications of their venoms. It presents the taxonomic classification, anatomy, morphology, and natural habitats of scorpions, detailing their reproductive processes. It further explores the chemical nature of scorpion venom, discussing its composition, toxicity, and physiological effects, as well as its varied functions and mechanisms of action on ion channels. The chapter also focuses on scorpionism, presenting comprehensive epidemiological data and clinical insights from across the globe and reviewing the origin, evolution, and intricate composition of scorpion venom, framing its functional complexity and evolutionary significance. The book also covers the preventative measures and current treatment strategies for scorpion envenomation. It also addresses the limitations of existing antivenom therapies and examines innovative approaches, including the use of pharmaceuticals to enhance treatment protocols. The final chapter provides the promising biomedical applications of scorpion venom toxins across various medical fields. It discusses the therapeutic potential of these toxins in treating a range of human diseases, from cancer and cardiovascular diseases to autoimmune disorders and diabetes. This book is intended for researchers, clinicians, and students of toxicology, pharmacology, and arachnology.
Orally Disintegrating Tablets of Amlodipine Besylate
In the present study, orally disintegrating tablets (ODTs) of amlodipine besylate was prepared by using two types of natural super disintegrants in different ratios by direct compression method. The basic approach followed in this study was to achieve rapid disintegration. The evaluation of ODTs of amlodipine was performed for general appearance, physical parameters such as hardness, friability, wetting time, weight variation, uniformity of drug content, in vitro disintegration, in vitro dissolution studies. The above-mentioned tests were performed using the official procedures and with modified testing procedures collected from various research articles. Further the ODT formulations were subjected to further evaluation testing.
